Gene DDB0216375 (Slime mold)

DDB0216375

Species: Slime mold
Alias: DdisK163, DDB0216375
External Links: DictyBase Link ,
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: MST

Sequence

Name Sequence Type Origin Length Description Download
DDB0216375.AA Protein None 1105 None Fasta, JSON
DDB0216375.kin_dom Protein Kinase Domain None 251 None Fasta, JSON

Protein domain

Protein domains of DDB0216375.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DDB0216375.AA MST 23-274 65 2.4e-217 697.54 In-house 1-254 (254) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-254/254
Sequence Identity: 65% (166 aa)

FDLIECLGRGSFGSVYKATYKKTGNIVAVKLVPINEDFQEILKEINIMKQCKSKYVVQYYGNYF--KDETCWIIMEYCAFGSVSDMMNITNRVLNEEQIA
||..|.||.||.||||||..|.||.|||.|.||.|||.|||.|||.||.||||||.|.|||.||  |...|||.||||..|||.|.|.||.|.|||.|||
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPVNEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQIA

LVCYSTLKGLYYLHRNSKIHRDIKPGNILVSEEGECKLADFGVSGQLSERTRKRNTVIGTPFFLAPEVIQEVGYDNKADIWALGISAIEMAEFHPPYHDL
...|.||.||.|||.|.|||||||.||||...|||||||||||||||.....|||||||||...|||||||..||.|||||.|||.||||||..|||.|.
CILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYSDI

HPMRVLFMIPTSTSPTLKEPHKWSPEFSDFIALCLAKEQSQRPSAKDLLKHSFF
||||..||||....||.|.|..||.||.||.. ||.|...||..|..||.|.|.
HPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase DDB0216375.AA STE20 23-274 50 8.9e-163 547.07 In-house 1-288 (288) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-288/288
Sequence Identity: 50% (144 aa)

FDLIECLGRGSFGSVYKATYKKTGNI----VAVKLVPINED------FQEILKEINIMKQCKSKYVVQYYGNYFKD----ETCWIIMEYCAFGSVSDMMN
..|.|..|.||.|.||||. |.||..    ||.| ......      ...|.|||.||||||....|.||| |.||    .  ||.||||. ||..|.|.
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---ITNR-----VLNEEQIALVCYSTLKGLYYLHRNSKIHRDIKPGNILVSEEGECKLADFGVSGQLSE-----RTRKRNTVIGTPFFLAPEVIQE----
   ....     ..|||||| .|. .|.|| |||.| .|||||| .|||..|.||.|||||||..||..     . .||||..|||...||||||.    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-VGYDNKADIWALGISAIEMAEFHPPYHDLHPMRVLFMIP--TSTSPTLKE--PHKWSPEFSDFIALCLAKEQSQRPSAKDLLKHSFF
  |||.|.|||.||| |||||| .|||.|.||||..||||  .  .||||.  |||||||| ||...|| |. ..||.|..||||.|.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase DDB0216375.AA STE 23-274 37 3.9e-137 461.88 In-house 1-359 (359) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-359/359
Sequence Identity: 37% (137 aa)

FDLIECLGRGSFGSVYKATYKK---------------TGNIVAVKLVPINED-------------------FQEILKEINIMKQCK--SKYVVQYYGNYF
...||..|.|.||.|||| ..|               ||.|.|.| ......                   .|.|||||.|||.|.  ....|.||| ||
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

KD-------ETCWIIMEYCAFGSVSDMMN---ITNRVLN----------EEQIALVCYSTLKG-LYYLHRNSKIHRDIKPGNILVSEEGECKLADFGVSG
|.       ...||.|||.. ||..|...   .... ||          |.||| .|...||| |||||.. .|||||||.|||.     .||.||||.|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLSE----------------RTRKRNTVIGTPFFLAPEVIQE------VGYDNKADIWALGISAIEMAEFHPPYHDLHPMRVLFMIPTS-----------
||..                .  ||||..||| . ||||||        ||| |.||| ||. .||||. .||.||.||||..||||..           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----TSPTLKE-----------------PHKWSPEFSDFIALCLAKEQSQRPSAKDLLK--HSFF
    ..|.|..                 |||||||| |||..|| |. ..||.|..|||  |.|.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase DDB0216375.AA YSK 23-274 49 3.2e-129 391.37 In-house 1-257 (257) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-257/257
Sequence Identity: 49% (128 aa)

FDLIECLGRGSFGSVYKATYKKTGNIVAVKLVPINEDFQEI---LKEINIMKQCKSKYVVQYYGNYFKDETCWIIMEYCAFGSVSDMMNI-TNRVLNEEQ
|   || |||||| |||.  ..|. .||.| .   ..  ||    .||..  ||.| |. .||| | ||   |||||||. ||..| |       . |..
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IALVCYSTLKGLYYLHRNSKIHRDIKPGNILVSEEGECKLADFGVSGQLSERTRKRNTVIGTPFFLAPEVIQE--VGYDNKADIWALGISAIEMAEFHPP
|| .    |||| ||| . |||||||  |.|.||.|. ||.||||.||. . . |||| .|||.. |||||..  ..|| ||||| ||| |.|||  .||
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPP

YHDLHPMRVLFMIPTSTSPTLKEPHKWSPEFSDFIALCLAKEQSQRPSAKDLLKHSFF
| |.|||||.| || .  |.|.  ...|  | .|...|| |. .||||||.||||.| 
YCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase DDB0216375.AA PAKL 23-274 47 6.2e-116 391.46 In-house 1-256 (256) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-256/256
Sequence Identity: 47% (122 aa)

FDLIECLGRGSFGSVYKATYKKTGNIVAVKLVPINED--FQEILKEINIMKQCKSKYVVQYYGNYFKD-ETCWIIMEYCAFGSVSDMMNITNRVLNEEQI
| . | || ||.||||||. | |.   |.|  .| |    ..| |||.| | ||. ..| |.|         || |.||. ||. ||| ..   |||.||
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQI

ALVCYSTLKGLYYLHRNSKIHRDIKPGNILVSEEGECKLADFGVSGQLSERTR-KRNTVIGTPFFLAPEVIQEVGYDNKADIWALGISAIEMAEFHPPYH
...   ||||| |||    ||||||  ||| .| .  |.|||||| ||    .   |  ||||.. |||.|    |.||.||| ||| |||||.  ||  
SVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINKQNYNNKCDIWSLGITAIEMADGFPPHY

DLHPMRVLFMIPTSTSPTLKEPHKWSPEFSDFIALCLAKEQSQRPSAKDLLKHSFF
|. ||| . |||    ||...|..|||.| ||.| |. |   .|.|. ||| | | 
DMPPMRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase DDB0216375.AA KHS 23-274 45 1e-97 329.23 In-house 1-258 (258) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-258/258
Sequence Identity: 45% (118 aa)

FDLIECLGRGSFGSVYKATYKKTGNIVAVKLVPIN--EDFQEILKEINIMKQCKSKYVVQYYGNYFKDETCWIIMEYCAFGSVSDMMNITNRVLNEEQIA
..|.  .| | .| ||||  .......|||.. ..  .||. | .|| .||.|.   .| |.| |.. .  ||.||||  ||. |.  .|   |.| |||
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGP-LSELQIA

LVCYSTLKGLYYLHRNSKIHRDIKPGNILVSEEGECKLADFGVSGQLSERTRKRNTVIGTPFFLAPEVI---QEVGYDNKADIWALGISAIEMAEFHPPY
 ||  ||.||.||| . |.|||||  |||....|. ||||||||.|..    ||   ||||...||||    .. ||..  ||||.|| |||.||  || 
YVCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPM

HDLHPMRVLFMIPTST--SPTLKEPHKWSPEFSDFIALCLAKEQSQRPSAKDLLKHSFF
 ||||||.||..  |    |.||. ||||. | .|. ..| |.  .||.|. ||.| |.
FDLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase DDB0216375.AA Ste20-DD1 23-274 47 2e-96 326.68 In-house 1-268 (268) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-268/268
Sequence Identity: 47% (126 aa)

FDLIECLGRGSFGSVYKA------TYKKTGN-IVAVKLVPIN----EDFQEILKEINIMKQC-KSKYVVQYYGNYFKDETCWIIMEYCAFGSVSDMMNIT
|  .|  | |||| |              .| ..|.| | .|    |.     ||| |.|   .  |.|.| | | |.    |.||||  ||. | | . 
FQIVEVIGQGSFGVVCTCRWMKKKDRNTNNNRVIACKFVEMNADDVEENSNLKKEIDILKNTMDCPYIVKYHGCYIKENMLMIVMEYCDGGSILDIMQMC

NRVLNEEQIALVCYSTLKGLYYLHRNSKIHRDIKPGNILVSEEGECKLADFGVSGQLSERTRKRNTVIGTPFFLAPEVIQE----VGYDNKADIWALGIS
   | ||||| .||   ||| ||| |  .||||| ||.|| .||  ||||||||  .     | ||||| |. ..||.|       ||| ||||| ||| 
SKRLIEEQIAAICYQIVKGLVYLHSNRITHRDIKAGNVLVNKEGQPKLADFGVSTIAVNQGFKMNTVIGSPYWMSPEIIMPPKGSQGYDQKADIWSLGIT

AIEMAEFHPPYHDLHPMRVLFMIPTSTSPTLKEPHKWSPEFSDFIALCLAKEQSQRPSAKDLLKHSFF
||||||  ||  .. | || | ||    |||| |  ||||| |||  || ..   |||| .|| | | 
AIEMAESKPPRFNVNPVRVIFVIPHQQPPTLKIPSNWSPEFNDFIKQCLNMNPDKRPSAQQLLNHPFI
Kinase DDB0216375.AA PAKA 23-274 41 1.1e-95 324.21 In-house 1-260 (260) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-260/260
Sequence Identity: 41% (109 aa)

FDLIECLGRGSFGSVYKATYKKTGNI--VAVKLVPINEDFQE--ILKEINIMKQCKSKYVVQYYGNYFKDETCWIIMEYCAFGSVSDMMNITNR----VL
.. .| .| |. |.||.|| .||..   ||.|   .... .   |. || .||.|| | .|.|.  |  |.  |..||| . |.  |    ...    ..
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

NEEQIALVCYSTLKGLYYLHRNSKIHRDIKPGNILVSEEGECKLADFGVSGQLSERTRKRNTVIGTPFFLAPEVIQEVGYDNKADIWALGISAIEMAEFH
.|.||| ||  .|.|| ..|... ||||||  |||.  .|. |..|||   ||..  .||||. ||| . |||||.   || | ||| ||| ||||.|  
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGE

PPYHDLHPMRVLFMIPTSTSPTLKEPHKWSPEFSDFIALCLAKEQSQRPSAKDLLKHSFF
||| .  | | .. | |   | .|.|.|||.|| || ..|| ..  .|.||..||.| |.
PPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase DDB0216375.AA MSN 23-274 43 6.5e-92 303.78 In-house 1-265 (265) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-265/265
Sequence Identity: 43% (117 aa)

FDLIECLGRGSFGSVYKATYKKTGNIVAVKLVPINEDFQEILK-EINIMKQ-CKSKYVVQYYGNYFK------DETCWIIMEYCAFGSVSDMMNIT-NRV
|.|.| .| | .| |||  ..|||...|.|.. ..||  | .| |||..|.    . .. ||| ..|      |.  |..||.|. ||| |..  | .. 
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQS

LNEEQIALVCYSTLKGLYYLHRNSKIHRDIKPGNILVSEEGECKLADFGVSGQLSERTRKRNTVIGTPFFLAPEVIQ-----EVGYDNKADIWALGISAI
| |. || .|   |.||..|| .  ||||||  |.|. .. | || ||||| ||.    .||| ||||...|||||.     .  ||...|.|..|| ||
LKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITAI

EMAEFHPPYHDLHPMRVLFMIPTSTSPTLKEPHKWSPEFSDFIALCLAKEQSQRPSAKDLLKHSFF
|||| .||  |.|||| ||.||  . |.||  .|||  | .|.  || |. .|||.....|||.| 
EMAEGQPPLCDMHPMRALFLIPRNPPPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase DDB0216375.AA SLK 23-274 41 4.5e-90 304.06 In-house 1-259 (259) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-259/259
Sequence Identity: 41% (108 aa)

FDLIECLGRGSFGSVYKATYKKTGNIVAVKLVPI--NEDFQEILKEINIMKQCKSKYVVQYYGNYFKDETCWIIMEYCAFGSVSDMMNITNRVLNEEQIA
...|  || | || ||||  | .. . | | . |  .|. .. . ||.|. .||  ..|. |. |. |.  |...|.|. | |  .|   ...| |.||.
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQ

LVCYSTLKGLYYLHRNSKIHRDIKPGNILVSEEGECKLADFGVSGQLSERTRKRNTVIGTPFFLAPEVI-----QEVGYDNKADIWALGISAIEMAEFHP
.||. .. .| .||.|  ||||.| ||||.  .|. .||||||| .. .  .|| | ||||...||||.     ..  || |||||.|||  ||||.  |
YVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEP

PYHDLHPMRVLFMIPTSTSPTLKEPHKWSPEFSDFIALCLAKEQSQRPSAKDLLKHSFF
|.|.. |||||. |  |  |||..| .|| ||.||.  || |.  .|.....|..| ..
PHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase DDB0216375.AA S_TKc 23-274 31 1.2e-88 301.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-231/231
Sequence Identity: 31% (85 aa)

FDLIECLGRGSFGSVYKATYKKTGNIVAVKLVPINEDFQEILKEINIMKQCKSKYVVQYYGNYFKDETCWIIMEYCAF--GSVSDMMNITNRV-----LN
..... .|.|.||.|||.. |||| |||.| ..     . |..||.|.|. . ...|..|. .   .  ...||||    |.. |..   .|      ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

EEQIALVCYSTLKGLYYLHRNSKIHRDIKPGNILVSEEGECKLADFGVSGQLSERTRKRNTVIGTPFFLAPEVIQEVGYDN-KADIWALGISAIEMAEFH
| ... ..| ....| |.|..  ||||.|| |||..|  . |..|||.. ||       .|..|||...||||.   ||.  |.|.|..|.  .||.   
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY

PPYHDLHPMRVLFMIPTSTSPTLKEPHKWSPEFSDFIALCLAKEQSQRPSAKDLLK-------HSFF
||..    | ..| .              |||. |||  || |. ..||.| ..|.       | .|
PPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DDB0216375.AA Pkinase 23-274 29 4.6e-80 277.09 Pfam 1-293 (293) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-293/293
Sequence Identity: 29% (87 aa)

FDLIECLGRGSFGSVYKATYKKTGNIVAVKLVPINEDFQEILK------EINIMKQCKSKYVVQYYGNYFKDETCWIIMEYCAFG----SVSDMMN-ITN
. .....|.||||.|||.. |.|| ||||| ..  ..  . ..      || ||| ......|..|. .  .  ....||||  |    . .|..    .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RVL--NEEQIALVCYSTLKGLYYLHRNSKIHRDIKPGNILVSEEGEC----KLADFGVSGQL-SERTRKRNTVIGTPFFLAPEVIQ-EVGYDNKADIWAL
...   |...  ..| .|.||.|.|... ||||.|| |||....|..    |..|||.. |.   . .  .|. |||...|||||.   .|. |.|.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GISAIEMAEFHPPYHDL----HPMRVLFMIPTSTSPTLKEPHKWS---------------------PEFSDFIALCLAKEQSQRPSAKDLLKHSFF
|.  .||.  .||. .     . .. ..||    .| |...  |.                     .|. |||  ||.|  ..||.|...|.| .|
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DDB0216375.AA Pkinase_Tyr 23-274 25 1.4e-33 114.35 Pfam 1-270 (270) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-270/270
Sequence Identity: 25% (71 aa)

FDLIECLGRGSFGSVYKATYK----KTGNIVAVKLV--PINED---FQEILKEINIMKQC-KSKYVVQYYGNYF-KDET--CWIIMEYCAFGSVSDMMNI
  ... ||.|.||.|||.|.|    .|.  |||| .     ..    .. ..|..||||  . . .|..||    ..|    .|.|||.. |.  |    
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

T---NRVLNEEQIALVCYSTLKGLYYLHRNSKIHRDIKPGNILVSEEGECKLADFGVSGQL--SERT-RKRNTVIGTPFFLAPEVIQEVGYDNKADIWAL
    .. |. ...   |.   ||. ||...  ||||.   |.||.|.. .| .||| .  .   .   |||       . .|||.|..  .  | |.|. 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GISAIEMAEFH-PP-YHDLHPMRVLFMI-PTSTSPTLKEPHKWSPEFSDFIALCLAKEQSQRPSAKDLLKHSFF
|.   |.  .   | | .. . .|. .|        .. |.. ..|  | . .| ... ..||. ...  |...
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYED--GYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL
Kinase DDB0216375.AA TyrKc 23-274 23 3.9e-18 67.5 SMART 1-280 (280) Show / Hide 
Range on Protein: 23-274
Range on HMM: 1-280/280
Sequence Identity: 23% (67 aa)

FDLIECLGRGSFGSVYKATYKKTGNIVAVKLVPINEDFQEILKEINIMKQC--KSKYVVQYYGNYFKD-------ETCWIIMEYCAFGSVSDMMNITNRV
  |.. ||.| || |||.|.|     |||| .  .   .....|..||..   . . .|. ||   ..       |  .|.|||.. |.  |    . . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LNEEQIALVCYSTLKGLYYLHRNSKIHRDIKPGNILVSEEGECKLADFGVSGQLSER----TRKRNTVI----GTP-----FFLAPEVIQEVGYDNKADI
|. ..    |.   .|  |||..  ||||.   |.||.|.. .| .||| |  . .      .|   .     |.        .|||.|..  .  | |.
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

WALGISAIEMAEF-HPPYHD-----LHPMRVLFMIPTSTSPTLKEPHK------WSPEFSDFIALCLAKEQSQRPSAKDLLKHSFF
|. |.   |.  .  .|| .     . . .|.  . .   .   . .        ..|  . .  | . . ..||. ...  |..|
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Calpain_III DDB0216375.AA Calpain_III 548-672 27 1.3e-20 71.45 Pfam 1-147 (156) Show / Hide 
Range on Protein: 548-672
Range on HMM: 1-147/156
Sequence Identity: 27% (42 aa)

YLSPTRVSGIW-SGESAGGCANTT-LWRKNPQYLLQITATT----------TIRITLRQ--------T-GDKLVHIGFYFARSNTGANDQFRRRITLTKE
  . | . | | .| .|||| |    . .||||....|  .          |. . | |          |  .. |||.  ...     . ..  .| ..
KWHMTMYQGSWVRGSTAGGCRNHPDTFWTNPQYRIHLTEPDDDDDDDEKKCTVIVALMQKNRRRKRKMGGPDMLTIGFHIYKVP-----EGQPQKHLDRD

YLVPG--LD----ITFLKSTEVSAKITMEPGYYVIIPATFEPNQEGSFELDV
...     .     |.  | ||.   ...|| |||.| ||||.|||.| | |
FFKHHFHQSIARSSTYINSREVCCRFRLPPGHYVIVPSTFEPHQEGDFCLRV
Calpain_III DDB0216375.AA Calpain_III 708-731 40 1.004357 3.87 Pfam 10-33 (156) Show / Hide 
Range on Protein: 708-731
Range on HMM: 10-33/156
Sequence Identity: 40% (10 aa)

EW-RGSSAGGSFSGSSATWKDNPKF
.| |||.|||.      |. .|| .
SWVRGSTAGGCRNHPD-TFWTNPQY
Calpain_III DDB0216375.AA Calpain_III 756-830 28 7.2e-09 31.54 Pfam 75-156 (156) Show / Hide 
Range on Protein: 756-830
Range on HMM: 75-156/156
Sequence Identity: 28% (24 aa)

YIGFYIFKADKNCPFISLTANNLYSK--------TSFVNGIEVVHTQQQMPPGCYIIVPCTYDSRQEGSFTLTCYSDCQQGSI
.|||.|.| ... |   |  . .  .        ....|. ||..   ..||| |.|||.|..  |||.|.|  .|...  . 
TIGFHIYKVPEGQPQKHLDRDFFKHHFHQSIARSSTYINSREVCCR-FRLPPGHYVIVPSTFEPHQEGDFCLRVFSEKPNDTQ
Calpain_III DDB0216375.AA Calpain_III 836-972 29 4.7e-41 140.94 Pfam 1-156 (156) Show / Hide 
Range on Protein: 836-972
Range on HMM: 1-156/156
Sequence Identity: 29% (46 aa)

SEQILTVHGEW-RGATSGGCLNHT-TWRNNAQYLIHNTSSSPT------KVTIMLEQLEKMDNQQLPF-------VGFYVAKS----PTPNLDKKLFSLT
. .. ...|.| || |.|||.||  |. .| ||.|| | ...       | |.... ..|  ...  .       .||.. |.    |.. ||.. |. .
KWHMTMYQGSWVRGSTAGGCRNHPDTFWTNPQYRIHLTEPDDDDDDDEKKCTVIVALMQKNRRRKRKMGGPDMLTIGFHIYKVPEGQPQKHLDRDFFKHH

-PKDIVGNTEFINDYQVHFTSIMEPNTSYIIIPSTFTPGIEYPFNLRVITNQHNVIQ
 ...|.... .|| ..|.  . ..| . |.|.|||| |. | .| ||| .. .| .|
FHQSIARSSTYINSREVCCRFRLPPGH-YVIVPSTFEPHQEGDFCLRVFSEKPNDTQ
Calpain_III DDB0216375.AA Calpain_III 978-1097 22 2.5e-11 39.88 Pfam 1-150 (156) Show / Hide 
Range on Protein: 978-1097
Range on HMM: 1-150/156
Sequence Identity: 22% (34 aa)

EWSTRKLSGEW-RGQSCGGRYSNTSSSWTLNPRFRFNLPRGGRF--------TIILAQAE----------KPSYNGIGFYYFKT--------------LQ
 |....  |.| ||.. ||   .   ..  || .|. |.             |.|.|  .          .| .  |||. .|               ..
KWHMTMYQGSWVRGSTAGGCRNHPD-TFWTNPQYRIHLTEPDDDDDDDEKKCTVIVALMQKNRRRKRKMGGPDMLTIGFHIYKVPEGQPQKHLDRDFFKH

DGTLREFVCKSGFICGKEIVLESSINEGVTGVVIPSTFEPNIQDSFNLTIYSE
   ... .  | .| . |... ...  |   |..||||||. . .| | ..||
H-FHQSIARSSTYINSREVCCRFRLPPGH-YVIVPSTFEPHQEGDFCLRVFSE