Gene TRKB (Human)

TRKB

Species: Human
Alias: GP145-TrkB, TRKB, NTRK2
External Links: iHOP , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , GeneCards
Annotation: Consensus chromosomal location: 9q21.33,

Classification

Group: TK
Family: Trk

Sequence

Name Sequence Type Origin Length Description Download
TRKB.NA RNA Sugen Kinome 5608 None Fasta, JSON
TRKB.AA Protein Sugen Kinome 838 None Fasta, JSON
TRKB.kin_dom Protein Kinase Domain Sugen Kinome 270 None Fasta, JSON

Protein domain

Protein domains of TRKB.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRRNT TRKB.AA LRRNT 31-65 23 1.4e-08 35.8 SMART 1-38 (38) Show / Hide 
Range on Protein: 31-65
Range on HMM: 1-38/38
Sequence Identity: 23% (9 aa)

ACPTSCKCS---ASRIWCSDPSPGIVAFPRLEPNSVDP
.|| .|.|.   .....|.|.. .....||  |. .. 
QCPRPCHCHPDFHTHVYCDDRNLTWNEVPRDIPPDTTY
LRRNT TRKB.AA LRRNT 31-60 31 2.4e-08 33.41 Pfam 1-31 (31) Show / Hide 
Range on Protein: 31-60
Range on HMM: 1-31/31
Sequence Identity: 31% (10 aa)

ACPTSCKCS--ASRIWCSDPSPGIVAFPRLEP
.|| .|.|.  .....|||.. . ...||  |
QCPRPCHCHHDHTHVYCSDRNLT-NHVPRDLP
LRRCT TRKB.AA LRRCT 148-195 21 1.2e-11 45.92 SMART 1-55 (55) Show / Hide 
Range on Protein: 148-195
Range on HMM: 1-55/55
Sequence Identity: 21% (12 aa)

NPFTCSCDIMWIKTLQEA---KSSPDTQ-DLYCLNESSKNI-PLANLQ--IPNCG
||. |.|...|.......   .  .| | |..| . .. .  ||. ..     |.
NPWNCDCHLRWFQRWLQQQHNRHVQDPQSDMRCASPEHMRGQPLFHYLHSDFKCP
IG TRKB.AA IG 203-284 24 4.2e-12 47.44 SMART 1-58 (58) Show / Hide 
Range on Protein: 203-284
Range on HMM: 1-58/58
Sequence Identity: 24% (21 aa)

APNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDS--GKQISCVAENLVGEDQD--SVNLTVH
 | .|| || ..||.| |.     ...|                   |.| |.. .||  .    |.|.   |...   ...|||.
PP-VTVKEGETVTLTC-VS-----QIWWY------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 TRKB.AA IGc2 209-273 32 2.7e-09 38.12 SMART 1-56 (56) Show / Hide 
Range on Protein: 209-273
Range on HMM: 1-56/56
Sequence Identity: 32% (21 aa)

EEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVG
.|| |.|| | ..|.|.||  |      .....    . ..|.|.|.. .|||.  .|.|.| .|
HEGQSVTLTCPATGNPDPNIHWYK----GQPLP----WNWTLTIKNVTPEDSGY-YTCYARNPWG
I-set TRKB.AA I-set 249-283 45 4.3e-08 29.99 Pfam 59-92 (92) Show / Hide 
Range on Protein: 249-283
Range on HMM: 59-92/92
Sequence Identity: 45% (16 aa)

SLRITNISSDDSGKQISCVAENLVGEDQDSVNLTV
.|.|.|. .||.||  .|||.| .||.. ...|||
TLTISNVQPDDEGK-YTCVATNSFGEAECTAELTV
I-set TRKB.AA I-set 205-226 40 0.002284 13.94 Pfam 9-30 (92) Show / Hide 
Range on Protein: 205-226
Range on HMM: 9-30/92
Sequence Identity: 40% (9 aa)

NLTVEEGKSITLSCSVAGDPVP
...| ||......| | ||| |
DVEVQEGETARFECQVTGDPPP
I-set TRKB.AA I-set 306-330 34 0.026822 10.31 Pfam 23-48 (92) Show / Hide 
Range on Protein: 306-330
Range on HMM: 23-48/92
Sequence Identity: 34% (9 aa)

TVKGNPKPALQWFYNGAILNE-SKYI
.|.|.|.|  .||..|. |.. |...
QVTGDPPPQVSWFKDGQPLRPDSDRH
I-set TRKB.AA I-set 357-372 43 0.134849 7.93 Pfam 71-86 (92) Show / Hide 
Range on Protein: 357-372
Range on HMM: 71-86/92
Sequence Identity: 43% (7 aa)

GDYTLIAKNEYGKDEK
| || .|.|..|..|.
GKYTCVATNSFGEAEC
Kinase TRKB.AA Trk 554-823 80 7.1e-225 753.36 In-house 1-275 (275) Show / Hide 
Range on Protein: 554-823
Range on HMM: 1-275/275
Sequence Identity: 80% (222 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV
||||.||||||||||||||||||||||||..||||||||||.||||||.|||||||||||.|||||||||...|||.|||||||||||||.||.|||||.
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKDASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDAM

LMAEGNP---PTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYS-TDYYRVGGHTMLPIRWMPPESIMYRKFTTE
..|...|   |..||..|||.||.|||.||||.|||||||||.||||||||.||.|||||||||||||| |||||||.||||||||||||||||||||.|
CYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKFTYE

SDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRV-LQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLL
|||||.|||.||.|||||||||||||.||||||.|||. |.|||.||||||..|||||||||..|.||| ||...
SDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase TRKB.AA Pkinase_Tyr 554-823 47 1.3e-148 503.99 Pfam 1-270 (270) Show / Hide 
Range on Protein: 554-823
Range on HMM: 1-270/270
Sequence Identity: 47% (132 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA---RKDFHREAELLTNL-QHEHIVKFYGVCV-EGDP--LIMVFEYMKHGDLNKFLR
|.. ..|||||||.|......  .|...|| ||||.||. ..     |.|| |||.....| .|..||..||||. .|.|  ...|.|||.|||| ..||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

AHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYY-RVGGHTMLPIRWMPPESIMYRK
.|          ...  || ...|....|||.|| ||.|....|||||.|||||.||. |||.|||..||.|..||| |..|...|||.||.||.|.|.|
KHR---------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK

FTTESDVWSLGVVLWEIFTYGKQP-WYQLSNNEVIECI-TQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLL
|||.||||| ||..|||||||.|| .. .||.||.| |  .|. . .|. ||.|.|.||. ||. .| .|   . ||  |
FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase TRKB.AA TyrKc 554-823 44 2e-144 487.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 554-823
Range on HMM: 1-280/280
Sequence Identity: 44% (136 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNL--QHEHIVKFYGVCVEG-------DPLIMVFEYMKHGDLNKF
|.|...|||||||.|.... .        | ||||.||. .   |.||.|||.....|  .|..||..||||...       .|| .|.|||.||||...
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYST-------DYYRV----GGHTMLPI
||.|.|.            |. ...|... |||.|| ||.|....|||||.||||||||. |||.|||.|||.|.        ||||.    ||.|||||
LRKHRPK------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

RWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQ-----LSNNEVIECITQGRVLQRPRT--------CPQEVYELMLGCWQREPHMRKNIKGIH
|||.||.|.|.||||.||||| ||..|||||||.||..      .|| ||||.. ||. . .|          ||.|.|..|. ||...|..| . . ||
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

TLL
 ..
ECF
Kinase TRKB.AA TK 554-823 26 2.9e-124 418.76 In-house 1-486 (486) Show / Hide 
Range on Protein: 554-823
Range on HMM: 1-486/486
Sequence Identity: 26% (129 aa)

IVLKRELGEGAFG---KVFLAECYNLCP--------------------EQDKILVAVKTLK---DASDNARKD--------------FHREAELLTN--L
|.| ..||||.||   .|...| ... |                    |. |. ||||.||   ..|.....|              . .|.... .  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHEHIVKFYGVCVEG------------DPLIMVFEYMKHGD----LNKFLRAHGPDAVLMAEGNP-----------------------------------
.|..||..||||..|             |...| |||.|||    | ..||.. |..  ......                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------PTELTQSQMLH-------------------IAQQIAAGMVYLASQ------HFVHRDLATRNCLVGENLL-----------VKIGDFGMS--
        |..||....|.                   ...|||.|| ||.|.      .|||||||.||||||||.            .||.|||.|  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

------RDVYSTDYYRVGG------------------------HTMLPIRWMPPESIM---------YRKFTTESDVWSLGVVLWEIFTYGKQPWYQ-LS
      ||.|| |.|.. .                         ..||||||.||...         |.||||.|||||.||..|||||||..|.|  .|
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

N---------NEVIECITQG--------------RVLQRPRTCP--------------QEVYELMLGCWQREPHMRKNIKGIHTLL
|          ||.|....|                . .|  ||              .|.|.||. ||...|  | . . .|  |
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TRKB.AA Musk 554-823 47 2.3e-122 406.22 In-house 1-282 (282) Show / Hide 
Range on Protein: 554-823
Range on HMM: 1-282/282
Sequence Identity: 47% (133 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDA
|.  |..|||||| || |    | |... ..|||| ||| ||.   .|| ||| ..    |  |||  |||  | |. . ||||  |||| ||..  | .
IIYVRDIGEGAFGRVFQARAPGLVPYEEETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHR

VLMAEGNPP-----------TELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESI
.  .  . .            .|     | .|.|||.|| ||    ||||||||||||..|.  ||| |||.|| .|. |||.  .    ||||||||||
TCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESI

MYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLL
.| .||.|||||. ||.||||| |. ||.| ..  |||  | || .|  |  |||.||.||  |||..|  |   . ||  .
WYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase TRKB.AA Ror 554-824 47 4e-116 392.09 In-house 1-276 (308) Show / Hide 
Range on Protein: 554-824
Range on HMM: 1-276/308
Sequence Identity: 47% (132 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDA
.    ||||..||||.  . . . . .  ..||.||.|. ||   ..|| .|..|   |.|  ||.  |||    |. |.|||| ||||  ||  . | .
VRFMEELGECQFGKVYKGHLMGPNFMYHCMAVAIKTCKHDASPAQWQDFRQEIMLMATLHHPNIVCLLGVCTMDQPYCMLFEYMNHGDLHEFLIMRSPHS

VLM----AEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTT
         .     | ..  |||| |||||| ||.| ||||||||.||||||| . ||| ||| .||.|| ||||. .  ..|||||.||.||| ||..
DHGCSSDDDRMVKSSLDHPDFLHIAIQIAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYSSDYYRMQHKSWMPIRWMSPEAIMYGKFSE

ESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQ
.||.|| |||||||. || ||.|  ||.|||| | .  .|  |  ||. .| ||  ||   |  |   | ||. |.
DSDIWSFGVVLWEIWSYGMQPYYGYSNQEVIEMIRNRHLLPCPHNCPTWIYSLMIECWHEIPSRRPRFKDIHSRLR
Kinase TRKB.AA InsR 554-825 44 2.3e-112 378.74 In-house 1-278 (278) Show / Hide 
Range on Protein: 554-825
Range on HMM: 1-278/278
Sequence Identity: 44% (124 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKI--LVAVKTLKD-ASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGP
||| ||.|.|.||.| .    .. |.   .   .|.||... ||.  | .|  ||.   .  . |.|. .|||  | |   | | |..|||  .||.. |
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

DAVLMAEGNPPTE-----LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRK
...     ||. .      . .||.  | .|. || |||.  ||||||| |||.| . . |||||||| ||.| .|||| ||  |||.|||.|||.   .
EEEF---NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGV

FTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECI-TQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQN
||| |||||.||||||. | | ||   ||| .| . |   | ||..|  ||. ..|||  |||  | ||   . |  .|..
FTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase TRKB.AA DDR 554-823 41 1.1e-102 347.48 In-house 1-306 (306) Show / Hide 
Range on Protein: 554-823
Range on HMM: 1-306/306
Sequence Identity: 41% (126 aa)

IVLKRELGEGAFGKVFLAECYNLC-----------PEQDKILVAVKTLKD-ASDNARKDFHREAELLTNLQ-HEHIVKFYGVCVEGDPLIMVFEYMKH-G
 . .  .||| || | | |  ..               . .|||||.|.  |...||.|||.|.  .  .  |  ||.  |||.. .|. |. |||   |
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLG

DLNKFLRAHG-PDAVLMAEG------NPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFG--MSRDVYSTDYYRVGG---
||| |. .|  ..  ||.        . || .  .. ..|. |||.|| ||.|  ||||||||||||||... .|| |||  |||  || ||||| |   
DLNQFWMEHEAENSGLMNCKADTQNCQKPT-ISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYYRVEGFTG

--HTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGK-QPWYQLSNNEVIECI-----TQGR--VLQRPRTCPQEVY-ELMLGCWQREPHMRKNI
     .||||| .|||.  |||| ||||. || .||.|.  . ||. ||..  ||| .     .||.  .| .|. ||.|.| .||. ||.|..  |   
RQRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQSQRPSF

KGIHTLL
. ||..|
EEIHKFL
Kinase TRKB.AA TK-Unique 554-823 36 9e-100 337.76 In-house 1-294 (294) Show / Hide 
Range on Protein: 554-823
Range on HMM: 1-294/294
Sequence Identity: 36% (108 aa)

IVLKRELGEGAFGKVFLAECYNLC-PEQDKILVAVKTLK-DASDNARKDFHREAELLTNLQ-HEHIVKFYGVCVEGD-PLIMVFEYMKHGDLNKFLRAHG
.......|||||| |. .|  ..  .. ... ||||.|| .|.|  ..|| .|.... .|  |..||...|.|.. | |  ...||.  |.| ..||  .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PD-------AVLM------AEGNPPTELTQSQMLHIAQQIAAGMVYLAS--QHFVHRDLATRNCLVGENLLVKIGDFGMSRDVY-STDYYRVGGHTMLPI
|.       . |        .........  ...|.| ||| || ||||  ...|||||..||.|..|.. .||.||||.||||  ..| . ..  ..||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

RWMPPESIM--YRKF-TTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTC-PQEVYELMLGCWQREPHMRKNIKGIHTLL
|||.|||.   .. . ||.|||||.||..|||||.|..| ..... ...|||..|  ...|  | ..|.|.||  |||.||..| ..  |   |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase TRKB.AA UTK 554-826 36 1.1e-99 337.54 In-house 1-296 (296) Show / Hide 
Range on Protein: 554-826
Range on HMM: 1-296/296
Sequence Identity: 36% (112 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK-----DFHREAE---LLTNLQ-HEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKF
. | |.||.|||| |..|.  .  .   . .||||...  .|  ..     || .||    .. ... |.......|||. . |...| |||. ||| ..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGEN-------LLVKIGDFG---MSRDVY---------STDYYRV
|| |.|..       .|. ||  |.|. | .||.|| ||.|..||||||| |||||...       ...||.|||   |||.|.         ...||. 
LRRHRPTPP-----ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMA

GGHTMLPIRWMPPESIMYR-KFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQG--RVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTL
 . ...||||| ||.. .. .||| |||||.|||.|||.|.|..|.  .|| .|.. .. |  . . .|. || .||.||. ||. .| .| ..   ..|
QHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDF---EDL

LQNL
.| .
VQQM
Kinase TRKB.AA Src 554-823 38 9.5e-88 297.82 In-house 1-255 (255) Show / Hide 
Range on Protein: 554-823
Range on HMM: 1-255/255
Sequence Identity: 38% (106 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV
| |.|.||.| || |. .  .|     ... ||||||| ..  . ..| .||.....|.||..|. | || ...|   | |||.|| | ..|..      
IKLCRKLGQGQFGEVWMG-YWN-----GNTKVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK------

LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYS--TDYYRVGGHTMLPIRWMPPESIMYRKFTTESD
   ||    .|   | . .| |.|.|| || |. ..||||| || |||||...|..|||  | .     | |      ..||.|. || | |..||. ||
-DGEGR---HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSD

VWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYE-LMLGCWQREPHMRKNIKGIHTLL
||| |. |.||.|||. |    .| ||.... .|  . .|..||.|.|| .|| ||...|  |   . ..  |
VWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase TRKB.AA ALK 554-825 41 4.1e-86 292.41 In-house 1-273 (273) Show / Hide 
Range on Protein: 554-825
Range on HMM: 1-273/273
Sequence Identity: 41% (114 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLK-DASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDA
| | | || |||| |. ..   .     .. ||.|||. |.|     ||  ||  . . .|. .|.  |.| .  |.  | |||  ||. .|||   |  
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHP

V-LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLV---GENLLVKIGDFGMSRDV-YSTDYYRVGGHTMLPIRWMPPESIMYRKFT
. |      |. || .  |.... .|.|  || ..||.||| | ||||    |    .||.||||.||. | .|||| || .|.|. |||||  |   ||
ESLQ-----PSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFT

TESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQN
. .|||| || .||||  |  |    .| ||.| .|.|  .  || ||| || .|  ||| .|  | .   |   .| 
SKTDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase TRKB.AA S_TKc 554-823 22 1.1e-52 182.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 554-823
Range on HMM: 1-231/231
Sequence Identity: 22% (64 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKH--GDLNKFLRAHGPD
  . |..|.||||||...   .     .. .||.| .|       ... || ..| . .|..|||.|.|... | | ||.||. .  ||| .... .|. 
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR-

AVLMAEGNPPTE--LTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTT-
        ...   ..  .  ....||. .. |. |....||||   | |. |   .||.|||..| .          .      .|.|| .   .... 
--------HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKC

ESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHT---------LL
..|.||.|..|.| .. |. |..   . ...  .            ..|. ... .|.|..|  |  .  . .          .
KCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TRKB.AA Pkinase 554-813 21 4e-45 160.62 Pfam 1-281 (293) Show / Hide 
Range on Protein: 554-813
Range on HMM: 1-281/293
Sequence Identity: 21% (64 aa)

IVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARK---DFH-REAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHG----DLNKFL
....| .|.|.||.|     |  .   . ..||||..|  ...  |   ... .|.... .|.|..||..|... ..| . ||.||. .|    ||  ..
YHIGRKIGSGSFGCV-----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

RAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLV----KIGDFGMSRDVYSTDYYRVGGHTMLP--IRWMPPE
..         .... . ..  .  ... ||. |. |. |. ..||||   |.|. .|  .    ||.||| .. ..   | . .  | .   ...|.||
ST--------WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPE

SIM-YRKFTTESDVWSLGVVLWEIFTYGKQPWYQL----SNNEVIECITQGRVLQRPRTCP-----------------------QEVYELMLGCWQREPH
 |. ... ....|.||.|..|.| .. |. |...     . .. ...| . .  . .. .|                       .|  ... .|... |.
VIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPK

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