Gene RIOK1 (Human)

RIOK1

Species: Human
Alias: bA288G3.1, RIOK1, MGC12903, AD034, FLJ30006
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 6p24.3-p25,

Classification

Group: Atypical
Family: RIO
Subfamily: RIO1

Sequence

Name Sequence Type Origin Length Description Download
RIOK1.NA RNA Sugen Kinome 2495 None Fasta, JSON
RIOK1.AA Protein Sugen Kinome 568 None Fasta, JSON
RIOK1.kin_dom Protein Kinase Domain None 242 None Fasta, JSON

Protein domain

Protein domains of RIOK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RIOK1.AA RIO1 160-381 72 4e-199 667.82 In-house 1-225 (225) Show / Hide 
Range on Protein: 160-381
Range on HMM: 1-225/225
Sequence Identity: 72% (164 aa)

QVLDPRTRMILFKMLTRGIITEINGCISTGKEANVYHASTANGE--SRAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNPRKMVKTWAEKEMRNLIRL
||.|||||||||||||||||||||||||||||.||||||..||.  ..|||||||||||||||.|||.||||||||.||.|||||.|.|||||||||.|.
QVIDPRTRMILFKMLTRGIITEINGCISTGKETNVYHASETNGKRAEYAIKIYKTSILVFKDREKYVDGEFRFRHGHCKHNPRKMIKIWAEKEMRNLKRI

NTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKAR-ELYLQVIQYMRRMYQDARLVHADLSEFNMLYHGGGVYIIDVSQSVEHDHPHALEF
...|||||||||..|.||.|.|||||.|.||.||..|..|.... ..|.|.||||||||||.|||||||||.|||||....|.|||||||||||||.|||
YQSEIPCPEPIMVKSNVLMMEFIGKDGMAAPRLKDYQYKERDQYFHYYHQMIQYMRRMYQDCRLVHADLSEYNMLYHNDKLYMIDVSQSVEHDHPHSLEF

LRKDCANVNDFFMRHSVAVMTVREL
||.||.|||..||.|.|....||..
LRMDCKNVNMYFMKHNVIIFPVRDI
Kinase RIOK1.AA RIO 158-395 44 4.2e-169 568.09 In-house 1-276 (276) Show / Hide 
Range on Protein: 158-395
Range on HMM: 1-276/276
Sequence Identity: 44% (124 aa)

VEQVLDPRTRMILFKMLTRGIITEINGCISTGKEANVYHASTANGE-----------SRAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNPRKMVKTW
.||..||.||||..||..||.......||..|||...||.|..|||           ..||||..|....||||.||..|||.|.|..||.|.|.|...|
YEQTNDPYTRMIMYKMVNRGMVESVGNCIGVGKESDIYHCSNENGEDEKEDSKVIPTECAIKIHRTGRTSFKDRKKYRDGEFYFKHRHCKHNWRYMHRLW

AEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKAR-ELYLQVIQYMRRMYQDARLVHADLSEFNMLYHGGGV-------Y
|||||||..||.....||||||....|||||.||..|.||||.....|..|.... ..|.|...||||.||..||||.|..||||..|.|..       |
AEKEMRNMKRLYQSGFPCPEPIDYKRHVLVMEFINHDQMPAPKYPMCQIHEHENMKHVYHQCMCYMRRLYQHCRLVHCDFNEFNMMWHDGKHDENDCGFY

IIDVSQSVEHDHPHALEFLRKDCANVNDFFMRHSV-AVMTVRELFEFV------------------TDPSITHENM
.||..|.|||||||||...|.||..||.|||...| .....||.|.||                  ......||||
MIDFPQMVEHDHPHALWYFRRDCKCVNMFFMKRFVYEPFPEREMFDFVGFGDGYKYAYPDFKRDVKRTDTLDHENM
RIO RIOK1.AA RIO 151-387 54 1e-139 471.39 SMART 1-253 (253) Show / Hide 
Range on Protein: 151-387
Range on HMM: 1-253/253
Sequence Identity: 54% (139 aa)

DKADRATVEQVLDPRTRMILFKMLTRGIITEIN--GCISTGKEANVYHAST----ANGESRAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNPRKMVK
||.|.||.|.|.||||||.|.||..||.|.|||  ||||||||||||||..     ||...|.|||.||...||....|..|.|||.|||.. |.||||.
DKEDYATYEEVFDPRTRMTLYKMVNRGYIEEINNHGCISTGKEANVYHAMGGDFDKNGNECAVKIYRTSTTEFKRMWRYIQGDFRFKHGYHHINWRKMVR

TWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKAR---ELYLQVIQYMRRMYQDARLVHADLSEFNMLYH------GG
 |||||.||| |.  | .|||.|| .| |||||.|||.|. ||| ||.|.. | ..    |.| |.. |||.||. ..||||||||.|||||       .
LWAEKEFRNLQRMYEAGVPCPKPIAWRRHVLVMEFIGDDGWPAPRLKDVEWEEWEMDFKWEYYWQIMEYMRKMYHECHLVHADLSEYNMLYHDLEDENDC

GVYIIDVSQSVEHDHPHALEFLRKDCANVNDFFMRHSVAVMT-VRELFEFVTD
.|.|||.|||||.|||..||||. |. |...|| |. | .   .||.||..|.
KVWIIDWSQSVECDHPMWLEFLERDIWNIINFFRRKGVDCDDIYREIFERITG
Kinase RIOK1.AA RIO1 193-381 53 1.6e-130 407.49 Pfam 1-200 (200) Show / Hide 
Range on Protein: 193-381
Range on HMM: 1-200/200
Sequence Identity: 53% (106 aa)

NVYHAST-ANGE-SRAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNPRKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIG-KDDMPAPL
||||| .  .|.  .|.|||.|....||....|....|||||.|...|.|.||..|||||.||| |.  | .|||.||... |||||.||| ||..||| 
NVYHAYSMEDGKDECAVKIYRTGTTCFKKMKRYRDYDFRFRHRYHHHNWRYMVRMWAEKEFRNLKRMYEAGVPCPKPIDWNRHVLVMEFIGDKDGWPAPR

LKNVQ----LSESKARELYLQVIQ-YMRRMYQDARLVHADLSEFNMLYHGG-GVYIIDVSQSVEHDHPHALEFLRKDCANVNDFFMRHSVA--VMTVREL
||.|.    |||..|.|.| ..|. |||||||...|||.||||.|.|.| . ...|||..|.||||||||||||..|| |...||.|. |.  ||..||.
LKDVEMELELSEEEAEEIYDEIIREYMRRMYQECGLVHGDLSEYNILVHDDGKPWIIDWPQAVEHDHPHALEFLERDCRNIINFFRRKGVDERVMDFREI
Kinase RIOK1.AA RIO3 155-396 47 2.2e-84 284.46 In-house 1-254 (254) Show / Hide 
Range on Protein: 155-396
Range on HMM: 1-254/254
Sequence Identity: 47% (120 aa)

RATVEQVLDPRTRMILFKMLTRGIITEINGCISTGKEANVYHAS-----------TANGESRAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNPRKMV
 .| |. .||.||....||.  |..  | |||.||||. |.||                   |||..||..  ||.||||.  .|||.  . | ||||. 
HSTAEKAVDPKTRLLMYKMVNSGMLETITGCIATGKESVVFHAYGGSMEDEKEDSKVIPTICAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLNPRKIH

KTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLYHGGGVYIIDVS
. |||||| || |.  | ||||  ..|. |.|||||||.|..||| ||.|.|   . .| | | .  ||..| .  ||||||||.|||.| | |..||||
RMWAEKEMHNLARMQRAGIPCPTVVLLKKHILVMSFIGHDQVPAPKLKEVKLNSEEMKEAYYQTLHLMRQLYHECTLVHADLSEYNMLWHAGKVWLIDVS

QSVEHDHPHALEFLRKDCANVNDFFMRHSV-AVMTVRELFEFVTDPSITHENMD
||||  ||| |||| .|| || .|| .  |   .. ||||. |.   || .|  
QSVEPTHPHGLEFLFRDCRNVSQFFQKGGVKEALSERELFNAVSGLNITADNEA