Gene MEKKalpha (Slime mold)

MEKKalpha

Species: Slime mold
Alias: mkkA, MEKKalpha, DDB0220118, DdisK154
External Links: DictyBase Link ,
Annotation:

Classification

Group: STE
Family: STE11
Subfamily: STE11-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
MEKKalpha.AA Protein None 1267 None Fasta, JSON
MEKKalpha.kin_dom Protein Kinase Domain None 260 None Fasta, JSON

Protein domain

Protein domains of MEKKalpha.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PB1 MEKKalpha.AA PB1 15-101 21 4.2e-18 67.4 SMART 1-95 (95) Show / Hide 
Range on Protein: 15-101
Range on HMM: 1-95/95
Sequence Identity: 21% (21 aa)

FIRIKCIL-GDDIRIIKFNSNISYGGLMNQLEQDFQC----PISIHQYE--DYEGD-KVTVKSKDDIMEALTMYFELKALN--PTKIISTKFFLKQL
 ...|| . |.|.|........|.  ||. ..| ...    |... .|.  | .|| .||... .|  |.. || .|.. .   ..  . . .. . 
PVDVKCRYVGGDTRRFSVPRDWSFDDLMSKVAQRCGHDNDQPFTL-KYQLPDEDGDAWVTITCDEDLQEMMEMYDSLES-QNKSSCWKTLRLHVFPF
PB1 MEKKalpha.AA PB1 15-101 30 7e-18 66.13 Pfam 1-86 (86) Show / Hide 
Range on Protein: 15-101
Range on HMM: 1-86/86
Sequence Identity: 30% (28 aa)

FIRIKCILGDDIRI--IKFNSNISYGGLMNQLEQDFQC-PISIHQYEDYEG-DKVTVKSKDDIMEALTMYFELKALNPTKIISTKFFLKQL
 .|||| .|.|||.  |.. .|||.  ||...|| ..|     .||.| .| |.||... .| .|.. .| ...     |  . .... . 
TVRIKCRYGGDIRRFIIHVRRNISFEDLMHKVEQRCKCDHTFKYQYPDEDGDDWVTITCDEDLQEMMEEYRSSE-----KSMTLRLHVFPS
Kinase MEKKalpha.AA STE11-Unclassified 495-754 49 2.8e-186 625.15 In-house 1-308 (308) Show / Hide 
Range on Protein: 495-754
Range on HMM: 1-308/308
Sequence Identity: 49% (152 aa)

WQKGQILGRGGYGSVYLGLNKDTGELFAVKQLEIVDINS-DPKLKNM-ILSFSKEIEVMRSLRHDNIVRYLGTS--LDQSFLSVFLEYIPGGSISSLLGK
||||...|.|..|.||...|..|||..||||.||.|.|| ....... | |..||..|...|.|.|||.|.|..   .......|.||.|||||.|.| |
WQKGEFIGKGSFGQVYKCMNCNTGEFMAVKQIEIHDYNSQQEDMQKEMIQSIQKEMKVLKQLNHKNIVQYYGCEIHKHEDCINIFMEYMPGGSIWSMLNK

FGAFSENVIKVYTKQILQGLSFLHANSIIHRDIKGANILIDTKGIVKLSDFGCSKSFS------------------GIVSQF-------KSMQGTPY---
.|.|.|.|||.||||||.||..||...||||||||||||||..||.||.||||.|...                   |....       ||||||||   
YGCFDEMVIKKYTKQILEGLAYLHSHGIIHRDIKGANILIDFDGICKLTDFGCAKQIEFDRTRTVRMNKIQNFDHYKICQHINSQQNHCKSMQGTPYQPF

WMAPEVIK---QTGHGRSSDIWSLGCVIVEMATAQPPWSNITE--LAAVMYHIASSNSIPNIPSHMS-----------QEAFDFLNLCFKRDPKERPDAN
||||||||   ||||.|.||||||||...||||...||||...  .......|..||.||.||.|.|           ||..|||..||..|||.||.||
WMAPEVIKNSTQTGHCRKSDIWSLGCTVIEMATGKHPWSNCQNDNFMWAIMKIVMSNQIPQIPEHLSPVCDFISCWISQECKDFLRKCFQIDPKKRPTAN

QLLKHPFI
|||.||||
QLLQHPFI
Kinase MEKKalpha.AA STE11 495-754 47 3.2e-174 585.06 In-house 1-303 (303) Show / Hide 
Range on Protein: 495-754
Range on HMM: 1-303/303
Sequence Identity: 47% (145 aa)

WQKGQILGRGGYGSVYLGLNKDTGELFAVKQLEIVDINSD-PKLKNMILS------FSKEIEVMRSLRHDNIVRYLGTSL---DQSFLSVFLEYIPGGSI
||||.|.|.| .|.||...|.|||||.|||| ||...|.. ....... |      . .||..|. |.| |||||.|..|   .......|.||.||||.
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

SSLLG-KFGA--FSENVIKVYTKQILQGLSFLHANSIIHRDIKGANILIDTKGI-VKLSDFGCSKSFSGIVSQFKS----------MQGTPY--------
||.|  |.|.  |.|.||..||||||.||..||.. ||||||||||||.|..|. .||.||||.|....| .....          |.||||        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMAPEVIKQTG---HGRSSDIWSLGCVIVEMATAQPPWSNITE-LAAVMYHIASS-NSIPNIPSHMS------QEAFDFLNLCFKRDPKERPDANQLLKH
|||||||||.|   .||..|||||||...||||..|||.|...  .| |..|... ...|.||.|||      .|. |||..||..|||.|| |||||.|
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

PFI
|||
PFI
Kinase MEKKalpha.AA STE 495-754 29 2e-117 396.38 In-house 1-359 (359) Show / Hide 
Range on Protein: 495-754
Range on HMM: 1-359/359
Sequence Identity: 29% (109 aa)

WQKGQILGRGGYGSVYLGLNKD---------------TGELFAVKQLEIVDINS----------DPKLKNMILSFSKEIEVMRSLR--HDNIVRYLGTSL
|.. ...|.|..|.||...|..               |||..|.||... . |.          . | .. . .. |||..|. ..  |.|||.|.|. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DQ-------SFLSVFLEYIPGGSISSLLG-KFGA-------------FSENVIKVYTKQILQG-LSFLHANSIIHRDIKGANILIDTKGIVKLSDFGCSK
.        . | ...||..|||.....  |.|              |.|..|.....|||.| |..|| . |||||||.||||.     |||.|||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

SFSGIVS----------------QFKSMQGTPYWMAPEVIKQ------TGHGRSSDIWSLGCVIVEMATAQPPWSNITELAAVMYHIASS----------
... ...                . ... ||| |||||||.|       |.....|||||||.|.|||| .|||.. . . | .. . ..          
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---NSIPNIPS-------------------HMSQEAFDFLNLCFKRDPKERPDANQLLK--HPFI
   . .| .|.                   ..|.|  ||.|.|...||..||.|.||||  ||||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MEKKalpha.AA MEKK15 495-754 48 2.3e-112 379.6 In-house 1-264 (264) Show / Hide 
Range on Protein: 495-754
Range on HMM: 1-264/264
Sequence Identity: 48% (129 aa)

WQKGQILGRGGYGSVYLGLNKDTGELFAVKQLEIVDINSDPKLKNMILSFSKEIEVMRSLRHDNIVRYLGTSLDQSFLSVFLEYIPGGSISSLLGKFGAF
|.||.|||.| || || ||  .|| | |||| |. .|.   | |   .    |......|.| ||| |||..|..  ...|....|||||||.. .||. 
WKKGNILGKGAYGTVYCGLT-NTGQLIAVKQVELDEIDKE-KAKQQYRKLQEEVDLLKTLKHKNIVAYLGVCLEDNVVNIFMQFVPGGSISSIINRFGPL

SENVIKVYTKQILQGLSFLHANSIIHRDIKGANILIDTKGIVKLSDFGCSKSFSGI---VSQ---FKSMQGTPYWMAPEVIKQTGHGRSSDIWSLGCVIV
 | |   ||||||||  .|| | ..||||||.|...   ||.|| |||| |  .      ..    |||.|||||||||||. ||.|| |||||.|| . 
DEMVFCKYTKQILQGVQYLHENCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLCWQGINRTHSDMLKSMRGTPYWMAPEVIMETGYGRKSDIWSIGCTVF

EMATAQPPWSNITELAAVMYHIASSNSIPNIPSHMSQEAFDFLNLCFKRDPKERPDANQLLKHPFI
|||| .||| ..  .||. |  |  . .| .| . | .| .| ..|  || .||| | ||||||||
EMATRKPPWADMDRMAAMFYIGAHRDPMPQLPVKFSEDARMFVRMCLTRDQHERPTASQLLKHPFI
Kinase MEKKalpha.AA S_TKc 495-754 28 1.1e-98 335.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 495-754
Range on HMM: 1-231/231
Sequence Identity: 28% (79 aa)

WQKGQILGRGGYGSVYLGLNKDTGELFAVKQLEIVDINSDPKLKNMILSFSKEIEVMRSLRHDNIVRYLGTSLDQSFLSVFLEYIPG--GSISSLLGKFG
.......|.|..|.||.. .|.||...|.|..                .. .||..... .|.|||.....  | ..| ...||..|  |.  ... | |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

A------FSENVIKVYTKQILQGLSFLHANSIIHRDIKGANILIDTKGIVKLSDFGCSKSFSGIVSQFKSMQGTPYWMAPEVIKQTGHGR-SSDIWSLGC
       |.| ... |..||...| ..| . |||||.| .|||.|.   .|..||| .. .       ... |||..|||||.   |.|. ..|.||.||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

VIVEMATAQPPWSNITELAAVMYHIASSNSIPNIPSHMSQEAFDFLNLCFKRDPKERPDANQLLK-------HPFI
.. ||.. .||..   ...... .|             |.|| ||.. |...||..|| | ..|.       ||..
ILYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MEKKalpha.AA Pkinase 495-754 31 7.8e-94 322.83 Pfam 1-293 (293) Show / Hide 
Range on Protein: 495-754
Range on HMM: 1-293/293
Sequence Identity: 31% (95 aa)

WQKGQILGRGGYGSVYLGLNKDTGELFAVKQLEIVDINSDPK-----LKNMILSFSKEIEVMRSLRHDNIVRYLGTSLDQSFLSVFLEYIPGG----SIS
...|...|.|..|.||.. .|.||...|||... ....|. .     |         ||..|..|.|.||||....  | . . . .|| .||    . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--------SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

SLLG--KFGAF--SENVIKVYTKQILQGLSFLHANSIIHRDIKGANILIDTKGIV----KLSDFGCSKSF-SGIVSQFKSMQGTPYWMAPEVIK-QTGHG
...   . |.|  ||...| | .|||.|| ..|...|||||.| .||||| .| .    |..|||..| |     | ...  |||..||||||. ....|
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

RSSDIWSLGCVIVEMATAQPPWSNI-----TELAAVMYHIASSNSIPNIPSH-------------------MSQEAFDFLNLCFKRDPKERPDANQLLKH
...|.||.||.. ||.. .||...       .  .... | .     ..|                     .|.|. ||.. |...|||.|| | |.|.|
PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PFI
|..
PWF
Kinase MEKKalpha.AA MEKK2 495-754 44 2.4e-93 316.4 In-house 1-262 (262) Show / Hide 
Range on Protein: 495-754
Range on HMM: 1-262/262
Sequence Identity: 44% (118 aa)

WQKGQILGRGGYGSVYLGLNKDTGELFAVKQLEIVDINSDPKLKNMILSFSKEIEVMRSLRHDNIVRYLGTSLDQS--FLSVFLEYIPGGSISSLLGKFG
|..|..|| | .| ||.    |||   |||| ..   ...|  .  . .   ||.... |.|. || | |   |.    ||.|.||.||||.   |  .|
WRRGKLLGQGAFGRVYVCYDVDTGRELAVKQVQFD--PDNPETRKEVQALECEIQLLKNLQHERIVQYYGCLRDNQEKTLSIFMEYMPGGSVKDQLKAYG

AFSENVIKVYTKQILQGLSFLHANSIIHRDIKGANILIDTKGIVKLSDFGCSKSFSGIVSQ---FKSMQGTPYWMAPEVIKQTGHGRSSDIWSLGCVIVE
|  |.| . ||.||| |...|| . |.|||||||||| |  | |||.||| ||    | ..    ||. ||||||.||||   | ||  |.||.|| .||
ALTETVTRKYTRQILEGMHYLHDHMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICMHITGMKSVTGTPYWMSPEVINGEGYGRKADVWSIGCTVVE

