Gene p38b (Human)

p38b

Species: Human
Alias: p38Beta, P38B, p38-2, P38-2, p38-BETA, P38BETA2, MAPK11, p38b, P38BETA, PRKM11, SAPK2, SAPK2B
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 22q13.33,

Classification

Group: CMGC
Family: MAPK
Subfamily: p38

Sequence

Name Sequence Type Origin Length Description Download
p38b.NA RNA Sugen Kinome 2420 None Fasta, JSON
p38b.AA Protein Sugen Kinome 364 None Fasta, JSON
p38b.kin_dom Protein Kinase Domain Sugen Kinome 285 None Fasta, JSON

Protein domain

Protein domains of p38b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase p38b.AA p38 24-308 73 7e-228 763.33 In-house 1-289 (289) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-289/289
Sequence Identity: 73% (213 aa)

LQGLRPVGSGAYGSVCSAYDARLRQK---VAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTP-ATSIEDFSEVYLVTTLMGADLNNIVKC
 | |.||||||||.||.|.|.| .||   ||.|||.||||| |||.|||||||||||..|||||.||||||| |.|..||..||.||..||||||||.||
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

QALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQG
|.|||.|.||||||.|||||||||||||||||||||.|||||||||||||||||..|.|||||||||||||||||||||||.|||||||||||||||..|
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELITG

KALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF
..||||.|.||||.|||.|.|||..|...||.||.||.||||.|.||..|....|.||||.||||| .||.||.|.|..|.||..|.||
RTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase p38b.AA MAPK 24-308 55 1.9e-198 665.57 In-house 1-328 (328) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-328/328
Sequence Identity: 55% (182 aa)

LQGLRPVGSGAYGSVCSAYDARLRQK------VAVKKLSRPFQSLIHARRTYRELRLLKHL-KHENVIGLLDVFTP-----ATSIEDFSEVYLVTTLMGA
 | |.|.|.|||| ||||.| |..||      ||.||.|||||...|..|||||..||.|. .|||.|.|||.|||     . |.|.| ..|.|. ||..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLNNIVKCQA-LSDEHVQFLVYQLLRG--LKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE-----------------MTGYVATRWYRAP
||..| |.|  |||.|.|...||.|||  |||||||..|||||||||..|||.|.|.|.||||||..| |                 ||.||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EIMLN--WMHYNQTVDIWSVGCIMAELLQ-GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKIS-SEHARTYIQSL---PPMPQKDLSSIFRG----ANPL
|||||  ||||...||.||||||.||.|. .| ||||.|||||...||||.||||.|.. .|. |||||.|||||   |..|.|.....| .    |||.
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AIDLLGRMLVLDSDQRVSAAEALAHAYF
||||| .|||.| |.| ...|||.| ||
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase p38b.AA ERK 25-308 50 1e-148 500.38 In-house 2-307 (307) Show / Hide 
Range on Protein: 25-308
Range on HMM: 2-307/307
Sequence Identity: 50% (156 aa)

QGLRPVGSGAYGSVCSAYDAR-----LRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK-HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVK
| . ..| |||| |||| |        .||||.|| ...|  .| . ||.||..||.|.| |||.|.|.|.. | .|.|.. ..|.|. ||  ||  | .
QIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMP-NSPEQYNDIYCVEELMETDLHQIIN

CQ-ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR----QADEE-------MTGYVATRWYRAPEIMLNWMHYNQTVDI
 | .|||.|.|...||.|.||||||||..|||||||||. ||..| | | ||||||     ..|        ||.||||||||||||||.|  |.. .||
SQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDI

WSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTP-SPEVLAKISSEHARTYIQSLPP--MPQKDLSSIFRGAN--PLAIDLLGRMLVLDSDQRVSAAE
||.|||.||.| .| |||| ||..|. || .. ||| | | | .| || |. || .||    | |....||  ||  |.||||| .||| |.|.| ...|
WSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEE

ALAHAYF
.|.| ||
CLEHPYF
Kinase p38b.AA CMGC 24-308 27 1.6e-139 461.66 In-house 1-513 (513) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-513/513
Sequence Identity: 27% (142 aa)

LQGLRPVGSGAYGSVCSAYDARLRQK--------------VAVKKLSRPFQSLIHAR----------RTYRELRLLKHLK-----------------HEN
 . ....|.|.|| |....| |  ||              ||.||...||   ..|.          |..||...||||.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VIGLLDVFTPATS------------IEDFSEVYLVTTLMGADLNNIVKCQA----------LSDEH------------VQFLV------YQLLRGLK--Y
...|.|.|..  |            . .| ..|||. .|. || .. | .           ||. |            .....      ||.|||||  |
IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

IHSAG--IIHRDLKPSNVAVNEDCEL--------------------RILDFGLARQADEE------------------------MTGYVATRWYRAPEIM
.||..  ||||||||.|. .|..|||                    .| ||||||. ...                        .| ||.|||||||||.
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LNW---------MHYNQTVDIWSVGCIMAELLQG--------KALFP-----------GSDYIDQLKRIMEVVGTP----------------SPEVLAKI
|.|         |||....|.||||||.||...|        | |||           |...||||..|..| |||                . |   .|
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

S--------------------SEHARTYIQS---LPPMPQKDLSSIFRG-----------------------------------ANPLAIDLLGRMLVLD
.                    ||.||.||||   .|. | |.....| .                                   ..|.||||| .||..|
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

SDQRVSAAEALAHAYF
 |.| .|..||.| ||
PDKRITAEQALQHPYF
Kinase p38b.AA JNK 25-263 45 1.2e-117 397.2 In-house 2-249 (309) Show / Hide 
Range on Protein: 25-263
Range on HMM: 2-249/309
Sequence Identity: 45% (113 aa)

QGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRP--FQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC--Q
| |...|.|| | ||.|.|. . |.||.||..||  ||   |..| |||. ..|...|.|.|... .|||....|.| .||.|  .| . | ...     
QNLKFIGQGAQGIVCMAFDQVTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFTPQETLEEFQDVYIVMEYMDWNLCQVIHSTFM

ALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--MTGYVATRWYRAPEIMLNWM-HYNQTVDIWSVGCIMAELL
 |  | . .|.|| ..| |. ||.|||||||||||. ||.|| | |.|||.|| .|.   || || ||.|||||. .  |  |   ||||||||||||..
ELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIMAEMI

QGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSL---P
... ||||.|.|||  .|.|. |||.|. . .   .|.|.|. ..   |
RHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQM-QPHVRNYVENRNMDP
Kinase p38b.AA ERK5 25-308 43 4.1e-117 395.38 In-house 2-295 (295) Show / Hide 
Range on Protein: 25-308
Range on HMM: 2-295/295
Sequence Identity: 43% (128 aa)

QGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKC-QALS
. .  .| |||| ||||   .  |.||.||.   |  .  |.||.|||..|.| .|.|.| . |.  |   . .. .|| |  || .||  |.   | ..
KIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPFT

DEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR-----QADEE---MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAE
 ||. . .||.||||||.||| .|||||||||. ||| |||.| |||.||      .|..   || |||||||||||.|.    | | .|.||||||. |
LEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFGE

LLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQS-LPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF
..  . .|||  ||.||. ||.|.|.|.| ..  .|..| . |.|. .|.   ||.. .. .| . |.|||.|||. .  .|.....|| | . 
MIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase p38b.AA ERK1 25-308 50 5.70000000001e-113 381.6 In-house 2-289 (289) Show / Hide 
Range on Protein: 25-308
Range on HMM: 2-289/289
Sequence Identity: 50% (145 aa)

QGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSD
  |. .| |||| |||||| . .|.||.||.| ||    .  || ||...|.  ||||.|.. |.   | .|| . .||.|  ||  ||  ..| | || 
TNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIR-ADTIEQMRDVYIVQCLMETDLYKLLKTQHLSN

EHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE------MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ
.|. . .||.|||||||||| ..||||||||. .|  |.|.| |||||| || |      .| |||||||||||||||   | . .||||||||.||.| 
DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS

GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF
 . .|||  |.|||  |. |.| || . |  |  | || |.||||  |.  . ..| .| . |.|||..||    ..|.   ||||| | 
NRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase p38b.AA ERK7 18-308 39 6.6e-103 348.19 In-house 1-292 (292) Show / Hide 
Range on Protein: 18-308
Range on HMM: 1-292/292
Sequence Identity: 39% (120 aa)

WEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLK-HENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNI
.|. .||      | |||| |  ||| | .| ||.||    |.  . | ||.||  .|. .. |.|.| |..|. .|    |.   |||   | .||...
YEIRKRL------GKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVI-RADNDRDI---YLVFEFMETDLHAV

VK-CQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR---------QADEEMTGYVATRWYRAPEIMLNWMHYNQTVDI
..  . | | |.|. .||||| .||.||. .|||||||||. .. .| ... ||||||         ...  .| ||||||||||||.|   .| . || 
IRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDM

WSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHA
||.|||..|.|.||..|||.  ..|. .|.|... |. | .. | |. | . .....  ..| |. ..... . ||||| |.||.  ..|..| .||.| 
WSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHP

YF
| 
YV
Kinase p38b.AA nmo 24-308 45 7.4e-102 314.06 In-house 1-292 (292) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-292/292
Sequence Identity: 45% (133 aa)

LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNN-IVKCQAL
 |  ||.| ||.| | |  | |  ..||.||.   ||.|. ..| .|||..|   ||.||. .||.  |.  .. | |.| || || .||   ||  |.|
IQPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPH-KDFFQEIYVVTELMQSDLHKIIVSPQHL

SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE----MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQ
| .||.  .||.||||||.|||.|.|||.|| |. || .| |.| ||||||  ...    ||  | | .||||||..   || . ||||||||| ||||.
SSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAELLG

GKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMP--QKDLSSIFR--GANPLAIDLLGRMLVLDSDQRVSAAEALAHAYF
 . ||     |.||. |....|||| | . |   | |.. .   |. |   . |  .     |.  |..|| |||. | |.|.|. .|||| | 
RRILFQAQSPIQQLQMITDLLGTPSMEDM-KYACEGAKAHMLRMPHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase p38b.AA S_TKc 24-308 28 1.1e-86 295.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-231/231
Sequence Identity: 28% (85 aa)

LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGA---DLNNIVKCQ
 . ||..|.||.|.|. ... .  ..||.|...         ....||...||. .|.|.. |.|||         ...|.|. ...    ||  . | .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKR

A-------LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQ-TVDIWSVGCI
        ..  |..|..||....|.|.|| |||||||||.|. ..|  .. | |||||||     | .. |.||.|||..    .|.   .|.||.|||
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

MAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALA-------H
..|.| |. .||      |........|                                      | |.|.. ..|. | ..| .| |||.       |
LYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

AYF
 .|
PWF
Kinase p38b.AA Pkinase 24-308 28 3.5e-79 274.17 Pfam 1-293 (293) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-293/293
Sequence Identity: 28% (88 aa)

LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSL---IHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGA-----DLNN
.. .|..|||..|.|. ...   ...||||..... ..    ...||. .|....|.|.|.|.. |.|.|.        ...|.|. ...      ||  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFD

IVK---CQAL--SDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCEL----RILDFGLARQ---ADEEMTGYVATRWYRAPEIMLNWMHYNQT
...     ..  |.....| .||.||||.|.|| |||||||||.|. .......    .| |||||.|    .. ||... |.||.|||. .   .| . 
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIRGGQYYGPK

VDIWSVGCIMAELLQGKALFPGS----DYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSA
||.||.|||..|.| |. .|||.    . .||...| .. |.| ..   . .|.  .. ..  .    . ..     ... ..|.. ..| .|  .| .|
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTA

AEALAHAYF
...| | .|
EQILQHPWF
Kinase p38b.AA MAPK-Unclassified 23-173 43 3.6e-64 219.51 In-house 2-157 (575) Show / Hide 
Range on Protein: 23-173
Range on HMM: 2-157/575
Sequence Identity: 43% (68 aa)

RLQGLRPVGSGAYGSVCSAYDARL-RQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIE-DFSEVYLVTTLMGA---DLNNIV
 .|..  .||||||.|| | | ..  |.|| ||. . |.  . ..|. ||.|.| .| |.|.| . |.|..      .|  .|.|. .|     ||  | 
EYQKN--IGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQII

KCQA--LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLAR
|     ....|.| . ||.||||||.|||.||||||||||. .|.|| .|| |||..|
KSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase p38b.AA MAPK-Unclassified 178-308 33 7.4e-44 152.03 In-house 404-575 (575) Show / Hide 
Range on Protein: 178-308
Range on HMM: 404-575/575
Sequence Identity: 33% (58 aa)

EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQG-----------KALFPGSD--------------------YIDQLKRIMEVVGTPSPEV
.||.||.|||||||||||    |   |||||.||| ||..|            . ||||.|                    ..||.| | .. |.|  |.
HMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEED

LAKISSEHARTYIQSLPPMPQKDLSSIFRGANP----------LAIDLLGRMLVLDSDQRVSAAEALAHAYF
.  | .  || ||||. . .. . ....  ..|          ..||..  ||. .   | .| .|| | ||
CNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase p38b.AA TyrKc 24-308 21 1.2e-13 -2.2 SMART 1-280 (280) Show / Hide 
Range on Protein: 24-308
Range on HMM: 1-280/280
Sequence Identity: 21% (67 aa)

LQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHL--KHENVIGLLDVFTPATSIEDF---SEVYLVTTLMGA-DLNNIV
.. ..  |.||.| |. .  ..  ..||||.|          .  .||.|....|  .|.|.. |. | |       |     ...|. .|   ||..  
ITLGKKLGEGAFGEVYKGT-WK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYL

KCQA--LSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEE--------MT-------GY--VATRWYRAPEIMLNWM
.     |. ..     .|  .|  |.|| ..|||||   |. |.|.   .| ||||.|  ...        .        |   .  ||. ||| . |  
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYG

HYNQTVDIWSVGCIMAELL-QGKALFPGS----DYIDQLKRIMEVVGTPSPEVL--AKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVL
 ..   |.|| |  | |..  |.   ||        ... .  .  . . .       .|                      | .. .   ..  .    
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS----------------------FVCCPDEMYQIMKQCWHE

DSDQRVSAAEALAHAYF
| ..| . .|   | .|
DPEDRPTFSEI--HECF
Kinase p38b.AA JNK 283-308 53 2.4e-07 23.48 In-house 284-309 (309) Show / Hide 
Range on Protein: 283-308
Range on HMM: 284-309/309
Sequence Identity: 53% (14 aa)

DLLGRMLVLDSDQRVSAAEALAHAYF
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DLLFRMLVINPDDRISVDDALQHPYI
Kinase p38b.AA Pkinase_Tyr 24-87 23 2.2e-05 18.85 Pfam 1-70 (270) Show / Hide 
Range on Protein: 24-87
Range on HMM: 1-70/270
Sequence Identity: 23% (17 aa)

LQGLRPVGSGAYGSVCSAYDA----RLRQKVAVKKLSRPFQSLIH--ARRTYRELRLLKHL-KHENVIGLL
.. ..  |.||.|.|. ..        ...||||.| ..  .  .   .   ||....|.| .|.|.. |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase p38b.AA Pkinase_Tyr 136-208 32 0.014908 9.27 Pfam 122-199 (270) Show / Hide 
Range on Protein: 136-208
Range on HMM: 122-199/270
Sequence Identity: 32% (26 aa)

RGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQA-DEEMTGYVAT-------RWYRAPEIMLNWMHYNQTVDIWS
.|. | .| ..|||||   |. |.|.   .| ||||||   ...   |...       .|. ||| . .   ..   |.||
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSDVWS