Gene p38a (Human)

p38a

Species: Human
Alias: MAPK14, Exip, SAPK2a, CSBP1, Mxi2, CSBP2, P38, p38a, p38, PRKM14, EXIP, SAPK2A, RK, p38alpha, CSPB1, MXI2, PRKM15, p38ALPHA
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 6p21.1-p21.3,

Classification

Group: CMGC
Family: MAPK
Subfamily: p38

Sequence

Name Sequence Type Origin Length Description Download
p38a.NA RNA Sugen Kinome 4353 None Fasta, JSON
p38a.AA Protein Sugen Kinome 360 None Fasta, JSON
p38a.kin_dom Protein Kinase Domain Sugen Kinome 285 None Fasta, JSON

Protein domain

Protein domains of p38a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase p38a.AA p38 24-308 77 1.8e-236 791.9 In-house 1-289 (289) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-289/289
Sequence Identity: 77% (223 aa)

YQNLSPVGSGAYGSVCAAFDTKTGLR---VAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTP-ARSLEEFNDVYLVTHLMGADLNNIVKC
||||.||||||||.||.|.|..|| .   ||.|||.|||||.||||||||||||||||.|||||.||||||| |.|...|.|||.|||.||||||||.||
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTG
|.|.|||.|||.|||||||||||||.||||||||||.||||||||.|||||||||.|||||||||||||||||||||||||.|||||||||||||||.||
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELITG

RTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
||||||.||||||. |....||| .|...||.||.|||||||..|||...|..||.||||.|.|||||||.||.||||||..|..|.||
RTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase p38a.AA MAPK 24-308 56 1.1e-207 696.22 In-house 1-328 (328) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-328/328
Sequence Identity: 56% (185 aa)

YQNLSPVGSGAYGSVCAAFDTK------TGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM-KHENVIGLLDVFTP-----ARSLEEFNDVYLVTHLMGA
||.|.|.|.|||| ||.|.|..      .| .||.||.|||||. .|.||||||..||.|. .|||.|.|||.|||     ..|||||||.|.|..||..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLNNIVKCQK-LTDDHVQFLIYQILRG--LKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE-----------------MTGYVATRWYRAP
||..| |.|. |.|||.|...||||||  |||||||..|||||||||..|||.|.|||.||||||..|.|                 ||.||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EIMLN--WMHYNQTVDIWSVGCIMAELLT-GRTLFPGTDHIDQLKLILRLVGTPGAELLKKIS-SESARNYIQSL---TQMPKMNFANVFIG----ANPL
|||||  ||||...||.||||||.||.|| ...||||.|.|||..||. ..|||  |....|. ||.||||||||   ...|| .....| .    |||.
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AVDLLEKMLVLDSDKRITAAQALAHAYF
|.||||||||.| |||||...||.| ||
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase p38a.AA ERK 24-308 50 5.9e-161 541.01 In-house 1-307 (307) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-307/307
Sequence Identity: 50% (157 aa)

YQNLSPVGSGAYGSVCAAFDTK-----TGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIV
|| ....| |||| ||.|.|..     || .||.|| ...|   | .|||.||..||.| | |||.|.|.|.. | .| |..||.|.|. ||  ||  | 
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMP-NSPEQYNDIYCVEELMETDLHQII

KCQ-KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR----HTDDE-------MTGYVATRWYRAPEIMLNWMHYNQTVD
. |  |.|||.|...||||.||||||||..|||||||||. ||..| ||| ||||||    . ..        ||.||||||||||||||.|  |.. .|
NSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMD

IWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTP-GAELLKKISSESARNYIQSLTQ--MPKMNFANVFIGAN--PLAVDLLEKMLVLDSDKRITAA
|||.|||.||.| ...|||| |...|. .|. . ||| . | |..| || |..|| .|     |. .. |.|  ||  |.|.|||||||| |.|||||..
IWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVE

QALAHAYF
..|.| ||
ECLEHPYF
Kinase p38a.AA CMGC 24-308 28 6.8e-147 486.3 In-house 1-513 (513) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-513/513
Sequence Identity: 28% (147 aa)

YQNLSPVGSGAYGSVCAAFDTKTGLR--------------VAVKKLSRPFQSIIHAK----------RTYRELRLLKHMK-----------------HEN
|......|.|.|| |. ..|..|. .              ||.||...||   ..||          |..||...|||..                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VIGLLDVFTPA---RSLEE--------FNDVYLVTHLMGADLNNIVKCQK----------LTDDH------------VQFLI------YQILRGLK--YI
...|.|.|..    ....|        ||..|||. .|. || .. | ..          |.. |            .....      ||||||||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAD--IIHRDLKPSNLAVNEDCEL--------------------KILDFGLARHTDDE------------------------MTGYVATRWYRAPEIML
||..  ||||||||.|. .|..|||                    || ||||||.....                        .| ||.|||||||||.|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

