Gene SgK069 (Human)

SgK069

Species: Human
Alias: SgK069, LOC646643
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , GeneCards
Annotation: Consensus chromosomal location: 19q13.43,

Classification

Group: Other
Family: NKF1

Sequence

Name Sequence Type Origin Length Description Download
SgK069.NA RNA Sugen Kinome 1156 None Fasta, JSON
SgK069.AA Protein Sugen Kinome 348 None Fasta, JSON
SgK069.kin_dom Protein Kinase Domain Sugen Kinome 264 None Fasta, JSON

Protein domain

Protein domains of SgK069.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SgK069.AA NKF1 62-325 49 8e-178 597.05 In-house 1-269 (269) Show / Hide 
Range on Protein: 62-325
Range on HMM: 1-269/269
Sequence Identity: 49% (133 aa)

YEEVRPLGQGCYGRVLLVTHRQKGTPLALKQLPKPRTSLRGFLYEFCVGLSLGAHSAIVTAYGIGIESAH--SYSFLTEPVLHGDLMAFIQP--KVGLPQ
||..|.||.||||..||..|||.||..|||..|||.|.|..|..|||.|..|..|..|||.|........  .|.|..|....||||..|||  ..|||.
YEIIRQLGEGCYGKILLCEHRQSGTRMALKFVPKPQTKLKDFHREFCYGCCLSHHHHIVTTYDVMFQTMDDTYYVFAQEYAPCGDLMEMIQPTNQRGLPE

PAVHRCAAQLASALEYIHARGLVYRDLKPENVLVCDP-ACRRFKLTDFGHTRPRGTLLRLAGPPIPYTAPELCAPPPLPEGLPIQPALDAWALGVLLFCL
....||.|||||||...|.|.||.||.|||||||.|| .|.|.||.|||||||||...|......||.|||.|...|..||.|..|..|.|..|||.||.
NYCKRCVAQLASALDFMHSRNLVHRDIKPENVLVFDPNDCQRVKLCDFGHTRPRGCTVRRVKHTWPYCAPEVCQELPKNEGFPCDPSHDVWQFGVLIFCC

LTGYFPWDRPLAEADPFYEDFLIWQASGQPRDRPQPWFGLAAAADALLRGLLDPHPRRRSAVIAIREHL
|||.|||.......||.||.|..||...||...||||. ....|....|.||.|||.||..|.......
LTGCFPWQKADWMCDPCYEWFMWWQRRKQPPMMPQPWRRFTPRAMRCFRKLLTPHPERRWPVKMMHKYM
Kinase SgK069.AA S_TKc 62-330 23 5.3e-39 136.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 62-330
Range on HMM: 1-231/231
Sequence Identity: 23% (66 aa)

YEEVRPLGQGCYGRVLLVTHRQKGTPLALKQLPKPRTSLRGFLYEFCVGLSLGAHSAIVTAYGIGIESAHSYSFLTEPVLH--GDLMAFIQPKVG-----
|| .|..|.| .|.| ...|.  |   |.|...      . .. |  .  .   |  ||. |..  .  ... . .| . .  |||. .|. . .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LPQPAVHRCAAQLASALEYIHARGLVYRDLKPENVLVCDPACRRFKLTDFGHTRPRGTLLRLAGPPIPYTAPELCAPPPLPEGLPIQP-ALDAWALGVL
 .|   . . ..|...||||.| .| ..|||||||.|...    . |..|||  |       . | |  | |||..         .  . . | |..|..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL---TTFCGTP-WYMAPEVL---------GYGKCKCDWWSCGCI

LFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQPRDRPQPWFGLAAAADALLRGLLDPHPRRRSAVIAIRE-------HLGRPWR
|. .|.|| |..          .......  |              | | ..|..|.  |..|  .  . .       |   || 
LYEMLCGYPPFP----------QMQMMFKKIG-----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCH---PWF
Kinase SgK069.AA Pkinase 62-325 20 1.2e-36 130.69 Pfam 1-293 (293) Show / Hide 
Range on Protein: 62-325
Range on HMM: 1-293/293
Sequence Identity: 20% (64 aa)

YEEVRPLGQGCYGRVLLVTHRQKGTPLALKQLPKPRTSLRGFLY-----EFCVGLSLGAHSAIVTAYGIGIESAHSYSFLTEPVLHG----DLMAFIQ--
|. .|..|.| .|.| . .|.  |   |.|...|....     .     | .. ..|  |  ||. |..  .. | | . .| . .|    ||...|.  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYISTW

PKVGL--PQPAVHRCAAQLASALEYIHARGLVYRDLKPENVLVC-DPAC-RRFKLTDFGH-----TRPRGTLLRLAGPPIPYTAPELCAPPPLPEGLPIQ
 . ..  .   . ... |....|||.|..| ..|||||||.|.  .. .  ..|..|||      . . . .  ..| | .| |||..      .| .. 
RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP-WYMAPEVIR-----GGQYYG

PALDAWALGVLLFCLLTGYFPWDRPLAEADPFYEDFLIWQASGQPRDRPQPWFGLA-------------------AAADALLRGLLDPHPRRRSAVIAIR
|. | |..|..|...|.|..|..      |. ...  . .  ..|. . . .                        ..  .....|.. | .|     | 
PKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL

EH--L
.|  .
QHPWF
Kinase SgK069.AA CAMK 143-264 21 1.2e-19 59.27 In-house 145-335 (425) Show / Hide 
Range on Protein: 143-264
Range on HMM: 145-335/425
Sequence Identity: 21% (41 aa)

G----DLMAFIQPK---------------VGLPQPAVHRCAAQLASALEYIHARGLVYRDLKPENVLVCDPA-------------CRRF--KLTDFGHTR
|    ||  .|. .                 ..   ..|.  |..||..|.| .. | |||||||.|..|               . ..  |..|||  .
GELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFAN

PRGT---------------------------LLRLAGPPIPYTA-PELCAPPP--------LPEGLPIQPALDAWALGVLLFCLLTGYFPWD
                               .    | | .| | ||.    .        . |  .. |. | |..||.|. .|.||.|..
KFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTP-EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFY
Kinase SgK069.AA MSK 165-262 35 6.3e-17 53.76 In-house 108-209 (277) Show / Hide 
Range on Protein: 165-262
Range on HMM: 108-209/277
Sequence Identity: 35% (37 aa)

AQLASALEYIHARGLVYRDLKPENVLVCDPAC-RRFKLTDFGHTR--PRGTLLRLAGP--PIPYTAPELCAPPPLPEGLP-IQPALDAWALGVLLFCLLT
..| .|....| .| ..|||||||.|  |    .. ||.|||  |  |..   |.  |   . | |||. .     .. .   .| | | |||.|. .||
RELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRR--GYAQDGGYDEACDWWSLGVILYTMLT

GYFP
|  |
GQVP
Kinase SgK069.AA Ciliate-E2-Unclassified 164-262 28 9.2e-17 54.69 In-house 149-269 (352) Show / Hide 
Range on Protein: 164-262
Range on HMM: 149-269/352
Sequence Identity: 28% (37 aa)

AAQLASALEYIHARG-LVYRDLKPENVLVCDPACR--RFKLTDFGHTR-------------------PRGTLLRLAGPPI--P-YTAPELCAPPPLPEGL
.||. ..|||.|  .  ..||.||||.|. |  ..  . |..|||  .                   ..  .   .| |.  | |||||      . .| 
FAQILQGLEYLHHKNNIIHRDIKPENILF-DNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPE------VLQGQ

PIQ----PALDAWALGVLLFCLLTGYFP
        . | |.|||.|...|.||.|
NYDHSKAYKCDIWSLGVILYEMLFGYYP
Kinase SgK069.AA AGC 164-190 44 5.8e-16 36.3 In-house 152-187 (395) Show / Hide 
Range on Protein: 164-190
Range on HMM: 152-187/395
Sequence Identity: 44% (16 aa)

AAQ-------LASALEYIHA-RGLVYRD-LKPENVL
||.       ...||||.|  .| ..|| |||||.|
AAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENIL
Kinase SgK069.AA Ciliate-E2 164-205 39 1.9e-12 39.03 In-house 166-201 (365) Show / Hide 
Range on Protein: 164-205
Range on HMM: 166-201/365
Sequence Identity: 39% (17 aa)

AAQLASALEYIHARG-LVYRDLKPENVLVCDPACRRFKLTDFG
.|.. .||||.| ..  ..||.||||.|.        |..|||
IACIILALEYLHSKNNIIHRDIKPENILF-------IKIIDFG
Kinase SgK069.AA CAMKL 143-191 34 7e-12 34.05 In-house 106-160 (297) Show / Hide 
Range on Protein: 143-191
Range on HMM: 106-160/297
Sequence Identity: 34% (19 aa)

GD--LMAFI--QPKVG--LPQPAVHRCAAQLASALEYIHARGLVYRDLKPENVLV
|.  |. .|  .....  .| .  .|   |. ||..|.| .| | ||.||||.|.
GEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILL
Kinase SgK069.AA RSK 164-205 46 1.5e-11 38.84 In-house 110-152 (278) Show / Hide 
Range on Protein: 164-205
Range on HMM: 110-152/278
Sequence Identity: 46% (20 aa)

AAQLASALEYIHARGLVYRDLKPENVLVCDPA-CRRFKLTDFG
.|....|.|..| .| ..|||||||.|  |    .. ||||||
MAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFG
Kinase SgK069.AA PKA 164-190 60 5.7e-10 39.45 In-house 106-133 (263) Show / Hide 
Range on Protein: 164-190
Range on HMM: 106-133/263
Sequence Identity: 60% (17 aa)

AA-QLASALEYIHARGLVYRDLKPENVL
|| |  .||||.|.  ..|||||||| |
AASQIVLALEYLHSQNIIYRDLKPENIL
Kinase SgK069.AA TyrKc 62-325 20 1.5e-09 -68.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 62-325
Range on HMM: 1-280/280
Sequence Identity: 20% (62 aa)

YEEVRPLGQGCYGRVLLVTHRQKGTPLALKQLPKPRTSLRGFLYEFCVGLSLG-AHSAIVTAYGIGIESA------HSYSFLTEPVLHGDLMAFIQPKVG
 .  . || |..|.| . | .   .. | | | .    .. |. |  .  .||  |  ||  ||. ...       . .  ..| . ||||  ... . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-LPQPAVHRCAAQLASALEYIHARGLVYRDLKPENVLVCDPACRRFKLTDFGHTRPRG---------TLLRL----AGP---PIPYTAPELCAPPPLPEG
 |. .  .  . | |.  ||.| .... |||   |.|| ..   . | .||| .|  .            |      |    ||  .|||          
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE----------

LPIQPAL---------DAWALGVLLFCLLT-GYFPWDRPLAEADPFYEDFLIWQASGQPRDRPQPWF--------GLAAAADALLRGLLDPHPRRRSAVI
     ..         | |. ||... ..| |  |.  .  .   . ... . .   | . .|||            ..  . . .   .  |  |    
-----CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFS

AIREHL
.|.| .
EIHECF
Kinase SgK069.AA CAMKL 242-324 23 3e-09 25.5 In-house 215-294 (297) Show / Hide 
Range on Protein: 242-324
Range on HMM: 215-294/297
Sequence Identity: 23% (21 aa)

PALDAWALGVLLFCLLTGYFPWD-----RPLAEADPFYEDFLIWQASGQPRDRPQPWFGLAAAADALLRGLLDPHPRRRSAVIAIREH
|. | |..||.|. ...||.|.|     .    .  .    | |.  ..   .| .|. .   .  |.|..| . | .|  .  |..|
PKVDIWSCGVILYAMVCGYLPFDDDTYNK----QGKDNI-YLYWKIMCG--YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH
Kinase SgK069.AA MARK 242-264 52 1.8e-08 23.98 In-house 185-207 (262) Show / Hide 
Range on Protein: 242-264
Range on HMM: 185-207/262
Sequence Identity: 52% (12 aa)

PALDAWALGVLLFCLLTGYFPWD
|. | |.|||.|. ...||||.|
PKVDIWSLGVVLYFMVCGYFPFD
Kinase SgK069.AA AGC 62-95 30 1.3e-07 14.22 In-house 1-40 (395) Show / Hide 
Range on Protein: 62-95
Range on HMM: 1-40/395
Sequence Identity: 30% (12 aa)

YEEVRPLGQGCYGRVLLVTHR------QKGTPLALKQLPK
.| ....|.| .|.| || ..      . |   |.| | |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKK
Kinase SgK069.AA MARK 166-205 42 1e-06 18.15 In-house 112-151 (262) Show / Hide 
Range on Protein: 166-205
Range on HMM: 112-151/262
Sequence Identity: 42% (17 aa)

QLASALEYIHARGLVYRDLKPENVLVCDPACRRFKLTDFG
|. ||..| | .. | ||.||||.|. .   .  |..|||
QIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFG
Kinase SgK069.AA CAMK 67-95 24 2e-06 15.94 In-house 1-41 (425) Show / Hide 
Range on Protein: 67-95
Range on HMM: 1-41/425
Sequence Identity: 24% (10 aa)

PLGQGCYGRVLLVTHRQKG------------TPLALKQLPK
 ||.| .| | |..|.. .            .  | | ..|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDK
Kinase SgK069.AA CAMKL 62-103 32 4e-06 15.54 In-house 1-43 (297) Show / Hide 
Range on Protein: 62-103
Range on HMM: 1-43/297
Sequence Identity: 32% (14 aa)

YEEVRPLGQGCYGRVLLVTH-RQKGTPLALKQLPKPRTSLRGF
|. .. ||.| .| | | || |  |.  | | . | ..... .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPW
Kinase SgK069.AA Ciliate-E2-Unclassified 62-95 29 1.3e-05 15.42 In-house 1-34 (352) Show / Hide 
Range on Protein: 62-95
Range on HMM: 1-34/352
Sequence Identity: 29% (10 aa)

YEEVRPLGQGCYGRVLLVTHRQKGTPLALKQLPK
|. .. .|||..| | .. |....   |.|.. |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKK
Kinase SgK069.AA Ciliate-E2 62-85 25 5.3e-05 13.1 In-house 1-24 (365) Show / Hide 
Range on Protein: 62-85
Range on HMM: 1-24/365
Sequence Identity: 25% (6 aa)

YEEVRPLGQGCYGRVLLVTHRQKG
|. .. .|||..| | ........
YKFIKKIGQGNFGSVYKCKVWKVQ
Kinase SgK069.AA Ciliate-E2 245-263 47 6.9e-05 12.7 In-house 278-296 (365) Show / Hide 
Range on Protein: 245-263
Range on HMM: 278-296/365
Sequence Identity: 47% (9 aa)

DAWALGVLLFCLLTGYFPW
| |.|||.|...|.|..|.
DIWSLGVILYEMLFGKPPF
Kinase SgK069.AA PKA 62-97 38 0.000535 14.95 In-house 1-36 (263) Show / Hide 
Range on Protein: 62-97
Range on HMM: 1-36/263
Sequence Identity: 38% (14 aa)

YEEVRPLGQGCYGRVLLVTHRQKGTPLALKQLPKPR
.| .. ||.| .||| |. |.. |   |.|.| |..
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQE
Kinase SgK069.AA MARK 62-95 32 0.000779 8.61 In-house 1-34 (262) Show / Hide 
Range on Protein: 62-95
Range on HMM: 1-34/262
Sequence Identity: 32% (11 aa)

YEEVRPLGQGCYGRVLLVTHRQKGTPLALKQLPK
|. .. .|.| |. | |..|.  |.  |.| ..|
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEK
Kinase SgK069.AA AGC 247-262 50 0.003735 2.41 In-house 287-304 (395) Show / Hide 
Range on Protein: 247-262
Range on HMM: 287-304/395
Sequence Identity: 50% (9 aa)

WA--LGVLLFCLLTGYFP
|.  ||.|.. .|||| |
WSFGLGCLMYEMLTGYPP
Kinase SgK069.AA RSK 245-262 55 0.003768 7.8 In-house 194-211 (278) Show / Hide 
Range on Protein: 245-262
Range on HMM: 194-211/278
Sequence Identity: 55% (10 aa)

DAWALGVLLFCLLTGYFP
| | ||||.. .|||. |
DWWSLGVLMYEMLTGCPP
Kinase SgK069.AA RSK 65-95 44 0.028386 4.56 In-house 1-34 (278) Show / Hide 
Range on Protein: 65-95
Range on HMM: 1-34/278
Sequence Identity: 44% (15 aa)

VRPLGQGCYGRVLLV---THRQKGTPLALKQLPK
.. |||| || | |.   ||...|.  | |.| |
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKK
Kinase SgK069.AA PKA 247-262 56 0.703901 1.08 In-house 183-198 (263) Show / Hide 
Range on Protein: 247-262
Range on HMM: 183-198/263
Sequence Identity: 56% (9 aa)

WALGVLLFCLLTGYFP
||||.| . .|.|| |
WALGILIYEMLAGYPP