Gene IrlB (Slime mold)

IrlB

Species: Slime mold
Alias: DDB0220009, IrlB, DdisK093
External Links: DictyBase Link ,
Annotation:

Classification

Group: Other
Family: IRE

Sequence

Name Sequence Type Origin Length Description Download
IrlB.AA Protein None 1448 None Fasta, JSON
IrlB.kin_dom Protein Kinase Domain None 269 None Fasta, JSON

Protein domain

Protein domains of IrlB.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IrlB.AA IRE 1030-1293 51 1.8e-169 569.3 In-house 1-292 (292) Show / Hide 
Range on Protein: 1030-1293
Range on HMM: 1-292/292
Sequence Identity: 51% (152 aa)

SNILGRGSNGTLVFKGLWSDKIPVAIKQMQKAFNPLINKEVEALISLTSKNCSNMIRYIDKEEDKLHVYLGLTLCDGSLQNLVESGKLNDFVISSNKS--
.||||||.|||||||| |...||||.|||||.|||.|..|...||.|.|.|..|.|||...|||. .|||.|.||.||||..||..|.|.|. |||.|  
NNILGRGCNGTLVFKGIWNGRIPVAVKQMQKEFNPFISREIQMLIKLESDNHPNVIRYYCQEEDDQFVYLALELCQGSLQDYVEQKKRNNFINSSNNSNN

-----------------IIELAKDILFGIQFLHSHDIVHNDLNPRNILTLIGKTSNNNNSSNNSFIISDLGLSKMEVESSYSFTSNI---PTGQGGYHPF
                 ...|.|... |.|.|||..|||.||.|.|||.  ..  .|.. .||.|.|||.||.||.||..|||| ||   |||..|.||.
NNKNNNNNNNQWQIHIRMWQLIKQCMNGLQHLHSQNIVHRDLKPHNILIHMNR--PNQHGENNRFMISDFGLCKMLVEGRYSFTRNIRSGPTGTWGWHPP

EVLQS---KRMTKSVDIFSLGCILFYLLTNGQHPFGNDKLFRIVNIISNKMNLTPLN-SNQLA----CTLIKSMISKDESIRPTIQNVLNHPLF
|.||.   ||.||||||||.||...|..||||||||||||.|..||...|.||..|.  |...    | ||..||..|.. ||||...||||.|
EMLQEFCQKRKTKSVDIFSMGCVFYYVMTNGQHPFGNDKLHRQANILKGKYNLDQLKHHNHWHIVIACDLIHQMIHHDPQKRPTIKECLNHPFF
Kinase IrlB.AA Ciliate-E2 1027-1293 18 4.8e-32 107.27 In-house 1-365 (365) Show / Hide 
Range on Protein: 1027-1293
Range on HMM: 1-365/365
Sequence Identity: 18% (73 aa)

RNESNILGRGSNGTLVFKGLWSDKIPVA----------------IKQMQKAFNPLINKEVEALISLTSKN--------------------CSNMIRYIDK
 .  ...|.|. |.      |...  .|                 |....| . ......|.. .  . .                    . | |.... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

EE--DKLHVYLGLTLCDG-SLQNLVESGKLNDFVISS------NKSIIELAKDILF---------------GIQFLHSHD-IVHNDLNPRNILTLIGKTS
 .  |. ..|| . .|.| .|. . .. |.. . . .       | |... | ||                ....|||   |.| |. | |||       
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

NNNNSSNNSFIISDLGLSKMEVES-----------SYSFTSNIPTGQGG-------------------YHPFEVLQ---------SKRMTKSVDIFSLGC
           |.|.||||   ..            | | .|  ... |                   | . |.|.         .|. ....||.|||.
---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV

ILFYLLTNGQHPFGNDKLFRIVNIISNKMNLT-----------------PLNSNQLACTLIKS----MISKDESIRPT-IQNVLNHPLF
||...|. |..||       . .|. .| ..                  ...  | .  |||     |. ||.. |.| .. .|||| |
ILYEMLF-GKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase IrlB.AA Pkinase 1027-1293 24 2.2e-25 90.82 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1027-1293
Range on HMM: 1-293/293
Sequence Identity: 24% (75 aa)

RNESNILGRGSNGTLVFKGLWSDK-IPVAIKQMQKAFNPLINKEV-----EALISLTSKNCSNMIRYIDKEEDKLHVYLGLTLCDG-----SLQNLVE--
     ..|.|| |. |.|. . .  . ||.|.. |  .    ..      |. | .   |. | .|..|  ||| |.|. . .|.|     .|  ...  
YHIGRKIGSGSFGC-VYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

-SGKLNDFVISSNKSIIELAKDILFGIQFLHSHDIVHNDLNPRNILTLIGKTSNNNNSSNNSFIISDLGLSK-MEVESSYSFTSNIPTGQGGYHPFEVLQ
 .|..  |   | . ..  .. || |....||. |.| || | ||  || .. ...     .. |.| ||.| .. . ..|   . ..|  .| . ||..
RHGCFY-F---SEWECKFYMYQILRGLEYCHSMGIIHRDLKPENI--LIDNNGHIDA----CVKICDFGLAKQFD-Y-NNS--MTTFCGTPWYMAPEVIR

-SKRMTKSVDIFSLGCILFYLLTNGQHPFGND-------KLFRIVNIISNKMNLTPLNSN--------------------QLACTLIKSMISKDESIRPT
 ..  ...||..|.||||...|. |. || ..       ....|..| . .      ...                    . .. .||... || . |||
GGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT

IQNVLNHPLF
.. .|.|| |
AEQILQHPWF
Kinase IrlB.AA CAMK 1032-1293 18 6.8e-21 63.41 In-house 1-425 (425) Show / Hide 
Range on Protein: 1032-1293
Range on HMM: 1-425/425
Sequence Identity: 18% (80 aa)

ILGRGSNGTLVFKGLWS-DK------------IPVAIKQMQK--AFN-------------------------PLINKEVEALISLTSK--------NCSN
.||||| |. |...    ..              |||| . |  . .                         |   |.|.  |.. .|        .  |
TLGRGSFGK-VKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

MIRYIDKEED-------------------KLHVYLGL---TLCDGS------LQNLVESGK----------LNDFVISSNKSIIELAKDILFGIQFLHSH
 |. ..  ||                   . |.|. .    .|.|       .. .|| |.          . .    . .    . . |. .....|||
IIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH

DIVHNDLNPRNILTLIGKTSNNNNS--------SNNSFIISDLGLSKMEVESSYSF---------------------TSNIPTGQGGYHP-FEVLQSKR-
.||| || | |||    ...... .        .||   |.| |....  ... .|                       . . |  .| .  |||..|. 
NIVHRDLKPENILLDDNNDDSDP-VEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-------------MTKSVDIFSLGCILFYLLTNGQHPFGNDKLFRIV--------------NIISNKMN-LTPLNSN----------------------Q
              ....|. |.|.||. .|. |  ||  |.  .|.              .|.. | .   |  |.                      |
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLC-GYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQ

LACTLIKSMISKDESIRPTIQNVLNHPLF
 .  ||..|  .| . |.||. .|||| .
ECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase IrlB.AA S_TKc 1027-1293 22 9.9e-21 76.11 SMART 1-231 (231) Show / Hide 
Range on Protein: 1027-1293
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

RNESNILGRGSNGTLVFKGLWSD-KIPVAIKQMQKAFNPLINKEVEALISLTSKNCSNMIRYIDKEEDKLHVYLGLTLCDG---SLQNLVESGKL--NDF
    ...|.|. |. |.|. . . .  ||||..       | .|.. | .    .. | ....|  .|  |.|. . .|||   .|  . .. .   ..|
YEILRKIGKGAFGK-VYKCRHKKTGRIVAIKIIK----EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

VISSNKSIIELAKDILFGIQFLHSHDIVHNDLNPRNILTLIGKTSNNNNSSNNSFIISDLGLSKMEVESSYSFTSNIPTGQGGYHPF---------EVLQ
...    .  ... |. .....||| |.| || | |||                  |.| ||..                    . |         ||| 
PFPE--HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------------HIKICDFGLARQL------------------TTFCGTPWYMAPEVL-

SKRMTK-SVDIFSLGCILFYLLTNGQHPFGNDKLFRIVNIISNKMNLTPLNSNQLACTLIKSMISKDESIRPTIQNVLN-------HPLF
    .| ..|. |.||||. .|. |. ||    .... ..|            . |. .|. .  || . |||.  .|.       || |
--GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IrlB.AA ULK 1027-1185 24 1.2e-18 61.74 In-house 1-191 (329) Show / Hide 
Range on Protein: 1027-1185
Range on HMM: 1-191/329
Sequence Identity: 24% (49 aa)

RNESNILGRGSNGTLVFKGLWSDK-----IPVAIKQMQ---KAFNP----------LINKEVEALISLT----SKN-CSNMIRYIDKEEDKLH--VYLGL
 . ...|| || |  |.||   ..     . ||.|...   .  ..          |...|.. .  |     .|| . | ....|  |.. |  .|. .
YCLNHCLGKGSFG-KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM

TLCDG-SLQNLVESGKLNDFVISSNKS---------------IIELAKDILFGIQFLHSHDIVHNDLNPRNIL--TLIGKTSNN--NNSSNNSFIISDLG
 .|.|  |...          |. ||                .|.  |.|| | ..||.| |.| |. | |||    ..|| .   ... |. . |.| |
EYCNGGDLEQY----------IKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKT-DSKKVHP-NGVLKIADFG

LSKM
..|.
FAKH
Kinase IrlB.AA Ciliate-E2-Unclassified 880-1293 12 4.1e-18 59.46 In-house 33-352 (352) Show / Hide 
Range on Protein: 880-1293
Range on HMM: 33-352/352
Sequence Identity: 12% (62 aa)

KKIQSII-EIQLEEENQKKKEMETIDEYEEININKKQINSNMKWGGIGEPSWISVKKDNKKSKSTITTSTTPTTTTPAKVITSQFKNEQTKKLIIENNKK
||||..   ...... ... ||... . .. ....|                                                                
KKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRK----------------------------------------------------------------

QNLINDNNNNNNNNNNNNNNNNNNNNNNKLNNIIQDEDFVSIGKFKFNRNESNILGRGSNGTLVFKGLWSDKIPVAIKQMQKAFNPLINKEVEALISLTS
                                                                                       .||.     .| .
---------------------------------------------------------------------------------------YNKIMQQ--ILLN

KNCSNMIRYIDKEEDKLHVYLGLTLC-DGSLQNLVES------------------GKLNDFVISSNKSII---ELAKDILFGIQFLHSHD-IVHNDLNPR
 .. . ..... ..|| ..|. . .| .|.|..  ..                   .. .. ...    .    ... || |...||.   |.| |. | 
HPHPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKY----KKAKFYFAQILQGLEYLHHKNNIIHRDIKPE

NILTLIGKTSNNNNSSNNSFIISDLGLSK---------------------MEVESS---YSFTSNIPTGQGGYHPFEVLQSKRMT----KSVDIFSLGCI
||  |. .  .     |.   |.|.|.||                     ..  .    ... .        | . ||||..       ...||.|||.|
NI--LFDNNGK-----NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMP-Q------YTAPEVLQGQNYDHSKAYKCDIWSLGVI

LFYLLTNGQHPFGNDKLFR-------------IVNIISNKMNL-----------TPLNSNQLACTLIK----SMISKDESIRPTIQNVLNHPLF
|...|..  .||.  .                . ....|...             | .... |  .|.    .|. |. . |.|.. .||||.|
LYEMLFGY-YPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase IrlB.AA ULK 1027-1185 25 8e-18 59.88 In-house 1-187 (324) Show / Hide 
Range on Protein: 1027-1185
Range on HMM: 1-187/324
Sequence Identity: 25% (48 aa)

RNESNILGRGSNGTLVFKGLWSDK----IPVAIKQMQKA-FNP------------LINKEVEALISLT---SKNCSNMIRYIDKEEDKLH--VYLGLTLC
 . ...|| || |  |.||   ..      ||.|...|  .|             |...|.. .  |    ..|. . ....|  |.. |  .|. . .|
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNHNNIYIIMEYC

DG-SLQNLVE-SGKLNDFV----ISSNKSIIELAKDILFGIQFLHSHDIVHNDLNPRNIL--TLIGKTSNN--NNSSNNSFIISDLGLSKM
.|  |... .  .||.  .    . | . .|.  |.|. | ..||.| |.| |. | |||    ..|| .   ... |. . |.| |..|.
NGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKT-DSKKVHP-NGVLKIADFGFAKH
Kinase IrlB.AA TKL 1033-1291 16 3.7e-16 54.67 In-house 1-364 (364) Show / Hide 
Range on Protein: 1033-1291
Range on HMM: 1-364/364
Sequence Identity: 16% (61 aa)

LGRGSNGTLVFKGLWSD---------KIPVAIKQMQKAFNPLINK---------------------------EVEALISLTSKNCSNMIRYID--KEEDK
.|.|. |  |.|| |             .||.|.. .  . . .|                           |.| . .. . .. | ....   .....
IGSGGFG-EVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

L-----------HVYLGLTLC-DGSLQNLVESGKLNDFVISSNKSIIELAKDILFGIQFLHSHD--------IVHNDLNPRNILTLIGKTSNNNNS----
            . ..   .|  ||| ...               .. .|.||  |...|||..        |.| ||...|||     | .. |     
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYMYNP

-SNNSFIISDLGLSKMEVES-----------------SYSFTSNIPTGQGGYHPFEVLQSK----------------RMTKSVDIFSLGCILFYLLTNGQ
 ..    |.|.|||..  .|                 ... |.. . |  .. . |||. .                  ....|..| | .|. .||  .
NADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR

HPFGNDKLFRIV---------NIISNKMNLTPLN---------SNQLAC-----TLIKSMISKDESIRPTIQNVLNHP
 |. ... . ..          ....| .  |.          ..   |      |..   . | . ||. | .| . 
-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IrlB.AA STE 1028-1293 17 1.1e-13 44.85 In-house 1-359 (359) Show / Hide 
Range on Protein: 1028-1293
Range on HMM: 1-359/359
Sequence Identity: 17% (65 aa)

NES-NILGRGSNGTLVFK-------GLWSDKIP---------VAIKQMQKAFN----------------PLINKEVEALISLTSKN---CSNMIRYIDKE
 |   ..|.|. || . .       .  . .           .||||| .  .                . . ....  |.. .|    . | ..|.. .
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

EDKL-------HVYLGLTLCD-GSLQNLVES--GKLNDFVISS-------NKSIIELAKDILFG-IQFLHSHDIVHNDLNPRNILTLIGKTSNNNNSSNN
...        .... . ..| |||  ....  |..... ...        . |.  ...|| |  ..|||| |.| |. | |||               
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------------

SFIISDLGLSKMEVES--------------SYSFTSNIPTGQGGYHPFEVLQS------KRMTKSVDIFSLGCILFYLLTNGQHPFGNDKLFRIVNIISN
   ..| |...  ..|              . .  .|  .|   .   ||.|       |  . ..|| |||| .  ..| |..|. . . .|    | .
-VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMAT-GKPPWHDMHPMRAMFMIPF

K--------------MNLTPLNSN---------------------QLACTLIKSMISKDESIRPTIQNVLN--HPLF
.               .  || ..                     .  .  |.    || . ||| .  |.  || .
NYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase IrlB.AA WEE 1068-1236 25 3e-12 37.45 In-house 47-234 (297) Show / Hide 
Range on Protein: 1068-1236
Range on HMM: 47-234/297
Sequence Identity: 25% (48 aa)

KEVEALISLT---SKNCS-NMIRYIDKEEDKLHVYLGLTLCDGS---LQNLVESGKLNDFVISSNKSIIELAKDILFGIQFLHSH-DIVHNDLNPRNILT
.||.|. .|.   .  .  . .||.   |.. | |.   .|.|.   ||..... . ..  .. .. |  .  ||. |....||. ..||.|. | ||  
REVYAHMVLGQIMDCDHHPHIVRYYSAWEEDDHMYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWM-IWQILVDICQGLHHIHSNCGMVHMDIKPENI--

LIGKTSNNNNS------------SNNSFIISDLGLSKMEVESSYSFTSNIPTGQGGYHPFEVLQ-SKRMTKS--VDIFSLGCILFYLLTNGQ
.|.| .| | .            .|. . | |.|..  ...|  . . ..  | . | . |.||  ...|..   ||||||. .. | .| .
FISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHV-TDMNSNNNNPHQEQEGDSRYMAPEILQGYYHYTHLYKADIFSLGITIYELACNMD
Kinase IrlB.AA AGC 1208-1293 22 4.6e-12 25.98 In-house 277-395 (395) Show / Hide 
Range on Protein: 1208-1293
Range on HMM: 277-395/395
Sequence Identity: 22% (28 aa)

EVLQSKRMTKSVDIFS--LGCILFYLLTNGQHPFGND-------------KLFRIVN----IISNKMNLTP---------LNSNQLACTLIKSMISKDES
|.|     .|..|. |  |||... .|| |. || .|             ..|  .     .|..|  . .          .  . |  ||| .. || .
EIL----YGKACDWWSFGLGCLMYEMLT-GYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPE

IRPT----------IQNVLNHPLF
 |..          .. . ||| |
KRLGCGGNDFGDKGAEEIKNHPWF
Kinase IrlB.AA ULK 1208-1293 23 1.9e-11 36.9 In-house 217-324 (324) Show / Hide 
Range on Protein: 1208-1293
Range on HMM: 217-324/324
Sequence Identity: 23% (26 aa)

EVLQSK--RMTKS---VDIFSLGCILFYLLTNGQHPFGNDKLFRIV----NIISNK------MNLTPLNSN---------QLACTLIKSMISKDESIRPT
..||..  ..  .   .||.|||||....|. |. || ..     .    . | |.      .. .|.. .         .    ||. |. .||. | .
QILQGQGEQKPYYDYKCDIWSLGCIFYEMLY-GKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRIS

IQNVLNHPLF
.. ..|||.|
WEEIFNHPWF
Kinase IrlB.AA ULK 1208-1293 24 3.7e-11 35.28 In-house 221-329 (329) Show / Hide 
Range on Protein: 1208-1293
Range on HMM: 221-329/329
Sequence Identity: 24% (27 aa)

EVLQSK--RMTKS---VDIFSLGCILFYLLTNGQHPFGNDKLFRIV-----NIISN------KMNLTPLN---------SNQLACTLIKSMISKDESIRP
..||..  ..  .   .||.|||||....|. |. || .   .  .     . | |      ... .||.           .    ||. |. .||. | 
QILQGQGEQKPYYDYKCDIWSLGCIFYEMLY-GKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRI

TIQNVLNHPLF
... ..|||.|
SWEELFNHPWF
Kinase IrlB.AA TyrKc 1027-1293 18 4.9e-10 -60.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 1027-1293
Range on HMM: 1-280/280
Sequence Identity: 18% (56 aa)

RNESNILGRGSNGTLVFKGLWSDKIPVAIKQMQ-KAFNPLINKEVEALISL--TSKNCSNMIRYIDKEEDK----LHVYLGLTLCD-GSLQNLVESGKLN
     .||.|  |. |.|| |.  |.||.| ..  |    . .| . . .|    .|  ... .. ... .      ... . ... |.|..   . . .
ITLGKKLGEGAFGE-VYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

DFVISSNKSIIELAKDILFGIQFLHSHDIVHNDLNPRNILTLIGKTSNNNNSSNNSFIISDLGLSKMEVES--------SYSF----TSN--IPTGQGGY
     ..|  .. . .|  | ..|||. ..| ||  ||.|   ..             ||| |||.   .          |.      ..  .|      
----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI---RW

HPFEVLQSKRMTKSVDIFSLGCILFYLLTNGQHPFGN-----DKLFRIVNIISNK-MNLTPLN---------SNQLACTLIKSMISKDESIRPTIQNVLN
 . |... .. |   |..| |  .. ..|.|| |  .      . ..... . .  .   | |         .  .   ..|.    | . ||| ...  
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--

HPLF
| .|
HECF
Kinase IrlB.AA WEE 1269-1293 48 1.3e-05 14.9 In-house 273-297 (297) Show / Hide 
Range on Protein: 1269-1293
Range on HMM: 273-297/297
Sequence Identity: 48% (12 aa)

LIKSMISKDESIRPTIQNVLNHPLF
|||.|. .| . |||.|  |.||. 
LIKWMMHPDPEQRPTCQQLLQHPVL
Kinase IrlB.AA AGC 1129-1158 40 3.8e-05 7.67 In-house 158-187 (395) Show / Hide 
Range on Protein: 1129-1158
Range on HMM: 158-187/395
Sequence Identity: 40% (13 aa)

IELAKDILFGIQFLHS-HDIVHND-LNPRNIL
| ..  |. ....||| ..|.| | | | |||
I-CG-CIVLALEYLHSHMGIIHRDYLKPENIL