Gene MLK3 (Human)

MLK3

Species: Human
Alias: PTK1, MGC17114, MLK3, MLK-3, MAP3K11, SPRK
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 11q12-q13.3,

Classification

Group: TKL
Family: MLK
Subfamily: MLK

Sequence

Name Sequence Type Origin Length Description Download
MLK3.NA RNA Sugen Kinome 3574 None Fasta, JSON
MLK3.AA Protein Sugen Kinome 847 None Fasta, JSON
MLK3.kin_dom Protein Kinase Domain Sugen Kinome 260 None Fasta, JSON

Protein domain

Protein domains of MLK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 MLK3.AA SH3 44-104 44 1.8e-21 78.55 SMART 1-58 (58) Show / Hide 
Range on Protein: 44-104
Range on HMM: 1-58/58
Sequence Identity: 44% (28 aa)

PVWTALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVG--GQVGIFPSNYVSRGG
|.  ||.||.... ||| ..||| ..||..|     |.||| |...  ||.|.|||||| .  
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-----DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 MLK3.AA SH3_1 47-97 37 1.6e-15 55.37 Pfam 1-49 (49) Show / Hide 
Range on Protein: 47-97
Range on HMM: 1-49/49
Sequence Identity: 37% (20 aa)

TALFDYEPSGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVG--GQVGIFPS
.||.||.... ||| ..||| ..|.... .     .|| |..   ||.|.|||
VALYDYQAQQPDELSFKKGDIIHVIEKSDD----WDWWKGRCNNTGQEGWFPS
SH3_2 MLK3.AA SH3_2 45-103 26 3.3e-12 45.63 Pfam 1-68 (68) Show / Hide 
Range on Protein: 45-103
Range on HMM: 1-68/68
Sequence Identity: 26% (19 aa)

VWTALFDYEP-SGQDE-----LALRKGDRVEVL---SRDAAISGDEGWWAG-QV--GGQV--GIFPSNYVSRG
.  ...||.| .. .|     | ..||| ..|.   ..|.      .|| .  .  ||..  | |||..|.  
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWD-----NWWWCWETIWGGRRMRGWFPSQWVEEC
Kinase MLK3.AA MLK 117-376 72 2.6e-202 674.81 In-house 1-280 (280) Show / Hide 
Range on Protein: 117-376
Range on HMM: 1-280/280
Sequence Identity: 72% (202 aa)

LRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVT---AESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPH
|...|.||.||||||||..|.||.|||||.||||..|...|   ||.||||||||.||.|||||||..||||.|.|||||||..||.|.|..||.|.|||
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGKRIPPH

VLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIE-----------------SDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKA
|||||||||||||.|||.||.||.|||||||.|||.|..|.                 ..||..|.||||||||||||||||.||||||||||||||||.
VLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKICLCMDEEMFQYAYCLKCGHHDMCNKQLKITDFGLAREWHKTTRMSAAGTYAWMAPEVIKE

STFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQL
||.||||||||.||||||||||||||||||.||||||||.||||||||||||||.|.||.|||.||||.||.|..|||||
STWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL
Kinase MLK3.AA MLK 117-376 47 6.2e-160 537.61 In-house 1-291 (291) Show / Hide 
Range on Protein: 117-376
Range on HMM: 1-291/291
Sequence Identity: 47% (140 aa)

LRLEEVIGIGGFGKVYRGSWRGEL-----VAVKAARQDPDEDISVT---AESVRQEARLFAMLAHPN----IIALKAVCLEEPN-LCLVMEYAAGGPLSR
....|.|| |.||||..| ||...     ||||..|.... |.|.|   .. ...|.|....| |||    ||....|||..|. .|.||||..||.|..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ALAGRR---------------VPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKT-T-QMSAAGTY
 |.|.|               .......|||.|.||||||||..| .|.||||||| |||... |.. ||.|.||||.|||..|.||.. |  ||.||||
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-ICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAGTY

AWMAPEVI---KASTFSKGSDVWSFGVLLWELLTGEVPYR-GIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQL
||||||||   .....|. .||||.||.|||.||.||||. ..|..|.|..||.|.|..||||||||....|| .|| ||||.||.|..|.|.|
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLK3.AA TKL 123-376 29 1.7e-104 353.45 In-house 1-364 (364) Show / Hide 
Range on Protein: 123-376
Range on HMM: 1-364/364
Sequence Identity: 29% (108 aa)