NW---------MHYNQTVDIWSVGCIMAELLTG--------RTLFP-----------GTDHIDQLKLILRLVGTP----------------GAELLKKIS
.|         |||....|.||||||.||..||        ..|||           |..|||||..| .. |||                  |  ..|.
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------SESARNYIQS---LTQMPKMNFANVFIG-----------------------------------ANPLAVDLLEKMLVLDS
                    ||.|||||||   . . |. .. |.| .                                   ..|.|.|||.|||..| 
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

DKRITAAQALAHAYF
||||||.|||.| ||
DKRITAEQALQHPYF
Kinase p38a.AA JNK 24-308 43 1.2e-128 433.74 In-house 1-309 (309) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-309/309
Sequence Identity: 43% (136 aa)

YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRP--FQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC--
||||...|.|| | ||.|||. |. |||.||..||  ||   |.|| |||. ..|. .|.|.|... .|||...||||.|||.|  .| . | ...    
YQNLKFIGQGAQGIVCMAFDQVTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFTPQETLEEFQDVYIVMEYMDWNLCQVIHSTF

QKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--MTGYVATRWYRAPEIMLNWM-HYNQTVDIWSVGCIMAEL
 .|  . . .|.||...| |. ||. ||||||||||  ||.|| |||.|||.||  |    || || ||.|||||. .  |  |   ||||||||||||.
MELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIMAEM

LTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSL---TQMPKMNFA-----NVFIG---ANPL-------AVDLLEKMLVLDSDKRIT
.... ||||.|||||  .| .. |||... ...   ...|||. ..   .. . .||      ..| .   ..|        | ||| .||| . |.|| 
IRHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQM-QPHVRNYVENRNMDPYYQPYNFHEHFPDTLFPDVMQSEPKDHLTCHMARDLLFRMLVINPDDRIS

AAQALAHAYF
  .|| | | 
VDDALQHPYI
Kinase p38a.AA ERK1 24-308 52 4e-119 402.06 In-house 1-289 (289) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-289/289
Sequence Identity: 52% (152 aa)

YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLT
| ||. .| |||| ||.| || .. |||.||.| ||    . .|| ||...|.  ||||.|.. |.   | ..|.. |||.|  ||  ||  ..| |.| 
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIR-ADTIEQMRDVYIVQCLMETDLYKLLKTQHLS

DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE------MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL
 ||. . .||||||||||||| ..||||||||| .|  |.||| |||||| .| |      .| |||||||||||||||   | . .||||||||.||.|
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

TGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
  | .|||   .||| .|| ..| |  . |. |  | ||||.|||   ||. .| .| .| . |.|||.|||    .||||  .|||| | 
SNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase p38a.AA ERK5 24-308 44 2.8e-118 399.25 In-house 1-295 (295) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-295/295
Sequence Identity: 44% (132 aa)

YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKC-QKL
|. .  .| |||| ||.|   |.| .||.||.   |  .  ||||.|||..|.| .|.|.| . |.  |   . |. ||| |  || .||  |.   | .
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR-----HTDDE---MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMA
| .|. . .|||||||||.|||..|||||||||| ||| ||||| |||.||      .|..   || |||||||||||.|.    | | .|.||||||. 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

ELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQS-LTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
|... | .|||   |.||.||.  .|.| . ... .|..  .||.|. . .    ..  |. .| . |.||| .||. .  .|||...|| | . 
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase p38a.AA nmo 25-308 45 8.10000000001e-105 323.33 In-house 2-292 (292) Show / Hide 
Range on Protein: 25-308
Range on HMM: 2-292/292
Sequence Identity: 45% (134 aa)

QNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNN-IVKCQKLT
|   |.| ||.| | .  | . | |||.||.   ||... .|| .|||..|   ||.||. .||.  |.  .. |...| || || .||   ||  |.|.
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPH-KDFFQEIYVVTELMQSDLHKIIVSPQHLS

DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE----MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTG
 |||.  .|||||||||.|||.|.|||.|| || || .| ||| ||||||  . .    ||  | | .||||||..   || . ||||||||| ||||  
SDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLGR

RTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYI-QSLTQMPKMNFANVFIG---ANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
| ||     |.||..|  |.|||  | . |   | |.. .     . |...          |.  ||.|| .||. | |||| . .|||| | 
RILFQAQSPIQQLQMITDLLGTPSMEDM-KYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase p38a.AA ERK7 24-308 39 2.8e-101 342.8 In-house 1-292 (292) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-292/292
Sequence Identity: 39% (117 aa)

YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMK-HENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVK-CQK
|. .. .| |||| |  |.| .|.  ||.||    |.  . | ||.||  .|. .. |.|.| |..|.      .   |.|||   | .||.....  . 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIR----ADNDRDIYLVFEFMETDLHAVIRKGNI

LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARH-TDDE--------MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCI
| | |.|. .||.|| .||.||...|||||||||. .. .| .|. ||||||  .. |        .| ||||||||||||.|   .| . || ||.|||
LKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCI

MAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYF
..|.|.|. .||||  ..|. .||.... | .| .. | |. | | .... | ..  . ... .. . |.||| ..||.  .||.|| |||.| | 
LGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase p38a.AA S_TKc 24-308 29 9.5e-93 315.35 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-231/231
Sequence Identity: 29% (90 aa)

YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA---DLNNIVKCQ
|. | ..|.||.|.|. . ..||| .||.|...         ....||...||. .|.|.. |.|||         ...|.|. ...    ||  . | .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKR

K-------LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQ-TVDIWSVGCI
.       ..  |..|..|||...|.|.||  ||||||||.|. ..|  ..|| ||||||.     | .. |.||.|||..    .|.   .|.||.|||
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

MAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALA-------H
..|.|.|...||      |........|                                      | | |...|.|. | .||.|| .||.       |
LYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

AYF
 .|
PWF
Kinase p38a.AA Pkinase 24-308 30 3.3e-85 294.17 Pfam 1-293 (293) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-293/293
Sequence Identity: 30% (93 aa)

YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYR--ELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGA-----DLNNI
|. ....|||..|.|. . . .|| .||||..... ..    ..  |  |....|...|.|.. |.|.|.        ...|.|. ...      ||  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY

VK---CQKL--TDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCEL----KILDFGLAR---HTDDEMTGYVATRWYRAPEIMLNWMHYNQTV
..     ..  ......| .|||||||.|.||  ||||||||.|. .......    || |||||.   .  ..||... |.||.|||. .   .| . |
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKV

DIWSVGCIMAELLTGRTLFPGT----DHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
|.||.|||..|.|.||..|||     . .||...| |  |.|  .   . .|.| .. ..  .      .  . . ... . |.....| .|  ||.||.
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAE

QALAHAYF
|.| | .|
QILQHPWF
Kinase p38a.AA MAPK-Unclassified 24-173 45 6.5e-67 228.62 In-house 1-157 (575) Show / Hide 
Range on Protein: 24-173
Range on HMM: 1-157/575
Sequence Identity: 45% (71 aa)

YQNLSPVGSGAYGSVCAAFDTKT-GLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLE-EFNDVYLVTHLMGA---DLNNIVK
|     .||||||.|| | |.|. .  || ||. . |.  . .||. ||.|.| .. |.|.| . |.|..   .  || |.|.|. .|     ||  | |
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

CQK--LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLAR
     . . |.| ..|||||||||.||| ||||||||||| .|.|| ..| |||..|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase p38a.AA MAPK-Unclassified 174-308 37 2.4e-49 170.24 In-house 400-575 (575) Show / Hide 
Range on Protein: 174-308
Range on HMM: 400-575/575
Sequence Identity: 37% (66 aa)

HTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTG-----------RTLFPGTD--------------------HIDQLKLILRLVGTP
|.  .||.||.|||||||||||    |   |||||.||| ||..             | ||||.|                    |.||.|.|.   |.|
HHCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMP

GAELLKKISSESARNYIQSLTQMPKMNFANVFIGANP----------LAVDLLEKMLVLDSDKRITAAQALAHAYF
  | .  | . ||| ||||. . . . |   .  ..|          .. |.. |||. .  ||||| ||| | ||
PEEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase p38a.AA TyrKc 24-308 22 2.4e-14 9.27 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-280/280
Sequence Identity: 22% (71 aa)

YQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHM--KHENVIGLLDVFTPA--RSLEEF---NDVYLVTHLMGA-DLNN
 . .   |.||.| |. .  .   . ||||.|          .  .||.|....   .|.|.. |. | |    .    |     ...|. .|   ||..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN----FMYIEPLMIVMEYMPHGDLKD

IVKCQK--LTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDE--------MT-------GY--VATRWYRAPEIMLN
  .  .  |. ..     .|| .|  |.||  .|||||   |  |.|.   || ||||.|  .|.        .        |   .  ||. ||| . |
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-N

WMHYNQTVDIWSVGCIMAELLT-GRTLFPG---TDHIDQLKLILRLVGTPGAELLKKI----SSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKM
   ..   |.|| |  | |..| | .  ||          . ....| . .     .     |                      | .. .   .. .. 
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------FVCCPDEMYQIMKQC

LVLDSDKRITAAQALAHAYF
   | ..| | ..   | .|
WHEDPEDRPTFSEI--HECF
Kinase p38a.AA Pkinase_Tyr 24-87 23 5.5e-05 17.51 Pfam 1-70 (270) Show / Hide 
Range on Protein: 24-87
Range on HMM: 1-70/270
Sequence Identity: 23% (17 aa)

YQNLSPVGSGAYGSVCAAFDT----KTGLRVAVKKLSRPFQSIIH--AKRTYRELRLLKHM-KHENVIGLL
 . .   |.||.|.|. .  .    .|.. ||||.| ..  .  .   .   ||....|.. .|.|.. |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase p38a.AA Pkinase_Tyr 132-221 35 0.019835 8.85 Pfam 118-213 (270) Show / Hide 
Range on Protein: 132-221
Range on HMM: 118-213/270
Sequence Identity: 35% (35 aa)

YQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHT-DDEMTGYVAT-------RWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLT-GRT
.|| .|. | .|  .|||||   |  |.|.   || ||||||   .|.   |...       .|. ||| . .   ..   |.|| |  | |..| |..
WQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSDVWSFGVLMWEIFTYGEQ