Gene RON (Human)

RON

Species: Human
Alias: CDw136, PTK8, MST1R, RON
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 3p14-p21.31,

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
RON.NA RNA Sugen Kinome 4785 None Fasta, JSON
RON.AA Protein Sugen Kinome 1400 None Fasta, JSON
RON.kin_dom Protein Kinase Domain Sugen Kinome 253 None Fasta, JSON

Protein domain

Protein domains of RON.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Sema RON.AA Sema 58-507 24 6.30000000001e-161 545.71 Pfam 1-484 (484) Show / Hide 
Range on Protein: 58-507
Range on HMM: 1-484/484
Sequence Identity: 24% (120 aa)

MVTYEGDRNESAVFVAIRNRLHVL-GPDLKSVQSLATGPAGDPGCQTCAACGPGPHGP---PGDTDTKVLVLDPALPALVSCGSSL-QGRCFLHDLEPQG
..|.. |.......|. ||...|| ...|. ............||..| .| .... |   . .... ......  . |..||. . ...|..|.|....
FHTLLHDEDRDRLYVGARNHVYVLNLNNLSERCYQKIHWPSSHGCEHCEECYMKGKDPPVWTECQNYIRVLHPYNDTHLYVCGTNAFHPVCWYHNLGHHH

TAVHLAAPACLFSA-HHNRPDDCPDCVASPLGTRVTVVEQGQASYFYVASSLDAAVAASFSPRSVSIRRLKADASGFAPGFVA--LSVLPKHLVSYSIEY
||.|.|...||||. |.. .| |..|...|......|..|......|.....|..||.||..|...|.|.| ....| ....   . ..|..  || | |
TADHQAEEHCLFSYDHDKEEDGCGRCPYDPKHNTTSVMVQDRFGELYSGTYIDSKVAYSFMGRDPWIYRSKGSHHPFRTEQHDSKWLNEPNFVDSYPIHY

VHSFHTGAFVYFLTVQPASVTDDP--SALHTRLARLSATEPELGDYRELVLDCRFAPKRRRR--GAPEGGQ-PYPVLRVAHSAPVGAQLATELSIAEGQE
||.|  . ||||.....|. ....  .. |.|.||... .... .|.|....|.|...|...  ..|.| . ....|. .. .|....||.||.|.. ..
VHDF-DDDFVYFFFRETAVEYSMNCGKTIHSRVARVCKNDMGGHRYLEMNKWCTFLKARLNCSVPGPDGYPFYFNELQDVFVLPTDNWLAHELGISWRNP

VLFGVFVTGKDGGPGVGPNSVVCAFPIDLLDTLIDEGVERCCESPVHPGLR-RGLDFFQSP-SFCPNPPGL---------EALSPNTSCRHFPLLVSSSF
|..|||.|......|...|| ||||.. .... ...|.....|.. |  |. |||.... .  .|||.|..         ..  ....| ... .|. ..
VIYGVFTTPWNIFRGPMHNSAVCAFHMNDINQVFNNGPFKHQEGCNHQWLPYRGLRVPYPRPGQCPNDPNHGNMSTKDLPDNTCNFIRCHPLMYEVVYPV

SRVDLFNGLLGPVQVTALYVT---RLDN---VTVAHMGTMDGRIL--QVELVRSL--NYLLYVSNFSLGDSGQ-PVQRDVSRLGD
....||.. ......|...|.   |. .   .||...||.|||..  ||.. |.   .|. .|.......... |.|... ....
HNRPLFMRQSVNYRFTQIAVDPRVRAGDGQWYTVMFIGTDDGRVHKKQVVVSRDSWPHYHEVVLEEIHVFPDPEPIQNMEISQKQ
Sema RON.AA Sema 55-508 21 3.3e-121 409.89 SMART 1-532 (532) Show / Hide 
Range on Protein: 55-508
Range on HMM: 1-532/532
Sequence Identity: 21% (115 aa)

VQAMVTYEGDRNESAVFVAIRNRLHVLG-PDLKSVQSLATGPAG-DPGCQT-------CAACGPGPH---GP---PGDTDTKVLVLDPA---LPALVSCG
 ..|. .|. .| . ..|. ||....|  |.|. .. ..|||.. .| |..       |  |  . .   ..   . |....||.....   .. |..||
YNHMLLDEDRGN-WRLYVGARNHIYQLSLPNLSKEWEHVTGPVIDWPSCPEPNEKCIKCQECQMKGKHFCPHNETWCDNYIRVLQPYNDHYYDTHLYVCG

SSLQGR---CFLHDLEPQGTAV-----HLAAPACLFSAHHN-RPDDCPDCVASPLGTRVTVVEQGQA---SYFYVASS-LDAAVAAS-FSPRSVSIRRLK
.  .|    |..|.|. .....     . . ..|..|..||  .. |..|...||.. ..|...|..   ...|....  . .||.| ........|||.
TNAFGPDVMCWYHNLGNHEPWDEMEQEDQIFTHCPHSKQHNRSESGCGKCPYDPLHNSTSVFVDGYNPDGGELYSGTVADFSGVAQSYHRSDPIIYRRLG

ADASGFAPGFVA--LSVLPKHL--VSYSIEYVHSFHT-----GAFVYFLTVQPASVT-----DDPSALHTRLARLSATE--------PELGDYRELVLDC
....||...|.   . ... ..  ..| . .||.|.      | ||||.....|.       ..... |.|.||.   .        ..   |... |.|
MFQDGFHFWFHPSRTDQYDSKWGYDLYEPHFVHAFEIPESNDGDFVYFFFRERAHEHMNRDCGYEKHYHSRVARVCKNDMGGQRLLQKKWTSYLKARLNC

RFAPKRRRRGAPEGGQ-PYPVLRVAHSAPVGAQLATELSIAEGQEVLFGVFVTGKDGGP----GVGPNSVVCAFPIDLLDTLIDEGVERCCESP---VHP
.. .|.||.      . ....|. .. .|.|| || .... |...||.||| .|.. .     .. |.| ||||...  .. ..||. .|.|.|    ||
SVPDKGRRP------EFYFNELQDVFVLPPGA-LAQDWGW-EQDDVLYGVFTQGQQWSSRDAANPWPGSAVCAFSMKDINRVFNEGPFKCYEGPNHQWHP

GLRRGLDFFQSPSF----------CPNPPGLEALSP-NTSCRHFPLLVSSSFSRVDLFNGLLGPVQVTALYVTRLDN-------VTVAHMGTMDGRILQV
  .... ...  .           |.... | .  . .  .   .. .........||.. .. ...|...|.| .|       .||...|| ||||..|
YNGNKVPWPRPGTCPSNHFREQRNCCHTKDLPDDVLCFIKHHPLMDEAVQPIHGRPLFVKTNTDYRFTHIAVDRVHNLDGHHNWYTVMFLGTDDGRIHKV

ELVRSLN-------YLLYVSNFSLGDSGQPVQRDVSRLGDH
 . || .       . . ...|.... |... ||..  .. 
VVWRSRHNQSWHGWESHVYEEFQVFPHGSEPIRDMQFSHKQ
IPT RON.AA IPT 683-767 24 1.4e-22 82.28 SMART 1-111 (111) Show / Hide 
Range on Protein: 683-767
Range on HMM: 1-111/111
Sequence Identity: 24% (27 aa)

EPVLIAVQPLFGPRAGGT-CLTLEGQSLSV-GTSRAVLVN------GTECLLARV------SEGQLLCATPPGA----TVASVPL----SLQVGGAQVPG
.||  ...| .||..|||  .|..|. . . ...| | ||      ...| . ..      |. |..| |||..    ....||.    ..|.....|..
DPVITRIHPNCGPCSGGTERITICGKNFDSDIQVRFVRVNVGGRVWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSPIPGQVPVRVTQEVQFCNDNVRT

S----WTFQYR
.    ..|.|.
QLSWPQPFTYV
IPT RON.AA IPT 568-682 26 6.6e-22 80.01 SMART 1-111 (111) Show / Hide 
Range on Protein: 568-682
Range on HMM: 1-111/111
Sequence Identity: 26% (32 aa)

PPKLTEFHPHSGPLRGST-RLTLCGSNFYLHPSGLVPEGTHQVTVG----QSPCRPLPKDSSKLRPVPRKDFVEEFECELEPLGTQ--AVGPTNVSLTVT
.|. |..||..||..| | |.|.||.||       . . ...|.||    ..|| ..| |...      ||. .. .|.. |  .|   .|. .|..|..
DPVITRIHPNCGPCSGGTERITICGKNFDS----DIQVRFVRVNVGGRVWEVPCTFQPWDYHG------KDSQTQIVCCTPPYHNQSPIPGQVPVRVTQE

NMPPGKHFRVDGTSVLRGFSFM
 .  ....|... |    |...
VQFCNDNVRTQL-SWPQPFTYV
PSI RON.AA PSI 526-568 28 3.1e-13 42.67 Pfam 1-57 (57) Show / Hide 
Range on Protein: 526-568
Range on HMM: 1-57/57
Sequence Identity: 28% (16 aa)

GCRHFLTCGRCLRAWHFMGCGWCGN--MCGQQK-----ECPGSW-------QQDHCP
.|... .|..||.|  ...||||..   | ..      .||..|        |..||
NCSQHTSCSSCLSARDPFYCGWCSSQHRCTRGHAYTYGQCPRWWQWMWWSWSQSQCP
TIG RON.AA TIG 684-766 29 5.9e-13 46.22 Pfam 1-82 (82) Show / Hide 
Range on Protein: 684-766
Range on HMM: 1-82/82
Sequence Identity: 29% (25 aa)

PVLIAVQP-LFGPRAGGTCLTLEGQSL-SVGTSRAVLVNGTECLLARVSEGQLLCATPPGATVASVPLSLQVGGAQVPGSWTFQY
|.. ...|   || .||| .|. || . .   .  ....||.|    .|. |. | |||...  ....|. |.|...... ||.|
PTITSISPNTTGPPSGGTTITITGQNFGNDS-DTKCYFGGTPCTVIWWSSTQIVCTTPPHTPG-THNVSV-VNGQWSSNPTTFTY
PSI RON.AA PSI 526-568 26 2.7e-09 38.14 SMART 1-56 (56) Show / Hide 
Range on Protein: 526-568
Range on HMM: 1-56/56
Sequence Identity: 26% (15 aa)

GCRHF--LTCGRCLRAWHFMGCGWC--GNMCGQQKECP------GSWQQ---DHCP
.|.|.   .|. || | ....||||  ...|  . .|.       .| .   ..||
NCSHYGVTSCSECLSARDPYRCGWCSWQHRCTHRHRCDERRFWRQNWEHGPHKQCP
TIG RON.AA TIG 569-681 21 1.7e-07 27.73 Pfam 1-82 (82) Show / Hide 
Range on Protein: 569-681
Range on HMM: 1-82/82
Sequence Identity: 21% (24 aa)

PKLTEFHP-HSGPLRGSTRLTLCGSNFYLHPSGLVPEGTHQVTVGQSPCRPLPKDSSKLRPVPRKDFVEEFECELEPLGTQAVGPTNVSLTVTNMPPGKH
|..| ..|  .||  | |..|. |.||           . ....| .|| .   .|. .            .|.. |.     |. |||. | .      
PTITSISPNTTGPPSGGTTITITGQNF------GNDS-DTKCYFGGTPCTVIWWSSTQI------------VCTTPPHT---PGTHNVSV-VNG------

FRVDGTSVLRGFSF
   ...|    |..
---QWSSNPTTFTY
IPT RON.AA IPT 769-873 24 1e-14 56.17 SMART 1-111 (111) Show / Hide 
Range on Protein: 769-873
Range on HMM: 1-111/111
Sequence Identity: 24% (29 aa)

DPVVLSISPNCGYIN---SHITICGQHLTS-AWHLVLSFHDGLRAV-ESRCERQL--------PEQQLCRLPEYVVRDPQGWVAGNLSARGDGAAGFTLP
|||...|.||||...   ..|||||... |  .  . ....| | | |..|. |         ..| .|..|.| ...|    .|.   |... ..|.. 
DPVITRIHPNCGPCSGGTERITICGKNFDSDIQVRFVRVNVGGR-VWEVPCTFQPWDYHGKDSQTQIVCCTPPYHNQSP---IPGQVPVRVTQEVQFCND

GFRFLPPPHPPSANLVPL
..|..    ... ..  .
NVRTQ--L-SWPQPFTYV
TIG RON.AA TIG 770-859 21 9.8e-08 28.55 Pfam 1-82 (82) Show / Hide 
Range on Protein: 770-859
Range on HMM: 1-82/82
Sequence Identity: 21% (20 aa)

PVVLSISP-NCGYI--NSHITICGQHL-TSAWHLVLSFHDGLRAVESRCERQLPEQQLCRLPEYVVRDPQGWVAGNLSARGDGAAGFTLPGFRF
|.. |||| ..| .  ...||| ||.. ... ..   | .   .|      . . |  |..|...         .|.|   .|. . .   |..
PTITSISPNTTGPPSGGTTITITGQNFGNDS-DTKCYFGGTPCTVI----WWSSTQIVCTTPPHT------PGTHNVSV-VNGQWSSNPTTFTY
Kinase RON.AA Met 1083-1335 64 1.2e-210 697.35 In-house 1-271 (271) Show / Hide 
Range on Protein: 1083-1335
Range on HMM: 1-271/271
Sequence Identity: 64% (175 aa)

HSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLS--RITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEG-LPHVLLPYMCHGDLLQFIRSPQRN
|.|.|||.||||.||||.|.|...|...||.|||.  |||..|....|||||..|....|||||.||||.|.||| .|.|.||||.||||..|||.||.|
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQNN

PTVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDI-LDREYYSVQQHRH-ARLPVKWMALESLQ--------TYR-FTTKS
|.|.|||.|..|||..|.|.|.|||||||||.|||||||.||||||||||.||. .|.||||...|.| |||||||||.|.||        ||| |||||
PCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPTYRQFTTKS

DVWSFGVLLWELLTRGAPPYRHIDP-FDLTHFLAQG--RRLPQPEYCPDSLY-QVMQQCWEADPAVRPTFR
|||||||..|||.|||||||.|.|. ||.||.|.||  |||||||||||.|| .||..||.|.|..||.| 
DVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
TyrKc RON.AA TyrKc 1082-1341 37 2.8e-135 456.66 SMART 1-280 (280) Show / Hide 
Range on Protein: 1082-1341
Range on HMM: 1-280/280
Sequence Identity: 37% (110 aa)

THSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGL--NHPNVLALIGIMLPPE------GLPHVLLPYMCHGDLLQFI
 . ....| |.||.||.|...      ||.|.|.|   .    .|.|.||  .|. |  .|||...|.|. . ..      . . ... ||.||||....
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RSPQRNPTVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDR-------EYYSVQQHRHAR--LPVKWMALESLQTYRF
|..... ..|||.|| .|.|. ||||......|||||||||...| .|||..||||.||| |        .||....|....  ||..|||.|......|
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TTKSDVWSFGVLLWELLTRGAPPYRH-----IDPFDLTHFLAQGRRLPQPEY--------CPDSLYQVMQQCWEADPAVRPTFRVLVGEV
|||||||||||..||..|.|..||       ...... ... ||.|.|||..        ||| .||.|.|||..||. ||||. .. . 
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Pkinase_Tyr RON.AA Pkinase_Tyr 1082-1341 40 3.7e-133 451.61 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1082-1341
Range on HMM: 1-270/270
Sequence Identity: 40% (109 aa)

THSDRVIGKGHFGVVYHGEYI-DQAQNRIQCAIKSLSRITEMQQ--VEAFLREGLLMRGL-NHPNVLALIGIMLPPEGL--PHVLLPYMCHGDLLQFIRS
 . ....|.|.||.||.|..  |. ...|..|.|.|   .  .|   |.|.||  .|. | .|||.. |.|. .. ..   . . ..||.||||| . |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

P---QRNPTVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWS
.   ....|.|||... .|.|. ||||......|||||||||...|...||..|||||||| . .|| .... ...||.||||.|......|||||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVLLWELLTRGAPP-YRHIDPFDLTHFL-AQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEV
||||.||..|.|. | |  ...... ...  .|.|.|.||.||| .|..|.|||..||. ||||. .. . 
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase RON.AA TK 1082-1341 21 1.1e-108 365.66 In-house 1-486 (486) Show / Hide 
Range on Protein: 1082-1341
Range on HMM: 1-486/486
Sequence Identity: 21% (107 aa)

THSDRVIGKGHFG---VVYHGEYIDQA----------------------QNRIQCAIKSLSRITEMQQVE----------------AFLREGLLMRG--L
 .  ...|.|.||   .|| ||....                       ......|.| |   ..|.| |                ....|  .|.   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

NHPNVLALIGIMLPPE-----------GLPHVLLPYMCHGD----LLQFIRSPQRN--------------------------------------------
.|||.. |.|. . .|           . . ... ||.|||    |... |.  ..                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------PTVKDLISFGLQVARSMEYLAEQ------KFVHRDLAARNCMLDESFT-----------VKVADFG---
                               .|...|. . .|.|. ||||...      .|||||||||||...|. .           .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARDILDREYYSVQQHR----------------------HARLPVKWMALESLQ---------TYRFTTKSDVWSFGVLLWELLTRG-APPYRHI
     ||||| ....| ... .                       ..||..||| |.|.         . .|||||||||||||.||..|.| .|.|  .
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

DP---------FDLTHFLAQG--------------RRLPQPEYCP--------------DSLYQVMQQCWEADPAVRPTFRVLVGEV
.           ..  .| .|               |.|||..||              . .|..|||||..||. ||||. |. . 
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RON.AA UTK 1082-1341 32 1.7e-87 297.01 In-house 1-296 (296) Show / Hide 
Range on Protein: 1082-1341
Range on HMM: 1-296/296
Sequence Identity: 32% (96 aa)

THSDRVIGKGHFGVVYHGEYIDQA--QNRIQCAIKSLSRITEM-QQVEA----FLREGL---LMRGLN-HPNVLALIGIMLPPEGLPHVLLPYMCHGDLL
..  | .|.|.||.|..... . .      ..|.| ..  ... || ..    |..|     .|  .. ||||| |.|. .  |. . ... ||. |||.
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ-HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLR

QFIRSPQRNPT-------VKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDES-------FTVKVADFG---LARDIL-------DREYYSVQQHRH
.. |.  ..|          ..... ...|| |.||....||||||||||| ....        ..|.||||   ..|..        . |.| ....  
SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ

ARLPVKWMALESLQTY-RFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQG--RRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEV
 |.|..||| |.|    |||||||||||||..||..|.|. || ..   ...|..  |  .|.|.|. ||...|..|..||..||. ||.|. || ..
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase RON.AA EGFR 1082-1342 37 5.8e-83 275.27 In-house 1-258 (258) Show / Hide 
Range on Protein: 1082-1342
Range on HMM: 1-258/258
Sequence Identity: 37% (98 aa)

THSDRVIGKGHFGVVYHGEYIDQAQN-RIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNP
.  ..| | | || || | .| ...| .|  ||| |   |. .. |..|.| . | ...||... |.|. . .. . ..   || .| || ..|  . | 
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ-M-QLVTQYMPYGCLLDYVRQHKDNI

TVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWEL
  ..|. ...|.|. |.|| |.. ||||||||| ..     ||..|||||. .|. .  .. ..  ...|.||||||...  ..| .|||||.|| .|||
GSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAK-LLEHDEKEY-HAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVTCWEL

LTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVE
.| |. ||  |   .   .| .| |||||. |   .|.|| .|| .|...||||. |. | .
MTFGQKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase RON.AA Axl 1083-1339 41 1e-80 274.49 In-house 2-267 (267) Show / Hide 
Range on Protein: 1083-1339
Range on HMM: 2-267/267
Sequence Identity: 41% (112 aa)

HSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLS-RITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEG-----LPHVLLPYMCHGDLLQF----
   ...|.| || |  |.   .    .. |.| .   |   ...| ||.|   |.  .||||. |||. .          | |.||.| ||||  |    
VLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLYS

-IRSPQRNPTVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVW
 .     .  .. |. | . .|  ||||....|.||||||||||| |  || ||||||.. | . .||   | . |..||||.|.|||    .| |||||
RLGDQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYY--RQGCIAKMPVKWIAIESLADRVYTSKSDVW

SFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVG
.||| .||. |||  ||  ..  ..  .| .| || ||| | | ||..| |||||||  ||.| ||  
AFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase RON.AA Src 1082-1341 37 1.7e-79 269.71 In-house 1-255 (255) Show / Hide 
Range on Protein: 1082-1341
Range on HMM: 1-255/255
Sequence Identity: 37% (101 aa)

THSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLP-HVLLPYMCHGDLLQFIR--SPQR
 .  | .|.|.|| |. | .    ..... |.|.|.. | |.. ||||.|  .|  | |.....|  .    |  |      ||.|| ||.. .  .  |
IKLCRKLGQGQFGEVWMGYW----NGNTKVAVKTLKPGT-MSP-EAFLQEAQIMKKLRHEKLVQLYAVCSQEE--PIYIVTEYMSHGSLLDYLKKDGEGR

NPTVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILD--REYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVL
.  ...||... |||. |.|| .....||||||||   .|.  .||||||||| ...   . |. ..   |..|.||.| | ..  |||.||||||||.|
HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARH--GAKFPIKWTAPEAINYGRFTIKSDVWSFGIL

LWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQ-VMQQCWEADPAVRPTFRVLVGEV
|.|. |.|  ||.  .  .    . .| |.|.|. |||.||. .|.|||..||  ||||  |    
LTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase RON.AA TK-Unique 1082-1341 33 1.3e-78 267.5 In-house 1-294 (294) Show / Hide 
Range on Protein: 1082-1341
Range on HMM: 1-294/294
Sequence Identity: 33% (100 aa)

THSDRVIGKGHFGVVYHGEYID---QAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLN-HPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQ
   ..|||.| || |..||.         ... |.| | .    ... .||.|  .|. |  |||.. ..|.   ... .. ...|.  |.|. ..|. .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

RN-------------------------PTVKDLISFGLQVARSMEYLAE--QKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLP
..                          . |||..|. |.|. |||||.  .|.|||||.|||..| | ...|..|||.|||. ... || .. .. |.|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQG-RIP

VKWMALESLQ--TYRF-TTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYC-PDSLYQVMQQCWEADPAVRPTFRVLVGEV
..|||.|||.  .  . ||||||||||||.||..| ||.||. ... |.   . .| |.||||.| .. .|..|..||  .|  ||.|| .. . 
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase RON.AA Csk 1083-1341 41 4.2e-68 231.48 In-house 2-251 (251) Show / Hide 
Range on Protein: 1083-1341
Range on HMM: 2-251/251
Sequence Identity: 41% (109 aa)

HSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRI-TEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHGDLLQFIRSPQRNP-
|    ||.| || |  |||    |||   |.| ...   .| |  ||| |   | .| |||  .|||. |   .   . . ||  | |. ..||  |.  
HLGECIGHGEFGDVMQGEY----QNR-KVAVKCIKCDGNGMAQ--AFLAEASVMTQLRHPNLVQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVI

TVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQH--RHARLPVKWMALESLQTYRFTTKSDVWSFGVLLW
| ..|. | . |.  |.|| . |||||||||||  ..|    || |||||..       . ||.     ..|.|| | | |   .|.|||||||||.|||
TRRQLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAKE------ECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLW

ELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEV
|.   |  ||  |   |  .    | |   || ||.. |.||.|||...|| ||||| ..   
EIYSFGRVPYPRIPLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase RON.AA FGFR 1181-1341 48 8.6e-68 230.13 In-house 134-293 (293) Show / Hide 
Range on Protein: 1181-1341
Range on HMM: 134-293/293
Sequence Identity: 48% (79 aa)

TVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTTKSDVWSFGVLLWEL
| |||.|.  |||| ||||| .| .||||||||    . .  |..|||||||| . .||        |||.||||.|.|.   .|..|||||.|||||| 
TQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYY--RKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEI

LTRGAPPYRHID-PFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEV
.| |  || ||    .|  .|  |.|.  |. |.  .| .| ||| . |  ||||  || . 
MTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase RON.AA Ryk 1250-1348 52 5.9e-47 146.38 In-house 201-292 (292) Show / Hide 
Range on Protein: 1250-1348
Range on HMM: 201-292/292
Sequence Identity: 52% (52 aa)

PVKWMALESLQTYRFTTKSDVWSFGVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVGEVEQIVSAL
|||||.|||||   . . ||||||||..||| | |  ||  |||| ..|.|. | ||.||  ||| |. ||  ||  .|. ||||       .|.|. |
PVKWMSLESLQHKHYSHASDVWSFGVTMWELMTLGQMPYMEIDPFEMYHYLKDGYRLQQPFNCPDELFTVMACCWHCMPEERPTF-------QQLVQCL
Kinase RON.AA S_TKc 1082-1345 23 7.5e-44 152.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 1082-1345
Range on HMM: 1-231/231
Sequence Identity: 23% (64 aa)

THSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIKSLSRITEMQQVEAFLREGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCH--GDLLQFIRSPQRN
 .  |.|||| ||.|| .  ..      ..||| ..        | ..||  ...  .|||.  |....    .  .. . |. .  |||...|.. .|.
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH

P-----TVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDESFTVKVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQTYRFTT-KSDVWSF
.     .  .  ..  |... .||. .....||||   | .|||  ..|..|||||| .           ..      .|| | |    ... |.|.||.
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

GVLLWELLTRGAPPYRHIDPFDLTHFLAQGRRLPQPEYCPDSLYQVMQQCWEADPAVRPTFRVLVG-----EVEQIV
|..|.|.|. | ||..  ... . . .            .... . ...|.. ||. |||   .          . .
GCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RON.AA Pkinase 1082-1341 21 9.1e-37 131.08 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1082-1341
Range on HMM: 1-293/293
Sequence Identity: 21% (64 aa)

THSDRVIGKGHFGVVYHGEYIDQAQNRIQCAIK--SLSRITEMQQVEAFL-REGLLMRGLNHPNVLALIGIMLPPEGLPHVLLPYMCHG----DLLQFIR
 |  |.||.| ||.||..  ..  .   . |.|  ..... . ....... .|  .|. |||||.. |....   .. ... ..|. .|    ||  .|.
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIS

-SPQRNP--TVKDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDESFTV----KVADFGLARDILDREYYSVQQHRHARLPVKWMALESLQ-TYRFTT
 . ...   . ...... .|..| .||. .....||||   |...|.  ..    |..|||||. .    | . .   .      .|| | ..     ..
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KSDVWSFGVLLWELLTRGAPPYRHI----DPFDLTHFLAQGRR----LPQPEYCP-------------------DSLYQVMQQCWEADPAVRPTFRVLVG
|.|.||.|..|.|.|. | ||...     .  |  . ... ..     . |. |.                   ... ...  |.. ||. |||.. .. 
KVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

E--V
   .
HPWF
Kinase RON.AA Ryk 1082-1232 23 1.2e-28 87.56 In-house 1-185 (292) Show / Hide 
Range on Protein: 1082-1232
Range on HMM: 1-185/292
Sequence Identity: 23% (44 aa)

THSDRVIGKGHFGVVYHGEYIDQAQ--------------NRIQCAIKSLSRITEMQQVEAFLREGLLMRGLN-HPNVLALIGIM--------LPPEGLPH
  .  ..  | || .||| ...                 .  .  .| .       ||  .| |..|..|.  |.|.|.. ..             . | 
IQYSCLVQEGTFGRIYHGIWNQVDDVNNGDVDDEEDTFCDCQDVFVKTVKDHASQMQVHCMLQESCLLYGISPHQNILPVLHVCSFGRFDRPIEDHDPPF

VLLPYMC-HGDLLQFIRS-----PQRNPTV--KDLISFGLQVARSMEYLAEQKFVHRDLAARNCMLDES---FTVKVADFGLARD
|..|.|   | | || .      |.   ..  ..| ....|..  |..|.    ||.|.|.||| .||      ||  |  | ||
VCYPHMNNWGNLKQFLQDCRHDKPKCHQAISTHQLVHMAIQITMGMMHLHKHRIVHKDIATRNCVIDEQNGRLQVKICDSALSRD