Gene RSKL2 (Human)
RSKL2
Sequence
Protein domains of RSKL2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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MIT | RSKL2.AA | MIT | 46-121 | 43 | 1.3e-30 | 108.99 | SMART | 1-81 (81) | Show / Hide |
Range on Protein: 46-121 Range on HMM: 1-81/81 Sequence Identity: 43% (35 aa) KRDYLVDAATQIRLALERDV--SEDYEAAFNHYQNGVDVLLRGIHVD-PNKERREAVKLKITKYLRRAEEIFNCHLQR--P .|||. |...| .|.. | ..|||.|..|||.|.|.|..||... |...||.|.. |...||.|.||| |||..| | QRDYYQKAIEYITQAVKADEDEWGDYEQAIEHYQKGIDYLMQGIKYEKPDEKRRHAIWAKCREYLDRMEEIKNCHDWRLCP |
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MIT | RSKL2.AA | MIT | 49-117 | 32 | 5.9e-24 | 86.35 | Pfam | 1-71 (71) | Show / Hide |
Range on Protein: 49-117 Range on HMM: 1-71/71 Sequence Identity: 32% (23 aa) YLVDAATQIRLALERDV-SEDYEAAFNHYQNGVDVLLRGIHVDPNKERREA-VKLKITKYLRRAEEIFNCH || | ... |.| | . .||.|...||.........|...|| ..||| .. |...|. |||.| ... YLQKAIELVKKAVEADEDAGNYEEAIQCYQEAIEYFMQAIKYEPNPKWREARLRQKMQEYMDRAEQIKEHL |
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Kinase | RSKL2.AA | RSKL | 153-539 | 49 | 0.0 | 890.69 | In-house | 1-436 (436) | Show / Hide |
Range on Protein: 153-539 Range on HMM: 1-436/436 Sequence Identity: 49% (214 aa) CRVVGVIEKVQLVQDPATGGTFVVKSLPRCHMVSRERLTIIPHGVPYMTKLLRYFVSEDSIFLHLEHVQGGTLW-------------------------- |||||.|.|||.|||||||.||.|..|||||||||.....|||.|||||.|.|||||||.|||||||||.|.|| CRVVGIIKKVQVVQDPATGNTFYVMKLPRCHMVSRDCSIFIPHNVPYMTQLVRYFVSEDHIFLHLEHVQPGQLWSFLRRMFDEAESRHVLWLAELKADVR ------------SHLLSQAHSRHSGLSSGSTQERMKAQLNPHLNLLTPARLPSGHAPGQDRIALEPPRTSPNLLLAGEAPSTRPQREAEGEPTARTSTSG .|.|||.|.||.....|..|||..|...||..|..|....||...|||||..||||||.........|..........|...|..... DGDTTSEVTVQICHNLSQYHDRHMQFQCGVKQERVQAMMDPHFSLMKPSDTSSGCTVGQDRIGMEPPRTSDFTIAGNSRPAAQIHYQQDEEYMPRAVAYF SSDLPKAPGGHLHLQARRAGQNSDAGPPRGLTWVPEGAGPVLGGCGRGMDQSCLSADGAGRGCGRATWSVREEQVKQWAAEMLVALEALHEQG-VLCRDL .||....|..|.|.|.||........|.....||.|.|......|.|.....|.....|.|.||...|...|....|||.||.|||.|||..| |.|||| QSDSKSQPCRHNHIQSRRQNHSPNSSPVQKIHWVFEQADKEMFYCYRWRIRQCVQKQRALRRCGWNYWDIPEQCIRQWACEMVVALHALHAEGHVICRDL HPGNLLLDQAGHIRLTYFGQWS-------EVEPQCCGEAVDNLYSAPEVGGISELTEACDWWSFGSLLYELLTGMALSQSHPSGIQAHTQLQLP---EWL .|.|.||||.|||.|||||||| .|..||..|||.|.|.|||||.|.||||||||||.|..|||||.||.|.|.||.|||.|||||.| ||. NPDNILLDQKGHIQLTYFGQWSGLTSDDNWVCQQCNREAVTNMYCAPEVGQIWELTEACDWWSYGAVLYELLCGMSLYQCHPHGIQRHTQLQMPSEKEWV SRPAASLLTELLQFEPTRRLGMGEGGVSKLKSHPFF |..|..|||.||||.|..|||||.|||...|.|||| SHHAKDLLTQLLQFNPMERLGMGQGGVDEIKAHPFF |
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Kinase | RSKL2.AA | AGC | 198-539 | 16 | 1.1e-64 | 165.2 | In-house | 90-395 (395) | Show / Hide |
Range on Protein: 198-539 Range on HMM: 90-395/395 Sequence Identity: 16% (75 aa) PYMTK-LLRYFVSEDS--IFLHLE----HVQ-----GG-TLWSHLLSQAHSRHSGLSSGSTQERMKAQLNPHLNLLTPARLPSGHAPGQDRIALEPPRTS |. .| | | ..| ... .| | || |..|| . PFIVKILHYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGR---------------------------------------------------- PNLLLAGEAPSTRPQREAEGEPTARTSTSGSSDLPKAPGGHLHLQARRAGQNSDAGPPRGLTWVPEGAGPVLGGCGRGMDQSCLSADGAGRGCGRATWSV | .. ----------------------------------------------------------------------------------------------RKEGRF REEQVKQWAAE-------MLVALEALHE-QGVLCRD-LHPGNLLLDQAGHIRLTYFGQWSEVEPQC---------------------------------- ||... .||| .. ||| ||. .|. .|| | | |.|||. |||.|| || . |. . DEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNW ------------------CGEAV---DNLYSAPEVGGISELTEACDWWS--FGSLLYELLTGMALSQSH-----------PSGIQAHTQ---------LQ . . | |||. . |||||| .| |.||.||| ... | . . .. QRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVK LP----------EWLSRPAASLLTELLQFEPTRRLGMGEG-----GVSKLKSHPFF .| .|.| | .|.. ||. .|..||| |.. |.. .|.||.| FPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF |
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Kinase | RSKL2.AA | Ciliate-E2 | 198-539 | 13 | 2.4e-25 | 83.97 | In-house | 92-365 (365) | Show / Hide |
Range on Protein: 198-539 Range on HMM: 92-365/365 Sequence Identity: 13% (56 aa) PYMTKLLRYFV--SEDSIFLHLEHVQGGTLWSHLLSQAHSRHSGLSSGSTQERMKAQLNPHLNLLTPARLPSGHAPGQDRIALEPPRTSPNLLLAGEAPS |. |. .| ....|.| .| .|||.|.... .. ..|.. .. PNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE------------------------------------------------------ TRPQREAEGEPTARTSTSGSSDLPKAPGGHLHLQARRAGQNSDAGPPRGLTWVPEGAGPVLGGCGRGMDQSCLSADGAGRGCGRATWSVREEQVKQWAAE . . |...|. .. ----------------------------------------------------------------------------------K-D-KYFTEKEIKYIMKQ MLV---------------ALEALHEQG-VLCRDLHPGNLLLDQAGHIRLTYFG---QWSEVEPQC-----CGEAVDNL---------------------- | ||| ||... .. ||. | |.|. | .. || . .. . .. |.. . ILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTI -----YSAPEVGGISE---------LTEACDWWSFGSLLYELLTGMALSQSHPSGIQAHTQ--LQLP----------------EW--LSRPAASLLTE-- | |||. . . ...||.||.| .|||.|.| .| . | ...| .| .| . |. CGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFG --LLQFEPTRRLGMGEGGVSKLKSHPFF .|| .| |.. | .... ||.| KRMLQKDPEKRIT----GWEQILNHPWF |
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Kinase | RSKL2.AA | Pkinase | 386-539 | 22 | 3.3e-20 | 72.53 | Pfam | 107-293 (293) | Show / Hide |
Range on Protein: 386-539 Range on HMM: 107-293/293 Sequence Identity: 22% (44 aa) EEQVKQWAAEMLVALEALHEQGVLCRDLHPGNLLLDQAGHI----RLTYFGQ-----WSEVEPQCCGEAVDNLYSAPEVGG-ISELTEACDWWSFGSLLY |...| .. ..| .|| .|..|.. ||| | |.|.|. ||| ... || . . . . .. | |||| .. . ..|.||.| .|| EWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILY ELLTGMALSQSH-----PSGIQAHTQLQL-------PEWLS-------------------RPAASLLTELLQFEPTRRLGMGEGGVSKLKSHPFF |.|.| . ..| . .| . . |.| | ... .... .|.. |..|.. .. ||.| EMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPWF |
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Kinase | RSKL2.AA | RSK-Unclassified | 386-432 | 44 | 4.4e-18 | 52.91 | In-house | 100-146 (283) | Show / Hide |
Range on Protein: 386-432 Range on HMM: 100-146/283 Sequence Identity: 44% (21 aa) EEQVKQWAAEMLVALEALHEQGVLCRDLHPGNLLLDQAGHIRLTYFG |..|. .|.| .||| || ... ||| | | .|.| ||..|| |. EDDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFD |
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Kinase | RSKL2.AA | SGK | 386-432 | 51 | 1.7e-14 | 40.76 | In-house | 124-170 (283) | Show / Hide |
Range on Protein: 386-432 Range on HMM: 124-170/283 Sequence Identity: 51% (24 aa) EEQVKQWAAEMLVALEALHEQGVLCRDLHPGNLLLDQAGHIRLTYFG | ... ||| ||| ||.| . ||| | |.||| ||..|| || EDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFG |
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Kinase | RSKL2.AA | p70 | 386-432 | 44 | 1.3e-13 | 45.78 | In-house | 127-173 (299) | Show / Hide |
Range on Protein: 386-432 Range on HMM: 127-173/299 Sequence Identity: 44% (21 aa) EEQVKQWAAEMLVALEALHEQGVLCRDLHPGNLLLDQAGHIRLTYFG |. .. ..| .||| ||..|. ||| | | .|.|.||. || || EDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFG |
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Kinase | RSKL2.AA | Akt | 386-432 | 43 | 2.3e-13 | 39.02 | In-house | 99-146 (264) | Show / Hide |
Range on Protein: 386-432 Range on HMM: 99-146/264 Sequence Identity: 43% (21 aa) EEQVKQWAAEMLVALEALHEQGVLCRD-LHPGNLLLDQAGHIRLTYFG |.. . .||. |.|.||.... || | | |.|.|. |||.|| || EDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFG |
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Kinase | RSKL2.AA | Akt | 496-539 | 32 | 1.1e-12 | 36.78 | In-house | 219-264 (264) | Show / Hide |
Range on Protein: 496-539 Range on HMM: 219-264/264 Sequence Identity: 32% (15 aa) QLQLP--EWLSRPAASLLTELLQFEPTRRLGMGEGGVSKLKSHPFF ... | .|.| . .|.. ||. |..||| |.... .|.||.| PVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF |
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Kinase | RSKL2.AA | RSK | 386-432 | 45 | 4.3e-12 | 39.66 | In-house | 100-150 (271) | Show / Hide |
Range on Protein: 386-432 Range on HMM: 100-150/271 Sequence Identity: 45% (23 aa) EEQVKQWAAEMLVALEALHEQGVLCRDLHPGNLLLDQA----GHIRLTYFG |. || .|| . |.| ||.||. ||| | | |.| |||... || EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFG |
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Kinase | RSKL2.AA | RSK-Unclassified | 496-539 | 34 | 1.4e-11 | 32.16 | In-house | 238-283 (283) | Show / Hide |
Range on Protein: 496-539 Range on HMM: 238-283/283 Sequence Identity: 34% (16 aa) QLQLP--EWLSRPAASLLTELLQFEPTRRLGMGEGGVSKLKSHPFF ....| . .|. . .|. ||| | .||| . | | |||| HVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF |
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S_TKc | RSKL2.AA | S_TKc | 150-539 | 13 | 2.5e-11 | -10.78 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 150-539 Range on HMM: 1-231/231 Sequence Identity: 13% (56 aa) LRGCRVVGVIE--KVQLVQDPATGGTFVVKSLPRCHMVSRERLTIIPHGVPYMTKLLRYFVSEDSIFLHLEHVQGGTLWSHLLSQAHSRHSGLSSGSTQE . |..| || .... || . .| .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------------------------------------------------------------- RMKAQLNPHLNLLTPARLPSGHAPGQDRIALEPPRTSPNLLLAGEAPSTRPQREAEGEPTARTSTSGSSDLPKAPGGHLHLQARRAGQNSDAGPPRGLTW ---------------------------------------------------------------------------------------------------- VPEGAGPVLGGCGRGMDQSCLS------------------------ADG---AGRGCGRATWS------VREEQVKQWAAEMLVALEALHEQGVLCRDLH . ..|. .|| . . . | ... ...... ||| .|..|.. ||| -----------EHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLK PGNLLLDQAGHIRLTYFGQWSEVEPQCCGEAVDNLYSAPEVGGISELTE-ACDWWSFGSLLYELLTGMALSQSHPSGIQAHTQLQLPEWLSRPAASLLTE | |.|||. || .. || .. . | |||| . .|||||.| .|||.|.| . . | .. ... |..| ... PENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG--SPEAKDFIRK LLQFEPTRRLGMGEGGV--SKLKSHPFF .||..|..|.. | .. |.||.| CLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | RSKL2.AA | SGK | 494-539 | 39 | 2.8e-11 | 30.63 | In-house | 239-283 (283) | Show / Hide |
Range on Protein: 494-539 Range on HMM: 239-283/283 Sequence Identity: 39% (18 aa) HTQLQLPEWLSRPAASLLTELLQFEPTRRLGMGEGGVSKLKSHPFF . ||.| | .| .|...||| .|. ||| ... |.|||| NQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFM-EIKNHPFF |
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Kinase | RSKL2.AA | PKC | 393-432 | 52 | 2.9e-11 | 32.6 | In-house | 106-145 (262) | Show / Hide |
Range on Protein: 393-432 Range on HMM: 106-145/262 Sequence Identity: 52% (21 aa) AAEMLVALEALHEQGVLCRDLHPGNLLLDQAGHIRLTYFG ||| ..|| |||.|. ||| | |||. |||... || AAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFG |
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Kinase | RSKL2.AA | PKC | 500-539 | 37 | 4e-11 | 32.14 | In-house | 220-262 (262) | Show / Hide |
Range on Protein: 500-539 Range on HMM: 220-262/262 Sequence Identity: 37% (16 aa) PEWLSRPAASLLTELLQFEPTRRLGM---GEGGVSKLKSHPFF | |||. |.|... ... .|..|||. .|.| ..|||| PRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF |
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Kinase | RSKL2.AA | p70 | 450-539 | 32 | 7.9e-11 | 35.59 | In-house | 204-299 (299) | Show / Hide |
Range on Protein: 450-539 Range on HMM: 204-299/299 Sequence Identity: 32% (31 aa) YSAPEVGGISELTEACDWWSFGSLLYELLTGM------ALSQSHPSGIQAHTQLQLPEWLSRPAASLLTELLQFEPTRRLGMGEGGVSKLKSHPFF | |||. . |.|||| | |.| ||| . . ... |.|| |. . |. || .|| |.| | . . . ..|||| YMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF |
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Kinase | RSKL2.AA | RSK | 386-432 | 46 | 1.1e-10 | 35.65 | In-house | 103-152 (278) | Show / Hide |
Range on Protein: 386-432 Range on HMM: 103-152/278 Sequence Identity: 46% (23 aa) EEQVKQWAAEMLVALEALHEQGVLCRDLHPGNLLLDQ---AGHIRLTYFG |. ... .|| .|.| ||.||. ||| | | |.|. |||.|| || EDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFG |
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Kinase | RSKL2.AA | RSK | 500-539 | 40 | 1.7e-10 | 33.88 | In-house | 232-271 (271) | Show / Hide |
Range on Protein: 500-539 Range on HMM: 232-271/271 Sequence Identity: 40% (16 aa) PEWLSRPAASLLTELLQFEPTRRLGMGEGGVSKLKSHPFF .. .|..| .||. .| |..||| | || |.||.| WDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF |
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Kinase | RSKL2.AA | RSK | 497-539 | 35 | 2.7e-10 | 34.17 | In-house | 234-278 (278) | Show / Hide |
Range on Protein: 497-539 Range on HMM: 234-278/278 Sequence Identity: 35% (16 aa) LQLP--EWLSRPAASLLTELLQFEPTRRLGMGEGGVSKLKSHPFF | .| . ||..| .|.. .|. .| .||| | .... .|.||.| LTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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Kinase | RSKL2.AA | Akt | 462-481 | 42 | 4.1e-07 | 18.71 | In-house | 180-200 (264) | Show / Hide |
Range on Protein: 462-481 Range on HMM: 180-200/264 Sequence Identity: 42% (9 aa) TEACDWWS-FGSLLYELLTGM | |.|||. .| ..||...|. TKAVDWWGSLGCVMYEMMCGR |
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Kinase | RSKL2.AA | RSK | 462-480 | 68 | 8e-07 | 21.37 | In-house | 190-208 (278) | Show / Hide |
Range on Protein: 462-480 Range on HMM: 190-208/278 Sequence Identity: 68% (13 aa) TEACDWWSFGSLLYELLTG ..||||||.| |.||.||| DKACDWWSLGVLMYEMLTG |
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Kinase | RSKL2.AA | RSK | 462-480 | 73 | 1e-06 | 19.84 | In-house | 183-201 (271) | Show / Hide |
Range on Protein: 462-480 Range on HMM: 183-201/271 Sequence Identity: 73% (14 aa) TEACDWWSFGSLLYELLTG ..|||||||| |.|| ||| DQACDWWSFGVLMYEMLTG |
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Kinase | RSKL2.AA | PKC | 450-480 | 45 | 2e-06 | 16.99 | In-house | 166-196 (262) | Show / Hide |
Range on Protein: 450-480 Range on HMM: 166-196/262 Sequence Identity: 45% (14 aa) YSAPEVGGISELTEACDWWSFGSLLYELLTG | |||. | ... |||.|| |.||.. | YIAPEILQYQEYGKSVDWWAFGVLMYEMMAG |
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TyrKc | RSKL2.AA | TyrKc | 150-533 | 9 | 1.1e-05 | -130.66 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 150-533 Range on HMM: 1-280/280 Sequence Identity: 9% (41 aa) LRGCRVV-----GVIEKVQLVQDPATGGTFVVKSLPRCHMVSRERLTIIPHGVPYMTKL---------LRYFVSE--------DSIFLHLEHVQGGTLWS .. .. |.. | .. . ||.| .. . . . |.|| | ... . ... .|.. .| | . ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD HLLSQAHSRHSGLSSGSTQERMKAQLNPHLNLLTPARLPSGHAPGQDRIALEPPRTSPNLLLAGEAPSTRPQREAEGEPTARTSTSGSSDLPKAPGGHLH .| . . YLRKHRPK-------------------------------------------------------------------------------------------- LQARRAGQNSDAGPPRGLTWVPEGAGPVLGGCGRGMDQSCLSADGAGRGCGRATWSVREEQVKQWAAEMLVALEALHEQGVLCRDLHPGNLLLDQAGHIR . .. ... | ||.... ||| | |.. .... --------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVK LTYFG---QWSEV-------EPQCCGE-AVDN--L---YSAPEVGGISELTEACDWWSFGSLLYELLTGMALSQSH-----PSGIQAHTQLQLPEWLSRP . || . . . | . | |||. .. |.. | |||| ...|..| . . | .... ... . . .| ISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQP AA--------------SLLTELLQFEPTRRLGMGEGGVSKL . .. .. ...| | . | .... PNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF |
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Kinase | RSKL2.AA | SGK | 466-481 | 50 | 4.6e-05 | 11.08 | In-house | 207-222 (283) | Show / Hide |
Range on Protein: 466-481 Range on HMM: 207-222/283 Sequence Identity: 50% (8 aa) DWWSFGSLLYELLTGM |||. |..|||...|. DWWCLGCVLYEMMYGL |
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Kinase | RSKL2.AA | RSK-Unclassified | 450-481 | 43 | 0.000249 | 8.94 | In-house | 188-219 (283) | Show / Hide |
Range on Protein: 450-481 Range on HMM: 188-219/283 Sequence Identity: 43% (14 aa) YSAPEVGGISELTEACDWWSFGSLLYELLTGM | |||. | | ||| | ..||.| |. YLAPEMIRRCGHTKAVDWWTLGIVMYEMLFGC |