Gene RSKL1 (Human)
RSKL1
Sequence
Protein domains of RSKL1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PX | RSKL1.AA | PX | 9-128 | 28 | 8.2e-17 | 60.18 | Pfam | 1-120 (120) | Show / Hide |
Range on Protein: 9-128 Range on HMM: 1-120/120 Sequence Identity: 28% (37 aa) ADLARFYTVTEPQRH----PRGYTVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKELWQIHKNLFRHSELFPPFAKGIVFGR---FDETVIEERRQC .... .|..|..| ......|... . ... ....| ||.||||| .|||.| . .. .||. ..||| ||| .||.||| DHFLQ-VHVVDPETHKHYGDKMHYYYVYEIHMNTNP--FQKKEWHVWRRYSDFHWLHKQLKRHFP-----MCIIPPLPPKHWFGRYNNFDEEFIEKRRQM AEDLLQFSANIPALYN-SKQLEDFFKGG |. || ...| | | .. . ||. LEQYLQRVCQHPELCNHCEVFHDFLHPD |
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| PX | RSKL1.AA | PX | 9-128 | 22 | 1e-15 | 59.47 | SMART | 1-142 (142) | Show / Hide |
Range on Protein: 9-128 Range on HMM: 1-142/142 Sequence Identity: 22% (33 aa) ADLARFYTVTEPQRHPRGY--TVYKVTARVVSRRNPEDVQEIIVWKRYSDFKKLHKELWQIHKNLFRHSELFPPFAKGIVFGR----------------- .... ||.|...|...| . ..... ........|.. |..||||| .||. | ..... .. .||. .|.| DHIFI-ITVVEFFTHGKHYHDGKHYYYVYEIHTKTNNHVKMWTVYRRYSDFHWLHHQLKRHFPQEK-RMCIIPPLPPKHWFVRYRYWMEHMSMMWWYSFN -FDETVIEERRQCAEDLLQFSANIPALYN----SKQLEDFFKGG ||| .||.||. |. || ...| . | .. . .|| NFDEDFIEKRRRGLERYLQRLCHHPEWINHYMVCEVVYEFFESS |
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| MIT | RSKL1.AA | MIT | 236-314 | 37 | 2.7e-28 | 101.26 | SMART | 1-81 (81) | Show / Hide |
Range on Protein: 236-314 Range on HMM: 1-81/81 Sequence Identity: 37% (31 aa) KRDYLEKAGELIKLALKKEE--EDDYEAASDFYRKGVDLLLEGVQGE-SSPTRREAVKRRTAEYLMRAESISSLYGKPQLDD .|||..|| |.|..|.| .| . |||.| . |.||.|.|..|...| ....||.|.... .|||.|.|.|.. . .|. QRDYYQKAIEYITQAVKADEDEWGDYEQAIEHYQKGIDYLMQGIKYEKPDEKRRHAIWAKCREYLDRMEEIKNCHDW-RLCP |
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| MIT | RSKL1.AA | MIT | 239-307 | 33 | 2.2e-25 | 91.3 | Pfam | 1-71 (71) | Show / Hide |
Range on Protein: 239-307 Range on HMM: 1-71/71 Sequence Identity: 33% (24 aa) YLEKAGELIKLALKKEE-EDDYEAASDFYRKGVDLLLEGVQGESSPTRREA-VKRRTAEYLMRAESISSLY ||.|| ||.| |....| . .||.| . |.............|..|..||| ......||. ||| | .. YLQKAIELVKKAVEADEDAGNYEEAIQCYQEAIEYFMQAIKYEPNPKWREARLRQKMQEYMDRAEQIKEHL |
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| Kinase | RSKL1.AA | RSKL | 341-416 | 40 | 8.1e-32 | 73.52 | In-house | 2-77 (436) | Show / Hide |
Range on Protein: 341-416 Range on HMM: 2-77/436 Sequence Identity: 40% (31 aa) RVLGVIDKVLLVMDTRTEQTFILKGLRKSSEYSRNRKTIIPRCVPNMVCLHKYIISEESVFLVLQHAEGGKLWSYI || |.|.||..| | | ||. . | . ||.. ..|| || |. | .| ||...|| | | ..| |||.. RVVGIIKKVQVVQDPATGNTFYVMKLPRCHMVSRDCSIFIPHNVPYMTQLVRYFVSEDHIFLHLEHVQPGQLWSFL |
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| Kinase | RSKL1.AA | Pkinase | 385-417 | 32 | 5.764499 | 0.96 | Pfam | 60-96 (293) | Show / Hide |
Range on Protein: 385-417 Range on HMM: 60-96/293 Sequence Identity: 32% (12 aa) PNMVCLHKYIISEESVFLVLQHAEGG----KLWSYIS || | |. . .. .. .|. ..||| |..||| PNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS |
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| Kinase | RSKL1.AA | RSKL | 814-1056 | 38 | 6.8e-203 | 502.6 | In-house | 105-436 (436) | Show / Hide |
Range on Protein: 814-1056
Range on HMM: 105-436/436
Sequence Identity: 38% (128 aa)
TEESLFRICSPLSGAN-EYIASTDTLKTEEVLLFTDQTDDLAKEEPTS--------------------------------LFQRDSETKGESGLVLEGD-
| | ||..||... .........|.|.|....|....|.|...|| ..|.|.|...... ....|
TSEVTVQICHNLSQYHDRHMQFQCGVKQERVQAMMDPHFSLMKPSDTSSGCTVGQDRIGMEPPRTSDFTIAGNSRPAAQIHYQQDEEYMPRAVAYFQSDS
------------------------KEIHQIFEDLDKKLALASR--------------------FYIPEGCIQRWAAEMVVALDALHREG-IVCRDLNPNN
..||..||..||......| ..|||.||..||.||||||.|||.|| ..||||||.|
KSQPCRHNHIQSRRQNHSPNSSPVQKIHWVFEQADKEMFYCYRWRIRQCVQKQRALRRCGWNYWDIPEQCIRQWACEMVVALHALHAEGHVICRDLNPDN
ILLNDRGHIQLTYFSRWS-------EVEDSCDSDAIERMYCAPEVGAITEETEACDWWSLGAVLFELLTGKTLVECHPAGINTHTTLNMP---ECVSEEA
|||...||||||||..|| .|...|...|...||||||||.|.|.||||||||.||||.|||.|..|..|||.||..||.|.|| |.||..|
ILLDQKGHIQLTYFGQWSGLTSDDNWVCQQCNREAVTNMYCAPEVGQIWELTEACDWWSYGAVLYELLCGMSLYQCHPHGIQRHTQLQMPSEKEWVSHHA
RSLIQQLLQFNPLERLGAGVAGVEDIKSHPFF
..|..|||||||.||||.|..||..||.||||
KDLLTQLLQFNPMERLGMGQGGVDEIKAHPFF
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| Kinase | RSKL1.AA | AGC | 882-1056 | 23 | 2e-70 | 180.38 | In-house | 122-395 (395) | Show / Hide |
Range on Protein: 882-1056
Range on HMM: 122-395/395
Sequence Identity: 23% (65 aa)
IHQIFEDLDKKLALA---SRFYIPEGCIQRWAAE-------MVVALDALHR-EGIVCRD-LNPNNILLNDRGHIQLTYFSRWSEVEDSC-----------
. .. ... | | ... .| ... .||| .| ||. ||. ||..|| | | ||||...||| || | . |. ...
L-YCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMK
-----------------------------------------DSDAI---ERMYCAPEVGAITEETEACDWWS--LGAVLFELLTGKTLVECH--------
. | |||. . |||||| ||....|.|||.. .
FHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHP
---PAGINTHTT---------LNMP----------ECVSEEARSLIQQLLQFNPLERLGAGVA-----GVEDIKSHPFF
|. . . .| . .|.||..||..||. .| .|||.| |.|.||.||.|
FRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
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| Kinase | RSKL1.AA | MAST | 1018-1056 | 56 | 1.1e-19 | 56.18 | In-house | 301-337 (337) | Show / Hide |
Range on Protein: 1018-1056 Range on HMM: 301-337/337 Sequence Identity: 56% (22 aa) ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFF .|.|.||. ||..||| ||..||||. |...||.|||| DCMSPEAQDLIKKLLQPNPKKRLGAN--GADEIKQHPFF |
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| Kinase | RSKL1.AA | Akt | 1014-1056 | 37 | 1.6e-16 | 49.22 | In-house | 220-264 (264) | Show / Hide |
Range on Protein: 1014-1056 Range on HMM: 220-264/264 Sequence Identity: 37% (17 aa) LNMP--ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFF ...| . .| |...|| .||. .| .|||.| ....||.||.| VKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF |
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| Kinase | RSKL1.AA | AktR | 1008-1056 | 40 | 3.3e-16 | 59.08 | In-house | 217-268 (268) | Show / Hide |
Range on Protein: 1008-1056 Range on HMM: 217-268/268 Sequence Identity: 40% (21 aa) INTHT--TLNMPECVSEEARSLIQ-QLLQFNPLERLGAGVAGVEDIKSHPFF |.... . |...|.....||| .||. || .||| . .| |.|||||.| IKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF |
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| Kinase | RSKL1.AA | RSK | 1013-1056 | 43 | 8.3e-16 | 54.56 | In-house | 233-278 (278) | Show / Hide |
Range on Protein: 1013-1056 Range on HMM: 233-278/278 Sequence Identity: 43% (20 aa) TLNMP--ECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFF .|.|| . .|.||..||...|. .| |||.| ..|.||.||.| SLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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| Kinase | RSKL1.AA | SGK | 1011-1056 | 43 | 2e-15 | 43.64 | In-house | 239-283 (283) | Show / Hide |
Range on Protein: 1011-1056 Range on HMM: 239-283/283 Sequence Identity: 43% (20 aa) HTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFF . |..| .| .|..|||.||| .| .|||. .. ..||.|||| NQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTK-RDFMEIKNHPFF |
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| Kinase | RSKL1.AA | NDR | 1012-1056 | 40 | 7.6e-15 | 41.59 | In-house | 299-350 (350) | Show / Hide |
Range on Protein: 1012-1056 Range on HMM: 299-350/350 Sequence Identity: 40% (21 aa) TTL-----NMPECV--SEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFF .|. . |... |.|| ||..|. .| .|||.. ||..||||||| QTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVDEIKSHPFF |
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| Kinase | RSKL1.AA | Pkinase | 967-1056 | 20 | 1.1e-14 | 53.01 | Pfam | 177-293 (293) | Show / Hide |
Range on Protein: 967-1056 Range on HMM: 177-293/293 Sequence Identity: 20% (25 aa) YCAPEVGA-ITEETEACDWWSLGAVLFELLTGKTLVECHP----AGINTHTTLNMPEC-----------------------------VSEEARSLIQQLL |.|||| .. . ..|.||.| .|.|.|.|... . .. ... . .|||....| .| YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL QFNPLERLGAGVAGVEDIKSHPFF ...| .|.. |.|. ||.| CKDPKKRPT-----AEQILQHPWF |
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| Kinase | RSKL1.AA | RSK | 1017-1056 | 47 | 1.6e-14 | 48.45 | In-house | 232-271 (271) | Show / Hide |
Range on Protein: 1017-1056 Range on HMM: 232-271/271 Sequence Identity: 47% (19 aa) PECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFF .. .|.|| .|. ..| .| ||||| |||.||.||.| WDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF |
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| Kinase | RSKL1.AA | S_TKc | 861-1056 | 23 | 6.3e-14 | 27.27 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 861-1056
Range on HMM: 1-231/231
Sequence Identity: 23% (59 aa)
LFQRDSETKGESGLVLEGDKEI-------------------------------HQIFE----------------DLDKKLALASR----FYIPEGCIQRW
. || | | . . . .|. || . . | |..|| ....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY
AAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYF--SRWSEVEDSCDSDAIERMYCAPEVGAITEETE-ACDWWSLGAVLFELLTGKTLVECHPA
..... ||. .|. ||. ||| | ||||.. || .. | .| .. . |.|||| . .|||||.| .|.|.|.|... .
MYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP----
GINTHTTLNMPECVSEEARSLIQQLLQFNPLERLGAGVAGV--EDIKSHPFF
. ...... |.||...|...||..| .|..| | .|||.||.|
--QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | RSKL1.AA | p70 | 910-948 | 48 | 2e-13 | 45.13 | In-house | 134-172 (299) | Show / Hide |
Range on Protein: 910-948 Range on HMM: 134-172/299 Sequence Identity: 48% (19 aa) AAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLTYF ..| ..|| || ||. ||| | |..|| .||. || | LSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDF |
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| Kinase | RSKL1.AA | SGK | 910-946 | 56 | 4.7e-13 | 36.19 | In-house | 131-167 (283) | Show / Hide |
Range on Protein: 910-946 Range on HMM: 131-167/283 Sequence Identity: 56% (21 aa) AAEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLT ||| | ||. || |. ||| | |||| . ||. || AAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLT |
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| Kinase | RSKL1.AA | NDR | 911-946 | 47 | 6.2e-12 | 32.44 | In-house | 111-146 (350) | Show / Hide |
Range on Protein: 911-946 Range on HMM: 111-146/350 Sequence Identity: 47% (17 aa) AEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLT ||||.|....|. |.. ||. | |.|.. .||| || AEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLT |
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| Kinase | RSKL1.AA | NDR | 967-997 | 50 | 7.1e-12 | 32.25 | In-house | 247-278 (350) | Show / Hide |
Range on Protein: 967-997 Range on HMM: 247-278/350 Sequence Identity: 50% (16 aa) YCAPEVGAI-TEETEACDWWSLGAVLFELLTG | |||| . |. ...|||||||....|.|.| YMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVG |
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| Kinase | RSKL1.AA | AktR | 910-999 | 33 | 2.3e-11 | 40.3 | In-house | 107-203 (268) | Show / Hide |
Range on Protein: 910-999 Range on HMM: 107-203/268 Sequence Identity: 33% (35 aa) AAEMVVALDALHRE-GIVCRDLNPNNILLNDRGHIQLTYF--SR------WSEVEDS-CDSDAIERMYCAPEVGAITEE---TEACDWWSLGAVLFELLT .|... ||. || . |. ||| | |||| ||. .| | |. .|...| |.. . | |||. ||.. . ..|||..|....|..| FAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPE----YMAPEM--ITKKKGHNKSVDWWAFGIFIYEMVT GKT | . GCP |
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| Kinase | RSKL1.AA | RSK | 910-946 | 52 | 3.4e-10 | 33.83 | In-house | 110-149 (278) | Show / Hide |
Range on Protein: 910-946 Range on HMM: 110-149/278 Sequence Identity: 52% (21 aa) AAEMVVALDALHREGIVCRDLNPNNILLND---RGHIQLT .|| |.|.. || ||. ||| | |||..| .||| || MAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLT |
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| Kinase | RSKL1.AA | MAST | 911-946 | 55 | 3.9e-10 | 26.47 | In-house | 109-144 (337) | Show / Hide |
Range on Protein: 911-946 Range on HMM: 109-144/337 Sequence Identity: 55% (20 aa) AEMVVALDALHREGIVCRDLNPNNILLNDRGHIQLT || | .|. || ||| ||| |.|.|. ||| || AETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLT |
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| Kinase | RSKL1.AA | p70 | 1014-1056 | 44 | 5.1e-10 | 32.6 | In-house | 257-299 (299) | Show / Hide |
Range on Protein: 1014-1056 Range on HMM: 257-299/299 Sequence Identity: 44% (19 aa) LNMPECVSEEARSLIQQLLQFNPLERLGAGVAGVEDIKSHPFF |..| ..|.| ||..|| .| .|.||| ..||..|||| LKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF |
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| Kinase | RSKL1.AA | RSK | 967-999 | 41 | 6.8e-10 | 32.72 | In-house | 174-210 (278) | Show / Hide |
Range on Protein: 967-999 Range on HMM: 174-210/278 Sequence Identity: 41% (16 aa) YCAPEVGAIT----EE--TEACDWWSLGAVLFELLTGKT |.|||. .. .. ..||||||||....|.|||.. YMAPEM--LKRANQQGGHDKACDWWSLGVLMYEMLTGCP |
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| Kinase | RSKL1.AA | Akt | 910-946 | 47 | 2.3e-09 | 26.0 | In-house | 106-143 (264) | Show / Hide |
Range on Protein: 910-946 Range on HMM: 106-143/264 Sequence Identity: 47% (18 aa) AAEMVVALDALHREGIVCRD-LNPNNILLNDRGHIQLT .||.. |...|| .|. || | | |||. ||| || CAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLT |
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| Kinase | RSKL1.AA | RSK | 910-946 | 46 | 2.9e-09 | 29.44 | In-house | 107-147 (271) | Show / Hide |
Range on Protein: 910-946 Range on HMM: 107-147/271 Sequence Identity: 46% (19 aa) AAEMVVALDALHREGIVCRDLNPNNILLNDR----GHIQLT .|| |.. || ||| ||| | |||. | ||| .. MAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKIC |
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| Kinase | RSKL1.AA | SGK | 967-998 | 43 | 5.4e-08 | 20.29 | In-house | 191-222 (283) | Show / Hide |
Range on Protein: 967-998 Range on HMM: 191-222/283 Sequence Identity: 43% (14 aa) YCAPEVGAITEETEACDWWSLGAVLFELLTGK | |||| . . . |||.||.||.|...|. YLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGL |
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| Kinase | RSKL1.AA | RSK | 979-999 | 57 | 1.6e-07 | 23.17 | In-house | 183-203 (271) | Show / Hide |
Range on Protein: 979-999 Range on HMM: 183-203/271 Sequence Identity: 57% (12 aa) TEACDWWSLGAVLFELLTGKT ..||||||.|....| ||| | DQACDWWSFGVLMYEMLTGCT |
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| Kinase | RSKL1.AA | Akt | 979-997 | 50 | 2.8e-07 | 19.26 | In-house | 180-199 (264) | Show / Hide |
Range on Protein: 979-997 Range on HMM: 180-199/264 Sequence Identity: 50% (10 aa) TEACDWWS-LGAVLFELLTG | |.|||. ||.|..|...| TKAVDWWGSLGCVMYEMMCG |
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| Kinase | RSKL1.AA | p70 | 967-998 | 43 | 4.6e-07 | 21.8 | In-house | 204-235 (299) | Show / Hide |
Range on Protein: 967-998 Range on HMM: 204-235/299 Sequence Identity: 43% (14 aa) YCAPEVGAITEETEACDWWSLGAVLFELLTGK |.|||. . |.||||||. .. |||. YMAPEILMRCGHNHAVDWWSLGCLMYDMLTGG |
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| Kinase | RSKL1.AA | MAST | 983-997 | 53 | 3e-06 | 14.23 | In-house | 251-265 (337) | Show / Hide |
Range on Protein: 983-997 Range on HMM: 251-265/337 Sequence Identity: 53% (8 aa) DWWSLGAVLFELLTG ||||.| ...|.|.| DWWSMGIIMYEFLVG |
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| Kinase | RSKL1.AA | Pkinase | 879-943 | 23 | 2.1e-05 | 20.2 | Pfam | 72-147 (293) | Show / Hide |
Range on Protein: 879-943 Range on HMM: 72-147/293 Sequence Identity: 23% (18 aa) DKEIHQIFEDLDK-----KLA--LA--SRFYI--PEGCIQRWAAEMVVALDALHREGIVCRDLNPNNILLNDRGHI ...|. ..| ... |. . .. . .| ..... ... .|. .|..||. ||| | |||....||| KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHI |
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