Gene TGFbR1 (Human)

TGFbR1

Species: Human
Alias: TGFbR1, TGF_beta_RI, AAT5, TbetaR-I, TGFBR1, ACVRLK4, ALK-5, ALK5, TGFR-1, SKR4
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 9q22-q31,

Classification

Group: TKL
Family: STKR
Subfamily: STKR1

Sequence

Name Sequence Type Origin Length Description Download
TGFbR1.NA RNA Sugen Kinome 6475 None Fasta, JSON
TGFbR1.AA Protein Sugen Kinome 503 None Fasta, JSON
TGFbR1.kin_dom Protein Kinase Domain Sugen Kinome 288 None Fasta, JSON

Protein domain

Protein domains of TGFbR1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Activin_recp TGFbR1.AA Activin_recp 34-114 22 9.8e-28 93.73 Pfam 1-121 (121) Show / Hide 
Range on Protein: 34-114
Range on HMM: 1-121/121
Sequence Identity: 22% (27 aa)

LQCF-CHL--------CT--KDN-----FTCVT----------DGLCFVSVTETTD---KVIHNS----MCIAEIDLIPRDRPFVCAP-----SSKTGSV
|.|. |.         |.  ..|     .|| |          || |.||.... |   . .|..    .|. .... |...||.| .     |. . . 
LKCYFCNGYWEYDYQICHENENNFEIPVHTCETHPDKMCFYCYDGQCYVSWEYNDDEEDTEQHQRMHMYGCWSLNENCPQCHPFMCKSYKHTHSPPHRHG

TTTYC-CN-QDHCNKIELPTT
....| |. .|.||... |..
HNHECWCCETDYCNRNLTPPP
Kinase TGFbR1.AA Type1 205-492 76 5.1e-283 776.85 In-house 1-290 (290) Show / Hide 
Range on Protein: 205-492
Range on HMM: 1-290/290
Sequence Identity: 76% (221 aa)

IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIK
|...| |||||.|||||||||||.||||||.||.|||||||.|||||||.||||||||||||.||||.||||||..||||||||.|||||.|.....|..
IQMIECIGKGRYGEVWRGKWRGENVAVKIFFSRDERSWFRETEIYQTVMMRHENILGFIAADMKDNGSWTQLWLITDYHEHGSLYDYLNRHTLDTQQMLR

LALSTASGLAHLHMEIVGTQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIY
||.|.|.|||||||||.|||  |||||||||.|||||.|||||.||||||||||||.. ||.|||..|.||||||||||||||...||..|||.|.||||
LAYSCACGLAHLHMEIFGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRHQQDTDQIDIGQNPRVGTKRYMAPEVLDETMNMNCFESYKMADIY

AMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL
..|||.|||||||..|||.|||||||||.||.|||.|.|||||| .||||||||||||....|.|||.|.||||.|..||.|||||||||
SFGLVMWEIARRCEVGGIVEDYQLPYYDWVPNDPSFEDMRKVVCVRKLRPNIPNRWQSHPCMRHMAKLMKECWYQNPHARHTALRIKKTL
Kinase TGFbR1.AA STKR 205-492 62 6.1e-227 740.11 In-house 1-312 (312) Show / Hide 
Range on Protein: 205-492
Range on HMM: 1-312/312
Sequence Identity: 62% (194 aa)

IVLQESIGKGRFGEVWRGKWRG----EEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDN-GTWTQLWLVSDYHEHGSLFDYLNRYTVTV
|.|.| |||||.||||.|||||    |.||||||.||.|.|||||.|||||.|.||||||.|||||.|.. |.|||.||...|||.|||.|||.|.|...
IQLIECIGKGRYGEVWKGKWRGNGEKETVAVKIFPSRDEQSWFRETEIYQTPMMRHENILQFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRHTIDW

EGMIKLALSTASGLAHLHMEIV--GTQ--GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIA-------PNHRVGTKRYMAPEVLDDSI
..|...|.|.|.|||||||||.  |||  .||||||||.||||||||..|||||||.|||.|||. |..|||.       .|..|||||||||||||...
HEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVLDGAM

NMKHFES-FKRADIYAMGLVFWEIARRCSIGG------IHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQ-SCEALRVMAKIMRECWYANGA
|...||| |||.|.|||||| |||||||. ||      |...||.|.|| ||..||.|.|.||||....||||||||. ...|.|.|.|.|.|||.....
NFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNHPSFEDMQKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEECWDHDPE

ARLTALRIKKTL
||||||..|||.
ARLTALCVKKTM
Kinase TGFbR1.AA Type2 205-492 40 5.8e-119 394.48 In-house 1-315 (315) Show / Hide 
Range on Protein: 205-492
Range on HMM: 1-315/315
Sequence Identity: 40% (126 aa)

IVLQESIGKGRFGEVWRGKWRGE-----EVAVKIFSSREERSWFREAEIYQT-VMLRHENILGFIAADN-KDNGT--WTQLWLVSDYHEHGSLFDYLNRY
| | | |||||||.||...| ..     .||||||. ..  ||  | .||.. ....||||| ||.|.  .  ..  | ..|||...|..||| ||| ..
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVKIFPEQDKQSWQNEKDIYSLPYHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLKQH

TVTVEGMIKLALSTASGLAHLHMEIV-GTQ---GKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDT--------IDIAPNHRVGTKRYMAPEV
|.. . . ..|.|.| |||||| ||  ..|    ||.|||||.||||.||| ..||||||.|||.| .  . .         | .    |||.|||||||
TIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAPEV

LDDSINMKH-FESFKRADIYAMGLVFWEIARRCSIGG---IHEDYQLPYYDLVPSD-PSVEEMRKVVCEQKLRPNIPNRWQSCEALR-VMAKIMRECWYA
|.  .| .   ..||..|.|||||| ||.. ||.  .      .||.|.   | .  ||.|.|. .| . . ||..|. |.  ...  .    . .|| .
LEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRCTDHYPDDEVPEYQMPFEEEVGQHDPSFEDMQELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDCWDH

NGAARLTALRIKKTL
   |||||. ..  .
DAEARLTAQCVQERM
Kinase TGFbR1.AA TKL 211-492 31 3.6e-111 375.64 In-house 1-364 (364) Show / Hide 
Range on Protein: 211-492
Range on HMM: 1-364/364
Sequence Identity: 31% (118 aa)

IGKGRFGEVWRGKWRG----------EEVAVKIFSSRE-------------------------ERSWFREAEIYQTVM---LRHENILGFIAADNKDN--
||.|.||||..|||||          ..||||.|.|..                         | ||||. |.....|   |||.||. |.....  .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------GTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIV--GTQGKPAIAHRDLKSKNILVKKNGT--------------C
       |.|.||..| .|...|||..||.      . ....||..|.|...||...   .|  ||.|.|||||||||||..|.|              |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

CIADLGLAVRHDSATDTIDIA---------------PNHRVGTKRYMAPEVLDDSINMKH----------FESFKRADIYAMGLVFWEIARRCSIGGIHE
.|.|.||. ...  ..  |..                ....||.|.||||||....| ..          || ....|.|..|.|.|||. ||       
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----P

DYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQS-------CEALRVMAKIMRECWYANGAARLTALRIKKTL
 |..||.. ...|| .||| ..||. .||| ||..||.         ... |.|.| .|| ..  .|.....|.|.|
YYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase TGFbR1.AA Pkinase 205-492 21 4.8e-60 210.58 Pfam 1-293 (293) Show / Hide 
Range on Protein: 205-492
Range on HMM: 1-293/293
Sequence Identity: 21% (70 aa)

IVLQESIGKGRFGEVWRGKWRGEE--VAVKIFSSREERSWFREA-----EIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHG----SLFDYLN
... . ||.| ||.|......|..  |||||.. |.|.||....     ||.   .|.|.||. .. .        . ...| .|.|.|    .||||. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

---RYTV--TVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTC----CIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVL
   . ..  . .  .. .. ...||...| .         | |||||. |||...||..    .|.| |||  .|      .  .....|| .||||||.
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVI

DDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEAL-----------------RVM
      .. .  ...|....|....| . .           .|... .  ...  ......|. . .|.  .....|.                   . .
R-----GGQYYGPKVDMWSCGCILYEMLCGR----------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

AKIMRECWYANGAARLTALRIKKT--L
 .... |.  . . |.||  |..   .
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase TGFbR1.AA MLK 205-411 26 9.3e-37 125.07 In-house 1-229 (291) Show / Hide 
Range on Protein: 205-411
Range on HMM: 1-229/291
Sequence Identity: 26% (67 aa)

IVLQESIGKGRFGEVWRGKWRGEE-----VAVKIFS-------SREERSWFREAEIYQTVMLRHEN----ILGFIAADNKDNGTWTQLWLVSDYHEHGSL
| ..| ||.| ||.||.|.||...     ||||..        . .. .|  | |...  .|.|.|    |  | .. ....    .. .|. | |.|||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP---CHFCIVMEYCEGGSL

FDYLNRYT---------------VTVEGMIKLALSTASGLAHLHMEIVGTQGKP-AIAHRDLKSKNILVK------KNGTCCIADLGLAV-RHDS-ATDT
...|.  .               .... ... ||  |.|.. ||..      .| .| ||||||.|||.       ..||. |.| |..   |.. .. .
YNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSM------APKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMM

IDIAPNHRVGTKRYMAPEVL----DDSINMKHFESFKRADIYAMGLVFWEI
       . || ..|||||.     .  ..|       .|..  |.|.||.
------SNAGTYAWMAPEVIQQFRCEKYSEK-------CDVWSWGVVLWEM
Kinase TGFbR1.AA TKL-Unique 207-475 27 9.5e-31 105.73 In-house 1-273 (290) Show / Hide 
Range on Protein: 207-475
Range on HMM: 1-273/290
Sequence Identity: 27% (82 aa)

LQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAE-IYQTV----MLR-HENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLN-------
  ..|| | .|.| .|||||..||.|.|.  .| | ... .  .  |    .|. |.||. ....  ..  .  .. .|..| ..||| |.|.       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

----RYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKN-----GTCCIADLGLAVRHDSATDTIDIAPN-----HRVGTKRYM
     .. . . ..|.|.  |.|. .|| ..     .| |.||||||.|.||  |         |.| ||.   .. .... . ..      |.|. |.|
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCE-----PP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWM

APEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECW
||||| ..   ...   . .|.|. | | |||| |.    |   |  || ..  .. .. || ... | ..|| |||..          .....||
APEVLRMNF--CQYS--EKSDVYSFGIVLWEIATRK----ITKTYKKPYQGM--DQEQWCEMVHYM-EENYRPPIPNHC-----PKEYRDLIQQCW
Kinase TGFbR1.AA S_TKc 205-471 21 1.8e-27 98.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 205-471
Range on HMM: 1-231/231
Sequence Identity: 21% (60 aa)

IVLQESIGKGRFGEVWRGKWRG--EEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEH--GSLFDYLNRYT----
  . . |||| ||.|.......  ..||.|| .    ..  || .| .    .|.||  .. .        . |..| .| ..  |.||||. ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---VTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHF
    .     ...  ....|...|        .  | |||||  |||. .  .  |.| ||| .            .. .||  |||||||         
RFPFPE-HARFYMYQICCALEYCH-------SH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---------

ESFK--RADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALR-----VMAKIM
 ..   ..|... | ...| . ..       ..|. .  ..      .|..    .. |. .  .|.   |||.      .   .
-GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TGFbR1.AA TK 205-392 15 3.3e-24 77.38 In-house 1-371 (486) Show / Hide 
Range on Protein: 205-392
Range on HMM: 1-371/486
Sequence Identity: 15% (60 aa)

IVLQESIGKGRFG---EVWRGKWRG---------------------------EEVAVKIFS---SREERSWFR-----------------EAEIYQTVML
|.| . .|.| ||   ||..|.|||                           ..||||.     . ...  |                  |... .  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHENILGFIAADNKDNGTW--------TQLWLVSDYHEHGS----LFDYLNRYT----------------------------------------------
.|.||. ....  .. .            ...|  | .||.    | ||| .                                                
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VTVEGMIKLALSTASGLAHLHME---IVGTQGKPAI---AHRDLKSKNILVKKNGT-----------CC
                               .|.. ..  ..  |.|...||              |    ||||   |.|| .|..           | 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEF--------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCK

IADLGLAV-------RHDSATDTIDIAPNHRVGT-----------------------KRYMAPEVLDDSI------NMKH
||| ||.        | .   |    . ....|.                        |.||||.|.| .      . |.
IADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKF
Kinase TGFbR1.AA STE 205-385 20 7.9e-21 70.36 In-house 1-235 (359) Show / Hide 
Range on Protein: 205-385
Range on HMM: 1-235/359
Sequence Identity: 20% (51 aa)

IVLQESIGKGRFGEVWRGKWR-----------------GEEVAVKIFSSREERS---------------WFRE---AEIYQTVMLR--HENILGFIAADN
  ..| |||| ||.| ... .                 || .|.|. . .....                 ..    ||     ..  |.||  .. .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KD---NGTWTQLWLVSDYHEHGSLFDYLNRYTVTV--------------EGMI-KLALSTASG-LAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCC
|.   ..  ..||..  | . ||| | ....  .               |  | . . ..  | |..||           | |||.|. |||.     . 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--------IIHRDIKPANILL-----VK

IADLGLAVRHDSATD------------TIDIAPNHRVGTKRYMAPEVLD
..| |.. . ..  .            |..   |. |||  .|||||..
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQ
TGF_beta_GS TGFbR1.AA TGF_beta_GS 175-203 72 3.2e-18 62.95 Pfam 1-29 (29) Show / Hide 
Range on Protein: 175-203
Range on HMM: 1-29/29
Sequence Identity: 72% (21 aa)

TTLKDLIYDMTTSGSGSGLPLLVQRTIAR
.|..|...|..||||||||||||||||||
KTMQDMMEDFCTSGSGSGLPLLVQRTIAR
GS TGFbR1.AA GS 175-205 67 6.6e-17 63.42 SMART 1-31 (31) Show / Hide 
Range on Protein: 175-205
Range on HMM: 1-31/31
Sequence Identity: 67% (21 aa)

TTLKDLIYDMTTSGSGSGLPLLVQRTIARTI
.|..|...| .|||||||||||||||.||.|
KTMHDMMEDTCTSGSGSGLPLLVQRTVARQI
Kinase TGFbR1.AA TyrKc 205-492 25 1.7e-16 44.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 205-492
Range on HMM: 1-280/280
Sequence Identity: 25% (78 aa)

IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVML--RHENILGFIAADNKD--NGTW---TQLWLVSDYHEHGSLFDYL--NRY
|.| . .| | ||||..|.|. ..||||   .  ..   |||.|    .|  .|.||. ....  ..  |  .    .|..|  | .||.| |||  .| 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMC--KLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYLRKHRP

TVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSA------TDTIDIA--PNHR-VGTKRYMAPEVLDD
..... ... ..  |.| ..||           . ||||   |.||..|.|. |.| ||.  ...       .|... .   . . .   | ||||..  
KLCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

SINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCE-----ALRVMAKIMRECWYANGAA
    .. .     |... | . |||  ..         | ||.. .  . | .|... | . . .|  ||     .     .   | .||..|| .. . 
----NYGKFTTKSDVWSFGVCMWEIFTYG---------QQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---PMSFVCCPDEMYQIMKQCWHEDPED

RLTALRIKKTL
| |   |.. .
RPTFSEIHECF
Kinase TGFbR1.AA CAMK 210-292 16 7.5e-15 43.58 In-house 1-155 (425) Show / Hide 
Range on Protein: 210-292
Range on HMM: 1-155/425
Sequence Identity: 16% (26 aa)

SIGKGRFGEVWRGKWR-G-------------EEVAVKIFS-------------------------------SREERSWFREAEIYQTVM-----LRHENI
 .|.|.||.| ... .               ..||.|| .                                . ... .|| || ...      |.|.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LGFIAADN--------KDNG-TWTQ--------LWLVS---DYHEHG----SLFDYL
. .. .           | . | ..        ...|    .| . |     ||||.
IKLYEVYEDPHYFKNTND-YET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYI
Kinase TGFbR1.AA Pkinase_Tyr 205-317 26 2.3e-14 49.27 Pfam 1-128 (270) Show / Hide 
Range on Protein: 205-317
Range on HMM: 1-128/270
Sequence Identity: 26% (35 aa)

IVLQESIGKGRFGEVWRGKWR------GEEVAVKIF--SSREE----RSWFREAEIYQTVML-RHENILGFIAADN-KDN-GTWTQLWLVSDYHEHGSLF
|.. . .|.| ||||..|.|.      . .||||.   .. .|    .. .|||.|     | .|.||. ....   ..  .   |...|  | .||.| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMK--QLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLL

DYLNRY-----TVTVEGMIKLALSTASGLAHLH
||| .       .|.. ... ..  |.|...|.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE
Kinase TGFbR1.AA Dicty4 205-237 54 1.2e-13 42.1 In-house 1-33 (277) Show / Hide 
Range on Protein: 205-237
Range on HMM: 1-33/277
Sequence Identity: 54% (18 aa)

IVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSR
|. .. |||| |||| .|.||| |||||.. ..
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNH
Kinase TGFbR1.AA Dicty4 303-384 36 1.4e-11 35.09 In-house 115-189 (277) Show / Hide 
Range on Protein: 303-384
Range on HMM: 115-189/277
Sequence Identity: 36% (31 aa)

IKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAV---RHDSATDTIDIAPNHRVGTKRYMAPEVL
...|...| |...||  .      | | |||||| |.|| || .  ..|.||.    .| . .|  . |    .||  .|||||.
MRMAFDAARGMNWLHCCN------PVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTA----CGTPCWMAPEVM
Kinase TGFbR1.AA CAMK 329-384 25 1.8e-10 29.21 In-house 200-292 (425) Show / Hide 
Range on Protein: 329-384
Range on HMM: 200-292/425
Sequence Identity: 25% (24 aa)

IAHRDLKSKNILVKKN-----------------GTCCIADLGLAVRHDSATDTI-------------------DIAPNHRVGTKRYMA-PEVL
|.|||||  |||. .|                 ..  |.| |.| . |.  .                     .   . ..||  ||| ||||
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVL
Kinase TGFbR1.AA Pkinase_Tyr 331-355 52 3.1e-05 18.36 Pfam 134-158 (270) Show / Hide 
Range on Protein: 331-355
Range on HMM: 134-158/270
Sequence Identity: 52% (13 aa)

HRDLKSKNILVKKNGTCCIADLGLA
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HRDLAARNCLVTENNVVKICDFGLA
Kinase TGFbR1.AA TK 425-492 13 0.000496 8.56 In-house 392-486 (486) Show / Hide 
Range on Protein: 425-492
Range on HMM: 392-486/486
Sequence Identity: 13% (13 aa)

QLPYYDLVPS------DPSVEEMRKVVCE---------------QKLR--PNIPN------RWQSCEALRVMAKIMRECWYANGAARLTALRIKKTL
| |||  ...      . ...|. . ...                 .   |. |         .....  ... .|..|| .. . | |   ... |
QEPYYGGMSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMH-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TGFbR1.AA Pkinase_Tyr 467-492 26 3.339593 1.31 Pfam 245-270 (270) Show / Hide 
Range on Protein: 467-492
Range on HMM: 245-270/270
Sequence Identity: 26% (7 aa)

MAKIMRECWYANGAARLTALRIKKTL
. ..|..|| .. . | |   |   |
IYDLMKQCWHYDPEDRPTFSEIHEQL