IGIGGFGKVYRGSWRG----------ELVAVKAARQDP-----------------------DEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPN-
|| ||||.||.| |||          . ||||  ...                        |...|   .  ..|...  .| ||||. ....|...|. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LCLVMEYAAGGP-LSRALAGRRVPPHVLVNWAVQIARGMHYLHCEAL-----VPVIHRDLKSNNILLLQPIE--SDDM-----EHKTL
            ||.||||. ||  |.. .      .|....|| .|||||.||| .        |.|||||||.|||. .  .  | ..     .. ..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYMYNPNADWCC

KITDFGLAREWHKT---------------------TQMSAAGTYAWMAPEVIKAS----------------TFSKGSDVWSFGVLLWELLTGEVPYRGID
||.||||.|.....                     | |.  ||..||||||.. .                ..|. .||.|||..|||.||...||....
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

CLAVA---------YGVAVNKLTLPIP------------STCPEPFAQLMADCWAQDPHRRPDFASILQQL
.  .          ..|....| .|||            ..||.....|| |||..||. || |  ||..|
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLK3.AA LZK 121-376 45 9.1e-84 282.31 In-house 5-241 (241) Show / Hide 
Range on Protein: 121-376
Range on HMM: 5-241/241
Sequence Identity: 45% (117 aa)

EVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRAL-AGRRVPPHVLVNWA
. .| |  | |.|| .|.| ||||  |.    ||           .    | |||||..| ||   |  | .||| . |.|   | ..| ..|. .|.| 
QWLGSGAQGAVFRGWFRNETVAVKKVRDLKETDI-----------KHLRKLKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEVLRERRTITPQLMVDWS

VQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKT--TQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLT
 ||| ||||||      .||||||| |||    |  .|.    .|| |||  ..| .   |.|| .|| ||||||||.    |   |.||||| |||.||
KQIAQGMHYLHQHK---IIHRDLKSPNIL----ISHNDV----VKICDFGTSHMWNEMDSTKMSFCGTVAWMAPEVIRNEPCSEKVDIWSFGVVLWEMLT

GEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQL
.|.||. .|  |. .||  | | ||.|||||| |  ||  || | |  || |  ||. .
CEIPYKDVDSMAIIWGVGSNSLHLPMPSTCPEGFKLLMKQCWSQKPRNRPSFRQILMHW
Kinase MLK3.AA TyrKc 117-376 32 2.2e-83 284.26 SMART 1-280 (280) Show / Hide 
Range on Protein: 117-376
Range on HMM: 1-280/280
Sequence Identity: 32% (96 aa)

LRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAML--AHPNIIALKAVCLEE-------PNLCLVMEYAAGGPLSRALAG
..|....| | ||.||.| |. . ||||  . |         |  ..|||.  .|   ||||..| .||...       . |..||||...| |   |  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RR--VPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKT--------TQM-----SAA--GTYAWMA
.|  ...  |.....|||.|| |||     ..|||||   |.|.  .         | ||.||||.|...          . .     ..     . |||
HRPKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEVIKASTFSKGSDVWSFGVLLWELLT-GEVPYRG-----IDCLAVAYGVAVNKLTLPIPS-------TCPEPFAQLMADCWAQDPHRRPDFASILQQL
||.|. ..|.  ||||||||..||..| |. || |     ..   |   |   .   . |.       .||.   |.| .||. ||. || |. | ...
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLK3.AA Pkinase 117-376 27 1.7e-80 278.5 Pfam 1-293 (293) Show / Hide 
Range on Protein: 117-376
Range on HMM: 1-293/293
Sequence Identity: 27% (82 aa)

LRLEEVIGIGGFGKVYRGSWRGE--LVAVKAARQDPDEDISVTAESVR-QEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGG----PLSRALA---
......|| |.||.||.. ..|.  .||||  . . .|. ..  . .| .|... ..| ||||. |. .. .......||||. ||     |.. .    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

GRRV--PPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAR---EWHKTTQMSAAGTYAWMAPEVIK-ASTFS
....  ..... ... ||.||. |.| .    .||||||. |||. .  . |.    ..||.|||||.   . ...  .. .||. .||||||. ..  .
HGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDA----CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

KGSDVWSFGVLLWELLTGEVPYRGI------DCLAVAYGVAVNKLTLPIPSTCP-------------------EPFAQLMADCWAQDPHRRPDFASILQQ
. .|.||.|..|.|.|.|. |..|       | ... . .   .|  ..| .|.                   |.. ... .|...||..|| .. ||| 
PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--L
  .
PWF
Kinase MLK3.AA Pkinase_Tyr 117-376 33 2.8e-72 245.43 Pfam 1-270 (270) Show / Hide 
Range on Protein: 117-376
Range on HMM: 1-270/270
Sequence Identity: 33% (95 aa)

LRLEEVIGIGGFGKVYRGSWR------GELVAVKAARQDPDED-ISVTAESVRQEARLFAML-AHPNIIALKAVCL-EEPN--LCLVMEYAAGGPLSRAL
... ...| | ||.||.| |.      .  ||||  ... ...      |.  .||..   |  ||||. | .||. ..    ...||||...| |   |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN--CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

AGR-----RVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQM-SAAG----TYAWMAPEVIK
  .     ..... |.....|||.|| ||.     . |||||   |.|.           .. ||.||||||  ... .   ..|       |||||.|.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLE---SKNCIHRDLAARNCLVTE--------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECIN

ASTFSKGSDVWSFGVLLWELLT-GEVP-YRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQL
 . |.  |||||||||.||..| || | | |..   |   .. .   .|.|  ||..  .|| .||..|| .|| |. |..||
YGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLK3.AA Dicty4 117-378 33 3.4e-69 229.97 In-house 1-277 (277) Show / Hide 
Range on Protein: 117-378
Range on HMM: 1-277/277
Sequence Identity: 33% (96 aa)

LRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCL----EEPNLCLVMEYAAGGPLSRALAG-----
.  |. || |.||.||.|.|||  |||| .  . . . . . .. |.|. . . . ||||. ..  |.    . . .| |.||   | | . |       
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-RRVPPH-VLVNW----AVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAR----EWHKTT-QMSAAGTYAWMAPEVIKA
  ....   |.      |  .|||| .|||   . .||||||| |.|          .... |..||||..    .  ... ||.|.|| .||||||   
QQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLV--------DKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMH

STFSKGSDVWSFGVLLWELLTGEVPYR--GIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQ--LEA
  .   .|| ||| .|||.||.. ||   ...   .. .|.  || .|||. || ....|...||  || .|| |. |.|.  ||.
QPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLK3.AA S_TKc 117-379 27 2e-66 227.88 SMART 1-231 (231) Show / Hide 
Range on Protein: 117-379
Range on HMM: 1-231/231
Sequence Identity: 27% (76 aa)

LRLEEVIGIGGFGKVYRGSWRG--ELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAG--GPLSRALAGRR---
 .. ..|| |.|||||.. ...  ..||.|  .           |..|.| ..  .  ||||. |. |. .  .|..||||. |  | | . .  |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----VPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFSK-GSD
     |. .   .. ||.... |.|      .||||||  |||| .          ..||.||||||.      ..  ||  .|||||.    ..|  .|
LRFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE----------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCD

VWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQ------QLEAL
.||.|..|.|.|.|. |..    ... . . .           .... ...  |.  || .||    .||      . . .
WWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLK3.AA TKL-Unique 119-376 33 4.1e-65 222.64 In-house 1-290 (290) Show / Hide 
Range on Protein: 119-376
Range on HMM: 1-290/290
Sequence Identity: 33% (99 aa)

LEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAES-VRQEARLFAMLA-HPNIIALKAVCL----EEPNLCLVMEYAAGGPLSRALA------
  ..|| ||.|.||.| |||. ||.|       ||.| . .   . | ..  .|  ||||  . ..|      .||.|.||||  || |   |.      
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

-----GRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAA-----------GTYAWMA
         .. . |. | .||.||.||| .    .||||||| |.|. .   .  .     || ||||..   | ..|..            |.. |||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWN---IKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMA

PEVIKA--STFSKGSDVWSFGVLLWELLTGEV------PYRGIDCLAVAYGVAV--NKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQL
|||..   ...|. |||.|||. |||..|...      ||.|.|  ...  |..   .. .|||. ||. .  |. .||..||  || | .|.  |
PEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLK3.AA TK 117-376 19 6.1e-65 216.37 In-house 1-486 (486) Show / Hide 
Range on Protein: 117-376
Range on HMM: 1-486/486
Sequence Identity: 19% (97 aa)

LRLEEVIGIGGFG---KVYRGSWRG---------------------------ELVAVKAARQDPDEDISVTAE-------------SVRQEARLFA--ML
..|....| | ||   .||.| |||                           . ||||  . . ...     .             .  .|. ..   ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

AHPNIIALKAVCLEE------------PNLCLVMEYAAGGP----LSRALAGRR----------------------------------------------
 ||||. | .||...            . ...||||...|     |   |  .|                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VPPHVLVNWAVQIARGMHYLHCEALV----PVIHRDLKSNNILLLQPIESDDMEHK--------TLKIT
                               ...| |. ...|||.|| ||| .  .     ..||||   |.|.     ....  |        . ||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH-SKNCEFIQNFVHRDLAARNCLV-----GENNVCKWHFDGCGPVCKIA

DFG--------LAREWHKTTQMSAAGTYA----------------------------WMAPEVIK---------ASTFSKGSDVWSFGVLLWELLT-GEV
|||        |||. .. .   ....|                             |||||...           .|.  |||||||||.||..| |..
DFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQE

PYR-----------GIDCLAVAYGVAVN-------------KLTLPIPSTCP--------------EPFAQLMADCWAQDPHRRPDFASILQQL
||            | |.  |   .                .. .| |  ||              | ...|| .||. || .||.|. ...||
PYYGGMSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLK3.AA DRK 117-378 35 3.3e-63 212.9 In-house 1-258 (258) Show / Hide 
Range on Protein: 117-378
Range on HMM: 1-258/258
Sequence Identity: 35% (95 aa)

LRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPH--V
      || |..| |.||.|||  |||| .  .  .|     |  ..|. |   | ||||.     |.. |  | .|||   | | . |    .      
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNE-FHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPL

LVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAR----EWHKTTQMSAAGTYAWMAPEVIKASTFSKGSDVWSFGV
.   .  .|.|| ||||   . .||||||| | |       |  ||   |. ||||.        ... | . ||  | ||||     .    ||.||..
MKQMMFDCAKGMIYLHCCNPI-IIHRDLKSHNLLV------D--EHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAI

LLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWAQDPHRRPDFASILQQLEA
 |||..| . || |.  . |   |   .. .|.|  || ...||| |||  ||  || .  .|. |||
VLWECVTRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase MLK3.AA ZAK 164-375 38 6.9e-63 215.23 In-house 41-257 (257) Show / Hide 
Range on Protein: 164-375
Range on HMM: 41-257/257
Sequence Identity: 38% (88 aa)

EARLFAMLAHPNIIALKAVCLEEPN-LCLVMEYAAGGPL--------SRALA----GRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLL
||     . | |||    .|.| ||    | |||  | |        |  ..    |      . . || |||.|||||| .| . .||||||| |. . 
EAEILSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSLYDYIHSNRSQEMDSSSGGNSM--DHIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVVI-

QPIESDDMEHKTLKITDFGLAR-EWHKTTQMSAAGTYAWMAPEVI-KASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCP
            .|| |||  |   | .| ||  || .|||||.|      .   ||||.|| |||.|| ||||.. . . ..  .     .| ||. ||
-------DKNGVCKICDFGTSRDFHHHCTHMSWVGTFPWMAPEMILQSEPVTETCDVWSYGVVLWEMLTREVPYKDYEEFQIFWMIVQKNIRLTIPPSCP

EPFAQLMADCWAQDPHRRPDFASILQQ
 ||.||| .||  ||  || .  |   
RPFKQLMHQCWKMDPKDRPNMRQIQSI
Kinase MLK3.AA UTK 117-376 30 8.5e-62 210.18 In-house 1-296 (296) Show / Hide 
Range on Protein: 117-376
Range on HMM: 1-296/296
Sequence Identity: 30% (94 aa)

LRLEEVIGIGGFGKVYRGSWR------GE-LVAVKAARQDPDEDISVTAE---SVRQEAR---LFAMLA-HPNIIALKAVCLEEPNLCLVMEYAAGGPLS
..| . .| | || |......      .| .||||...  ...|   . |    .. |||   . .... |||.. | .||. |  ...|.||...| |.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ--HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

RALA-GRR--------VPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEH------KTLKITDFG---LAREWH---------
  |   |.        .  | .. .|..|||||.|||.     ..||||   |.|.       .| .       . || |||   ..|. .         
SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCG---FVHRDLAARNCLV-------HMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYW

----KTTQMSAAGTYAWMAPEVIKAS-TFSKGSDVWSFGVLLWELLT-GEVPYRGIDCLAVAYGVAVNK-LTLPIPSTCPEPFAQLMADCWAQDPHRRPD
     . |   . . .|||||..    .|.  ||||||||..||..| | .|| |.   .|.  |     . .| |  ||.|  .|| .||..|| .|||
ESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPD

FASILQQL
|  ..||.
FEDLVQQM
Kinase MLK3.AA ZAK 117-136 40 0.00031 11.17 In-house 1-20 (257) Show / Hide 
Range on Protein: 117-136
Range on HMM: 1-20/257
Sequence Identity: 40% (8 aa)

LRLEEVIGIGGFGKVYRGSW
. . . .| | || |||. |
IQFFDHCGVGTFGSVYRANW