Gene TGFbR2 (Human)

TGFbR2

Species: Human
Alias: TAAD2, TGFbR2, HNPCC6, MFS2, TbetaR-II, TGFBR2, TGFR-2, TGFbeta-RII, TbetaRII, RIIC, AAT3, TGF_beta_RII, FAA3
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 3p21-24,

Classification

Group: TKL
Family: STKR
Subfamily: STKR2

Sequence

Name Sequence Type Origin Length Description Download
TGFbR2.NA RNA Sugen Kinome 4704 None Fasta, JSON
TGFbR2.AA Protein Sugen Kinome 592 None Fasta, JSON
TGFbR2.kin_dom Protein Kinase Domain Sugen Kinome 296 None Fasta, JSON

Protein domain

Protein domains of TGFbR2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
EcTbetaR2 TGFbR2.AA ecTbetaR2 72-190 61 7.5e-78 269.75 Pfam 1-120 (120) Show / Hide 
Range on Protein: 72-190
Range on HMM: 1-120/120
Sequence Identity: 61% (74 aa)

FPQLCKFCDVRFSTCDNQKSCMSNCSITSICEKPQEVCVAVWRKNDENITLETVCHDPKLPYHDFILEDAASPKCIMKEKKKPGETFFMCSCSSD-ECND
 |||||||||| ||||.|..|||||.||||||||.|||||.|||||||.|.|||||||..... | |.|. ..|| |||||  ..||.||||. . ||||
MPQLCKFCDVRHSTCDGQGTCMSNCNITSICEKPEEVCVAIWRKNDENVTMETVCHDPQYKLYGFMLDDYNNSKCVMKEKKSMSGTFHMCSCNEEQECND

NIIFSEEYNTSNPDLLLVIF
 .||...||.. ||..... 
MLIFNNQYNPHSPDHNKEVV
Kinase TGFbR2.AA Type2 269-563 49 4.8e-209 696.64 In-house 1-315 (315) Show / Hide 
Range on Protein: 269-563
Range on HMM: 1-315/315
Sequence Identity: 49% (157 aa)

IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSD-INLKHENILQFLTAEERKTELG---KQYWLITAFHAKGNLQEYLTR
|.|..|.|||||..|.||....|..|. .||||||||.....||..||||.|. ....|||||||..||.|....|   ..|||.|.||.||.|..||..
IQLMELIGKGRFGCVWKAQWHNNNGEK-RTVAVKIFPEQDKQSWQNEKDIYSLPYHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLKQ

HVISWEDLRKLGSSLARGIAHLHSDHT-PCG--RPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSV--------DDLANSGQVGTARYMAPE
|.|.|........|.|||.||||.... .|.  ..|.||.|||.||.|.|||||.|||..||||..|..|. ..        .|..|.|||||.||||||
HTIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAPE

VLESRMNLEN-VESFKQTDVYSMALVLWEMTSRCNAVG---EVKDYEPPFGSKVREH-PCVESMKDNVLRDRGRPEIPSFWLNHQGIQ-MVCETLTECWD
|||...|... ...|||.|.|.|.||||||.|||....   ||..|..||...|..| |..|.|.. |.|.|.||..|..|..|.|.| |.|||...|||
VLEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRCTDHYPDDEVPEYQMPFEEEVGQHDPSFEDMQELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDCWD

HDPEARLTAQCVAERF
||.|||||||||.||.
HDAEARLTAQCVQERM
Kinase TGFbR2.AA STKR 269-563 46 6.4e-191 621.9 In-house 1-312 (312) Show / Hide 
Range on Protein: 269-563
Range on HMM: 1-312/312
Sequence Identity: 46% (146 aa)

IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELG-KQYWLITAFHAKGNLQEYLTRHVI
|.|....||||..||.|.|...| .|. |||||||||.....||..|..|.......|||||||..|....|| . .||||||..| .|.|..||.||.|
IQLIECIGKGRYGEVWKGKWRGN-GEK-ETVAVKIFPSRDEQSWFRETEIYQTPMMRHENILQFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRHTI

SWEDLRKLGSSLARGIAHLHSDHT---PCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLA-------NSGQVGTARYMAPEVLES
.|... ..  |.|.|.|||| ...    ....|..|.|||.||.|||||||.|||..||||..|.||. ...|..       ...|||| ||||||||..
DWHEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVLDG

RMNLENVES-FKQTDVYSMALVLWEMTSRCNAVG------EVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWL-NHQGIQMVCETLTECWDHD
.||....|| ||..|.|.|.||.||...||...|      .|..|..||   |..||..| |.. | |.| ||.||. |. ||......|.|..||||||
AMNFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNHPSFEDMQKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEECWDHD

PEARLTAQCVAERF
|||||||.||....
PEARLTALCVKKTM
Kinase TGFbR2.AA Type1 269-556 39 2.7e-119 324.7 In-house 1-283 (290) Show / Hide 
Range on Protein: 269-556
Range on HMM: 1-283/290
Sequence Identity: 39% (113 aa)

IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVIS
|..   .||||. ||...| .       |.||||||   . .||. | .|.. . ..|||||.|  |  . ..   | |||| .| .| |  ||.||...
IQMIECIGKGRYGEVWRGKWRG------ENVAVKIFFSRDERSWFRETEIYQTVMMRHENILGFIAADMKDNGSWTQLWLITDYHEHGSLYDYLNRHTLD

WEDLRKLGSSLARGIAHLHSDHTPCG-RPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESF
 ... .|  |.| |.|||| . .      |  | |||.|| ||.||....||  |.||..| .     .|...  .||| ||||||||.. || .  ||.
TQQMLRLAYSCACGLAHLHMEIFGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRHQQDTDQIDIGQNPRVGTKRYMAPEVLDETMNMNCFESY

KQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTA
| .|.||..||.||.. ||.  | |.||..|.   | . | .| |.. |  .. || ||. | .|. .. .    .||| . |.||.||
KMADIYSFGLVMWEIARRCEVGGIVEDYQLPYYDWVPNDPSFEDMRKVVCVRKLRPNIPNRWQSHPCMRHMAKLMKECWYQNPHARHTA
Kinase TGFbR2.AA TKL 275-563 26 3.3e-93 315.98 In-house 1-364 (364) Show / Hide 
Range on Protein: 275-563
Range on HMM: 1-364/364
Sequence Identity: 26% (101 aa)

VGKGRFAEVYKAKLKQNTSEQF-----ETVAVKIFPYEE-------------------------YASWKTEKDIFSDIN---LKHENILQFLTAEERKTE
.|.|.|.||||.|...... ..     ..||||.|. ..                          |||  .. ..       |.|.||.||. .  . . 
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

---------LGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLT--------------C
           .|..... .. .|.| .||.     |. . ..  . |||...|||.... .. |.||.||||||.||||....|              |
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

CLCDFGLSLRLDPTLSVDDLA---------------NSGQVGTARYMAPEVLESRMNLEN----------VESFKQTDVYSMALVLWEMTSRCNAVGEVK
..|||||| ..... .  | .               .. |.|| |.||||||.  ||...           | ....||||...||||. .||       
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----P

DYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLN-------HQGIQMVCETLTECWDHDPEARLTAQCVAERF
 |..|. . .  .| .| |   |  .. ||.||. |.|       ..  . ... ...|||||||.|...|.. .|.
YYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase TGFbR2.AA Pkinase 269-563 21 1.8e-52 185.41 Pfam 1-293 (293) Show / Hide 
Range on Protein: 269-563
Range on HMM: 1-293/293
Sequence Identity: 21% (73 aa)

IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKT-------EKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKG----N
...   .|.| |..|||.. | .      .|||||.....  |||        |  |   .|  |.||.... . |.    .. ..... .. .|     
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN--HPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMD

LQEYLT---RHVI--SWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTC----CLCDFGLSLRLDPTLSVDDLANSGQVGTAR
| .|..   . ..  |......    ..||....||           |.|||||..|||..|. ..    ..|||||.  .|      .  ... .|| .
LFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPW

YMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGI-------------
||||||.      .. .  .  |..|. ..|.|| ..           ||| ...  |.   ...  . |..|.|   ...  . .              
YMAPEVIR-----GGQYYGPKVDMWSCGCILYEMLCGR----------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF

----QMVCETLTECWDHDPEARLTAQCVAER--F
    .  .. .. |.. ||. |.||... .   |
HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase TGFbR2.AA S_TKc 269-564 19 1.6e-27 98.68 SMART 1-231 (231) Show / Hide 
Range on Protein: 269-564
Range on HMM: 1-231/231
Sequence Identity: 19% (61 aa)

IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYASWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAK--GNLQEYLTRHV
 |.  ..||| |..|||.. |       . ||.|| .     . . | .| .    .|.|| ... . .      . ..... .     |.| .|. .. 
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRG

-------ISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRM
       ..  . |..   ........||         . |.||||| .|||. .  .  .|||||. .|           . ..||  |||||||    
RHGLRFPFPE-HARFYMYQICCALEYCHS---------HGIIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL----

NLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCV
      ...  |..|   .|.|| ...                      .. | ....                  . ... .  |.. ||| |.||.. 
----GYGKCKCDWWSCGCILYEMLCGYPPFP-----------------QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTAEAL

A-------ERFS
.         . 
QDEWDIKCHPWF
Kinase TGFbR2.AA MLK 269-485 24 9.9e-27 89.83 In-house 1-232 (291) Show / Hide 
Range on Protein: 269-485
Range on HMM: 1-232/291
Sequence Identity: 24% (63 aa)

IELDTLVGKGRFAEVYKAKLKQNT-SEQFETVAVKIFP-------YEEYASWKTEKDIFSDINLKHEN----ILQFLTAEERKTELGKQYWLITAFHAKG
|.. . .|.| | .|.|.. . .. .    .||||..         ..  .|. |...     |.|.|    | ||. .    .. .... ... . ..|
IQFHEWIGSGSFGKVWKGRWRNKDIVAK--IVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGV---CLQPPCHFCIVMEYCEGG

NLQEYLTRH---------------VISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKN------DLTCCLCDFGLSLRLDPTLSV
 | ..|                  |.. . . .     |||.. |||.        .||.||||||.|||. .      ..|.  ||||.|         
SLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAP------KPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR--------

DDLANS-----GQVGTARYMAPEVL---ESRMNLENVESFKQTDVYSMALVLWEMTSR
 |. ..     .. ||...|||||.   .. .. | .      ||.| ..||||| .|
-DWHQMCTNMMSNAGTYAWMAPEVIQQFRCEKYSEKC------DVWSWGVVLWEMLTR
Kinase TGFbR2.AA STE 269-482 20 4.5e-23 78.38 In-house 1-261 (359) Show / Hide 
Range on Protein: 269-482
Range on HMM: 1-261/359
Sequence Identity: 20% (57 aa)

IELDTLVGKGRFAEVYKAKLKQ-----NTSEQ------FETVAVKIFPYEEY-----------ASWK---TEKDIFSDI----NLK--HENILQFLTAEE
 |.   .||| | .||||. .       | |.       | .|.|. ..|.             ..|    ...|  .|    ...  |.|| ... ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

RK---TELGKQYWLITAFHAKGNLQEYLTR---------------HVISWEDLRKLGSSLARG-IAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTC
..   .. . . |..  . . | | . . .               |... . ...   .. .|  ..||| |         |.|||.|..|||.     .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---------IIHRDIKPANILL-----V

CLCDFGLSLRLDPTLSVDDLAN--------SGQ------VGTARYMAPEVLESRMNLEN-VESFKQTDVYSMALVLWEM
 |||||.. .|..... . . .        ..|      |||  .|||||.. . .  .  .   . |..|  ....||
KLCDFGVCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEM
Kinase TGFbR2.AA TK 269-486 14 1.5e-22 71.75 In-house 1-391 (486) Show / Hide 
Range on Protein: 269-486
Range on HMM: 1-391/486
Sequence Identity: 14% (59 aa)

