Gene SRPK1 (Human)
SRPK1
Sequence
Protein domains of SRPK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | SRPK1.AA | SRPK | 80-653 | 53 | 0.0 | 1183.33 | In-house | 1-554 (554) | Show / Hide |
Range on Protein: 80-653 Range on HMM: 1-554/554 Sequence Identity: 53% (321 aa) YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPN---------------------DPNREMVVQLLDDFKISGVNG |||||||||||||||||.||.|....||||.||||.||||||.|||.||..||..||| ||||..||||||.||..|.|| YHVIRKLGWGHFSTVWLCWDMQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKEYYEDYKRDCKEFDPNRCHVVQLLDHFKHRGPNG THICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQ-- .|.|||||||||.|||||...||||.|..|||.|..|||.||||||.||.||||||||||.||.||..||.|.|||.||||..|...||.|.|.|||| NHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVLLCVNQDYIKRMAAEWTEWQKMGMQMPSSSMVQTAPQHQ -PKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEIN .....|||||||||.|||||.|.|..||..|....||...... ..|.||............|..|.|..|..|...|..|..............|.. TQCQQQKMSKNKKKKMKKKQKQQQEQQEKNQQQKQQMEDDQNDN--EDNNQEDNDNEQDNKNNQNQENNMENEQEEKENTNKQKKNQKKKEQHKDKKEQE CNGVIEVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPC |..|....|. ..|. ||| ||...|||.||.........||.||.|.. .. .|.. . ..|...|... CQNVQKQNND-----------------------------PNFE-SQN-DSQMEQETNSCNNQEHKQEKTMQCQDSTKQQNKQ-DQQKEGQKQSEESECES EDEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAE---KLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFE ||.||| ||.|||....|.||. |.|.||||||||||||.|||||||||||||.||.||.|||||||||||||||||||||||||| EDMQEQ-------------AGKFLVWWKNPRNADLDHKIKIKIADLGNACWVHHHFTEDIQTRQYRSPEVIIGAGYNTPADIWSTACMAFELATGDYLFE PHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPW |||||.|.||.||||.||||.||.|......||||.|||.|||.|.||.|||||.|..||.||||||.|||. |.|||.|||...|||||||.|||.||| PHSGEDYSRDDDHIAHIIELCGKIPWHFALSGKYSREFFNKKGELRHIPKLKPWPLMNVLIEKYEWSHEEAKQFEDFLMPMLHYNPEKRATAKECLQHPW L | L |
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| Kinase | SRPK1.AA | CMGC | 80-653 | 14 | 1e-123 | 408.73 | In-house | 1-513 (513) | Show / Hide |
Range on Protein: 80-653
Range on HMM: 1-513/513
Sequence Identity: 14% (113 aa)
YHVIRKLGWGHFSTVWLSWD--------------IQGKKFVAMKVVKSAEHYTE-------------TALDEIRLLKSVR----------NSDPNDPNRE
|..|.|.|.|....|. .| ......||.| .|... |.| .||.||..|| .. . ||......
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRD-DPDNKHHN
MVVQLLDDFKISGVNGT-------------HICMVFEVLGHHLLKWIIKSN--YQG------------------------LPLPCVKKIIQQVLQGLD--
.|.|.| |. .. .|. |...||| ..| |.. | . . ||| ... ... ...|.|.||.
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK
YLHTKC-RIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQ
|.| .. .|||.|.||||||.. | ..|.|. . | .| .
YCHSHWGNIIHRDLKPENILINHNCELITRM-M----W-KS-----E-----------------------------------------------------
KRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSS
----------------------------------------------------------------------------------------------------
QNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGN
. . ||. ... ..||.| |.
----------------------------------------------------------------------------D-W-NPC----QKNGRLKICDFGL
ACWVHKH------------------------FTEDIQTRQYRSLEVLIGSG----------YNTPADIWSTACMAFELATG--------DYLFEPHSGE-
|.|.|.| .|....|| ||. |.|.|.. |.|| |.|| .|. .|. || ..|| .||..
ARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYP
----EYTRDEDHIALIIELLGKVPRKLIVAGK-------YSKEFFTKKGDLKHITKLK-------------------------PWGLFEVLVEKYEWSQE
.... |....|...||. . ..| .|| ...|...... . .....| || . . ... |...
NDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPN
--------------------------------EAAGFTDFLLPMLELIPEKRATAAECLRHPWL
. . |.| ||.. |.|| ||...|.||..
WDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
|
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| Kinase | SRPK1.AA | CLK | 80-653 | 15 | 9.2e-62 | 183.65 | In-house | 1-350 (350) | Show / Hide |
Range on Protein: 80-653
Range on HMM: 1-350/350
Sequence Identity: 15% (95 aa)
YHVIRKLGWGHFSTVWLSWDIQG-KKFVAMKVVKSAEHYTETALDEIR-LLKSVRNS-DPNDPNREMVVQLLDDFKISGVN-GTHICMVFEVLGHHLLKW
| .. .|| | |..| || . ||.|| |.....| |.| | ||. .|.. . ||| ..| .....| |. . . |||.||| .| .
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFD----YGHGHICIVFELYGLSIYDF
IIKSN------YQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNE--QYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNK
. . | |...|. .... | .. . || . ...||| |||||.. |.. .... .. .
MKSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLH-DMKLTHTDLKPENICF-VDSRFTHFDCTFKYNHKKKIN--------------------------
KKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINYTQ
----------------------------------------------------------------------------------------------------
NSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPL
----------------------------------------------------------------------------------------------------
DNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGNAC---WVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDED
. . . . . . ... | |.| | | .. ..||.|| || | |...| |.|| .| ||| ||. || |. .
-------KKS-NNCVCHYWHVKNTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHD------NRE
HIALIIELLG-KVPRKLIVAG---KYSKEFF---TKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWL
| |.. ...| .| | . | ....| .| . . . . | . . ..|. . | . ||| | || |... | ||.
HLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLDWDWHNSDGRYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
|
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| Kinase | SRPK1.AA | S_TKc | 80-653 | 13 | 3.3e-46 | 160.75 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 80-653
Range on HMM: 1-231/231
Sequence Identity: 13% (78 aa)
YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGH---HLLKWI
|...||.| | |..|.. ... .. ||.|..| |... ||..||. . || .|.|.| | .|..||.| ... |.. |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK------HHPN---IVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYI
IKSNYQG----LPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRR-------LAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSK
| ...| .| ......|....|.|.| . .||| |.|||||||. . ||..
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE------HIKICDFGLARQL------------------------------
NKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINY
----------------------------------------------------------------------------------------------------
TQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNG
----------------------------------------------------------------------------------------------------
PLDNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNT-PADIWSTACMAFELATGDYLFEPHSGEEYTRDED
| . |. |.. ||| ||.. ..|.|| |. .|...| .|.
-------------------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP------------
HIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLR-------HPWL
.........| . ||. .|. |||| || |.|. |||.
QMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
|
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| Kinase | SRPK1.AA | DYRK | 80-221 | 31 | 1.6e-31 | 111.03 | In-house | 1-137 (320) | Show / Hide |
Range on Protein: 80-221 Range on HMM: 1-137/320 Sequence Identity: 31% (45 aa) YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKS | .. .| | |. | || .... ||.|.... . . .|..||..|. .. .. .. .|...| |. . | |.||| | | . . YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQ--DPDDKYHCVHMYDYFYHRN----HLCIVFELLSMNLYEFLKNN NYQGL-PLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL . ||. .| |.|..||.|..|..||.. .||| |.|||||.| HFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIML |
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| Kinase | SRPK1.AA | DYRK | 486-653 | 28 | 2.2e-28 | 100.64 | In-house | 138-320 (320) | Show / Hide |
Range on Protein: 486-653 Range on HMM: 138-320/320 Sequence Identity: 28% (55 aa) KNA-EKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAG |.. | .|..| | .| .|.... || | ||. ||..| |... |.|| | || || || .|| . | .|.|.|.||. |...| .| KQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLF---PGENE---YDQLACIMEVLGMPPKWMIDKG --KYSKEFFTK---------KGDLK----------HITKLKPWGLFEVLVE-KYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWL .. ..||.. .. | |.|| .. ... . |.||.. .|.. |.|| |... |.|||. RCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF |
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| Kinase | SRPK1.AA | DYRK2 | 80-221 | 35 | 1.5e-27 | 86.37 | In-house | 1-135 (318) | Show / Hide |
Range on Protein: 80-221 Range on HMM: 1-135/318 Sequence Identity: 35% (51 aa) YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKS | . .| | | | | |..|| |.. . ..|. ||| |. | |.. | .| .|| | . |.|..|| |. | . | | YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKD--NTMNCVHMLDYFYFRN----HHCITFELLSMNLYEYIKKN NYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL ..||. | | . ....||.|. || | .||| | ||||||| HFQGFSLQLVRRFAHSILQCLRFLH-KNNIIHCDLKPENILL |
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| Kinase | SRPK1.AA | DYRK1 | 80-221 | 32 | 2.5e-22 | 74.82 | In-house | 1-137 (321) | Show / Hide |
Range on Protein: 80-221 Range on HMM: 1-137/321 Sequence Identity: 32% (46 aa) YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKS | .. .| | | | .| | ...||.|..| . . |. ||||| . . |.. .. .|.| |. |.|.|||.| | . YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKE--MKYYIVHLKRHFMFR----NHLCLVFELLSYNLYDLLRNT NYQGLPLPCVKKIIQQVLQGLDYLHT-KCRIIHTDIKPENILL ...| | ..|. ||... | .. | ||| |.||||||| HFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILL |
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| Kinase | SRPK1.AA | CDC2 | 80-222 | 31 | 7.3e-22 | 63.5 | In-house | 1-137 (301) | Show / Hide |
Range on Protein: 80-222 Range on HMM: 1-137/301 Sequence Identity: 31% (47 aa) YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTE-----TALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLK | |.|.| | . | | | .. ||.| .. . ||. || .|| . ..|| .|.| | ... . |||| | ..| | YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELK----DHPN---IVKLHDVIHQ-----NKLYMVFEYLDMDLKK WIIKSNY--QGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLS .|. . .|. ||... | |||....|.. ||.| |.|| |||.. YMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQR-RIMHRDLKPQNILID |
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| Kinase | SRPK1.AA | Pkinase | 80-222 | 28 | 2.5e-21 | 76.52 | Pfam | 1-142 (293) | Show / Hide |
Range on Protein: 80-222 Range on HMM: 1-142/293 Sequence Identity: 28% (45 aa) YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALD------EIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGH--- ||..||.| | |..|.. .. | ||.|..| | . . ||...|... . .|.|.| | ..||.||.| ... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLN--------HPNIVRLYDWFED----KDHIYMVMEYCEGGLY --HLLKWIIKSNYQGL--PLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLS | .| ... .. . .|... |.|.||.|.| ..||| |.||||||.. VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILID |
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| Kinase | SRPK1.AA | DYRK2 | 486-595 | 31 | 1.7e-18 | 56.46 | In-house | 136-245 (318) | Show / Hide |
Range on Protein: 486-595
Range on HMM: 136-245/318
Sequence Identity: 31% (37 aa)
KNAEKLKVKIADLGNACWVHK-HFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAG
| . . .|..| | | .| .. .||.| ||. || .| |... |.|| | . || || || || . | .|...|.||. |.|..
KQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF---PGENE---NDQFACMMEVLGMPPKKFFDTW
-----KYSKEFFTKKG
.. | ||....
FYIHCFRRKYFFNSHC
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| Kinase | SRPK1.AA | DyrkP | 486-594 | 34 | 9.9e-17 | 50.98 | In-house | 140-242 (323) | Show / Hide |
Range on Protein: 486-594 Range on HMM: 140-242/323 Sequence Identity: 34% (38 aa) KNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGK | | .||| | | .|..| | .| | || ||.|| | |.|| |. || || || .| .| ..| .| .. |. KSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLFQNDNIQGL------LARVIGIIGPFPEWMMQEGR YSKEFFTKK . |||.| LVQNFFTRK |
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| Kinase | SRPK1.AA | YAK | 80-221 | 31 | 6.1e-16 | 50.28 | In-house | 1-139 (347) | Show / Hide |
Range on Protein: 80-221 Range on HMM: 1-139/347 Sequence Identity: 31% (46 aa) YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSV-RNSDPNDPN-REMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWII | | || | | | . .| ||.|. | | ||..|.. |||. | .. ..| | | | |.||| | | . YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFF----VHKNHFCLVFEMLSNNLYEYLK KSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL .. |. .. |.| |. | | .||| | |||||.| QNKFCGFSFQLIRQWTKQILDGMCVLENK-QIIHCDLKPENIML |
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| Kinase | SRPK1.AA | Pkinase | 492-653 | 23 | 6.4e-16 | 57.37 | Pfam | 150-293 (293) | Show / Hide |
Range on Protein: 492-653 Range on HMM: 150-293/293 Sequence Identity: 23% (40 aa) KVKIADLGNAC---WVHKHFTEDIQ-TRQYRSLEVLI-GSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLG---KVPRKLIVA .|||.| | |. . ... . .. |. |.. ||. |..| ...|.|| |. .|...| .| ... . |....| . .| . .. CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCS GKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWL . |.. |.. . | . ..||.| . ||. .|.. |.|| ||...| |||. ISYFF-FRH-W-H------------F-HWTF-HNWSEE----CKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | SRPK1.AA | DYRK1 | 487-602 | 33 | 6.7e-16 | 51.87 | In-house | 139-248 (321) | Show / Hide |
Range on Protein: 487-602 Range on HMM: 139-248/321 Sequence Identity: 33% (39 aa) NAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKY |. . ..|| | | .| . . . || | ||| |||.| |.. |.|| |. |. ||. || || . . | . |.| || |...| . NPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLF---SGSN---EVDQMNKIVEVLGMPPKHMIDQAPK SKEFFTKKGDLKHITK .. .|.|. | . | AHKYFEKDPDNTWYCK |
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| Kinase | SRPK1.AA | CDK4 | 80-226 | 27 | 1.7e-15 | 49.47 | In-house | 1-148 (290) | Show / Hide |
Range on Protein: 80-226 Range on HMM: 1-148/290 Sequence Identity: 27% (43 aa) YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYT-----ETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNG--THICMVFEVLGHHL | . .| | . ||. |.. .||| | |. . || ... . . || .|.|.| .. . . . . | |||| | YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQF--EHPN---IVKLMDVCHVMDTDRAEMKITMVFEHCDWDL LKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQ .. | |.| . .|.. | | |.|.||. . ||| | ||.|||.. . . HTYLDKCPPPGMPPCTIKHMMHQLLRGVDFLHSHR-IIHRDLKPQNILVTSDGH |
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| Kinase | SRPK1.AA | YAK | 486-591 | 33 | 7.8e-10 | 29.19 | In-house | 140-239 (347) | Show / Hide |
Range on Protein: 486-591 Range on HMM: 140-239/347 Sequence Identity: 33% (36 aa) KNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGK .. .| .|| | | .| | . || | ||| |.... | | | || | || | .| | || . | ||. ||. | .| |. CKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFLGLPIFPGNS--EY----NQIKRIIDMLGYPPSWMIDQGR YSKEFF .. .| FKNKYF |
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| Kinase | SRPK1.AA | DyrkP | 189-221 | 57 | 6.8e-09 | 24.71 | In-house | 108-139 (323) | Show / Hide |
Range on Protein: 189-221 Range on HMM: 108-139/323 Sequence Identity: 57% (19 aa) VKKIIQQVLQGLDYLHTKCRIIHTDIKPENILL ..|| ||.| .|||.| |.|| |.||||||. LQKITQQILIALDYIHS-LRLIHCDLKPENILM |
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| Kinase | SRPK1.AA | CDK4 | 517-544 | 53 | 2.9e-08 | 24.21 | In-house | 175-202 (290) | Show / Hide |
Range on Protein: 517-544 Range on HMM: 175-202/290 Sequence Identity: 53% (15 aa) YRSLEVLIGSGYNTPADIWSTACMAFEL ||. ||| | |||| |.|| .| .|. YRAPEVLLQSYYNTPVDMWSVGCIFAEM |
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| Kinase | SRPK1.AA | DYRK2 | 626-653 | 39 | 4.6e-07 | 18.67 | In-house | 291-318 (318) | Show / Hide |
Range on Protein: 626-653 Range on HMM: 291-318/318 Sequence Identity: 39% (11 aa) FTDFLLPMLELIPEKRATAAECLRHPWL |.||.. .| |..| |... |.|||. FIDFIKRCFEWDPSERMTPSQALKHPWI |
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| Kinase | SRPK1.AA | CDC2 | 628-653 | 46 | 5.5e-07 | 16.96 | In-house | 276-301 (301) | Show / Hide |
Range on Protein: 628-653 Range on HMM: 276-301/301 Sequence Identity: 46% (12 aa) DFLLPMLELIPEKRATAAECLRHPWL | | || . |.|| .| | |.||.. DLLMQMLQYDPQKRISAKEALQHPYF |
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| Kinase | SRPK1.AA | TyrKc | 80-312 | 16 | 3e-06 | -122.49 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 80-312 Range on HMM: 1-280/280 Sequence Identity: 16% (50 aa) YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSV--RNSDPNDPNREMVVQLLDDFKISGVNG---THICMVFEVLGHHLLK . ..||| |.| .|.. . || |..|. | ..|.|..... .. . .|.|. .| | ...|.| | || ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHH--------PNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK WIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNE-----------------------QYI-------RR-------LAAEATE .... |... .. |. .| .||| | ..|| |. |.|.. | .|. .. .| |. DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI- WQRS---------------------GAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQ----------AELLEKRMQEIEEMEKESGPGQKRPNKQ . . |..|..| . ..... . .. |. .| .|. . |.. . . | .||. . -NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ----MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPE-----DRPTFS EESESP | | EIHECF |
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| Kinase | SRPK1.AA | CDC2 | 505-551 | 33 | 4e-06 | 14.38 | In-house | 157-209 (301) | Show / Hide |
Range on Protein: 505-551 Range on HMM: 157-209/301 Sequence Identity: 33% (18 aa) HKHFT--EDIQTRQYRSLEVLIGSG-YNTPADIWSTACMAFEL---ATGDYLF .. | .. |. ||. |.| |. |.|| |.|| | |. .| .|| IRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLF |
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| Kinase | SRPK1.AA | DyrkP | 80-129 | 30 | 5e-06 | 15.0 | In-house | 1-50 (323) | Show / Hide |
Range on Protein: 80-129 Range on HMM: 1-50/323 Sequence Identity: 30% (15 aa) YHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLK | .. || || | | . . ||.. | . ..|||.||. YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLR |
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| Kinase | SRPK1.AA | CDK4 | 628-653 | 42 | 5e-06 | 16.55 | In-house | 265-290 (290) | Show / Hide |
Range on Protein: 628-653 Range on HMM: 265-290/290 Sequence Identity: 42% (11 aa) DFLLPMLELIPEKRATAAECLRHPWL |.|. || ..|| .| .|| ||.. DLLQKMLCYNHHKRMSAYQCLQHPYF |
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| Kinase | SRPK1.AA | DyrkP | 626-653 | 42 | 3.6e-05 | 12.21 | In-house | 296-323 (323) | Show / Hide |
Range on Protein: 626-653 Range on HMM: 296-323/323 Sequence Identity: 42% (12 aa) FTDFLLPMLELIPEKRATAAECLRHPWL | || .| . .| || | |.|||. FIDFVRQCLQIDFTRRPTAKEALQHPWF |
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| Kinase | SRPK1.AA | YAK | 626-653 | 32 | 0.000123 | 11.24 | In-house | 320-347 (347) | Show / Hide |
Range on Protein: 626-653 Range on HMM: 320-347/347 Sequence Identity: 32% (9 aa) FTDFLLPMLELIPEKRATAAECLRHPWL |.||. .|.| | .| .. || . FIDFINQLLQLNPRERWKPMQAMQHPFI |
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| Kinase | SRPK1.AA | DYRK1 | 626-653 | 32 | 0.001026 | 8.36 | In-house | 294-321 (321) | Show / Hide |
Range on Protein: 626-653 Range on HMM: 294-321/321 Sequence Identity: 32% (9 aa) FTDFLLPMLELIPEKRATAAECLRHPWL | | .. ||. |..| | . |.|... FKDLIKRMLQYDPKQRITPYYALQHSFF |
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