Gene PAK3 (Human)

PAK3

Species: Human
Alias: bPAK, MRX30, PAK3beta, CDKN1A, OPHN3, MRX47, hPAK3, PAK3
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: Xq22-q23,

Classification

Group: STE
Family: STE20
Subfamily: PAKA

Sequence

Name Sequence Type Origin Length Description Download
PAK3.NA RNA Sugen Kinome 2268 None Fasta, JSON
PAK3.AA Protein Sugen Kinome 580 None Fasta, JSON
PAK3.kin_dom Protein Kinase Domain Sugen Kinome 252 None Fasta, JSON

Protein domain

Protein domains of PAK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD PAK3.AA PBD 70-105 42 9.7e-12 46.25 SMART 1-38 (38) Show / Hide 
Range on Protein: 70-105
Range on HMM: 1-38/38
Sequence Identity: 42% (16 aa)

ISLPS-DFEHTIHVG-FDAVTGEFTNSPFQTSRPVTVA
||.|. .|.|..||| .|. |||||. |.| .. ... 
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
PBD PAK3.AA PBD 69-95 53 1.2e-11 43.42 Pfam 1-28 (60) Show / Hide 
Range on Protein: 69-95
Range on HMM: 1-28/60
Sequence Identity: 53% (15 aa)

EISLP-SDFEHTIHVGFDAVTGEFTNSP
.|| | ..|.||.|||.|. ||.||. |
MISTPLTNFKHTMHVGWDGQTGFFTGMP
PBD PAK3.AA PBD 128-163 58 4.4e-12 44.91 Pfam 25-60 (60) Show / Hide 
Range on Protein: 128-163
Range on HMM: 25-60/60
Sequence Identity: 58% (21 aa)

EGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYD
.| |..|..|||.|.|.| |||.|||||.||..|| 
TGMPPEWQKLLQSSGISKPEQKHNPQAVFDVVQFYQ
Kinase PAK3.AA PAKA 304-555 73 5.8e-202 677.24 In-house 1-260 (260) Show / Hide 
Range on Protein: 304-555
Range on HMM: 1-260/260
Sequence Identity: 73% (190 aa)

YTRFEKIGQGASGTVYTALDIATGQE--VAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETC------M
|...|||||||||.||.| .|.|.||  |||||||...||||||||||||||.|.|..|||||.||||| |||||||||..||.||||.|..|      |
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

DEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGE
||||||.|||||||.|.|.||...|||||||||||||||||||.||||||||.|.||.||.|||||||||||||..|| |..||||||||||||||.|||
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGE

PPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL
||||||.||||.|||||||.|....|...|  |.|||..||..||||| ||.|||.||||
PPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase PAK3.AA STE20 304-555 50 1.4e-169 569.62 In-house 1-288 (288) Show / Hide 
Range on Protein: 304-555
Range on HMM: 1-288/288
Sequence Identity: 50% (144 aa)

YTRFEKIGQGASGTVYTALDIATGQE----VAIKQMNLQQQ----PKKELIINEILVMRENKNPNIVNYLDSYLVG----DELWVVMEYLAGGSLTDVVT
|. .||||||..|.||.| .. ||..    ||||.||| ..    ...|.|..||..|.. |.||||.|..|||..    ||||.||||..||||||...
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

ETC----------MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITP-----EQSKRSTMVGTPYWMAPEVVTR----
...          |.| |||..|||.||.||.||||..||||||.|||||..||.|||.|||.|||.|.     .|.|| |.|||||||||||. .    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIA--TNGTPELQN--PERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL
 | |. |.|||||||.||||.||||||....|.||...|.  .|..|.|..  |.. |  |.||...||..|.. | .|..||.|||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase PAK3.AA PAKB 305-555 57 5.3e-140 471.4 In-house 2-252 (252) Show / Hide 
Range on Protein: 305-555
Range on HMM: 2-252/252
Sequence Identity: 57% (144 aa)

TRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVC
. . ||| |  |.|  | .. ||. ||.|.|.|  |   ||  ||. .||. . ||||.  .|||||||||||||.. ||.|||.||.| |.| |||.||
DNYVKIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHTRMNEEQIATVC

RECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPL
| .||||..||.  ||||||||| |||  || |||.|||||||.  |  ||  .|||||||||||. |  ||..||||||||| ||||.||||| || ||
RQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPPL

RALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL
.|.  |  .  | |.|  . | . |.||.|.|  |. .| .|.|||.||||
QAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL
Kinase PAK3.AA STE 304-555 33 3.2e-134 452.2 In-house 1-359 (359) Show / Hide 
Range on Protein: 304-555
Range on HMM: 1-359/359
Sequence Identity: 33% (124 aa)

YTRFEKIGQGASGTVYTALDI------ATGQE---------VAIKQMNLQQQ-----------------PKKELIINEILVMRENK--NPNIVNYLDSYL
... ||||.||.||||.|...       ||..         .|||||||...                  ... |..|| .|.. .   ||||.|...|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG-------DELWVVMEYLAGGSLTDVVTETCMD---------------EGQIAAVCRECLQA-LDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCA
..       ||||..|||..||||.|.. ....                | |||..||..|.. |..|||...||||||..||||     |||.|||.|.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QITPE----------------QSKRSTMVGTPYWMAPEVVTR------KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATN-----------
|.|..                |.|| |.|||| ||||||...      | |. |.||||||...|||..|.||. ...|.||...|..|           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----GTPELQN-----------------PERLSAVFRDFLNRCLEMDVDRRGSAKELLQ--HPFL
    . | |..                 |...|  |.||.|.||..| . | .|..||.  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase PAK3.AA YSK 304-555 46 9.5e-115 347.01 In-house 1-257 (257) Show / Hide 
Range on Protein: 304-555
Range on HMM: 1-257/257
Sequence Identity: 46% (119 aa)

YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKK-ELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTE---TCMDEGQ
.|. |.|| |  | || . |  |.. ||||  .| .     |.|  || .  . . |.| .|. ||| .  ||..|||..|||. |         .|| .
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIWSLGIMAIEMVEGEPP
|| . || |..||.|||...||||||. |.||  .| ||| |||  .|||  | || |.|||||||||||.     .|  |.||||||| |.||  ||||
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPP

YLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL
|    |.|.. ||  |  |.|.  .  |  | .| . ||. |   | |||||| | | 
YCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase PAK3.AA MST 304-555 44 5.70000000001e-102 324.91 In-house 1-254 (254) Show / Hide 
Range on Protein: 304-555
Range on HMM: 1-254/254
Sequence Identity: 44% (115 aa)

YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYL--VGDELWVVMEYLAGGSLTDVV--TETCMDEGQ
..  ||.|||. | || |... ||..||||...       . ||.||  | . |...|| | .||.     ..| |||| ..||. |..  |     | |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQ

IAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYL
||....  || |. ||.|  ||||||. ||||  .|  || |||  .| |  . || | .|||||||||| .   |  |.||||||| |||| ||.||| 
IACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYS

NENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL
.  | ||. .| ..  | ...||. |  | ||. .||  . . | .|..|||||| 
DIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase PAK3.AA S_TKc 304-555 32 8.70000000001e-101 342.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 304-555
Range on HMM: 1-231/231
Sequence Identity: 32% (88 aa)

YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAG--GSLTDVVTETC-------
|.  .|||.|| |.|| . .. ||..||||...       | |..|| .... . ||||...|..   |.|..||||. |  |.| |.  .         
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP-KVDIWSLGIMAIEMVE
..| ... .... ..||...||...||||.| .||||     .|..|||...|.       .|..|||..|||||.    ||. |.|.||.|.. .||. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQ-------HPFL
|.||.   .. . . .|              |  ..||...||..| ..| .| |.||       ||..
GYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PAK3.AA Pkinase 304-555 30 9.6e-99 339.15 Pfam 1-293 (293) Show / Hide 
Range on Protein: 304-555
Range on HMM: 1-293/293
Sequence Identity: 30% (89 aa)

YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIIN----EILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGG----SLTDVVT---E
|.. .|||.|..|.|| . .. ||..||.|..... . .......    || .|.. . |||| ..|..  .|....||||. ||    .| |...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TCM--DEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSV----KLTDFGFCAQI-TPEQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSL
.|.  .| ..  .... |..|...||. .||||.|..|||.  .| .    |..|||...|. .  .|  .| .|||..|||||.  .. ||||||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIMAIEMVEGEPPYLNE----NPLRALYLIATNGTPELQNPERLS---------------------AVFRDFLNRCLEMDVDRRGSAKELLQHPFL
|.. .||. |.||. ..    | .. ...|. .. |.|  ..  .                       ..||...||..|  .| .|...||||..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PAK3.AA MKC 304-555 37 8e-83 281.47 In-house 1-260 (260) Show / Hide 
Range on Protein: 304-555
Range on HMM: 1-260/260
Sequence Identity: 37% (99 aa)

YTRFEKIGQGASGTVYTALD-----IATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGD-ELWVVMEYLAGGSLTDVVTE-TCMD
|.  ...| |. |||| |.          ..|||| |.     ..    ||| . .  . |||| |. |....| |.| |||.. || |..         
YKFLHQVGKGGFGTVYCAKYNNPHSTYDKCRVAIKKMPHVTKKHQRNNLNEIGFLNYCNHPNIVKYHCSHMKHDDEIWMVMEFMQGGTLEEASQNSHKFC

EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEP
| .|| ||.| ||.|. ||... .|||.|| ||    || .|| |||.|.  . | ...  |.| |.||.||    |...  .||||.|| . ||. |.|
ESCIAYVCKEMLQGLMYLHEHNIVHRDLKSANIMMNTDGEIKLIDFGLCIDVSHE-KEEIHMCGSPFWMSPEMIQQKQHSYPCDIWSFGICLLEMANGRP

PYLNENPLRALYLIATNGTPE---LQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL
|.  .... |  . ||||      .  |.. |  |.|||. ||.||   | .| .||.|||.
PH-HKSRMKAMFMVATNGCKFPKEFDDPCHWSDCFHDFLWQCLQMDPHKRPTAEQLLKHPFI
Kinase PAK3.AA KHS 304-555 44 1.9e-82 277.1 In-house 1-258 (258) Show / Hide 
Range on Protein: 304-555
Range on HMM: 1-258/258
Sequence Identity: 44% (115 aa)

YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTET-CMDEGQIAA
|    ..| |  | || | ||.... .|.| . .. .   ..|  ||..|.. . |||| |  |||  | ||..|||  |||| |.   |  . | ||| 
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAY

VCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEV--VTRK-AYGPKVDIWSLGIMAIEMVEGEPPYL
|||| ||.|..|||.. .|||||  ||||  .| ||| |||  ||||   .||   .||||||||||  | ||  |.   |||..|| |||. |  ||  
VCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMF

NENPLRALYLIATNG--TPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL
.  |.|||.|..  .   |.|.. .. |. | .|.  .|  .  .| .|. ||||||.
DLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase PAK3.AA STE11 304-555 34 4.5e-78 265.69 In-house 1-303 (303) Show / Hide 
Range on Protein: 304-555
Range on HMM: 1-303/303
Sequence Identity: 34% (106 aa)

YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPK----------K----ELIINEILVMRENKNPNIVNYLDSYLV---GDELWVVMEYLAGGSL
... |.||.|| ||||..... ||...|.||. .| . .          .    ..|  || .|.  . .||| |... |     |.. . ||| .||||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

TDVVTET--C--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGS-VKLTDFGFCAQITPEQSKRST----------MVGTPY--------
 ..      .  .||  |    .  |..| .|||...|||||| .||||  ||  .||.||| . ..  . .. ..          | ||||        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMAPEVVTRKA---YGPKVDIWSLGIMAIEMVEGEPPYLNE--NPLRALYLIATNGTPELQNPERLS------AVFRDFLNRCLEMDVDRRGSAKELLQH
||||||...     || |.||||||   |||. | ||. |   |.  |.. |... .|  . ||..|      .  ||||..|.| |   | .| .||||
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

PFL
||.
PFI
Kinase PAK3.AA SLK 304-555 39 1.6e-76 257.62 In-house 1-259 (259) Show / Hide 
Range on Protein: 304-555
Range on HMM: 1-259/259
Sequence Identity: 39% (103 aa)

YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTE--TCMDEGQIA
.     .| || | || | .  ...  | | ...... . |  . || .. | | ||||. ...| . ..||...|. .|| .  .. |    . | ||.
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQ

AVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT-----RKAYGPKVDIWSLGIMAIEMVEGEP
 ||.. ..||..||||.|||||.|  |||. ||| |.| |||  |. . .  || | .|||||||||||       . |  |.|||||||  ||| ..||
YVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEP

PYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL
|. . ||.| |  |.    |.|..| . |  |.||| .||. |.. | ....|.||...
PHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase PAK3.AA TyrKc 304-555 22 8.2e-23 83.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 304-555
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

YTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMREN--KNPNIVNYLDSYLVG-------DELWVVMEYLAGGSLTDVVTETC
 |  .|.| || |.|| .  .   ..||.| ..      .| ...|. .|..   ..||||. .   . .       . |..|||| ..|.| |   .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--MDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPE----QSKRSTMV----GTP-----YWMAPEVVTRKAYGPKV
      .    |    .  ..|||...||||.   |.|.| .. || .||| .  |. .     ||   ..    |.       |||||.   . . .| 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DIWSLGIMAIEMVE-GEPPYLN-----ENPLRALYLIATNGTPELQNPER--------LSAVFRDFLNRCLEMDVDRRGSAKELLQHPFL
|.|| |..  |.   |..|| .      .. ... .. . .   .  |.          ..   .   .| . | . | . .|.  | ..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYR--MPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase PAK3.AA Pkinase_Tyr 304-498 27 7e-22 74.73 Pfam 1-216 (270) Show / Hide 
Range on Protein: 304-498
Range on HMM: 1-216/270
Sequence Identity: 27% (59 aa)

YTRFEKIGQGASGTVYTALDI----ATGQEVAIKQMNLQQQPK---KELIINEILVMREN-KNPNIVNYLDSYL-VGDE--LWVVMEYLAGGSLTDVVTE
 |  .|.|.|| |.|| .        |...||.| .. .  ..   .|  ..|. .|..  ..||||...   .  |.   ...|||| ..|.| |   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

T-----CMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQI--TPEQ-SKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSL
        .  ..   |..  .....|.|.. ||||.   |.|.. .. || .||| .  |  . .   ||.       |||||.   . .  | |.|| 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GIMAIEMVE-GEPP-Y
|.   |..  || | |
GVLMWEIFTYGEQPTY