Gene PIK3R4 (Human)

PIK3R4

Species: Human
Alias: MGC102700, VPS15, PIK3R4, p150, P150
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 3q21-q22.1,

Classification

Group: Other
Family: VPS15

Sequence

Name Sequence Type Origin Length Description Download
PIK3R4.NA RNA Sugen Kinome 5078 None Fasta, JSON
PIK3R4.AA Protein Sugen Kinome 1358 None Fasta, JSON
PIK3R4.kin_dom Protein Kinase Domain Sugen Kinome 284 None Fasta, JSON

Protein domain

Protein domains of PIK3R4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase PIK3R4.AA VPS15 26-314 57 2.1e-214 718.58 In-house 1-296 (296) Show / Hide 
Range on Protein: 26-314
Range on HMM: 1-296/296
Sequence Identity: 57% (172 aa)

FEYDKSLGSTRFFKVARAKHREGLVVVKVFAIQDPTLPLTSYKQELEELK--IRLNSAQNCLPFQKASEKASEKAAMLFRQYVRDNLYDRISTRPFLNNI
..|.|.||||||.||..|||.||..|||||...|.|..|..|||..||.|  .....|.||.|.||  .....|||...||||..||||||||||||..|
CHYVKNLGSTRFMKVCKAKHHEGYIVVKVFVKHDDTYSLEPYKQRIEEIKKNLMQHPAFNCCPYQK--VIETDKAAYMMRQYVKHNLYDRISTRPFLQMI

EKRWIAFQILTAVDQAHKSG-VRHGDIKTENVMVTSWNWVLLTDFASFKPTYLPEDNPADFNYFFDTSRRRTCYIAPERFVDGGMFATELEY--MRDPST
||.|||||.|.|..|.||.| |.|||||.||..||||||..|||||.|||.||||||||||..||||||||||||||||||...........  |||..|
EKKWIAFQTLCALEQCHKQGNVCHGDIKSENILVTSWNWCYLTDFACFKPCYLPEDNPADFTFFFDTSRRRTCYIAPERFVSNTEQDQDSNNGNMRDIHT

PLVDLNSNQRTRGELKRAMDIFSAGCVIAELFTEG-VPLFDLSQLLAYRNG--HFFPEQVLNKIEDHSIRELVTQMIHRE-PDKRLEAEDYLKQQRGN
...|...|....|||..|||||||||||||||.|| .|.||.|||..||.|  |...||...||.|..||.|...||... |.||...|.||.. || 
DSIDRQQNPWLFGELTPAMDIFSAGCVIAELFCEGDQPPFDYSQLCKYRSGEYHPNREQIMEKIQDEHIRNLCHHMIQKDNPMKRMSCEEYLNKWRGF
Kinase PIK3R4.AA S_TKc 26-320 15 8.5e-14 25.38 SMART 1-231 (231) Show / Hide 
Range on Protein: 26-320
Range on HMM: 1-231/231
Sequence Identity: 15% (48 aa)

FEYDKSLGSTRFFKVARAKHRE--GLVVVKVFAIQDPTLPLTSYKQELEELKIRLNSAQNCLPFQKASEKASEKAAMLFRQYVRD---NLYDRISTRPF-
.|  . .|.  | || ...|..   .| .|.             .. . |..|  .     .   . .     .   ..  |.     .|.|.|  |.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDF--ASFKPTYLPEDNPADFNYFFDTSRRRTC----YIAPERFVDGGMF
     ..  . | .. ||. |..  |. |. | |.| ||.....   . ..||  | .                     .  |    |.||| .      
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------------------TTFCGTPWYMAPEVL------

ATELEYMRDPSTPLVDLNSNQRTRGELKR-AMDIFSAGCVIAELFTEGVPLFDLSQLLAYRNGHFFPEQVLNKIEDHSIRELVTQMIHREPDKRLEAEDY
                            . . |. | ||...|... | |.|.  . . ...             ... .... .. ...|.||. | . 
-------------------------GYGKCKCDWWSCGCILYEMLC-GYPPFP-QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EA

LKQQRGNAFPEIF
|. ..  .  . |
LQDEWDIKCHPWF
Kinase PIK3R4.AA NIM1 110-167 43 3.1e-09 23.29 In-house 87-144 (258) Show / Hide 
Range on Protein: 110-167
Range on HMM: 87-144/258
Sequence Identity: 43% (25 aa)

LYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDF
|| .|...  |  |.   |  ||. ||   |  .. | ||| |||| || | | . ||
LYTHIHQEGKLREIHCKPIFAQIVSAVKHMHSRNIVHRDIKAENVMYTSNNCVKVGDF
Kinase PIK3R4.AA CK2 118-156 33 4.3e-09 22.5 In-house 90-128 (288) Show / Hide 
Range on Protein: 118-156
Range on HMM: 90-128/288
Sequence Identity: 33% (13 aa)

PFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVMV
. |.  . |.  |..| |.|..|. |. | |.| .|.|.
QTLTDYDIRYYMFELLKALDYCHSMGIMHRDVKPHNIMI
Kinase PIK3R4.AA NuaK 109-155 40 6.3e-09 19.05 In-house 85-131 (252) Show / Hide 
Range on Protein: 109-155
Range on HMM: 85-131/252
Sequence Identity: 40% (19 aa)

NLYDRISTRPFLNNIEKRWIAFQILTAVDQAHKSGVRHGDIKTENVM
.||| || .  |   | | .  || .||   || .. | | | ||..
ELYDYISECKSLPEREARHFFRQIVSAVHYCHKHRICHRDLKLENIL
Kinase PIK3R4.AA CMGC 126-158 27 2e-07 19.5 In-house 184-219 (513) Show / Hide 
Range on Protein: 126-158
Range on HMM: 184-219/513
Sequence Identity: 27% (10 aa)

RWIAFQILTAVD--QAHKSG--VRHGDIKTENVMVTS
| ...|||....    |. .  . | |.| ||.....
R-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINH
Kinase PIK3R4.AA Ciliate-C3 128-167 40 3.6e-07 22.06 In-house 101-140 (140) Show / Hide 
Range on Protein: 128-167
Range on HMM: 101-140/140
Sequence Identity: 40% (16 aa)

IAFQILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDF
|. ||| |.|  |   . ||||| .|... | . . . ||
ISKQILQAIDYLHEHNIVHGDIKFSNILINSKDEIKIIDF
Kinase PIK3R4.AA CMGC 238-264 26 8.9e-07 17.31 In-house 315-363 (513) Show / Hide 
Range on Protein: 238-264
Range on HMM: 315-363/513
Sequence Identity: 26% (13 aa)

AMDIFSAGCVIAELFTE-------GVPLFD---------------LSQL
..|. |.||..||..|        | |||                . ||
PIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQL
Kinase PIK3R4.AA PDK1 131-167 32 3e-06 14.45 In-house 118-154 (307) Show / Hide 
Range on Protein: 131-167
Range on HMM: 118-154/307
Sequence Identity: 32% (12 aa)

QILTAVDQAHKSGVRHGDIKTENVMVTSWNWVLLTDF
.|..|..  |. |. | |.| ||..... . ...|||
EIIDALEHLHSNGIIHRDLKPENILLDKDMHIMITDF
Kinase PIK3R4.AA CDKL 126-167 41 4e-06 16.79 In-house 101-143 (286) Show / Hide 
Range on Protein: 126-167
Range on HMM: 101-143/286
Sequence Identity: 41% (18 aa)

RWIAFQILTAVDQAHKSGVRHGDIKTENVMVT-SWNWVLLTDF
| . .||| |... ||  . | ||| ||  .| .   | | ||
RKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDF
Kinase PIK3R4.AA MSK 126-167 35 5e-06 16.43 In-house 104-148 (277) Show / Hide 
Range on Protein: 126-167
Range on HMM: 104-148/277
Sequence Identity: 35% (16 aa)

RWIAFQILTAVDQAHKSGVRHGDIKTENVMVTSW---NWVLLTDF
| |  ..  |||. |. |. |.|.| ||.. ..      | |.||
RMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDF
Kinase PIK3R4.AA Ciliate-E2-Unclassified 128-167 27 5e-06 16.93 In-house 148-191 (352) Show / Hide 
Range on Protein: 128-167
Range on HMM: 148-191/352
Sequence Identity: 27% (12 aa)

IAFQILTAVDQAHKSG-VRHGDIKTENVMVTSWN---WVLLTDF
.. ||| . .. |... . | ||| ||..... .    . ..||
YFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDF
Kinase PIK3R4.AA CDKL 238-259 45 0.013299 4.72 In-house 180-200 (286) Show / Hide 
Range on Protein: 238-259
Range on HMM: 180-200/286
Sequence Identity: 45% (10 aa)

AMDIFSAGCVIAELFTEGVPLF
. || ..|||.||... | ||.
PVDIWAIGCVMAEMID-GQPLW
Kinase PIK3R4.AA MSK 287-313 22 0.018751 4.1 In-house 251-277 (277) Show / Hide 
Range on Protein: 287-313
Range on HMM: 251-277/277
Sequence Identity: 22% (6 aa)

RELVTQMIHREPDKRLEAEDYLKQQRG
..|....  . | ||| ..| ...   
KDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase PIK3R4.AA CK2 238-259 31 0.090803 0.2 In-house 176-197 (288) Show / Hide 
Range on Protein: 238-259
Range on HMM: 176-197/288
Sequence Identity: 31% (7 aa)

AMDIFSAGCVIAELFTEGVPLF
..|. | ||..| .  . .|.|
SLDMWSLGCMFASMIFKKEPFF
HEAT PIK3R4.AA HEAT 418-448 32 3.8e-05 21.68 Pfam 1-31 (31) Show / Hide 
Range on Protein: 418-448
Range on HMM: 1-31/31
Sequence Identity: 32% (10 aa)

ITPYLLHFSNDSVPRVRAEALRTLTKVLALV
| |.||.  ||....||. |...|....  .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT PIK3R4.AA HEAT 463-493 29 0.003646 14.82 Pfam 1-31 (31) Show / Hide 
Range on Protein: 463-493
Range on HMM: 1-31/31
Sequence Identity: 29% (9 aa)

ILPGIAHLAQDDATIVRLAYAENIALLAETA
||| . .. .|.   ||.| .. .. |.| .
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT PIK3R4.AA HEAT 577-608 28 0.217681 8.67 Pfam 1-31 (31) Show / Hide 
Range on Protein: 577-608
Range on HMM: 1-31/31
Sequence Identity: 28% (9 aa)

LLSHMITFLNDKNDWHLRGAFFDSIVGVAAYV
.|.|... |||. ||. | | . ... .. ..
ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC
HEAT PIK3R4.AA HEAT 616-646 25 0.153025 9.2 Pfam 1-31 (31) Show / Hide 
Range on Protein: 616-646
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

LKPLLQQGLSDAEEFVIVKALYALTCMCQLG
. |.| ..|.| .. |   |...|. .|.  
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT PIK3R4.AA HEAT 656-686 12 30.610349 1.23 Pfam 1-31 (31) Show / Hide 
Range on Protein: 656-686
Range on HMM: 1-31/31
Sequence Identity: 12% (4 aa)

FASDIAPFLCHPNLWIRYGAVGFITVVARQI
. . .   |..|.  .|. |.  ........
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
WD40 PIK3R4.AA WD40 983-1021 22 4.9e-13 40.14 Pfam 1-39 (39) Show / Hide 
Range on Protein: 983-1021
Range on HMM: 1-39/39
Sequence Identity: 22% (9 aa)

GLLVAHLHEHKSAVNRIRVSDE-HSLFATCSNDGTVKIWN
. ... . .|...|. ......  ...|..| |||..||.
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 PIK3R4.AA WD40 982-1021 20 4e-11 44.21 SMART 1-46 (46) Show / Hide 
Range on Protein: 982-1021
Range on HMM: 1-46/46
Sequence Identity: 20% (10 aa)

KGLLVAHLHEHKS--AVNRIRVSDEH------SLFATCSNDGTVKIWN
.  .|. .. |..  .|. ..... .      ...|..| |||..||.
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 PIK3R4.AA WD40 1031-1070 18 0.025025 10.47 SMART 1-46 (46) Show / Hide 
Range on Protein: 1031-1070
Range on HMM: 1-46/46
Sequence Identity: 18% (9 aa)

TTRSILTYSRIGG--RVKTLTFCQGS------HYLAIASDNGAVQLLG
| . . |..   |  .| ...... .      .||| .| .| . .  
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 PIK3R4.AA WD40 1132-1169 20 0.048435 8.66 SMART 1-46 (46) Show / Hide 
Range on Protein: 1132-1169
Range on HMM: 1-46/46
Sequence Identity: 20% (10 aa)

AWTLKHDLK--SG--LITSFAVDIHQ------CWLCIGTSSGTMACWD
  .. | .|  .|   .|. ... .        .|. |   ||  .||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 PIK3R4.AA WD40 1133-1169 25 28.332319 0.53 Pfam 1-39 (39) Show / Hide 
Range on Protein: 1133-1169
Range on HMM: 1-39/39
Sequence Identity: 25% (10 aa)

WTLKHDLKSGLITSFAVDIHQC---WLCIGTSSGTMACWD
|..|| .     .  ....|.    .|. |   ||   ||
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 PIK3R4.AA WD40 1171-1214 12 0.66229 1.49 SMART 1-46 (46) Show / Hide 
Range on Protein: 1171-1214
Range on HMM: 1-46/46
Sequence Identity: 12% (6 aa)

RFQLPISSHCHPSRARIRRLSMHPLY----QSWVIAAVQGNNEVSMWD
  ..  . ..| . .... .. ||      .. ..|.   .. . .||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 PIK3R4.AA WD40 1229-1269 21 1.5e-05 18.61 Pfam 1-39 (39) Show / Hide 
Range on Protein: 1229-1269
Range on HMM: 1-39/39
Sequence Identity: 21% (9 aa)

APPLSELQPSPHSVHGIYCSPADGNPILLTAGSDMKIRFWD
  .....    |.|  . ..|  . ..|.... | .|| ||
WKCKHTF-GHTHWVTCCAWHPD-MGHYLASGSRDGTIRIWD
WD40 PIK3R4.AA WD40 1228-1269 16 0.000112 22.79 SMART 1-46 (46) Show / Hide 
Range on Protein: 1228-1269
Range on HMM: 1-46/46
Sequence Identity: 16% (8 aa)

SAPPLSELQPSPH--SVHGIYCSPAD----GNPILLTAGSDMKIRFWD
.  ......   .  .|...  .| .    .. .|.... | .||.||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 PIK3R4.AA WD40 1319-1358 22 4.5e-07 22.97 Pfam 1-39 (39) Show / Hide 
Range on Protein: 1319-1358
Range on HMM: 1-39/39
Sequence Identity: 22% (9 aa)

RGPESLPVGHHDIITDVATFQTTQGFIVTASRDGIVKVWK
. . .   || . .|..|  .  . .....|||| ...|.
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 PIK3R4.AA WD40 1317-1358 16 7.6e-05 23.35 SMART 1-46 (46) Show / Hide 
Range on Protein: 1317-1358
Range on HMM: 1-46/46
Sequence Identity: 16% (8 aa)

PRRGPESLPVGHHD--IITDVATFQTT-----QGFIVTASRDGIVKVWK
. .   ... || .   .|.|.  ..        .....| || ...|.
T-KCVHTFK-GHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD