Gene TIF1a (Human)
TIF1a
Sequence
Protein domains of TIF1a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| RING | TIF1a.AA | RING | 56-130 | 17 | 3.7e-10 | 40.99 | SMART | 1-23 (23) | Show / Hide |
Range on Protein: 56-130 Range on HMM: 1-23/23 Sequence Identity: 17% (13 aa) CAVCHQNIQSRAPKLLPCLHSFCQRCLPAPQRYLMLPAPMLGSAETPPPVPAPGSPVSGSSPFATQVGVIRCPVC |..|.. |..||| | ||. |. ||.| CPICLE------PVVLPCGH-FCY-CI--------------------------------------------CPIC |
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| Zf-C3HC4 | TIF1a.AA | zf-C3HC4 | 56-82 | 30 | 1.6e-05 | 17.01 | Pfam | 1-33 (48) | Show / Hide |
Range on Protein: 56-82 Range on HMM: 1-33/48 Sequence Identity: 30% (10 aa) CAVCHQN-IQSRAPKLLPCLHS-----FCQRCL |..||.. .. | ..||.|. ||. |. CWICHCEWKDPNNPLIHPCGHRGSLKWFCHSCI |
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| PHD | TIF1a.AA | PHD | 126-140 | 23 | 3.236557 | 2.27 | Pfam | 1-17 (54) | Show / Hide |
Range on Protein: 126-140 Range on HMM: 1-17/54 Sequence Identity: 23% (4 aa) RCPVCSQ--ECAERHII .|.||.. ... .| YCCVCQKCDWDDDGDMI |
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| Zf-C3HC4 | TIF1a.AA | zf-C3HC4 | 127-136 | 30 | 11.533313 | 0.08 | Pfam | 1-10 (48) | Show / Hide |
Range on Protein: 127-136 Range on HMM: 1-10/48 Sequence Identity: 30% (3 aa) CPVCSQECAE |..| .|... CWICHCEWKD |
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| BBOX | TIF1a.AA | BBOX | 158-205 | 25 | 2.4e-13 | 51.56 | SMART | 1-51 (51) | Show / Hide |
Range on Protein: 158-205 Range on HMM: 1-51/51 Sequence Identity: 25% (13 aa) KSNQVCTSCEDNAEANGFC-VECVEWLCKTCIRA--HQRVKFTKDHTVRQK .. ..|........|. || ..| ..||..| .. ||..|....|.|. HRPPMCDNHQQHEPAHFFCVEDCQQCLCWDCDESGEHQANKLFRGHQVVPL |
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| Zf-B_box | TIF1a.AA | zf-B_box | 159-205 | 20 | 1e-06 | 30.69 | Pfam | 1-45 (45) | Show / Hide |
Range on Protein: 159-205 Range on HMM: 1-45/45 Sequence Identity: 20% (10 aa) SNQVCTSCEDNAEANGFCVECVEWLCKTCIRA-HQRVKFTKDHTVRQK .. .| ... ... .| .| . .| |. . |.. . .|.|||. QM-YCPEHPE-EPLEYYCQDCQQCICEDCAVHGHKGNG-FKKHTVVPI |
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| PHD | TIF1a.AA | PHD | 181-190 | 40 | 1.250521 | 3.56 | Pfam | 45-54 (54) | Show / Hide |
Range on Protein: 181-190 Range on HMM: 45-54/54 Sequence Identity: 40% (4 aa) EWLCKTCIRA ||.|. |. . EWYCPRCKCC |
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| BBOX | TIF1a.AA | BBOX | 218-259 | 27 | 7.7e-14 | 53.23 | SMART | 1-51 (51) | Show / Hide |
Range on Protein: 218-259 Range on HMM: 1-51/51 Sequence Identity: 27% (14 aa) QRPVFCPFHK-KEQLKLYC-ETCDKLTCRDCQLL-EH------KEHRYQFI .||. |..|. .| ....| |.|... |.|| . || . |..... HRPPMCDNHQQHEPAHFFCVEDCQQCLCWDCDESGEHQANKLFRGHQVVPL |
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| Zf-B_box | TIF1a.AA | zf-B_box | 219-259 | 32 | 3e-09 | 41.27 | Pfam | 1-45 (45) | Show / Hide |
Range on Protein: 219-259 Range on HMM: 1-45/45 Sequence Identity: 32% (15 aa) RPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKE-----HRYQFI .. || |..| |..||..|... |.|| . .|| |... | QM-YCPEHPEEPLEYYCQDCQQCICEDCAVHGHKGNGFKKHTVVPI |
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| BBC | TIF1a.AA | BBC | 266-392 | 31 | 3.6e-45 | 157.29 | SMART | 1-132 (132) | Show / Hide |
Range on Protein: 266-392 Range on HMM: 1-132/132 Sequence Identity: 31% (42 aa) QKVIIDTLITKLMEKTKYIKFTGNQIQNRIIEVN-----QNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESLAKDHRMKLMQQQQEVAGLSKQLEHVM ..... ...|||..|.........||||.| .|. .|...|||.|......|| ..|...|..|..|.. .......||||.| ....||||.. HREKLEQHLTKLRKKHWECEDAMKQIQNIIQQVQPGHVDENHEDVEQCIRAHFDDLMNWLNRRKKMMLMDLDEQCENKQKWLMQQMQTMTQKQEQLEHCC HFSKWAVSSGSSTALLYSKRLITYRLRHLLRA .|. ||...|..|..|.||.||.....||... QFCQWALNMGDCTEFLQSKKLIIFQCCHLHKQ |
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| PHD | TIF1a.AA | PHD | 828-873 | 38 | 1.9e-19 | 62.33 | Pfam | 1-54 (54) | Show / Hide |
Range on Protein: 828-873 Range on HMM: 1-54/54 Sequence Identity: 38% (21 aa) WCAVCQN-----GGELLCCE-KCPKVFHLSCHVPTLT--NFPSGEWICTFCRDL .|.||| .|...||. .||. ||..|| |.|. . |.|||.|. |. YCCVCQKCDWDDDGDMICCDNGCPRWFHQYCHGPPLEPEEIPEGEWYCPRCKCC |
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| PHD | TIF1a.AA | PHD | 828-871 | 35 | 1.2e-13 | 52.53 | SMART | 1-39 (39) | Show / Hide |
Range on Protein: 828-871 Range on HMM: 1-39/39 Sequence Identity: 35% (16 aa) WCAVCQNGGELLCCE-KCPKVFHLSCHVPTLTNFPSGEWICTFCR .| ||. | ...|. .|.. .|. |. |.|. |.| |.| || YC-VCGK-G-MIQCDPGCDRWYHQ-CLGPPLE-PPDG-WYCPRCR |
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| Zf-C3HC4 | TIF1a.AA | zf-C3HC4 | 846-870 | 32 | 2.540605 | 1.98 | Pfam | 26-48 (48) | Show / Hide |
Range on Protein: 846-870 Range on HMM: 26-48/48 Sequence Identity: 32% (8 aa) KVFHLSCHVPTLTNFPSGEWICTFC |.|. || . . . ||.. | .| KWFCHSCIKRWWNH--SGNTQCPIC |
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| BROMO | TIF1a.AA | BROMO | 901-1006 | 40 | 1.9e-41 | 144.96 | SMART | 1-118 (118) | Show / Hide |
Range on Protein: 901-1006 Range on HMM: 1-118/118 Sequence Identity: 40% (49 aa) TPIDKRKCERLLLFLYCHEMSL------------AFQDPVPLT---VPDYYKIIKNPMDLSTIKKRLQEDYSMYSKPEDFVADFRLIFQNCAEFNEPDSE .| ..||..|| ..||... |..||. .||||.||||||||.||||.|.. . . .|.||.||.|.|.|| .|||||| DPK-QKKCQELLKEVMCHKHDHGDPMNRGRPYAWPFMQPVDRKELNYPDYYDIIKNPMDLKTIKKKLENHQY--QSMEEFVDDFMLMFNNCMTYNEPDSE VANAGIKLENYFEELLKNLYP | ...||...|||... ..| VYKMAKKLQKFFEEKWREFPP |
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| Bromodomain | TIF1a.AA | Bromodomain | 908-992 | 34 | 6.5e-29 | 96.69 | Pfam | 1-89 (89) | Show / Hide |
Range on Protein: 908-992 Range on HMM: 1-89/89 Sequence Identity: 34% (31 aa) CERLLL--FLYCHEMSLAFQDPV---PLTVPDYYKIIKNPMDLSTIKKRLQEDYSMYS-KPEDFVADFRLIFQNCAEFNEPDSEVANAGIK |.... .. |. . .|..|| . .||||.|||.|||||||...| . . |. ...| .|..|...|| ..|.|||..... | CDQIMDMKYIMEHPICEPFWHPVDPDRDEYPDYYDIIKHPMDLSTIQQKL--KNNKYRNNIAEFWHDMELMWHNCMTYNGPDSPIYKDARK |
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