IELDTLVGKGRFA---EVYKAKLKQN---------------------TSEQFETVAVKIFP---YEEYASWKT--------------EKDIFSDIN---L
|.|    |.| |    ||||.....                      .... ..||||.      .. .  .               |  . .  .   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHENILQFLT-AEERKT-------ELGKQYWLITAFHAKGN----LQEYLTRH-----------------------------------------------
.|.||....    . ..        ... ..... . ..|.    |..|| ..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------VISWEDLRK-------------------LGSSLARGIAHLHSDH-TPCGRPKMPI---VHRDLKSSNILVKNDLT-----------CCLC
           ..  ||                         .|.| ..||| . .        |   |||||   |.|| ....           | ..
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCE-F------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIA

DFGLSL-------RLDPTLSVDDLANSGQVGT-----------------------ARYMAPEVLESRMNLEN---VESFKQTDVYSMALVLWEMTSRC
|||||        | ..  .    ..|. .|.                        |.||||.|..|   |         ..||.|   ..||. ...
DFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYG
Kinase TGFbR2.AA ULK 269-482 22 2.3e-20 68.99 In-house 1-245 (324) Show / Hide 
Range on Protein: 269-482
Range on HMM: 1-245/324
Sequence Identity: 22% (59 aa)

IELDTLVGKGRFA-EVYKAK-LKQNTSEQFETVAVKIFP-----YEEYA--------SWKTEKDIFSDI-NLKHEN--ILQFLTAEERKTELGKQYWLIT
..|.   ||| |.  |||..  |.||  | . ||.|. .       ..         . | |  |   . .|||.|  | ...   | ...  . ...|.
YCLNHCLGKGSFGVKVYKGRNKKTNT--QNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNH--NNIYIIM

AFHAKGNLQEYLTRHVISWEDL-----------RKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDL------------TCCLCDFGLSL
 .   |.|..|. ..  . |             ..    .. |  .||         |. |.|||.| .|||..|.             .. ..|||.. 
EYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELH---------KHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAK

RLDPTLSVDDLANSGQV------GTARYMAPEVLESRMNLENVESF-KQTDVYSMALVLWEM
 .|     ...  . .|      ||  ||||..|...  .|. .   . .|..|.  .. ||
HVDNNNMEQQMCQT-CVNEKRIKGTPLYMAPQILQGQ--GEQKPYYDYKCDIWSLGCIFYEM
Kinase TGFbR2.AA Dicty4 367-482 32 2.7e-19 61.15 In-house 106-210 (277) Show / Hide 
Range on Protein: 367-482
Range on HMM: 106-210/277
Sequence Identity: 32% (39 aa)

ISWEDLRK---LGSSLARGIAHLHS-DHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDD-LANSGQVGTARYMAPEVLESRMNL
..|.. ..   .. . |||...||. .          |.||||||.|.||  ...   |||||| .  .  .  | .  ....||. .|||||. ..   
LDWPLIKRAMRMAFDAARGMNWLHCCN--------PVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQ--MTACGTPCWMAPEVMMHQPYN

ENVESFKQTDVYSMALVLWEM
| .      |||| ..||||.
EKA------DVYSFGIVLWEI
Kinase TGFbR2.AA TyrKc 269-563 22 9.6e-17 48.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 269-563
Range on HMM: 1-280/280
Sequence Identity: 22% (73 aa)

IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFP-YEEYASWKTEKDIFSDINL--KHENILQFLTAEERKTELG-------KQYWLITAFHAKGNL
|.|.   | | | ||||...|       ..||||    .   .    |  | .  .|  .|.||.... .       .       ....... . ..|.|
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA-REDFMREARIMC--KLGGHHPNIVRLYGV----CTQQGRNFMYIEPLMIVMEYMPHGDL

QEYLTRHV--ISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPT----LSVDDLAN----SGQ-VGTA
..|| .|   ....|| .     |.| ..|||          ...||||   |.||....|.  .|||||  ..       | |        .|  .   
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEP-----PFGSKVREHPCVESMKDNVLRDRGRPEIPSFWLNHQGI------Q
| ||||..      ... ..| .||.|   ..||. ...      . |.         . |.|.          .....|...|   .    .      .
RWMAPECI-----NYGKFTTK-SDVWSFGVCMWEIFTYG-----QQPYPGMIQQMMSNQEVIEY----------VKQGYRMPQPPNDY--P-MSFVCCPD

MVCETLTECWDHDPEARLTAQCVAERF
 . .  ..||..||| | | . . |.|
EMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase TGFbR2.AA LRRK 356-485 28 1.7e-13 44.11 In-house 140-278 (351) Show / Hide 
Range on Protein: 356-485
Range on HMM: 140-278/351
Sequence Identity: 28% (45 aa)

GNLQEYLT---RH-------VISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILV---K---------NDLTCCLCDFGLSL--RLDP
|.|...|    ..       .|||  . |.    |.|...||| |.|      ||.|||||| |||.   .         .. .. ..|||.|     ..
GDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS-HNP------PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFH

T-LSVDDLANSGQVGTARYMAPEVLESRMNLE-NVESFKQTDVYSMALVLWEMTSR
. .       .| ||. ..||||.    |. . ..|   ..|.|| ...|||  .|
MGVA------KGCVGNPGWMAPEI----MRYNGEEEYTEKVDCYSFGMILWELLTR
Kinase TGFbR2.AA Pkinase_Tyr 323-426 26 2.1e-12 42.6 Pfam 59-158 (270) Show / Hide 
Range on Protein: 323-426
Range on HMM: 59-158/270
Sequence Identity: 26% (29 aa)

NL-KHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRH-----VISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDL
.| .|.||.... .  .. | . |..... . ..|.| .|| .|      .. .|| .     |.| ..|.| .         ..||||   |.||....
QLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---------CIHRDLAARNCLVTENN

TCCLCDFGLS
..  |||||.
VVKICDFGLA
Kinase TGFbR2.AA Pkinase_Tyr 269-303 37 2e-06 22.55 Pfam 1-35 (270) Show / Hide 
Range on Protein: 269-303
Range on HMM: 1-35/270
Sequence Identity: 37% (13 aa)

IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKI
|...   |.| | ||||...|   ...  .||||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKM
Kinase TGFbR2.AA LRRK 269-304 18 3e-06 18.18 In-house 1-59 (351) Show / Hide 
Range on Protein: 269-304
Range on HMM: 1-59/351
Sequence Identity: 18% (11 aa)

IELDTLVGKGRFA-EVYKAKLKQ----------------------NTSEQFETVAVKIF
..   ..|.| |. .||.||...                      |.   ...||.|..
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKW
Kinase TGFbR2.AA Dicty4 269-305 35 0.00031 10.22 In-house 1-31 (277) Show / Hide 
Range on Protein: 269-305
Range on HMM: 1-31/277
Sequence Identity: 35% (13 aa)

IELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFP
|  . . ||| |.||||.. ..        ||||...
INIEQRIGKGSFGEVYKGTWRG------KEVAVKKLN
Kinase TGFbR2.AA LRRK 537-565 31 0.001222 8.73 In-house 323-351 (351) Show / Hide 
Range on Protein: 537-565
Range on HMM: 323-351/351
Sequence Identity: 31% (9 aa)

MVCETLTECWDHDPEARLTAQCVAERFSE
|... ...||.|||. | ... . .| |.
MYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase TGFbR2.AA TK 542-563 36 0.002608 6.1 In-house 465-486 (486) Show / Hide 
Range on Protein: 542-563
Range on HMM: 465-486/486
Sequence Identity: 36% (8 aa)

LTECWDHDPEARLTAQCVAERF
...||..||| | | . . |..
MQQCWHYDPEDRPTFSQLHEQL
Kinase TGFbR2.AA Pkinase_Tyr 542-563 36 0.007554 10.27 Pfam 249-270 (270) Show / Hide 
Range on Protein: 542-563
Range on HMM: 249-270/270
Sequence Identity: 36% (8 aa)

LTECWDHDPEARLTAQCVAERF
...||..||| | | . . |..
MKQCWHYDPEDRPTFSEIHEQL
Kinase TGFbR2.AA Dicty4 542-553 58 0.025523 3.74 In-house 252-263 (277) Show / Hide 
Range on Protein: 542-553
Range on HMM: 252-263/277
Sequence Identity: 58% (7 aa)

LTECWDHDPEAR
...||||||. |
IQWCWDHDPQHR