Gene SgK495 (Human)

SgK495

Species: Human
Alias: SHIK, MGC4796, RP11-268J15.4, STK40, SgK495
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 1p35.1,

Classification

Group: CAMK
Family: SgK495

Sequence

Name Sequence Type Origin Length Description Download
SgK495.NA RNA Sugen Kinome 3863 None Fasta, JSON
SgK495.AA Protein Sugen Kinome 435 None Fasta, JSON
SgK495.kin_dom Protein Kinase Domain Sugen Kinome 171 None Fasta, JSON

Protein domain

Protein domains of SgK495.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SgK495.AA SgK495 158-328 91 1.2e-160 500.4 In-house 1-171 (171) Show / Hide 
Range on Protein: 158-328
Range on HMM: 1-171/171
Sequence Identity: 91% (156 aa)

NLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDM
||||.||.||||||||||.||.||||.||||||||||||||||||||||..||.|||||||||||||||.||||||||||||||||||||||||||||||
NLQHHVIHEKRLSERETVYIFHDVVRIVEALHQKNIVHRDLKLGNMVLNCHTHQITITNFCLGKHLVSEHDLLKDQRGSPAYISPDVLSGRPYRGKPSDM

WALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLEAL
|||||||||||||||||||||||||||||||||||||.||||||||||||||||||||||||.|..|.||.
WALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPQDGRVSENTVCLIRKLLVLDPQQRLTATQVIEAV
Kinase SgK495.AA CAMK 159-326 23 2.3e-62 199.44 In-house 151-421 (425) Show / Hide 
Range on Protein: 159-326
Range on HMM: 151-421/425
Sequence Identity: 23% (64 aa)

LQHYVIKE---------------KRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRT----------------HRITITNFCLGKHLVS--
|  |...                .|..|||.  .|  ..  |. .|..||||||||. |  |...                 . | |. | . ... .  
LFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGE

---------------------EGDLLKDQRGSPAYIS-PDVLSG-------------RPYRGKPSDMWALGVVLFTMLYGQFPFYDS-------------
                     ||...|.. |.|.|.. | ||.|             .|| |...|||..||.|..|| | .|||..             
NNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGM

IPQELFRKIKAAEYT-IPE-------------DGRVSEN--------TVCLIRKLLVLDPQQRLAAADVLE
 ..|||.||....|. .|.             ....|..          .||||.|. ||..|. ....|.
NDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLN
Kinase SgK495.AA CAMKL 157-326 30 3.7e-45 141.98 In-house 108-293 (297) Show / Hide 
Range on Protein: 157-326
Range on HMM: 108-293/297
Sequence Identity: 30% (57 aa)

INLQHYVIKE----KRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTH-RITITNFCLGKH---L-VSEGDLLKDQRGSPAYISPDVLSG
. |..|..|.    .|..|.|.  .|  .|  |. .|...|||||.|. |  | ..    | |. | .. .     . .|..|| . |||.| .| ...|
MDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQG

--RPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQ-------ELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLE
  .||.|.. |.|..||.|..|..|..|| |   .       .|..||.   | .|   .||     ||||.|. .| .|  . ....
NNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMN
Kinase SgK495.AA GIN4 159-330 35 7.8e-44 137.64 In-house 121-293 (293) Show / Hide 
Range on Protein: 159-330
Range on HMM: 121-293/293
Sequence Identity: 35% (62 aa)

LQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMW
|  |.... .| ||| . .|  ..  |   |  ||.|||||  |..| .. .|| |  | .   |  ...||.   ||| | .|.. .|.||.| .||.|
LFNYLVDHGPLPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIADFGMA-ALETDNKLLETSCGSPHYAAPEIVMGIPYHGFASDVW

ALGVVLFTMLYGQFPFYDS--IPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLEALSA
. ||.|| .| |. || .     ..|  |..  .| .|.|  .| .   ||||.||.||..|.   |.|.    
SCGVILFALLTGHLPFDEEDGNIRKLLLKVQKGKYEMPSDDEISREAQDLIRKILVVDPEKRIKTRDILKHPLI
Kinase SgK495.AA AMPK 162-324 38 1.1e-41 121.59 In-house 90-248 (254) Show / Hide 
Range on Protein: 162-324
Range on HMM: 90-248/254
Sequence Identity: 38% (63 aa)

YVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKPSDMWALG
|..| .||.|||.   |  ..  || .|. .|||||||. |. |.   ..| |  | | . . ..|..||   ||| | .| . ||..| |   | |  |
YIVKHGRLQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLD-HNKNIKIVDFGLSN-MMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCG

VVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADV
|.|. || |  || |.   .|..|||. ||.||..  .|..   ||...|  ||..|.   |.
VILYAMLCGYLPFDDENTPTLYKKIKNGEYYIPKF--LSPEAKDLIKHMLQVDPMKRITIHDI
Pkinase SgK495.AA Pkinase 156-328 23 2.6e-39 140.08 Pfam 88-293 (293) Show / Hide 
Range on Protein: 156-328
Range on HMM: 88-293/293
Sequence Identity: 23% (49 aa)

LINLQHYVI--KEKRL--SERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHR---ITITNFCLGKHL-VSEGDLLKDQRGSPAYISPDVLSG
.. | .|.   .....  ||.|   ..| ..| .| .|...|.|||||. |  .... |    . |. | | |..    .  ...  |.| |..| |. |
VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRG

RPYRGKPSDMWALGVVLFTMLYGQFPFYDS------IPQELFRKIKAAEYTIPEDGRVS-------------------ENTVCLIRKLLVLDPQQRLAAA
..| |...|||..|..|. || |..||...       .......|. ...  ...   |                   |.   .|...| .||..|. |.
GQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

DVLEA--L
..|.   .
QILQHPWF
Kinase SgK495.AA Trbl 162-326 40 4.4e-39 120.82 In-house 88-252 (256) Show / Hide 
Range on Protein: 162-326
Range on HMM: 88-252/256
Sequence Identity: 40% (67 aa)

YVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRT-HRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRP-YRGKPSDMWA
|| . ||| |.|  ..|. ..  |   ||  || |||||   |  ..   ..   .   .  .  | | | |  | |||.|| .|. .. | ||. ||| 
YVRHRKRLCEEEAARLFHQMCQAVAHCHQHGIVLRDLKLRRFVFKDEERTKLQLESLEDSCIMTGEDDSLWDKHGCPAYVSPEILCTQGSYSGKAADMWS

LGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLE
|||.|.||| |..||.|| |  || ||   .. |||   .|    |||| ||  .|  |. | ..|.
LGVMLYTMLVGRYPFHDSEPCNLFTKIRRGQFCIPE--HLSPKARCLIRCLLRREPSERMTAQHILL
Kinase SgK495.AA MARK 158-326 34 5.1e-39 125.3 In-house 88-258 (262) Show / Hide 
Range on Protein: 158-326
Range on HMM: 88-258/262
Sequence Identity: 34% (60 aa)

NLQHYVIKE--KRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRT-HRITITNFCLGKHLVSEGDLLKDQRGSPAYISPDVLSGRPYRGKP
.| .|...    ||.|.|. .||  .|  |. .|.|||||||.|. |  . ... | | |. | .. . . .| .|.   |.|.| .| .....|| |..
ELYDYIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSIC-IPPGQKLNTFCGTPPYMAPEIFLKKPYDGPK

SDMWALGVVLFTMLYGQFPFYDSI--PQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLE
 |.|.|||||..|. |.||| ..     ||..|| . .|.||    ||     ||..||...| .|  . ....
VDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH--VSKECRNLIQRLLTVNPEERPTIEEIMK
Kinase SgK495.AA CAMK-Unique 159-326 20 1.1e-37 121.87 In-house 122-359 (363) Show / Hide 
Range on Protein: 159-326
Range on HMM: 122-359/363
Sequence Identity: 20% (49 aa)

LQHYVIK--------------------EKRLSE--RETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKR---------------THRITITNFCLGK
|. ...|                    . ..||  ..|  |.  .. .|. .|...|||||||| | .....                ..| ...| | .
LFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCC

HLVSEGDL--LKDQRGSPAYISP--------------DVLSGRPYRGKPS---DMWALGVVLFTMLYGQFPFYDSIPQ--------ELFRKIKAAEY-TI
|. .      ..   |.| |..|               |. ...| .. |   | |.|||....|| |  ||. .           |.|..|....| . 
HYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYENHDKEIFECICKGDYCNF

PED--GR---VSENTVCLIRKLLVLDPQQRLAAADVLE
...  ..   .|..   .. .....|| .|. |.  ||
DWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLE
Kinase SgK495.AA Ciliate-E2 158-326 20 1.7e-34 115.86 In-house 120-361 (365) Show / Hide 
Range on Protein: 158-326
Range on HMM: 120-361/365
Sequence Identity: 20% (52 aa)

NLQHYVI------------KEKRLSERETVVIFYDVVR---------------VVEALHQKN-IVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGD-
.|..| .            . |...|.|   |.. ...                .| ||.|| |.|||.|. | ..      | |. | | | .  . . 
DLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQN

--------LLKDQR-----------------------GSPAYISPDVLSGRPY--------RGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAA
        .... .                       |.| | .| .|.| .|         .. .|.|.|||.|. ||.|..||        ...||  
RTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------QQQIKQC

EYTIP----------------EDGRVSENTVCLIRK----LLVLDPQQRLA-AADVLE
.. .|                .   .|...  ||.|    .|. ||..|.  . ..|.
KIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase SgK495.AA ULK 158-318 24 2e-33 115.95 In-house 103-312 (324) Show / Hide 
Range on Protein: 158-318
Range on HMM: 103-312/324
Sequence Identity: 24% (52 aa)

NLQHYVIKE---------KRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHR-----------ITITNFCLGKHLVSEG---DLLKDQR
.|..|  |          ||||| |.. .|.. .    .||..||.|||.|. |  ... ..            . |. |...||. ...   .... . 
DLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQTCV

------GSPAYISPDVLSGR----PYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELF----RK----------IKAAEYTIP---EDGRVSENTVCLI
      |.| | .| .|.|.    ||  . .|.| ||.... ||||. ||. . .....    .           ||     .|   .|  .|...  ||
NEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLI

RKLLVLDPQQR
|..|. |. .|
RRMLQYDEKDR
S_TKc SgK495.AA S_TKc 35-332 21 7.6e-30 106.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 35-332
Range on HMM: 1-231/231
Sequence Identity: 21% (66 aa)

FILGPRLGNSPVPSIVQCLARKDGTDDFYQLKILTLEERGDQGIESQEERQGKMLLHTEYSLLSLLHTQDGVVHHHGLFQDRTCEIVEDTESSRMVKKMK
. ..  .|     .  .|  .|  |.  . .||.                     .  | ..|.     . .|. .. |||                   
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK------------------EHIRREIQILKK--HHPNIVKLYDVFQD-------------------

KRICLVLDCLCAHDFSDKTADLINLQHYVIKEKR------LSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLGKHLVSEGD
.....|....          || .| .|  | .|      ..| ..  ..| ... .| .|...|.|||||  |  |..   .| |. | | ..|     
DHLYMVMEYC--------DGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-----

LLKDQRGSPAYISPDVLSGRPYRGKPSDMWALGVVLFTMLYGQFPFYDSIPQELFRKIKAAEYTIPEDGRVSENTVCLIRKLLVLDPQQRLAAADVLE--
  . . |.| |..| ||   .| ....|.|..|..|. ||.|. ||.   .|..|.||.            |.    .|||.|. ||..|. | ..|.  
--TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

---ALSAII
   ..   .
WDIKCHPWF
TyrKc SgK495.AA TyrKc 35-328 14 2.3e-07 -103.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 35-328
Range on HMM: 1-280/280
Sequence Identity: 14% (47 aa)

FILGPRLGNSPVPSIVQCLARKDGTDDFYQL---KILTLEERGDQGIESQEERQGKMLLHTEYSLLSLL--HTQDGVVHHHGLFQ---------DRTCEI
  ||  ||.     .... ..        .    | |  .               .. .. | .... |  | .  .|  .|            .  . .
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA--------------REDFMREARIMCKLGGHHP-NIVRLYGVCTQQGRNFMYIEPLMIV

VEDTESSRMVKKMKKRICLVLDCLCAHDFSDKTADLINLQHYVIKEKRLSERETVVIFYDVVRVVEALHQKNIVHRDLKLGNMVLNKRTHRITITNFCLG
.|  .     .  .|.                                |. .. . . ... .  | ||.||..||||   |  ....  .. |. | | 
MEYMPHGDLKDYLRKHRPK-----------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLS

KHLVSE------GDLLKDQR--GSP-----AYISPDVLSGRPYRGKPSDMWALGVVLFTML-YGQFPFYD-----SIPQELFRKIKAAEYTIPEDG----
. . ..      .|  . .   |.         .| ..  . .  | || |. ||... .. ||| | ..       .||.....|. ..  . .     
RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK-SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPM

---RVSENTVCLIRKLLVLDPQQRLAAADVLEAL
   . ..    ....    || .|   ... | .
SFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF