Gene TIF1g (Human)
TIF1g
Sequence
Protein domains of TIF1g.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| RING | TIF1g.AA | RING | 125-184 | 21 | 1.6e-10 | 42.24 | SMART | 1-23 (23) | Show / Hide |
Range on Protein: 125-184 Range on HMM: 1-23/23 Sequence Identity: 21% (13 aa) CAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIRCPVC |..| . |..||| | || |. ||.| CPICLE---------PVVLPCGH-FCY-CI--------------------------CPIC |
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| Zf-C3HC4 | TIF1g.AA | zf-C3HC4 | 125-154 | 25 | 0.001011 | 11.81 | Pfam | 1-33 (48) | Show / Hide |
Range on Protein: 125-154 Range on HMM: 1-33/48 Sequence Identity: 25% (9 aa) CAVCQQSLQSRREAEPKLLPCLHS-----FCLRCL |..|.. . . | ..||.|. || |. CWICHCEWKDPNN--PLIHPCGHRGSLKWFCHSCI |
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| PHD | TIF1g.AA | PHD | 124-185 | 18 | 0.040612 | 3.19 | SMART | 1-39 (39) | Show / Hide |
Range on Protein: 124-185 Range on HMM: 1-39/39 Sequence Identity: 18% (13 aa) TCAVCQQSLQSRREAEPKLLPCL-------HSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIRCPVCR .| ||.. .. | | ||. .| . | .|| || YC-VCGK---------G-MIQCDPGCDRWYHQ-CLGPPLE-----------------PPDG-WYCPRCR |
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| BBOX | TIF1g.AA | BBOX | 271-312 | 31 | 5.3e-13 | 50.44 | SMART | 1-51 (51) | Show / Hide |
Range on Protein: 271-312 Range on HMM: 1-51/51 Sequence Identity: 31% (16 aa) QRPVFCPVHK-QEQLKLFC-ETCDRLTCRDCQLL-EH------KEHRYQFL .||. |..|. | ...|| |.|. . |.|| . || . |....| HRPPMCDNHQQHEPAHFFCVEDCQQCLCWDCDESGEHQANKLFRGHQVVPL |
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| BBOX | TIF1g.AA | BBOX | 212-259 | 25 | 4.7e-12 | 47.29 | SMART | 1-51 (51) | Show / Hide |
Range on Protein: 212-259 Range on HMM: 1-51/51 Sequence Identity: 25% (13 aa) KSEQVCTSCEDNASAVGFC-VECGEWLCKTCIEA--HQRVKFTKDHLIRKK .....|....... |. || ..|...||..| |. ||..|....| .. HRPPMCDNHQQHEPAHFFCVEDCQQCLCWDCDESGEHQANKLFRGHQVVPL |
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| Zf-B_box | TIF1g.AA | zf-B_box | 272-312 | 28 | 2e-09 | 42.01 | Pfam | 1-45 (45) | Show / Hide |
Range on Protein: 272-312 Range on HMM: 1-45/45 Sequence Identity: 28% (13 aa) RPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKE-----HRYQFL .. || |..| |...|..|... |.|| . .|| |... . QM-YCPEHPEEPLEYYCQDCQQCICEDCAVHGHKGNGFKKHTVVPI |
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| Zf-B_box | TIF1g.AA | zf-B_box | 213-259 | 16 | 8.9e-07 | 31.48 | Pfam | 1-45 (45) | Show / Hide |
Range on Protein: 213-259 Range on HMM: 1-45/45 Sequence Identity: 16% (8 aa) SEQVCTSCEDNASAVGFCVECGEWLCKTCIEA-HQRVKFTKDHLIRKK .. .| .... . .| .|.. .| |... |.. . .|.| ... QM-YCPEHPEEP-LEYYCQDCQQCICEDCAVHGHKGNG-FKKHTVVPI |
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| RING | TIF1g.AA | RING | 217-279 | 14 | 0.007808 | 6.72 | SMART | 1-23 (23) | Show / Hide |
Range on Protein: 217-279 Range on HMM: 1-23/23 Sequence Identity: 14% (9 aa) CTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVH |. | . .. .|| |. || ||. CPICLE-----PVVLPCGH-FCY-CI---------------------------------CPIC |
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| PHD | TIF1g.AA | PHD | 234-244 | 45 | 0.203927 | 6.02 | Pfam | 44-54 (54) | Show / Hide |
Range on Protein: 234-244 Range on HMM: 44-54/54 Sequence Identity: 45% (5 aa) GEWLCKTCIEA |||.|. |... GEWYCPRCKCC |
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| BBC | TIF1g.AA | BBC | 319-445 | 32 | 4.7e-47 | 163.57 | SMART | 1-132 (132) | Show / Hide |
Range on Protein: 319-445 Range on HMM: 1-132/132 Sequence Identity: 32% (43 aa) QKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVN-----ETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVM .. ..| .|.|| .|... ..|. |.||.|..|. |. ..|||.|......|.|..|...| .|..|.......|..| ||. ..|....|..|.. HREKLEQHLTKLRKKHWECEDAMKQIQNIIQQVQPGHVDENHEDVEQCIRAHFDDLMNWLNRRKKMMLMDLDEQCENKQKWLMQQMQTMTQKQEQLEHCC NFTNWAIASGSSTALLYSKRLITFQLRHILKA .|..||. .|..|..|.||.||.||..| .|. QFCQWALNMGDCTEFLQSKKLIIFQCCHLHKQ |
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| PHD | TIF1g.AA | PHD | 889-934 | 38 | 1.2e-16 | 53.58 | Pfam | 1-54 (54) | Show / Hide |
Range on Protein: 889-934 Range on HMM: 1-54/54 Sequence Identity: 38% (21 aa) WCAVCQN-----GGDLLCCE-KCPKVFHLTCHVPTLL--SFPSGDWICTFCRDI .|.||| .||..||. .||. ||. || |.| |.|.|.|. |. YCCVCQKCDWDDDGDMICCDNGCPRWFHQYCHGPPLEPEEIPEGEWYCPRCKCC |
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| PHD | TIF1g.AA | PHD | 889-932 | 35 | 1.7e-13 | 52.07 | SMART | 1-39 (39) | Show / Hide |
Range on Protein: 889-932 Range on HMM: 1-39/39 Sequence Identity: 35% (16 aa) WCAVCQNGGDLLCCE-KCPKVFHLTCHVPTLLSFPSGDWICTFCR .| ||. | ...|. .|.. .|. |. |.|. |.| |.| || YC-VCGK-G-MIQCDPGCDRWYHQ-CLGPPLE-PPDG-WYCPRCR |
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| Zf-C3HC4 | TIF1g.AA | zf-C3HC4 | 907-931 | 28 | 3.63551 | 1.53 | Pfam | 26-48 (48) | Show / Hide |
Range on Protein: 907-931 Range on HMM: 26-48/48 Sequence Identity: 28% (7 aa) KVFHLTCHVPTLLSFPSGDWICTFC |.|. .| . . . || . | .| KWFCHSCIKRWWNH--SGNTQCPIC |
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| BROMO | TIF1g.AA | BROMO | 959-1082 | 32 | 4.1e-32 | 113.91 | SMART | 1-118 (118) | Show / Hide |
Range on Protein: 959-1082
Range on HMM: 1-118/118
Sequence Identity: 32% (45 aa)
SPVDQRKCERLLLYLYCHELSI------------EFQEPVPAS---IPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMK
.| |.||..|| ..||. . |..||... .|.||.|||.||||.|.||||.. . | ...||.|..|.|.|| .||
DPK-QKKCQELLKEVMCHKHDHGDPMNRGRPYAWPFMQPVDRKELNYPDYYDIIKNPMDLKTIKKKLENHQY---QSMEEFVDDFMLMFNNCMTYNE---
VVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEIYS
|||| ...| .||.|..|..
--------------PDSEVYKMAKKLQKFFEEKWREFPP
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| Bromodomain | TIF1g.AA | Bromodomain | 966-1051 | 30 | 1.3e-28 | 95.71 | Pfam | 1-89 (89) | Show / Hide |
Range on Protein: 966-1051 Range on HMM: 1-89/89 Sequence Identity: 30% (28 aa) CERLLL--YLYCHELSIEFQEPV---PASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQ-IPDDFVADVRLIFKNCERFNEMMKVVQVYADT |.... |.. |... |..|| ....|.||.|||.||||||...|| ....|. ...| .|..|...||...|. .. ..|.. CDQIMDMKYIMEHPICEPFWHPVDPDRDEYPDYYDIIKHPMDLSTIQQKL---KNNKYRNNIAEFWHDMELMWHNCMTYNGPDSPIYKDARK |
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