Gene PKD1 (Human)

PKD1

Species: Human
Alias: PRKCM, PKC-MU, PKD1, PKD, PRKD1, PKCM
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 14q11.2 ,

Classification

Group: CAMK
Family: PKD

Sequence

Name Sequence Type Origin Length Description Download
PKD1.NA RNA Sugen Kinome 3712 None Fasta, JSON
PKD1.AA Protein Sugen Kinome 920 None Fasta, JSON
PKD1.kin_dom Protein Kinase Domain Sugen Kinome 257 None Fasta, JSON

Protein domain

Protein domains of PKD1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PKD_Nterm_DUF PKD1.AA PKD_Nterm_DUF 49-137 46 3.7e-45 148.41 In-house 1-87 (87) Show / Hide 
Range on Protein: 49-137
Range on HMM: 1-87/87
Sequence Identity: 46% (42 aa)

ISFHLQIGLSREPVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYG-MYDKILLFRHDPTSENILQLVKAASDIQEGDLIEVVLSASA
 .||.|.|..||.| .    ..  .|. ..| ||....||.|.||... .||||.|||||..|.||||... |||. ||.|||.||||..
CHFHFQCGFHREMVCV---EGHELTLTALKELACQFIEQKYPDCGCCNRLYDKIYLFRHDYNSPNILQMITSASDVTEGCLIEIVLSACP
C1_1 PKD1.AA C1_1 147-199 43 1.9e-16 64.03 Pfam 1-55 (55) Show / Hide 
Range on Protein: 147-199
Range on HMM: 1-55/55
Sequence Identity: 43% (24 aa)

HALFVH-SYRAPAFCDHCGEMLWG-LVRQGLKCEGCGLNYHKRCAFKIPNNCSGV
|   .| ... |.||.||||..|| | .||.||. |..|.|.||. | |..| . 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKD1.AA C1 140-196 24 7.3e-15 56.63 SMART 1-61 (61) Show / Hide 
Range on Protein: 140-196
Range on HMM: 1-61/61
Sequence Identity: 24% (17 aa)

EDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQ-----GLKCEGCGLNYHKRCAFKIPN-------NC
........         |..|.||..|.||. .|     |..|. |....||.|. |.|.       .|
HHWHWWRF--------KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 PKD1.AA C1_3 158-189 25 0.000646 11.46 Pfam 1-30 (30) Show / Hide 
Range on Protein: 158-189
Range on HMM: 1-30/30
Sequence Identity: 25% (8 aa)

AFCDHCGEMLWGLVRQGLKCEGCGLNYHKRCA
 .|. ||. . .  . . .|  |  . |..||
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
C1 PKD1.AA C1 279-328 32 9.6e-21 76.15 SMART 1-61 (61) Show / Hide 
Range on Protein: 279-328
Range on HMM: 1-61/61
Sequence Identity: 32% (20 aa)

HTFVIHSYTRPTVCQYCKKLLKGLFRQ-----GLQCKDCRFNCHKRCAPKVPN-------NC
|....... .|| |..|.|...|.|.|     |..| .|...|||.|..|||.       .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_1 PKD1.AA C1_1 279-331 40 3.9e-19 73.9 Pfam 1-55 (55) Show / Hide 
Range on Protein: 279-331
Range on HMM: 1-55/55
Sequence Identity: 40% (22 aa)

HTFVIH-SYTRPTVCQYCKKLLKG-LFRQGLQCKDCRFNCHKRCAPKVPNNCLGE
| .| | .. .|| | .|.... | |..||..| .| .|||.||..|||..| . 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1_3 PKD1.AA C1_3 290-321 25 0.002653 9.9 Pfam 1-30 (30) Show / Hide 
Range on Protein: 290-321
Range on HMM: 1-30/30
Sequence Identity: 25% (8 aa)

TVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCA
  |. |.. ...  . .  |  | |. |..||
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
PH PKD1.AA PH 431-549 22 7.1e-14 52.68 Pfam 1-92 (92) Show / Hide 
Range on Protein: 431-549
Range on HMM: 1-92/92
Sequence Identity: 22% (27 aa)

VMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTS
|.||||.  .. |   .|...  | ..|. ....|. .|. . ||||.. ....|...       .||||.|.| .                  .... .
VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDK-YRPKGSIPLSDC-QVTKVPDN------KRPHCFQIRT-DR-----------------RTYYFQ

GVGADVARMWEIAIQHALM
   .. .. |  ||| |. 
AESEEEMNDWMQAIQSACR
PH PKD1.AA PH 431-551 17 4.7e-10 40.64 SMART 1-82 (82) Show / Hide 
Range on Protein: 431-551
Range on HMM: 1-82/82
Sequence Identity: 17% (21 aa)

VMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTS
| ||||. ...     .|... .|...|.......   .. ..||||.. .... .            ||||.. .                   . . .
VIKEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK---KPKGSIPLSDC-TVRE-P------------CFEIHH-DR------------------TYYFQ

GVGADVARMWEIAIQHALMPV
   .. ...|  ||| |. . 
CESEEEMQEWMQAIQKAIHNN
Kinase PKD1.AA PKD 591-847 86 1.5e-233 782.18 In-house 1-260 (260) Show / Hide 
Range on Protein: 591-847
Range on HMM: 1-260/260
Sequence Identity: 86% (225 aa)

IFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQ--ESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPE
||||||||||||||||||.||.|||.||.|.||||||||||  |.|.||||||||...|||||.||||.|||.|.||||||.||||||||||||||||.|
IFPDEVLGSGQFGIVYGGIHRHTGRHVAVKVIDKLRFPTKQSGEEQMRNEVAILQQVCHPGVVCLECMCETPDRIFVVMEKMHGDMLEMILSSEKGRLNE

HITKFLITQILVALRHLHFKNIVHCDLKPENVLLASA-DPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSG
..|||||||||.||..||..||||||||||||||.|. ..||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
RVTKFLITQILCALKYLHHQNIVHCDLKPENVLLSSMGSDFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSG

TFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWL
||||||||||.|||||||||||||||||||..|||||||||||||||||.|||.||||||
TFPFNEDEDINDQIQNAAFMYPPNPWKEISENAIDLINNLLQVKMRKRYTVDKCLSHPWL
Kinase PKD1.AA CAMK 596-847 23 1.7e-107 347.52 In-house 1-425 (425) Show / Hide 
Range on Protein: 596-847
Range on HMM: 1-425/425
Sequence Identity: 23% (99 aa)

VLGSGQFGIVYGGKHRKTG------------RDVAIKIIDK----------------LRFP----------TKQESQLRNEVAILQN-------LHHPGV
.||.|.||.|. ..|..|.            . ||||||||                ...            | . ..|.|..|...       |.|| .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNLECMFE------------TPER--------VFVVM---EKLHG-----DMLEMILSSEK-------------GRLPEHITKFLITQILVALRHLHFKN
..|  ..|            | ..        .. ||   |   |     |....| . ..             ||..|. ..... ||. |....| .|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHCDLKPENVLLASADPFP--------------QVKLCDFGFARIIGE------------------------KSFRRSVVGTPAYLA-PEVLRN-----
|||.||||||.|| . ..                ..|..|||||... .                            . ..|||.| | ||||.      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------KGYNRSLDMWSVGVIIYVSLSGTFPFNED---------------EDIHDQIQNAAFMYPPNP------------WKEISHE--------AI
         ..|... ||||.||| |. |.|..||..|               .... .|... . .|| .            |..|| |        ..
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLINNLLQVKMRKRYSVDKTLSHPWL
|||...|||   ||....  |.|||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PKD1.AA RAD53 594-847 34 4.4e-102 304.88 In-house 4-305 (305) Show / Hide 
Range on Protein: 594-847
Range on HMM: 4-305/305
Sequence Identity: 34% (105 aa)

DEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFP------TKQESQLRNEVAILQNLHHPGVVNLECMFETP-ERVFVVMEKLHG-DMLEMILSSEKGR
...|||| ||.|. .. .||.. |||||||| .|       .| ..|..||| ||..|.|| .....  |.|| . .. |.|.  | . .. | |. |..
SKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSN-KRC

---LPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFP---------------QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNK-
   . | . |..  |.. |.. || ..|.| ||||||.|... |                  ..|. ||| ....||.|| .   |||.|.||||...| 
QMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITSKG

--------------GYNRSLDMWSVGVIIYVSLSGTFPFNED-------EDIHDQIQN-AAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSH
              ||... |.|| |.| |..|.|. || .|        .. .|| | . . .|.  |..|| || |||...|.|   |||..|. |.|
HNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEALNH

PWL
||.
PWM
Kinase PKD1.AA S_TKc 591-847 33 7.7e-95 322.29 SMART 1-231 (231) Show / Hide 
Range on Protein: 591-847
Range on HMM: 1-231/231
Sequence Identity: 33% (92 aa)

IFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHG---DMLEMILSSEKGR--
    ...|.| || || ..|.|||| ||||||.          ..|.|..||.. ||| .|.|  .|.. .....||| . |   |....| .  ...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNR-SLDMWSVGVIIY
  .||  ..|.. ||. || ..| ..|.|.||||||.|| .     ..|.||||.||..      ....||| |.|||||   ||.. . |.||.|.|.|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

VSLSGTFPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLS-------HPWL
  |.|  ||    ...  ...             |.||.|.|...||.  .||... . |        |||.
EMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKD1.AA AGC 591-847 21 3.5e-87 224.72 In-house 1-395 (395) Show / Hide 
Range on Protein: 591-847
Range on HMM: 1-395/395
Sequence Identity: 21% (86 aa)

IFPDEVLGSGQFGIVYGGKHR------KTGRDVAIKIIDKLR--FPTK--QESQLRNE------------VAILQNLH----------HPGVVN-LECMF
     |.| | || ||  ...       ||.  |.|...| .    .|  .. .  .|              ||....          || .|. | . |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETPER--VFVVME----KLH-----GD-MLEMILSS--EKGRLPEHITKFLITQ-------ILVALRHLHF-KNIVHCD-LKPENVLLASADPFPQVKLC
.....  .. |||     .      |. .| ..|     .||..|  ..| . .       |. || .||  ..|.| | |||||.|| .      .||.
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLT

DFGFARIIG---------------------------------------------------EKSFRRSVVG--TPAYLAPEVLRNKGYNRSLDMWS--VGV
|||.. ..                                                    ..    . .|  || |.|||.|    |... | ||  .|.
DFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGC

IIYVSLSGTFPFNEDE------------DIHDQIQ------NAAFMYPPN------PWKEISHEAIDLINNLLQVKMRKRYS----------VDKTLSHP
..|  |.|  ||. |.            .....|.      |    .|..      .....| || |||. ||..  .||            ..   .||
LMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHP

WL
| 
WF
Kinase PKD1.AA Pkinase 591-847 31 4.7e-79 273.75 Pfam 1-293 (293) Show / Hide 
Range on Protein: 591-847
Range on HMM: 1-293/293
Sequence Identity: 31% (93 aa)

IFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRN--EVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGD----MLEMILS-SEK
.   ...||| || || ..|..||. ||.|||.| .   ... ..|.  |..|...|.|| .| | ..||.. .. .||| . |.     |  ..| ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRL--PEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFP--QVKLCDFGFARI--IGEKSFRRSVVGTPAYLAPEVLR-NKGYNRSLDMWS
|..  .|.  || ..||| .| ..| ..|.|.||||||.|.   .. .   ||.||||.|.   .  .|   ...||| |.||||.| ...| .. ||||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

VGVIIYVSLSGTFPFNED--------EDIHDQIQNAAFMYPPNPWKEIS-----------------HEAIDLINNLLQVKMRKRYSVDKTLSHPWL
.|.|.|  |.| .|| ..          ....|  . ....   | .||                  |..|.|...|.... ||.. .  | |||.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PKD1.AA CAMKL 589-847 30 7.5e-77 244.75 In-house 1-297 (297) Show / Hide 
Range on Protein: 589-847
Range on HMM: 1-297/297
Sequence Identity: 30% (94 aa)

YQIFPDEVLGSGQFGIVYGGKH-RKTGRDVAIKIID--KLRFPTKQESQ-----------LRNEVAILQNLH---HPGVVNLECMFETPER------VFV
|.|   ..|| | || |  ..| | ||. |||||||  |..  .. ..            .| |..|.. |.   || .. |  ..||||       .. 
YRI--GKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYL

VMEKLHGD---MLEMILSSEK--GRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASAD-PFPQVKLCDFGFARIIGE-----KSFRRSVVGT
|||   |    ....| . ..  ||.||| .... .||. |. ..| ..||| |.||||.|| . .    ..|..||||. .. .       . .   |.
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQKLKTFCGS

PAYLAPEVLRN--KGYN-RSLDMWSVGVIIYVSLSGTFPFNEDEDI---------HDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTL
|.| |||..    | |. .  |.|| ||| |. . |..||..| .          . .|    ...|  .|...| ...|||  .|||.  ||....  .
PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPP--IWYHVS-DCRDLIRKMLQVNPEKRPTIHQIM

SHPWL
.|||.
NHPWM
Kinase PKD1.AA Ciliate-E2 595-847 23 7.3e-70 238.42 In-house 5-365 (365) Show / Hide 
Range on Protein: 595-847
Range on HMM: 5-365/365
Sequence Identity: 23% (88 aa)

EVLGSGQFGIVYGGKHRKTGR------------------DVAIKIIDKLRFPTKQESQLRNEVAILQNLH----------------HPGVVNLECMFE--
...|.|.||.|| .|..|...                   |.|||. . ..  .|  |. .|  |.. ..                || ....   |.  
KKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEK

TPERVFVVMEKLHG-DMLEMILSS-----------------EKGRLPEHITK-------FLITQILVALRHLHFKN-IVHCDLKPENVLLASADPFPQVK
. . .. ||| . | |... | ..                 | ... ..|..       | |..|..||..|| || |.| |.||||.|.        .|
DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IK

LCDFGFARIIGEKSFRRS--------------------------------VVGTPAYLAPEVLRNKG---------YNRSLDMWSVGVIIYVSLSGTFPF
..|||..... ... .|.                                ..||| |.|||.|..|.         |. . |.||.|||.|  |.| .||
IIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF

NEDEDIHDQIQNAAFMYPPN--------------PWKEISHEAIDLINN----LLQVKMRKRYS-VDKTLSHPWL
       .||..  . .|..               ||..| |..|||..    .||..  ||..  .. | |||.
------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase PKD1.AA ULK 591-847 29 3e-65 223.09 In-house 1-324 (324) Show / Hide 
Range on Protein: 591-847
Range on HMM: 1-324/324
Sequence Identity: 29% (95 aa)

IFPDEVLGSGQFG-IVYGGKHRKT---GRDVAIKIIDKLRF-PTKQES-------QLRNEVAILQNLH---HPG--VVNLECMFETPER--VFVVMEKLH
.  ...||.|.||  || |.. ||   . .||.|.|||  .   |.|.       .|.||. |.. |.   ||   .| |  .|||.    .. .||   
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GDMLEMILSSEKG--------RLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPF---------PQVKLCDFGFARIIGE----KSFRRS
|  || ..   |.        ||.| ...  . ||. ....|| .||.|.|.||.| |.   .|          ...|..|||||... .    .  . .
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

VV------GTPAYLAPEVLR----NKGYNRS-LDMWSVGVIIYVSLSGTFP----FNEDE----DIHDQ-------IQNAAFMYPPN-PWKEISHEAIDL
 |      ||| | ||..|     .| |. .  |.||.|.|.|  | |  |    ||...    .  ..       |.|  . .|.. . . || | .||
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDL

INNLLQVKMRKRYSVDKTLSHPWL
|  .||.. ..| | .  ..|||.
IRRMLQYDEKDRISWEEIFNHPWF
Kinase PKD1.AA ULK 591-847 28 1.3e-64 221.02 In-house 1-329 (329) Show / Hide 
Range on Protein: 591-847
Range on HMM: 1-329/329
Sequence Identity: 28% (95 aa)

IFPDEVLGSGQFGIVYGGKHRKT----GRDVAIKIIDKLRF-PTKQESQ-------LRNEVAILQNLH--------HPGVVNLECMFETPER--VFVVME
.  ...||.|.|| || |.. ||    . .||.|.|||  .   ..|..       |.||. |.. |.        || .| |  .|||.    .. .||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

KLHGDMLEMILSSEKG---------RLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPF---------PQVKLCDFGFARIIG----EKS
   |  || ...  |.         ||.| ...  . ||| ....|| .||.|.|.||.|.|.   .|          ...|..|||||. .     |. 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

FRRSVV------GTPAYLAPEVLR----NKGYNRS-LDMWSVGVIIYVSLSGTFP----FNEDE-----DIHDQ-------IQNAAFMYPPN-PWKEISH
   . |      ||| | ||..|     .| |. .  |.||.|.|.|  | |  |    ||..      .  ..       |..  . .|.. . . || 
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

EAIDLINNLLQVKMRKRYSVDKTLSHPWL
| .|||  .||.. ..| | .  ..|||.
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase PKD1.AA CAMK1 694-847 38 1e-63 184.04 In-house 113-276 (276) Show / Hide 
Range on Protein: 694-847
Range on HMM: 113-276/276
Sequence Identity: 38% (63 aa)

LITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVK--LCDFGFARIIGEKS-FRRSVVGTPAYLAPEVLRN---KGYNRSLDMWSVGVIIYVSLSG
.. ||| |. ..| |.|||.|||||| |... |.  ..|  ..||| ..|..... .   ..||| | ||||| .   |.|  . ||||.||| |. | |
IMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYILLCG

TFPFNEDE-D--IHDQIQNAAFMYPPNPWKEISHE-AIDLINNLLQVKMRKRYSVDKTLSHPWL
  ||...  |  . ..| .. . .| . | .|| . | |.|...| |   |||.... | |||.
YPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase PKD1.AA Ciliate-E2-Unclassified 594-847 25 3.1e-63 216.4 In-house 4-352 (352) Show / Hide 
Range on Protein: 594-847
Range on HMM: 4-352/352
Sequence Identity: 25% (91 aa)

DEVLGSGQFGIVYGGKHRKTGRDV-------AIKIIDKLRFPTK----QESQLRNEVA-------------ILQNLHHPGVVNLECMFETPERVFVVMEK
 ...|.|.||.||  .|.|..  .        |.|....   .|    .| .  |.               ||.|. || .|... .|.. . .. |||.
IKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVMEY

L-HGDMLEMILSSEK---------------GRLPEHITK-----FLITQILVALRHLHFKN-IVHCDLKPENVLLASAD-PFPQVKLCDFGFARIIGE--
. .||....| ...|                ...|  .|     |.. |||..| .|| || |.| |.||||.|. .    . ..|..|||... ...  
CEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNY-YIKIIDFGISKKYQQNN

--------------KSFRRSVVGTPAYL----APEVLRNKGYNRS----LDMWSVGVIIYVSLSGTFPFN--EDED----------------IHDQIQNA
              .    ...||| |.    |||||....|. |     |.||.|||.|  | |..||.   .|.                ....|.. 
NCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQK

AFMYPPNPW----KEISHEAIDLIN----NLLQVKMRKRYSVDKTLSHPWL
 . .|. ||    | .| ||.|.||     .|.... ||.. .. | |||.
NIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase PKD1.AA CAMK1 589-668 28 2.8e-27 76.28 In-house 1-88 (276) Show / Hide 
Range on Protein: 589-668
Range on HMM: 1-88/276
Sequence Identity: 28% (26 aa)

YQIFPDEVLGSGQFGIVYGGKHRKT---GRDVAIKIID-KLRFPTKQE---SQLRNEVAILQN---LHHPGVVNLECMFETPERVFVVME
|...  ...|.| |..|| ..|..|   |...|||.|| |    .| .    .|.||..|...   ..|| ...... .|... .  |||
YEFG--KEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVME
Kinase PKD1.AA TyrKc 591-827 20 1.1e-14 15.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 591-827
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

IFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNL--HHPGVVNLECMFETP-------ERVFVVMEKL-HGDMLEMILS
|  ...||.|.||.|| |. .   ..||.| . .       .  ...|  |. .|  ||| .|.|     ..       | ...|||   ||| .. . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEK--------SFRRSV-VGTP-----AYLAPEVLRNK
...  |.        .||    ..|| ||..| ||   |.|...     .|| .||| .| |...          | .   |.        .|||... .
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

GYNRSLDMWSVGVIIY--VSLSGTFPFN------EDEDIHDQIQNAAFMYPPNP--------------------WKEISHE---AIDLINNL
 ..   | || || ..   .. .. . .      ...... ....   | .|                      |.|  ..     ...  .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase PKD1.AA Pkinase_Tyr 594-653 32 3.2e-09 31.85 Pfam 4-69 (270) Show / Hide 
Range on Protein: 594-653
Range on HMM: 4-69/270
Sequence Identity: 32% (22 aa)

DEVLGSGQFGIVYGGKHR----KTGRDVAIKIIDKLRFPTKQ--ESQLRNEVAILQNL-HHPGVVNL
...||.|.|| || |. .    .|. .||.|.. |     .|     . .|..|. .| ||| .|.|
GKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRL
Kinase PKD1.AA Pkinase_Tyr 701-769 27 0.011514 9.65 Pfam 123-192 (270) Show / Hide 
Range on Protein: 701-769
Range on HMM: 123-192/270
Sequence Identity: 27% (20 aa)

ALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGT-----PAYLAPEVLRNKGYN
.. .|. ||..| ||   |.|...     .|| |||| || | ...   .....        .|||..... ..
GMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFT