Gene MNK2 (Human)
MNK2
Sequence
Protein domains of MNK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | MNK2.AA | MNK | 84-368 | 75 | 2.9e-235 | 787.87 | In-house | 1-292 (292) | Show / Hide |
Range on Protein: 84-368 Range on HMM: 1-292/292 Sequence Identity: 75% (220 aa) QLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQ-PGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEA .|....|||||.|.||||.|.....|||||||.|| |||.|.|||||||..|.||||||.|.|||.||..|||||||||||||..|.||..|.||.| || KLTDEHLGEGAYASVQTCVNIQSGKEYAVKIIDKQGPGHSRKRVFREVETFYHCQGHRNILQLIEWFEDDDRFYLVFEKMRGGPLLQHIQQRKHFTEHEA SVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSG---IKLNGDC-SPISTPELLTPCGSAEYMAPEVVEAFS-EEASIYDKRCD |.|..|.||||||.|||||||||||||||||||||.|.|||||||||||| |.||.|| .||.||||||||||||.||||||.||. .||..|||||| SQVIKDIASALDFMHNKGIAHRDLKPENILCEHPNHVCPVKICDFDLGSGRPPIHLNHDCSQPITTPELLTPCGSAEFMAPEVVDAFVYDEAHYYDKRCD LWSLGVILYILLSGYPPFVGRCG-SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV ||||||||||.|.|||||||.|| .||||||||||..||||||..||||.||||.|.|.|||..||||||.||||||||||||||||.|||| LWSLGVILYIMLCGYPPFVGHCGDEDCGWDRGEACRDCQNMLFHCIQEGHYEFPEKEWHHISEEAKDLISNLLVRDAKQRLSAAQVLNHPWV |
|||||||||
| Kinase | MNK2.AA | MAPKAPK | 84-368 | 58 | 1.9e-217 | 680.47 | In-house | 1-292 (292) | Show / Hide |
Range on Protein: 84-368 Range on HMM: 1-292/292 Sequence Identity: 58% (170 aa) QLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEE----EDRFYLVFEKMRGGSILSHIHK--RRHF .|...|||||....|||| .. | |||||||.|.||||.|....||||....||||.|....|..||. ...||||.|.|.||....||.. ..|| KLWKEVLGEGIYGKVQTCVHKRTGQEYAVKILEDQPGHSRQKARREVELHWHCQGHPNIVQIIDWFENMYQFDKCFYLVMECMEGGELFQHIQQRGHKHF NELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDC-SPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRC .| ||| ...|..||.||||...|||||||||||||...|...|||.|||.....|.||.|| .||.||||.|||....|||||||.||. ||..|||.| TEREASQIMKDICSAVDFLHSMNIAHRDLKPENILCTDTNHNCPVKLCDFGFAKEIHLNHDCTTPITTPELMTPCYTPYYMAPEVVGAFK-EAHTYDKSC DLWSLGVILYILLSGYPPFVGRCG-SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV |.||||||.||.|.|||||...|| .||.|||||||..||||.|..||||.|||||..|.|||..|||||.|||.||..|||...||..|||. DMWSLGVIMYIMLCGYPPFYSNCGDEDCSWDRGEACRDCQNMMFHRIQEGQYEFPDEEWSHISEEAKDLIRKLLRRDPTQRLTIEQVMNHPWI |
|||||||||
| Kinase | MNK2.AA | CAMK | 89-368 | 26 | 8.20000000001e-113 | 364.97 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 89-368
Range on HMM: 1-425/425
Sequence Identity: 26% (114 aa)
VLGEGAHARVQTCINLITS------------QEYAVKIIEKQ----------------------------PGHIRSRVFREVEMLYQCQG------HRNV
.||.|. . | ||. | |..|.|||.|. .. | .|.||.|.. ..|| |.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
LELIEFFEE-------------------EDRFYLVF---EKMRGG----SILSHIHKR---------------RHFNELEASVVVQDVASALDFLHNKGI
. |.|..| ....|.|. | . || ....| .. ..|.| ||. ... ..||....|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI
AHRDLKPENILCEHPN--------------QVSPVKICDFDLGSGIKLNGDCS----------------PISTPELLTPCGSAEYMA-PEVVEAFS----
.||||||||||. . | .. ..||.|| . .. . .. |.... . |.||. |||| |||.. .
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM
-----EEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG-SDCGWDRGEACPA---CQNMLFESIQEGKYEFPDKD------------WAHISCA-----
|| |.. || ||.||||||.|.||||| | |. ..|. | | ... ||| |..|||.||.. | .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICE-D--E---WIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFV
---AKDLISKLLVRDAKQRLSAAQVLQHPWV
.||||.|.|..| ..|....|.|.|||.
SQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
|
|||||||||
| S_TKc | MNK2.AA | S_TKc | 83-368 | 31 | 4.4e-90 | 306.5 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 83-368 Range on HMM: 1-231/231 Sequence Identity: 31% (94 aa) YQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRG--GSILSHIHKRRH---- |.. . ..|.|| ..| |.. | ...|.||| .. ||...| . .| |. |...|.. |..|.|.| . | |. ...|.||.. YEILR-KIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --FNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDK |.| .| ... ...||...|..|| ||||||||||. . .||||| | . | ||. .||||||. |.| FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL--------GYGK -RCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQ-------HP .|| ||.|.|||..|.||||| ..|.|. | | |||.|.|.|..| ..|..| ..|| || CKCDWWSCGCILYEMLCGYPPFP-----------------QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHP WV |. WF |
|||||||||
| Kinase | MNK2.AA | RSK | 85-368 | 32 | 3.1e-79 | 269.53 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 85-368 Range on HMM: 1-278/278 Sequence Identity: 32% (97 aa) LQED-VLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSR----VFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRH--- |... .| |.. .. |.. | |.||.|...| | . ...|.. | ||.| .. .| . |..|. .||. | .||| . |. |..| LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC FNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQV-SPVKICDFDLGSGIKLNGDCSPIS-TPELLTPCGSAEYMAPEVVEAFSEEASIYDK | | ||... ...|...|| .|| |||||||||| .. . .|..||.. |.. ... . . |.|...||||||.. . .|| FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFC---KQF----RCDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHDK RCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLS-----AAQVLQHPWV ||.|||||..| .|.|.||| | .. . .. ... ||.||. .. . |. .| .|||||.|.| || ..||. |....|||| ACDWWSLGVLMYEMLTGCPPFQG-PND-----------NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
|||||||||
| Kinase | MNK2.AA | CAMK1 | 83-295 | 34 | 3.2e-74 | 215.12 | In-house | 1-216 (276) | Show / Hide |
Range on Protein: 83-295 Range on HMM: 1-216/276 Sequence Identity: 34% (77 aa) YQLQEDVLGEGAHARVQTCINLIT---SQEYAVKIIE-KQ--PGHIR---SRVFREVEMLYQCQ--GHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHI |... ...|.|| . | |.. | ..||.|.|. |. .. . .. .|.|.. .. | |. ..|..|... |||| | . || .. | YEFG-KEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI HKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVK--ICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEA .. ...| .|. ... ..||. ..| |||.||||||||.|.. . |..| |.|| | .. . . . |.||. .|.||||.| . . VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDEN-------LMKTACGTPGYVAPEVLECKK--D SIYDKRCDLWSLGVILYILLSGYPPF ||| ||.|| |||.|||| ||||| KPYDKACDMWSIGVITYILLCGYPPF |
|||||||||
| Pkinase | MNK2.AA | Pkinase | 83-368 | 29 | 8e-74 | 256.37 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 83-368 Range on HMM: 1-293/293 Sequence Identity: 29% (93 aa) YQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHI--RSRVFR--EVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGG----SILSHIH-- |.. . ..|.|. ..| |.. |....|||||.|. . . . .| |.... . .| |...|...||..|. |.|.| ..|| . ..|. YHIGR-KIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW KRRHF--NELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQV-SPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEA ... | | |. .. ....|...|..|| ||||||||||. . ... ..|||||| | .. . . . |.||. .||||||. .. RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIR----GG SIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHIS-----------------CAAKDLISKLLVRD . |....| ||.|.|||..|.|.||| |. . .. ..|. ... | .....|. | || ..||.|...| .| QYYGPKVDMWSCGCILYEMLCGRPPFPGH-------C-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKD AKQRLSAAQVLQHPWV |.|..|.|.|||||. PKKRPTAEQILQHPWF |
|||||||||
| Kinase | MNK2.AA | CAMKL | 83-368 | 28 | 7.2e-71 | 225.36 | In-house | 1-297 (297) | Show / Hide |
Range on Protein: 83-368 Range on HMM: 1-297/297 Sequence Identity: 28% (92 aa) YQLQEDVLGEGAHARVQTCIN-LITSQEYAVKIIEKQ----PGHIRSR-----------VFREVEMLYQCQ--GHRNVLELIEFFEEEDR------FYLV |.. . .||.|. . |. ... ..| ...|.|||.|. ..... ..||.. . . . .| |. | | .| .. .||| YRIGK-TLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV FEKMRGGS--ILSHIHKRRH----FNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPN-QVSPVKICDFDLGSGIK-LNGDCSPISTPE--LL | ||. . .| |..| . | || . . ||....|..||.|||.|||||| . . . .||.|| .. .. | .|. | MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPC------IFGPGQKLK TPCGSAEYMAPEVVEAFSEEASI-YD-KRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLIS | ||| .|||||... . || . | ||.||||| .. || || . . . . .. |.. | .| |..| | |.| ..|||. TFCGSPPYMAPEIFQG----NNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYN-K------QGKDNI-YLYWKIMCG-YYPP--IWYHVS-DCRDLIR KLLVRDAKQRLSAAQVLQHPWV |.|... ..| .. |...|||. KMLQVNPEKRPTIHQIMNHPWM |
|||||||||
| Kinase | MNK2.AA | MSK | 85-368 | 32 | 4.6e-68 | 229.18 | In-house | 1-277 (277) | Show / Hide |
Range on Protein: 85-368 Range on HMM: 1-277/277 Sequence Identity: 32% (95 aa) LQED-VLGEGAHARVQTCINLITSQEYAVKIIE----KQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNE | . .|.|. . | . | ..||.||. | . . .|. | ||.| |. .| . | .. .||| | .|| . || ||.|| | LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE LEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLW |..... . .|.|..| ||| |||||||||| . . .||. || . . ..... . . ||.. .|||||... .. . ||. ||.| SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGF-ARLFPQDEEWRMKS-----PCFTLHYMAPEMLRRGYAQDGGYDEACDWW SLGVILYILLSGYPPFV--GRCGS-DCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV ||||||| .|.| || .. .. | . . . |..|. || | .| .|||||..|| .| | ||.. ..| | SLGVILYTMLTGQVPFQQNEDDRQHSC---------NSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK |
|||||||||
| Kinase | MNK2.AA | Ciliate-E2 | 83-368 | 23 | 1.1e-65 | 224.5 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 83-368
Range on HMM: 1-365/365
Sequence Identity: 23% (92 aa)
YQLQEDVLGEGAHARVQTCINLIT-----------------------SQEYAVKIIEKQPGHIRSR---VFREVE----------MLYQCQGHRNVLELI
| ... ..|.|... | | . . ...||.||..|. . .. ..||.. .| | . | |.....
YKFIK-KIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLN-HPNIIKMY
EFFE--EEDRFYLVFEKMRGGSILSHIHKRRH-----------FNELEASVVVQDVAS---------------ALDFLHNKG-IAHRDLKPENILCEHPN
|.|. .. .|||.| ||. ...| .... |.| |.. . . ... || .||.|. | |||.||||||
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----
QVSPVKICDFDLGSGIKL-NGDCSPISTPELLTP-----------------------CGSAEYMAPEVVEAFSEE----ASIYDKRCDLWSLGVILYILL
.||.|| | .. | ... . .... ||...|||||... ... ||. ||.||||||||..|
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML
SGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDK--------------DWAHISCAAKDLISK----LLVRDAKQRLS-AAQVLQHPWV
.|.||| .. |...|..|| . .| ..| .||||.| .|..| ..|.. . |.|.|||
FGKPPF-----------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
|
|||||||||
| Kinase | MNK2.AA | CDPK | 84-298 | 34 | 1.7e-46 | 140.77 | In-house | 1-216 (271) | Show / Hide |
Range on Protein: 84-298 Range on HMM: 1-216/271 Sequence Identity: 34% (78 aa) QLQEDVLGEGAHARVQTCINL-ITSQEY-AVKIIEKQ--PGHIR-SRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFE--KMRGGSILSHIHKRRH . ..|||.|. | ... .|.|| |.|||.| . ..|.|.| | | | |.. . ||.. |. .|.|.| || . | ..| YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQL-DHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGH FNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVS----PVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIY |.| ||. ... . ||. |...| |||||||||| . . | ..|. |... . | . . . || |.|||| . | FTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQN-QKI--EDKKMSQRCGTPYYIAPEVLQK------KY DKRCDLWSLGVILYILLSGYPPFVGR .. ||.||.||||||||.||||| |. NEKCDIWSCGVILYILLCGYPPFYGK |
|||||||||
| Kinase | MNK2.AA | RSK | 83-227 | 34 | 1e-34 | 121.32 | In-house | 1-149 (271) | Show / Hide |
Range on Protein: 83-227 Range on HMM: 1-149/271 Sequence Identity: 34% (51 aa) YQLQEDVLGEGAHA---RVQTCINLITSQEYAVKIIEKQPGHIRSRVF-REVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFN | |.| ..|.|.. .. |. | |.||.|||.| ...|| |.. . | .. | . |. | |.. . |||| .. .. | . | YELHE-CIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS ELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHP-NQVSPVKICDF | |.. . .|.|...|| .||.|||||||||| . . .||||| EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDF |
|||||||||
| Kinase | MNK2.AA | CDPK | 319-368 | 54 | 4.2e-29 | 86.57 | In-house | 222-271 (271) | Show / Hide |
Range on Protein: 319-368 Range on HMM: 222-271/271 Sequence Identity: 54% (27 aa) FESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWV .|....|||.| ...|.||| |||||.|.|..| |.|.||.|.|||||. MEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF |
|||||||||
| Kinase | MNK2.AA | CAMK1 | 315-368 | 45 | 6.5e-28 | 78.17 | In-house | 222-276 (276) | Show / Hide |
Range on Protein: 315-368 Range on HMM: 222-276/276 Sequence Identity: 45% (25 aa) QNMLFESIQEGKYEFPDKDWAHISCA-AKDLISKLLVRDAKQRLSAAQVLQHPWV .|.||| | ...|||| . | .|| |||.|...|. | |.|....|.|.|||. DNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
|||||||||
| Kinase | MNK2.AA | RSK | 247-298 | 42 | 1.3e-15 | 52.4 | In-house | 162-208 (271) | Show / Hide |
Range on Protein: 247-298 Range on HMM: 162-208/271 Sequence Identity: 42% (22 aa) LLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGR |.|.|..|.||||||. .|. || ||.||..|. |.|..||... LMTFCYTANYMAPEVL-----KRQGHDQACDWWSFGVLMYEMLTGCTPFQNK |
|||||||||
| Kinase | MNK2.AA | RSK | 322-368 | 38 | 1.1e-14 | 49.04 | In-house | 220-271 (271) | Show / Hide |
Range on Protein: 322-368 Range on HMM: 220-271/271 Sequence Identity: 38% (20 aa) IQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSA-----AQVLQHPWV |..|.. . |. || ||||....| || .||.| .|..||||. IKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF |
|||||||||
| Kinase | MNK2.AA | TyrKc | 83-366 | 18 | 4.9e-11 | -44.23 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 83-366
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)
YQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQC-QGHRNVLELIEFFEEE-------DRFYLVFEKMRGGSILSHIHKR
.| . .||||| .| .. .. ||| . . | || ... . | |.. |. .. . ..|.| | .|. .....|.
ITLGK-KLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH
RH-FNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLN---GDCSPISTPELLTPCG--SAE------YMAPEVV
|. .. . ..|. ..|| |.. |||| |.| ... |||.|| | |. | . .. . .. ||||.
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQG-----ESKDYYRKKEHKGGKTMLPIRWMAPECI
EAFSEEASIYDKRCDLWSLGVILY-ILLSGYPPFVG---RCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKD-----WAHISCAAKDLISKLLVRDA
... | || || .. |. | .| | . .. ... ..| ...|.. . .. . . . ..... .|.
-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQE----------VIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDP
KQRLSAAQVLQHP
..| . ... .
EDRPTFSEIHECF
|
|||||||||
| Kinase | MNK2.AA | Pkinase_Tyr | 111-206 | 23 | 1.1e-07 | 26.59 | Pfam | 32-137 (270) | Show / Hide |
Range on Protein: 111-206 Range on HMM: 32-137/270 Sequence Identity: 23% (25 aa) AVKIIEKQPGHI---RSRVFREVEMLYQCQGHRNVLELIEFFE-EEDR--FYLVFEKMRGGSILSHIHK----RRHFNELEASVVVQDVASALDFLHNKG |||.. . | | .||.... | | |.. |. ... |.|.| | .|. |.. .| ..... . ...|.....|..|. AVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN IAHRDL . |||| CIHRDL |
|||||||||