Gene RNAseL (Human)

RNAseL

Species: Human
Alias: RNS4, MGC104972, DKFZp781D08126, RNASEL, MGC133329, RNAseL, PRCA1
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1q24-q25.3,

Classification

Group: Other
Family: Other-Unique

Sequence

Name Sequence Type Origin Length Description Download
RNAseL.NA RNA Sugen Kinome 4166 None Fasta, JSON
RNAseL.AA Protein Sugen Kinome 741 None Fasta, JSON
RNAseL.kin_dom Protein Kinase Domain Sugen Kinome 218 None Fasta, JSON

Protein domain

Protein domains of RNAseL.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank RNAseL.AA Ank 24-56 30 0.007136 14.62 Pfam 1-33 (33) Show / Hide 
Range on Protein: 24-56
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

EDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEE
. .  |  |... ... |. ||. ||.|| |  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank RNAseL.AA Ank 58-90 39 6.5e-08 32.79 Pfam 1-33 (33) Show / Hide 
Range on Protein: 58-90
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

GGWTPLHNAVQMSREDIVELLLRHGADPVLRKK
 |.|||| |... ....|..|| ||||. .. .
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank RNAseL.AA Ank 91-123 42 4.3e-07 29.83 Pfam 1-33 (33) Show / Hide 
Range on Protein: 91-123
Range on HMM: 1-33/33
Sequence Identity: 42% (14 aa)

NGATPFILAAIAGSVKLLKLFLSKGADVNECDF
.| ||  ||.. |... .|..|..|||||  | 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank RNAseL.AA Ank 124-156 33 6e-06 25.79 Pfam 1-33 (33) Show / Hide 
Range on Protein: 124-156
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

YGFTAFMEAAVYGKVKALKFLYKRGANVNLRRK
.|||. . |. .| .. .|.| ..||.||.. .
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank RNAseL.AA Ank 167-200 52 7.8e-09 36.12 Pfam 1-33 (33) Show / Hide 
Range on Protein: 167-200
Range on HMM: 1-33/33
Sequence Identity: 52% (18 aa)

GGATALMDAAEKGHVEVLKILLDEMGADVNACDN
 | |.|. |...||.||.| ||.  |||||| |.
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank RNAseL.AA Ank 272-304 30 8.5e-05 21.56 Pfam 1-33 (33) Show / Hide 
Range on Protein: 272-304
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

DGKTALLLAVELKLKKIAELLCKRGASTDCGDL
|| |.| ||..   ......| ..||. .  | 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank RNAseL.AA Ank 201-237 29 0.000931 17.81 Pfam 1-33 (33) Show / Hide 
Range on Protein: 201-237
Range on HMM: 1-33/33
Sequence Identity: 29% (11 aa)

MGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGE
.|. .|  | ..      . .  .||.||||||..  
DGFTPLHLACRCG----HTEVVKMLLQHGADVNAQDD
Ank RNAseL.AA Ank 238-271 35 0.001078 17.58 Pfam 1-33 (33) Show / Hide 
Range on Protein: 238-271
Range on HMM: 1-33/33
Sequence Identity: 35% (12 aa)

RGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDS
 | ||| ||... |.  |. ||.    ..| .| 
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank RNAseL.AA Ank 308-325 44 55.621279 0.58 Pfam 10-26 (33) Show / Hide 
Range on Protein: 308-325
Range on HMM: 10-26/33
Sequence Identity: 44% (8 aa)

ARRNYDHSLVKVLLSHGA
.|.. ... || ||.|||
CRCG-HTEVVKMLLQHGA
Kinase RNAseL.AA Ribonuc_2-5A 591-722 34 5e-62 217.19 Pfam 1-137 (137) Show / Hide 
Range on Protein: 591-722
Range on HMM: 1-137/137
Sequence Identity: 34% (48 aa)

SRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGEHIDEEKHKKMKLKIGD-PS
.|.|.|..|.....|. |...|.||..|..  |... .|..|..||  ..|..|.|.| ||.|.|...|.|||...||...|..|.|...|| ..|| |.
KRLRFLCDVSDRFEIEDRDPPSPILQALER-TSRCVVGFGDWHKKIDKAFMDDMGKYYRKRKNYYGDSVRDLLRAMRNKKHHYHEMKPEEMKEILGDLPD

---LYFQKTFPDLVIYVYTKLQ--NTEYRKHFPQTHSP
    ||...||.|....|...|  ..|...||.....|
GFLQYFTERFPHLLMHCYHVMQECHCEHEEHFHKYYKP
Kinase RNAseL.AA Other-Unique 372-589 12 1.7e-24 80.29 In-house 1-249 (249) Show / Hide 
Range on Protein: 372-589
Range on HMM: 1-249/249
Sequence Identity: 12% (32 aa)

ADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQS-----------------------------SRENSHLVTFYGSESHRGHLFVCVTLCEQTLE
 .... | |   |... .  |..|.. ..  .  .|..                              ..|... ..||... . .|. .|.  ||....
IKDIGKGTYGRVYKQHHNKKKKYCAKKTKHHKI-HCMDMDNNKREQIYHYQIIHCIFYWTMNHCHLCFCYEHCPNMIFYIMYPWYHHHCECQCQCEHWMN

ACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGY---------THQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVK
 | ..|. ....|..     . ...|.  .. .|  ...         .||....... .  .   ..|. . | .|  ... ....|...  .... ..
CCHMIHNLHHLHNNNHIHCDINPNNIWINQNNIHMCHNCGHNIPTIIIEHQHIKIMDFNNN-N-MMYFAPEF-SCRWCSPETFDYWPLGEKIDQYHFGCY

KGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTW
. ..... .......  ....| |..||  | |.. .|....|.   . ....   
HFHMNCQHWIFHYHDV-QHWPPHESPKDI-HILICQCECCHQCM-VNPYQNPNCFY
Kinase RNAseL.AA PUG 657-708 30 1.3e-16 62.44 SMART 1-66 (66) Show / Hide 
Range on Protein: 657-708
Range on HMM: 1-66/66
Sequence Identity: 30% (20 aa)

NTVGDLLKFIRNLGEHIDEE-----------KHKKMKLKIGDPSLYFQKTFPDLVI---YVYTKLQ
..|.|||...||...|..||           ...||.   |....||...||||.|   ..|....
ESVRDLLRYMRNIYHHPREEKFRKIRMENKAFKEKMGQVPGGFECYFTCGFPDLMIHAWEHYFFCK
S_TKc RNAseL.AA S_TKc 365-586 19 8.4e-11 -18.52 SMART 1-231 (231) Show / Hide 
Range on Protein: 365-586
Range on HMM: 1-231/231
Sequence Identity: 19% (50 aa)

IDEKYKIADTSEGGIYLGFYEK--QEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQ---TLEACLDVHRGEDV-ENEED
 .   ||   . |  |..   |  ..||.|       ...||...|..     ..|..|..  . .||...  .|..   .|   .. ....        
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

EFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQ---------EVKRDLEDLGR---------LVLYVVKKGSISFE
  || ..  |..|.. .|   |  | || |.|||.|.     ..||  . .   . .         ||       |.          .||    |   |.
-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL--TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEMLCGYPPFP

DLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLG-------HPFF
    | ..   ..  ..| ||.| ....     |    ..|        ||.|
----QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RNAseL.AA IRE 401-504 18 8.9e-08 22.59 In-house 37-168 (292) Show / Hide 
Range on Protein: 401-504
Range on HMM: 37-168/292
Sequence Identity: 18% (24 aa)

AQREVSCLQ--SSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDV--------------HRGEDVENEEDEFA-----RNVLSSIFKAVQELHLSC
..||.. |.   | . ....  | .|. . ...  ..||. .|    .                  ....|.....      ..... ... .| || | 
ISREIQMLIKLESDNHPNVIRYYCQEEDDQFVYLALELCQGSLQDYVEQKKRNNFINSSNNSNNNNKNNNNNNNQWQIHIRMWQLIKQCMNGLQHLH-SQ

GYTHQDLQPQNILIDS--------KKAAHLADF
.  | || |.||||.         .. . ..||
NIVHRDLKPHNILIHMNRPNQHGENNRFMISDF
Kinase RNAseL.AA RSK 461-504 33 1.3e-05 16.21 In-house 103-149 (271) Show / Hide 
Range on Protein: 461-504
Range on HMM: 103-149/271
Sequence Identity: 33% (16 aa)

ARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSK----KAAHLADF
...... |..|.. || | |  | || | |||.|..      . ..||
VKFYMAEIALAMEYLH-SQGIVHRDLKPENILYDDESGNPGHIKICDF
Kinase RNAseL.AA MELK 457-504 39 2e-05 14.12 In-house 95-141 (254) Show / Hide 
Range on Protein: 457-504
Range on HMM: 95-141/254
Sequence Identity: 39% (19 aa)

EDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF
|.| .| ..  |  |.  .| | || |.||.|.|.|.| ..   | ||
EEEETRHFFRQIVSAIAYVH-SQGYAHRDLKPENLLFDEDHHLKLIDF
Kinase RNAseL.AA CDK4 482-504 56 2.3e-05 14.15 In-house 132-154 (290) Show / Hide 
Range on Protein: 482-504
Range on HMM: 132-154/290
Sequence Identity: 56% (13 aa)

THQDLQPQNILIDSKKAAHLADF
.| || |||||. | .   ||||
IHRDLKPQNILVTSDGHVKLADF
Kinase RNAseL.AA Ciliate-E4 482-503 45 3.9e-05 13.64 In-house 129-150 (150) Show / Hide 
Range on Protein: 482-503
Range on HMM: 129-150/150
Sequence Identity: 45% (10 aa)

THQDLQPQNILIDSKKAAHLAD
||.|| |.||..|      .||
THGDLKPSNIFFDQYFMVKIAD
Kinase RNAseL.AA GEK 458-504 31 4.4e-05 12.52 In-house 99-144 (269) Show / Hide 
Range on Protein: 458-504
Range on HMM: 99-144/269
Sequence Identity: 31% (15 aa)

DEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF
...||  .. .  |.. .|   .| | |..| |.|.| .    ||||
EDMARFYIAEMVMAIDSVH-QLHYVHRDIKPDNVLLDMNGHIRLADF
Kinase RNAseL.AA RSK-Unclassified 459-509 31 4.5e-05 11.31 In-house 101-150 (283) Show / Hide 
Range on Protein: 459-509
Range on HMM: 101-150/283
Sequence Identity: 31% (16 aa)

EFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIK
. .|. .| .  |   ||.  .    || | ||. .    . | ||| ||.
DDVRFYASEVTAALEYLHK-RDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQ
Kinase RNAseL.AA SAK 558-586 44 8.3e-05 12.01 In-house 226-254 (254) Show / Hide 
Range on Protein: 558-586
Range on HMM: 226-254/254
Sequence Identity: 44% (13 aa)

ETKDLIHRLFHPGEHVRDCLSDLLGHPFF
| .||||.. .   | |  ||  | ||| 
EAQDLIHKMLRKNPHERITLSTVLCHPFM
Kinase RNAseL.AA ERK7 462-504 32 8.4e-05 12.01 In-house 103-144 (292) Show / Hide 
Range on Protein: 462-504
Range on HMM: 103-144/292
Sequence Identity: 32% (14 aa)

RNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADF
. ..  ...|.. .| |    | || | |||.||.    ..||
QYIMYQLLRAIKYMH-SGNVIHRDLKPSNILLDSECMVKVCDF
TyrKc RNAseL.AA TyrKc 365-662 12 0.000145 -148.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 365-662
Range on HMM: 1-280/280
Sequence Identity: 12% (44 aa)

IDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRA--QREVSCLQSS-RENSHLVTFYGSESHR-------GHLFVCVTLCEQ-TLEACLDVHRGEDV
|  . |.     | .|.| .  ..||||.  |.. |.   || . . .   .. ..| .||  ..        . |.. . ...   |   |  ||..  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

ENEEDEFARNVLSSIFKAVQELHL---------------SCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGD------PQEVKRDLEDLGR------
                  ..  .|               | .. | ||   |.|..... .  .||  | ..  |       .  .   .. |.      
------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR

------LVLY-----------------VVKKGSISFEDLKA--QSNEEVVQLSPDEETKDLIHR----LFHPGEHVRDCLSDLLGHPFFWTWESRYRTLR
      .  .                 .   |    ..      ||.||...  . .  .  .                                     
WMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------

NVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKF-YEKRGNFYQNTVGDL
                               |   .... . .||.  ..  |.| .| .  . ..
-------------------------------FVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI-HECF
Kinase RNAseL.AA GEK 557-586 46 0.001615 7.19 In-house 238-269 (269) Show / Hide 
Range on Protein: 557-586
Range on HMM: 238-269/269
Sequence Identity: 46% (15 aa)

EETKDLIHRLFHPGEHV--RDCLSDLLGHPFF
||.||||..|  . ||   |. ..|   ||||
EEAKDLIRQLICSQEHRLGRNGIQDFKKHPFF
Kinase RNAseL.AA IRE 552-586 32 0.009987 4.79 In-house 253-292 (292) Show / Hide 
Range on Protein: 552-586
Range on HMM: 253-292/292
Sequence Identity: 32% (13 aa)

QLSPDEETK-----DLIHRLFHPGEHVRDCLSDLLGHPFF
||... . .     ||||   |. .  |   .  | ||||
QLKHHNHWHIVIACDLIHQMIHHDPQKRPTIKECLNHPFF