Gene PKCh (Human)

PKCh

Species: Human
Alias: PRKCH, nPKC-eta, PRKCL, MGC26269, PKC-L, PKCh, MGC5363, PKCL
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 14q23.1,

Classification

Group: AGC
Family: PKC
Subfamily: PKCh

Sequence

Name Sequence Type Origin Length Description Download
PKCh.NA RNA Sugen Kinome 3522 None Fasta, JSON
PKCh.AA Protein Sugen Kinome 683 None Fasta, JSON
PKCh.kin_dom Protein Kinase Domain Sugen Kinome 260 None Fasta, JSON

Protein domain

Protein domains of PKCh.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C2_PKD PKCh.AA C2_PKD 9-167 28 2.2e-29 100.08 In-house 1-183 (183) Show / Hide 
Range on Protein: 9-167
Range on HMM: 1-183/183
Sequence Identity: 28% (52 aa)

NGYLRVRIGEAVGLQPTRWSLRHSLF---KKGHQLLDPYLTVSVDQVR----VGQTSTKQKTNKPTYNEEFCANVTDGGHLELAVFHETPLGYDHFVANC
 | .|||...| || |.    .| |      . .. |||. | || .     .||| .| ||  |  |..| ..|..| |......|   .. . .||.|
MGFCRVRLCRADGLKPKMFQHWHNLTFGKPADCEAIDPYCVVHVDEKHENQHIGQTTQKKKTFYPEWNKCFDHHVYEGRHIQIVCMHNAIMPPNKMVAEC

TLQFQELLRTTGA-SDTFEGWVDLEPEGKVFVVITLTGSFTEATLQR---------------DRIFKHFTRKRQRAMR-RRVH
|  . ..  . .  |.. . |..||| |||.| | .  . |..  .                 | .  |.|.|  ||| ...|
TMKLEDCIEMCKTNSGITHIWINLEPQGKVHVQIKWFNEDTDHKHHCDMIHPVPVLKMMKEFKRQRPGFNRRRGNAMRHAKIH
C2 PKCh.AA C2 12-102 26 1.8e-17 62.05 Pfam 1-90 (90) Show / Hide 
Range on Protein: 12-102
Range on HMM: 1-90/90
Sequence Identity: 26% (26 aa)

LRVRIGEAVGLQPTRWSLRHSLFKKGHQLLDPYLTVSVDQVRV----GQTSTKQKTNKPTYNEEFCAN--VTDGGH-LELAVFHETPLGYDHFVANCT
|||.. || .| |. |        ..  . ||| .|.......     .|.....|  |..||.|  .  . |. | |.. |...  .| |.|.  |.
LRVHVIEARNLPPMDW--------DKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNTLNPVWNETFTFDVPPPDLQHTLRFTVWDWDRFGRDDFIGQCC
C2 PKCh.AA C2 11-117 17 1.7e-15 58.69 SMART 1-92 (92) Show / Hide 
Range on Protein: 11-117
Range on HMM: 1-92/92
Sequence Identity: 17% (22 aa)

YLRVRIGEAVGLQPTRWSLRHSLFKKGHQLLDPYLTVSVDQVRVGQTSTKQKTN---KPTYNE---EFCANVTDGGHLELAVFHETPLGYDHFVANCTLQ
 |.|.| || .|                   ||| .|.       .|.....|.    |..||   .|  .|..   |.. |...       |.  |.. 
TLTVHIIEARNLP------------------DPYVKVY-------KTKVVKNTLSGFNPVWNEWMETFYFDVHP-Q-LRFEVWDH------DFIGHCCIP

--------------FQELLRTTGASDT
              ....|   .    
PNNPHWHQWDGCIHLSDIL-GYRH-WW
C1_1 PKCh.AA C1_1 172-225 41 2e-20 78.67 Pfam 1-55 (55) Show / Hide 
Range on Protein: 172-225
Range on HMM: 1-55/55
Sequence Identity: 41% (23 aa)

HKFMAT-YLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQ
|.....  ..|||.|.||.||.|| .|.||..||.|  ..|.|||.. .. | |.
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCh.AA C1 172-222 35 4.4e-16 60.68 SMART 1-61 (61) Show / Hide 
Range on Protein: 172-222
Range on HMM: 1-61/61
Sequence Identity: 35% (22 aa)

HKFMATYLRQPTYCSHCREFIWGVFG----KQGYQCQVCTCVVHKRCHHLIVT-------AC
|.....   .||||.|||..|||.|     .|||.|..|  ..||.||. .         .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_1 PKCh.AA C1_1 246-298 47 2.3e-22 85.43 Pfam 1-55 (55) Show / Hide 
Range on Protein: 246-298
Range on HMM: 1-55/55
Sequence Identity: 47% (26 aa)

HKFSIH-NYKVPTFCDHCGSLLWG-IMRQGLQCKICKMNVHIRCQANVAPNCGVN
|..  | |.| ||||.|||...|| . .||..|  |..|.| ||. .|.|.|| |
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKCh.AA C1 246-295 27 2.6e-18 68.07 SMART 1-61 (61) Show / Hide 
Range on Protein: 246-295
Range on HMM: 1-61/61
Sequence Identity: 27% (17 aa)

HKFSIHNYKVPTFCDHCGSLLWGIMRQ-----GLQCKICKMNVHIRCQANVAP-------NC
|.......  ||.|.||....||. .|     |..|  ||...| .|...|..       .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
Kinase PKCh.AA PKC 355-614 70 9.60000000001e-213 696.16 In-house 1-262 (262) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-262/262
Sequence Identity: 70% (186 aa)

FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEA
|.|..|||||||||||||. |.|  .||.||||||||.|||||||||||||.|.||..|||||.|.|||||.||||||||.|||||||||||..|||.|.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF
.|||||||||.||.|||.||||||||||||||||||||.|.||||||||...||.||.|||||||||||||||.. ||..|||||.|||.|||..|..||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQG--GEHAILRHPFF
..|.||.||..|..|...|| ||...|..|.|.||||||..|||. .|.  ||..| .||||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase PKCh.AA Eta 355-614 79 3.1e-210 704.7 In-house 1-261 (261) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-261/261
Sequence Identity: 79% (208 aa)

FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEA
|.||.|||||||||||||..|.|...||.||||||||.|||||||||||||||||||.|||||||.|||||.||||||||.||||||||.||..|.|||.
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

RARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF
||||||||...||||||..|.|||||||||.||||||||||||||||||||.||.||.||||||||||||||||| |||.|||||||||.|||.||..||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLT-QGGEHAILRHPFF
||.|||||||.||.|.|.||.|||..|..|||.||||||..|||..| |||||||..||||
EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase PKCh.AA AGC 355-614 35 9.60000000001e-196 511.91 In-house 1-395 (395) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-395/395
Sequence Identity: 35% (140 aa)

FEFIRVLGKGSFGKVMLARVK------ETGDLYAVKVLKKDV-ILQDD--DVECTMTE------------KRILSLARN---------HPFLTQ-LFCCF
|||..|.||||||||.|.| |       ||..||.|||||.. |....  .||.||||            ..||.....         |||... |...|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTPDR--LFFVME----FVN-----GG-DLMFHIQ---KSRRFDEARARFYAAE-------IISALMFLHD-KGIIYRD-LKLDNVLLDHEGHCKLADFG
|..|.  |.||||    .||     || .|..|.|   |..|||| ||||||||       |..|| .||. .|||.|| ||..|.|||..||.||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MCKEGICNG--------------------------------------------------VTTATFCG--TPDYIAPEILQEMLYGPAVDWWA--MGVLLY
.||||. .|                                                  ..| ||||  ||.|.|||||    ||.|.|||.  .|.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLCGHAPFEAEN----------EDDLFEAIL------NDEVVYP----------TWLHEDATGILKSFMTKNPTMRLGSLTQG----GEHAILRHPFF
|||.|. || ..|          ....|. |.      |..| .|           |. ..|  ..| ...|.|. |||.. ..    |   | .||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase PKCh.AA Alpha 355-614 63 8.99999999999e-161 540.41 In-house 1-259 (259) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-259/259
Sequence Identity: 63% (165 aa)

FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEA
| |. |||||||||||||  | |  |||.|.|||||| |||||||||.|||.| |    |||.|.  ||||.|||.||||.|||||||.|||.  .| | 
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

RARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF
 | ||||||  .| ||| |||||||||||||.|| ||| |.||||||||.. ...|| |||||||||||||     || .||||| |||||||. | .||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFF
. | ||.||.|| . .|.||  .   |  | |.|.||.|  |||. .. ||. |  ||||
DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGC-GPDGEQDIREHPFF
Kinase PKCh.AA Delta 355-614 60 1.4e-145 489.91 In-house 1-259 (259) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-259/259
Sequence Identity: 60% (158 aa)

FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEA
| | .||||||||||||| .|.. . ||.| |||||.|.|||||||| |.|.|.|| .||||..||| ||| . ||||||..||||||.|||...||||.
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

RARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF
||||||.|||..| ||| ||||||||||||||||..|| |.|||||||| .    .. |||||||||||||..  .|  .||||. |||.|||| | .||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGS-LTQGGEHAILRHPFF
. |.||.||..|.||.  || |. ..|...||  . ..|. |||.  .  |.  | .|.||
HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGD--IRQHCFF
Kinase PKCh.AA Akt 355-614 48 6.00000000001e-137 440.35 In-house 1-264 (264) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-264/264
Sequence Identity: 48% (129 aa)

FEFIRVLGKGSFGKVMLARVKETGDLY-AVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDE
|.|..||||||||||.|.. | |...| | ||||||.|.| . || |.||..||   . |||...|   |||.|.|.|||...|||.| .|.|. |||.|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

ARARFYAAEIISALMFLHDKGIIYRD-LKLDNVLLDHEGHCKLADFGMCKEG-ICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWA-MGVLLYEMLCG
 |||||.||||.|. .|| |.||||| ||. |.|.|..|| .|.|||.|||. | .. .| |||||| |.|||||.   .. |||||.  |...|||.||
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

HAPFEAENEDDLFEAILNDEVVYP--TWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFF
  || ... . .|. |.| .| .|   |.  ..  ....  .|.|..|||. . .. . | |||.|
RPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGG-GPNDAQEIKRHPWF
Kinase PKCh.AA SGK 355-614 42 4.3e-132 410.43 In-house 1-283 (283) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-283/283
Sequence Identity: 42% (121 aa)

FEFIRVLGKGSFGKVMLARVKET------------------GDLYAVKVLKKDVIL-------QDDDVECTMTEK-RILSLARNHPFLTQLFCCFQTPDR
|.|. |.||||||||.... |..                  ...||.|||.|. |.       .   .  .|.|.  ||..  .|||. .|   |||.. 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNM-KHPFIVNLHYAFQTKWK

LFFVMEFVNGGDLMFHIQKSRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQE
|.|||..||||.. .|.|. ..| | |||||||||..||  ||.. ||||||| .|.||||.|||.| ||| |||||    || |||||| | |||.|. 
LYFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRK

MLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFF
  .. .|||| .| .||||. |  ||.  |   ... |.| .   |.    ||  ...   .|.|. |||.   ..|  | .||||
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFME--IKNHPFF
Kinase PKCh.AA Iota 355-614 54 7.1e-123 411.27 In-house 1-271 (271) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-271/271
Sequence Identity: 54% (149 aa)

FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFDEA
|| |||.|.||. ||.... |.|  .||.||.||... .|.|..   ||| .   | |||||  |  ||||. |||||.|||||||||||.|. |.  | 
FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPEE

RARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPF
 ||||.|||. || |||..||||||||||||||||||| || |.||||||| .| ||.|||||| |||||||    || .|||||.|||..||. | .||
HARFYSAEICLALNFLHERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF

---------EAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQG--GEHAILRHPFF
         .   || ||  ||  ..  |  |   |...||.|. |.|. |||   |   | . |  ||||
DIVGNMDNPDQNTEDYLFQVILEKQIRIPRSLSVRAAHVLKGFLNKDPKERLGCHPQTNEGFMDIKEHPFF
Kinase PKCh.AA PKN 355-614 51 6.4e-110 371.48 In-house 1-260 (260) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-260/260
Sequence Identity: 51% (135 aa)

FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARN--HPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRRFD
| .| |||.| ||||.|.. |.||..||.|.|||  |.  |.||  |.||||.  .    |||| .|| |||| .  .||||.. ||||| || .   |.
FRCIAVLGRGHFGKVLLSQYKHTGEYYAIKALKKQDIVARDEVESLMCEKRIFEVVNRMRHPFLVNLFACFQTEEHVCFVMEYAMGGDLMMHIHED-VFS

EARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHA
|.||.|||| ..  | .||.. ||||||||||.|||.||. |.||||.||||.  |  |.||||||...|||.| .  |  ||||| .|||.|||| | .
EPRACFYAACVVLGLQYLHEHKIIYRDLKLDNLLLDTEGYVKIADFGLCKEGMGYGDRTSTFCGTPEFLAPEVLTDTSYTRAVDWWGLGVLIYEMLVGEC

PFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFF
||  ..|...|..|.||.| || .|  .|  |..  . |||  |||.  .  |  |  .|||
PFPGDDEEEVFDCIVNDDVRYPRFLSVEAIAIMRRLLRKNPERRLGAGERDAED-IKMQPFF
Kinase PKCh.AA S_TKc 355-614 37 2.5e-103 350.51 SMART 1-231 (231) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-231/231
Sequence Identity: 37% (100 aa)

FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNG--GDLMFHIQKSRR--
.|..|..|||.||||...| |.|| ..|.|..|          | .. | .||.   .||.. .|. .||. |.|..|||...|  |||. .|.| .|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGP-AVDWWAMGVLLY
    |.| .||||...|..|| ..|..|||.|||| .|.|||.  | |..|||....         ||||||.|.|||.|    ||. ..|||. |..||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGG-EHAILRHPFF
|||||  ||.  ... .|. |.           ..|  ...  ..|.|. |..       | .|  ||.|
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKCh.AA RSK 358-614 40 3.1e-102 345.93 In-house 1-278 (278) Show / Hide 
Range on Protein: 358-614
Range on HMM: 1-278/278
Sequence Identity: 40% (112 aa)

IRVLGKGSFGKVMLARVK---ETGDLYAVKVLKKDVILQDD-DVECTMTEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGGDLMFHIQKSRR---
..|||.|..||| | | .    || .||.||||| .| | . |.. |||| .||.. ..|||. .|.  |||.. |. .||...||.|  |.|| ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDH---EGHCKLADFGMCKEGICN-GVTTATFCGTPDYIAPEILQ----EMLYGPAVDWWAMGV
|.| .|.||.|||..|. .||..|||.||||..|.|.|.   ||| || ||| ||.. |. .  | |||.| .|.|||.|     .  .. |.|||  ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LLYEMLCGHAPFEA---ENEDDLFEAILNDE--VVYP--TWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFF
|.|||| |. || .   .| ..... |.. .  .  |    | ..|  ...  ....| .|||.   ..   |..||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGC-GPQDAEEIKQHPWF
Kinase PKCh.AA Pkinase 355-614 31 5.3e-85 293.49 Pfam 1-293 (293) Show / Hide 
Range on Protein: 355-614
Range on HMM: 1-293/293
Sequence Identity: 31% (94 aa)

FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTM-TEKRILSLARNHPFLTQLFCCFQTPDRLFFVMEFVNGG----DLMFHIQ--K
....|..|.||||.| ... | ||...|||..||. .  . |.. .  .| .|.    |||.  .|...|...|.. .|||...||    ||. .|.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

SRRF--DEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHC----KLADFGMCKEG-ICNGVTTATFCGTPDYIAPEILQ-EMLYGPAVDWWA
...|  .|  ..||. .|...| ..|..|||.||||..|.|.|..||.    |..||| .|   . |.. . ||||||.|.|||...    |||.||.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

MGVLLYEMLCGHAPFEAE------NEDDLFEAILNDEVVYPTWLH---------------------EDATGILKSFMTKNPTMRLGSLTQGGEHAILRHP
.|..|||||||. ||  .      ... ... |.  .. .. .                       |..  ..|.  .|.|. |..       . || ||
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT------AEQILQHP

FF
.|
WF
Kinase PKCh.AA S_TK_X 615-678 41 2.1e-27 98.29 SMART 1-79 (79) Show / Hide 
Range on Protein: 615-678
Range on HMM: 1-79/79
Sequence Identity: 41% (33 aa)

KEIDWAQLNH--RQIEPPFRPRIK----SREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDE---------FRNFSYVS
..||| .| .  ..|||||.|.||    | .|.|||||.| .|.|.|||.|.. .. ..|.|         ||.|.|| 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase PKCh.AA Pkinase_C 634-680 44 1.1e-18 69.0 Pfam 1-46 (46) Show / Hide 
Range on Protein: 634-680
Range on HMM: 1-46/46
Sequence Identity: 44% (21 aa)

RIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE
..||..|.|||||.| .| |..|| |.  .. ..|..||.|.||.|.
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase PKCh.AA TyrKc 355-609 20 1.2e-15 30.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 355-609
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

FEFIRVLGKGSFGKVMLARVKETGDLYAVKVLKKDVILQDDDVECTMTEKRILSLA-RNHPFLTQLFCCFQTP-------DRLFFVMEFVNGGDLMFHIQ
 .....|| | ||.|.... |      |||.||.|       .|  | | ||..    .|| . .|. .  ..       . |. |||.. .|||  ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KSRR-FDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCKEGICN-------GVTTATFCGTPD------YIAPEILQEMLYG
|.|. .  .    ..  | .   .||.|..| |||   |.|.......| .|||.....           . ...  .  .        ||| ...  . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

PAVDWWAMGVLLYEML-CGHAPFEA-----ENEDDLFEAILNDEVVYPTWL----------HEDATGILKSFMTKNPTMRLGSLTQGGEHAIL
.. | |. ||...|..  |  | .       . ....| . . .   .              |  . | |.    .| .|    .    | ..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI---HECF
Kinase PKCh.AA Pkinase_Tyr 421-502 25 1.3e-07 26.41 Pfam 72-159 (270) Show / Hide 
Range on Protein: 421-502
Range on HMM: 72-159/270
Sequence Identity: 25% (22 aa)

CCF-QTPD-RLFFVMEFVNGGDLMFHIQK----SRRFDEARARFYAAEIISALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCK
.|  |    ... |||.. .|||  . .|     ....  .   ....| ... .|..|..| |||   |.|.......| .|||...
VCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase PKCh.AA Pkinase_Tyr 355-389 35 4e-06 21.26 Pfam 1-39 (270) Show / Hide 
Range on Protein: 355-389
Range on HMM: 1-39/270
Sequence Identity: 35% (14 aa)

FEFIRVLGKGSFGKVMLARVK----ETGDLYAVKVLKKD
 .|...||.|.||.|.... |    .|.   |||.|| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG
Kinase PKCh.AA Pkinase_Tyr 522-566 27 0.748433 3.51 Pfam 182-228 (270) Show / Hide 
Range on Protein: 522-566
Range on HMM: 182-228/270
Sequence Identity: 27% (13 aa)

APEILQEMLYGPAVDWWAMGVLLYEMLC-GHAP-FEAENEDDLFEAI
||| .... .  . | |. |||..|..  |  | ..     ...|.|
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI