Gene DNAPK (Slime mold)
DNAPK
Sequence
Protein domains of DNAPK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| HEAT | DNAPK.AA | HEAT | 997-1028 | 21 | 2.617302 | 4.93 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 997-1028 Range on HMM: 1-31/31 Sequence Identity: 21% (7 aa) ILPNVVNLAEKSPNRQIKVAAGELLHSVLLMM ||| .... . .|. ... || . | ... . ILPHLLKCLN-DPDWEVREAACWCLGQLCEHC |
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| HEAT | DNAPK.AA | HEAT | 1094-1125 | 21 | 0.527116 | 7.34 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 1094-1125 Range on HMM: 1-31/31 Sequence Identity: 21% (7 aa) LLNAIVDAVGNPLDGARRDFAGQCLCEFAKWS .|.... . | | |. | .||..... . ILPHLLKCLNDP-DWEVREAACWCLGQLCEHC |
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| HEAT | DNAPK.AA | HEAT | 1144-1174 | 25 | 0.004983 | 14.35 | Pfam | 1-31 (31) | Show / Hide |
Range on Protein: 1144-1174 Range on HMM: 1-31/31 Sequence Identity: 25% (8 aa) ILKRIYSLAHHPDPYKRLGAAISFNQLYRIF || . .. ..||. |. |. .. ||.... ILPHLLKCLNDPDWEVREAACWCLGQLCEHC |
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| HEAT | DNAPK.AA | HEAT | 1483-1496 | 42 | 57.890651 | 0.27 | Pfam | 1-14 (31) | Show / Hide |
Range on Protein: 1483-1496 Range on HMM: 1-14/31 Sequence Identity: 42% (6 aa) FVQLLVKCLMDPQS ....|.||| || . ILPHLLKCLNDPDW |
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| NUC194 | DNAPK.AA | NUC194 | 1979-2377 | 37 | 8.8e-250 | 840.89 | Pfam | 1-446 (446) | Show / Hide |
Range on Protein: 1979-2377 Range on HMM: 1-446/446 Sequence Identity: 37% (169 aa) DELKITLIDKFCVPLISHMKENILVQIFSQHLSSLMSIIQPLQPKYLSDSQERKSSIIEKICCFHLIEALYQSLPSAIIKE---KINPFFYDKPDG---- .....|..|..|..|..|......||.||.|....|..|.....|||....|....||.|.||...||..|..||...|.. .||...|..... NNVRQTMLDRYCCTLLWHCSYDTIVQFFSRHIKDIMDMIMSRFTKYLTNEWEFEHQIIKKMCCYKMIEVMYSRLPKDEIHSDDCCINQAYYGSDHTTLGA --KGTELTAAIMKAAHSAKSEKL-TSDDKYVTRSLCTKYHGAAFSALASVIVSTQTKENFFHVFFFKENKDKNEYLWENIIDTDQVF---NFQPETNFLV .|.|||.|.||..|.|..|.. |.|.......||.|||.||...|...|..|.|...|.|||.|.||..||||.|||.||.|... .|..|..... PIEGNELTKALMKSCHDAFTENMPTGDSQLLEKRLCRKYHCAAYNCLIALISCTFTELKFYHVFLFRENPEKNEYIWENLIDCDRCYLYDEFPQEIEVPM SYSTPQSLFANDLR-----------------YLSSQ--YLVDSSLSQDFIAKNFLEGDNNSTTNNNNGDDGIIMQGQSQSGDNENQISND---------- .............| ||||| |..||||||......|..|...||.|....|||||||..||.......|..| ERKKKYVAIRKEARVQSDQVDAWNSHQDEPKYLSSQLSYMMDSSLSQEMSQFDFSTGVQSSTFNYSSQDDGIIMQKASQHHFRKQEIAEDMSMTQDDVME IEIDQVNSNPSMIAMLKIIDFYQKKFVVTPPSSILFGQQSQQPKPTVGDMPKWMFEIYQKL-QQGVHPNIVIFMIKIIINRPQYFERFHELWIPILMDYV .|.|..|....|..|...|.|.......||..|||||.|..||||||||||.||....||| .|..|.||..|..|.|||..|.|......||..||... LEMDEINQHECMATMCGCIKFHMHRNNITPKVSILFGDQGAQPKPTVGDMPPWMKFLHQKLGNQQQHLNIRLFIAKVIINCEQWFRPYAKFWIGPLMQLI V----SEGNGGNGLHYFVRDVCFILLKWPNIYKSQDGGGGTTLEKH | ..||||.||||.|.|.|...|.|..|...||||||.|...| VKLIECDGNGGRGLHYMVVDICVTILSWTSIATPQDGGGGNTRDEH |
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| Kinase | DNAPK.AA | PIKK | 3883-4178 | 32 | 2.3e-97 | 329.79 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 3883-4178 Range on HMM: 1-290/290 Sequence Identity: 32% (97 aa) TISSFDTNVLVMGSLRKPKRVKIHGNDELDYPFLIKGGEDLRLDQRIQQLFGIMNEILKRDTACNKRSLNVTTYQVVPMTSKVGIIEWLNDTKPLREILE | ..| | || ...|||. | | |. ||.| ||.||||.|||..|||..|| .| .|..| || |. .|| |.||... |.|||.... .|.||. RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK EQLAHQLKTPRSNVSISKLESTKYHNDWINSFAKYLKPNSPVGPLYQQMFIHATRDDCAKKLEKQHSKVPENLLQNGIWSLSSSPESYLFIRNSFARSLA . . . | . .. . | ||. |.| .. . .| |..... . ...| ...| ..... |. ...||... | ...||.| QWCQKKHI--RHEQEAQMNYQTCMYRDWLKQMS-YYK---HQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYA SFSVCSYVIGIGDRHLENFLISQRDGRLIGIDFGHAFGTATQFLPIPELMPFRLTRQFTSFLRPLDSVGLLNHNMTYTLTALQNQKEILLTTMDVF . .. |..|.||||.||..| . | ...||||..|. |.|.|| ||..||||||... .. | |.. . .. .. ...|.|.|...|| VMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF |
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| Kinase | DNAPK.AA | DNAPK | 4031-4188 | 39 | 1.5e-63 | 217.48 | In-house | 144-301 (301) | Show / Hide |
Range on Protein: 4031-4188 Range on HMM: 144-301/301 Sequence Identity: 39% (62 aa) MFIHATRDDCAKKLEKQHSKVPENLLQNGIWSLSSSPESYLFIRNSFARSLASFSVCSYVIGIGDRHLENFLISQRDGRLIGIDFGHAFGTATQFLPIPE |. . || . || .|.| .... . .|...| || | |.|. | . .. |||||||.||.. | |.|||||.|| ||||||.|| MYQGENRDKIVQSFRKQEDKIPRDVFRRAFVRMSTTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPE LMPFRLTRQFTSFLRPLDSVGLLNHNMTYTLTALQNQKEILLTTMDVFVKEPLLDWSK ||||||||.|. . |. |.. | . |.. .. ||. ..|||...|..|| . LMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFDWKN |
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| Kinase | DNAPK.AA | PI3_PI4_kinase | 3912-4188 | 19 | 1.5e-60 | 212.3 | Pfam | 1-300 (300) | Show / Hide |
Range on Protein: 3912-4188
Range on HMM: 1-300/300
Sequence Identity: 19% (67 aa)
DYPFLIKGGEDLR--LDQRIQQLF-----------------------GIMNEILKRDTACNKRSLNVTTYQVVPMTSKVGIIEWLNDTKPLREILEEQL-
.|||. |||.||| |.|. |.. ..|| ..| | ....|......| ..|. .. |.|||.... ...||. . .
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV
--------------------AHQLKTPRSNVSISKLESTKYHNDWINSFAKYLKPNSPVGPLYQQMFIHATRDDCAKKLEKQHSKVPENLLQNGIWSLSS
. .|. | . .. |.. .|.| . | . |. .
KCKHKHFNKEHKMWMKMWPDWWHLM----------------------------------------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNP
SP-ESYLFIRNSFARSLASFSVCSYVIGIGDRHLENFLI--SQRDGRLIGIDFGHAFG-TATQFLPIPELMPFRLTR------QFTSFL------RPLDS
.. | .. |. |.||.| .| .|..|.||||..|... .| |..|||||.|. ....... ||..|||.|. .. . . |.
DAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGD
VGLLNHNMTYTLTALQNQKEILLTTM-------DVFVKEPLLDWSK
|.. . . .. || ......... . .|. .|..|..
YGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS
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| Kinase | DNAPK.AA | PI3Kc | 3914-4238 | 20 | 4.3e-54 | 186.93 | SMART | 1-336 (336) | Show / Hide |
Range on Protein: 3914-4238 Range on HMM: 1-336/336 Sequence Identity: 20% (72 aa) PFLIKGGEDLRLDQRIQQLFGIMNEILKRDTACNKRSLNVTTYQVVPMTSKVGIIEWLNDTKPLREIL--EEQLAHQLKTPRSNVSISKLESTKYHNDWI ... |.|.||| |.|..|.|..|| |...|..|..|.| ...| ..|. .| |.||| .....|..|. . ... .. . .. .| . AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDML-VPEI----Q NSFAKYLKPNSPVGPLYQQMFIHATRDDCAKKLEKQHSKVPENLLQNGIWSLSSSP-ESYLFIRNSFARSLASFSVCSYVIGIGDRHLENFLISQRDGRL . ..|. ... .. . | .|.|.. | |.. ...... |.. |. . .| |.. |. |.||.| .. .|. ||||||..|... .| . -K-NMYMMIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHC IGIDFGHAFGTATQFLPIP-----ELMPFRLTRQFTSFLR----PLDSVGLLNHNMTYTLTALQNQKEILLTTMDVFVKEPL-LDWSKLATRLVKEQGKH ..|||||.|| . ...| . |..|||||... | . |. . ...|. ... ..... ..|. |. .|.. .. ... . FHIDFGHIFGHG-PKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRF PKD--TKNVWFPKQ----KIQIAKKKLELVNPAYITLEELSGSV . | ... .... .... .. .| ....... .. RLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY |
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| Kinase | DNAPK.AA | DNAPK | 3881-3981 | 52 | 2.3e-49 | 170.32 | In-house | 1-101 (301) | Show / Hide |
Range on Protein: 3881-3981 Range on HMM: 1-101/301 Sequence Identity: 52% (53 aa) HVTISSFDTNVLVMGSLRKPKRVKIHGNDELDYPFLIKGGEDLRLDQRIQQLFGIMNEILKRDTACNKRSLNVTTYQVVPMTSKVGIIEWLNDTKPLREI || | || | || |||.|||. | | || . ||..||.||||.|||| ||| .|| |. | .| | |. || ..|||. | |||.. | |..| HVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTVVLKDI L | L |
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| Kinase | DNAPK.AA | ATR | 4067-4178 | 28 | 9e-23 | 74.06 | In-house | 157-267 (267) | Show / Hide |
Range on Protein: 4067-4178 Range on HMM: 157-267/267 Sequence Identity: 28% (32 aa) PESYLFIRNSFARSLASFSVCSYVIGIGDRHLENFLISQRDGRLIGIDFGHAFGTATQFLPIPELMPFRLTRQFTSFLRPLDSVGLLNHNMTYTLTALQN |... |. . || |.... |.||.|||| .| || . | .. .|. |. || .||..|||||. . |. . || . . .. ... PQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRD QKEILLTTMDVF ... .. .| | HRDDIMSVWDCF |
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| Kinase | DNAPK.AA | ATR | 3882-3983 | 34 | 1.4e-21 | 69.89 | In-house | 1-102 (267) | Show / Hide |
Range on Protein: 3882-3983 Range on HMM: 1-102/267 Sequence Identity: 34% (35 aa) VTISSFDTNVLVMGSLRKPKRVKIHGNDELDYPFLIKGGEDLRLDQRIQQLFGIMNEILKRDTACNKRSLNVTTYQVVPMTSKVGIIEWLNDTKPLREIL |. || | .. ||.|||.. ..| | | . | .||| | | .. ..| ....| .| ... || |.|. .. .|||| |.| || || AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL EE .. DK |
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| Kinase | DNAPK.AA | ATM | 4074-4186 | 37 | 5.3e-20 | 60.24 | In-house | 137-248 (304) | Show / Hide |
Range on Protein: 4074-4186 Range on HMM: 137-248/304 Sequence Identity: 37% (42 aa) RNSFARSLASFSVCSYVIGIGDRHLENFLISQRDGRLIGIDFGHAFGTATQFLPIPELMPFRLTRQFTSFLRPLDSVGLLNHNMTYTLTALQNQKEILLT | . || | |. |..|.|||| | || |. || | || . || || .|||||| . | |. . | .| ||| RLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAF-EQGKILPTPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLT TMDVFVKEPLLDW ..| . .|| || IVEVLLYDPLFDW |
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| Kinase | DNAPK.AA | FRAP | 4060-4188 | 30 | 1.9e-18 | 64.47 | In-house | 123-251 (251) | Show / Hide |
Range on Protein: 4060-4188 Range on HMM: 123-251/251 Sequence Identity: 30% (39 aa) IWSLSSSPESYLFIRNSFARSLASFSVCSYVIGIGDRHLENFLISQRDGRLIGIDFGHAFGTATQFLPIPELMPFRLTRQFTSFLRPLDSVGLLNHNMTY .| | . | .. | . |||| |. |..|.||||. | .. |... |||| | | . .||. |||||| . . | . LWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCEL TLTALQNQKEILLTTMDVFVKEPLLDWSK . . .|| .. .. || ||. | VMKVIREHKESVMAVLEAFVYDPLFYWRL |
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| Kinase | DNAPK.AA | FRAP | 3912-3970 | 38 | 3.2e-17 | 59.92 | In-house | 1-59 (251) | Show / Hide |
Range on Protein: 3912-3970 Range on HMM: 1-59/251 Sequence Identity: 38% (23 aa) DYPFLIKGGEDLRLDQRIQQLFGIMNEILKRDTACNKRSLNVTTYQVVPMTSKVGIIEW .| ||.|| ||.| | |. ||||..| .|. .. .|. |... | ..|. . |.| | EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGW |
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| Kinase | DNAPK.AA | ATM | 3916-3988 | 41 | 3.4e-17 | 51.1 | In-house | 3-77 (304) | Show / Hide |
Range on Protein: 3916-3988 Range on HMM: 3-77/304 Sequence Identity: 41% (31 aa) LIKGGEDLRLDQRIQQLFGIMNEILKRDTACNKRSLNVTTYQVVPMTSKVGIIEWLNDTKPLRE--ILEEQLAHQ |.|| .||| | .|| | . | .|.| | || | . ||.|||. . |..|| | | . | | ||. LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIDKFLINNEDGAHK |
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| Kinase | DNAPK.AA | SMG1 | 4052-4115 | 42 | 6.4e-13 | 38.99 | In-house | 165-228 (242) | Show / Hide |
Range on Protein: 4052-4115 Range on HMM: 165-228/242 Sequence Identity: 42% (27 aa) PENLLQNGIWSLSSSPESYLFIRNSFARSLASFSVCSYVIGIGDRHLENFLISQRDGRLIGIDF | ||| .|| |. . . |.||| | |. |.||.|||||.| || | . ||. PPNLLAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY |
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| Kinase | DNAPK.AA | SMG1 | 3891-3977 | 32 | 9.3e-12 | 35.07 | In-house | 1-87 (242) | Show / Hide |
Range on Protein: 3891-3977 Range on HMM: 1-87/242 Sequence Identity: 32% (28 aa) VLVMGSLRKPKRVKIHGNDELDYPFLIKGGEDLRLDQRIQQLFGIMNEILKRDTACNKRSLNVTTYQVVPMTSKVGIIEWLNDTKPL . .. |||.. | | ||.| || ||| || || | |.| . | | |. . |.| | || ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPL |
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| FATC | DNAPK.AA | FATC | 4267-4295 | 41 | 7.8e-10 | 34.53 | Pfam | 1-29 (33) | Show / Hide |
Range on Protein: 4267-4295 Range on HMM: 1-29/33 Sequence Identity: 41% (12 aa) VCSSVKEQIDCLIDQSTDPNILSRAWVGW . || .|.|.||.. |||. |.....|| EPLSVEQQVDRLIQEATDPENLCQMYIGW |
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