MATAQPPWSNITELAAVMYHIASSNSIPNIPSHMSQEAFDFLNLCFKRDPKERPDANQLLKHPFI
| | .||| .   .||. . ||  .  | .|.|.||.| ||| .||..  ..|| |. ||.| |.
MLTEKPPWAEYEAMAAI-FKIATQPTNPQLPQHVSQHARDFLKRCFVEIKQDRPSAEELLRHHFV
Kinase MEKKalpha.AA STE20 495-754 35 1.5e-87 297.14 In-house 1-288 (288) Show / Hide 
Range on Protein: 495-754
Range on HMM: 1-288/288
Sequence Identity: 35% (104 aa)

WQKGQILGRGGYGSVYLGLNKDTGEL----FAVKQLEIVDIN--SDPKLKNMILSFSKEIEVMRSLRHDNIVRYLGTSLDQ----SFLSVFLEYIPGGSI
... . .|.|.||.||.. .|.|||.     |.|.... . .  .     ... .  ||| .|. ..| |||.|.|. |      . | .  ||  |||.
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-----DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSL

SSLLG---KFG------AFSENVIKVYTKQILQGLSFLHANSIIHRDIKGANILIDTKGIVKLSDFGCSKSFSG-----IVSQFKSMQGTPYWMAPEVIK
. ..    | |       ..|  | . ....||||..||.| |||||||..|||....| |||.||| . ...      . .. ... |||||||||||.
TDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQ

Q-----TGHGRSSDIWSLGCVIVEMATAQPPWSNITELAAVMYHIA-SSNSIP--NI--PSHMSQEAFDFLNLCFKRDPKERPDANQLLKHPFI
.      |..  .||||||  . |||. .|| ...  . | |..|. ..|  |      |.. |.|  ||...|  .||..|| | ||||||||
CMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRA-MFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MEKKalpha.AA ASK 500-754 42 3.4e-86 286.69 In-house 1-254 (254) Show / Hide 
Range on Protein: 500-754
Range on HMM: 1-254/254
Sequence Identity: 42% (110 aa)

ILGRGGYGSVYLGLNKDTGELFAVKQLEIVDINSDPKLKNMILSFSKEIEVMRSLRHDNIVRYLGTSLDQSFLSVFLEYIPGGSISSLL-GKFGAFS--E
.||.| || || | ...|    |.| ..  | .              ||.. . ||| |||.|||.  ..... .|.| .||||.|.||  |.| .   |
VLGKGTYGIVYAGRDMHTQVRIAIKEIPERDSR-------YVQPLHEEIALHKQLRHRNIVQYLGCCSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNE

NVIKVYTKQILQGLSFLHANSIIHRDIKGANILIDT-KGIVKLSDFGCSKSFSGIVSQFKSMQGTPYWMAPEVIKQT--GHGRSSDIWSLGCVIVEMATA
| .. ||||||.||..|| | |.|||||| |.|. |  |.||.|||| .|   ||    .. .||  .|||||| |   |.|.. ||||.|| .|||||.
NTMNFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPCTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMATG

QPPWSNITELAAVMYHIASSNSIPNIPSHMSQEAFDFLNLCFKRDPKERPDANQLLKHPFI
.||.  . |  | |...      |.||. .|.|. .|.  ||. ||..|. |..||. ||.
KPPFHELGEPQAAMFKVGMYKKHPEIPEELSAECKNFILRCFEPDPCKRASAQDLLQDPFL
Kinase MEKKalpha.AA Dicty2 495-754 40 1.2e-84 287.5 In-house 1-264 (264) Show / Hide 
Range on Protein: 495-754
Range on HMM: 1-264/264
Sequence Identity: 40% (109 aa)

WQKG-QILGRGGYGSVYLGLNKDTGELFAVKQLEIVDINSDPKLKNMIL-SFSKEIEVMRSLRHDNIVRYLGTSLDQSFLSVFLEYIPGGSISSLLGKFG
 | |  ..|.|. | || ||.. ||.  | || .|  .    | ..  . | ..||.  . |.| |||.|..    .. |  .|||| .|| |  . |||
YQIGDEKIGKGAFGTVYKGLHIETGDFVAIKQINI--MKKKTKISEEQHQSIMQEIHLLKKLNHHNIVKYIEHIETENHLYIILEYIENGSLSKIIKKFG

AFSENVIKVYTKQILQGLSFLHANSIIHRDIKGANILIDTKGI---VKLSDFG-CSKS-FSGIVSQFKSMQGTPYWMAPEVIKQTG--HGRSSDIWSLGC
 |.|  . .| .|.|.||  || . .||||||.||||| . |    .||.||| ...  .| . | . .  |||||||||||   |  .  ..|||||||
CFPESLCCIYIYQVLKGLVYLHRQGVIHRDIKAANILITKEGKSGVIKLADFGVATHIDYSDDDSRY-TVVGTPYWMAPEVIQMSGNHCCTACDIWSLGC

VIVEMATAQPPWSNITELAAVMYHIASSNSIPNIPSHMSQEAFDFLNLCFKRDPKERPDANQLLKHPFI
 | |. |  || .    ..| |. .  ..  | .|   | |  |||  ||..|| .|..| |||.|| |
TIIELLTGNPPYWDLNPMHA-MFRMV-QDDHPPLPNDISPECKDFLMQCFCKDPNQRMTAKQLLHHPWI
Kinase MEKKalpha.AA PAKA 495-754 36 1.9e-69 237.06 In-house 1-260 (260) Show / Hide 
Range on Protein: 495-754
Range on HMM: 1-260/260
Sequence Identity: 36% (99 aa)

WQKGQILGRGGYGSVYLGLNKDTGEL--FAVKQLEIVDINSDPKLKNMILSFSKEIEVMRSLRHDNIVRYLGTSLDQSFLSVFLEYIPGGSISSLLGKFG
 .. . .| |. |.||.. |. |..   .|.||...    ...  |..|.    || ||.. .|.|||.|. . | .. | | .||  ||.   .. .. 
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNM----KNQPKKELII---NEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCC

-----AFSENVIKVYTKQILQGLSFLHANSIIHRDIKGANILIDTKGIVKLSDFGCSKSFSGIVSQFKSMQGTPYWMAPEVIKQTGHGRSSDIWSLGCVI
      ..|. |    ...||||.|.|....||||||  |||... | ||. |||     .   .. ..| |||||||||||..   ..  ||||||  .
NIQCNYMDEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMA

VEMATAQPPWSNITELAAVMYHIASSNSIPNI--PSHMSQEAFDFLNLCFKRDPKERPDANQLLKHPFI
 ||.  .||  | . | | || || .| .| |  |  .|||. |||..| . |...|..| .||.|||.
IEMIEGEPPYLNEPPLRA-MYLIA-TNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase MEKKalpha.AA MEKK1 495-634 42 8.7e-43 148.47 In-house 1-139 (266) Show / Hide 
Range on Protein: 495-634
Range on HMM: 1-139/266
Sequence Identity: 42% (59 aa)

WQKGQILGRGGYGSVYLGLNKDTGELFAVKQLEIVDINSDPKLKNMILSFSKEIEVMRSLRHDNIVRYLGTSLDQSFLSVFLEYIPGGSISSLLGKFGAF
| |||..| | . | |      || | ||||   .  ||     . .    |||  |  . | .|.| .|   ..|   || |  ||||.. || ..|||
WTKGQQIGTGAFSSCYMAQDVKTGTLMAVKQITYCRNNSS-DQEDVMEEIRKEIRMMAHFNHPHIIRMMGATCHDSHYNVFIEWMPGGSVAHLLKDYGAF

SENVIKVYTKQILQGLSFLHANSIIHRDIKGANILIDTKG
.. |.  |. |.. |||.|| | |||||.|||| |.|  |
KNSVVINYIHQVCRGLSYLHDNQIIHRDVKGANLLMDSTG
Kinase MEKKalpha.AA TyrKc 495-754 25 5.2e-28 100.29 SMART 1-280 (280) Show / Hide 
Range on Protein: 495-754
Range on HMM: 1-280/280
Sequence Identity: 25% (75 aa)

WQKGQILGRGGYGSVYLGLNKDTGELFAVKQLEIVDINSDPKLKNMILSFSKEIEVMRSL--RHDNIVRYLGTSLDQ-------SFLSVFLEYIPGGSIS
 ..|..||.| .| ||.|  |   .  ||| |              .  | .|...|..|  .|.|||| .|  ..|         | . .|| |.|.  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

SLLGKFGA-FSENVIKVYTKQILQGLSFLHANSIIHRDIKGANILIDTKGIVKLSDFGCSKSFSGI------VSQFKSMQ--GTP-----YWMAPEVIKQ
. | | .  ..      .  || .| ..|| . .||||.   |.|.. ...|| |||| |.            .  ....  |.       |||||.|. 
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

TGHGRSSDIWSLGCVIVEMAT-AQPPWSNI----TELAAVMYHIASSNSIPNIPS-------HMSQEAFDFLNLCFKRDPKERPDANQLLKHPFI
      ||.|| | .. |. |  |.|....     . . |. .. . .  |  |.       ....| ..    | ..||..||  ...  | ..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase MEKKalpha.AA MEKK1 659-754 42 5.4e-25 88.48 In-house 169-266 (266) Show / Hide 
Range on Protein: 659-754
Range on HMM: 169-266/266
Sequence Identity: 42% (42 aa)

GTPYWMAPEVIKQTGHGRSSDIWSLGCVIVEMATAQPPWSN--ITELAAVMYHIASSNSIPNIPSHMSQEAFDFLNLCFKRDPKERPDANQLLKHPFI
||   |||||      ||| |||| || |.||... ||| |  .    . .. ||| |  | ||.|.|    |    |   .| .||    |||||  
GTIAFMAPEVLRGQQYGRSCDIWSVGCCIIEMCCTKPPWNNEKHSNHYQLIFKIASANTPPPIPEHLSPGLRDITLRCLEAQPQDRPPVMELLKHPVF
Kinase MEKKalpha.AA Pkinase_Tyr 495-642 27 5.7e-23 78.41 Pfam 1-156 (270) Show / Hide 
Range on Protein: 495-642
Range on HMM: 1-156/270
Sequence Identity: 27% (45 aa)

WQKGQILGRGGYGSVYLGLNK----DTGELFAVKQLEIVDINSDPK-LKNMILSFSKEIEVMRSL-RHDNIVRYLGTSL-DQSF--LSVFLEYIPGGSIS
 ..|. ||.| .|.||.|  |    .|.   ||| |     ..... .  .. .| .|...|..| .|.||||..|  . ..    . . .|| |.|.  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE---GAMHEQN--CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

SLLGK----FGAFSENVIKVYTKQILQGLSFLHANSIIHRDIKGANILIDTKGIVKLSDFG
. | |     ....   .  .  || .|...|... .||||.   |.|.. ...|| .|||
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase MEKKalpha.AA Pkinase_Tyr 663-754 26 2.1e-08 29.09 Pfam 180-270 (270) Show / Hide 
Range on Protein: 663-754
Range on HMM: 180-270/270
Sequence Identity: 26% (25 aa)

WMAPEVIKQTGHGRSSDIWSLGCVIVEMAT-AQPP-WSNITELAAVMYHIASSNSIPNIPSHMSQEAFDFLNLCFKRDPKERPDANQLLKHPFI
|||||.|.       ||.|| | .. |. |  . | . ..   . |. .|. ..    .| . ..|  | . .| . ||..||   ..  | ..
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL
FBOX MEKKalpha.AA FBOX 849-889 31 1.4e-10 42.35 SMART 1-41 (41) Show / Hide 
Range on Protein: 849-889
Range on HMM: 1-41/41
Sequence Identity: 31% (13 aa)

LPINLIILIFREIKPNFVNTLSRVCKHWKQIIDDDELWNKY
.||...  ||  ..|    ....||..|..|||....|.|.
MPIEILNEIFSHLDPKDRCRCRKVCRKWRSIIDSHDFWFKH
F-box MEKKalpha.AA F-box 844-891 27 6.6e-09 34.17 Pfam 1-46 (46) Show / Hide 
Range on Protein: 844-891
Range on HMM: 1-46/46
Sequence Identity: 27% (13 aa)

SINIILPINLIILIFREIKPNFVNTLSRVCKHWKQIIDDDELWNKYCS
.    ||. ..  ||.   |  . ....|||.|..|.|.. .|  .|.
FPWSDLPDDILREIFSHMDPKDLCRCRCVCKRWRSIVDSP-FWF-FCL
WD40 MEKKalpha.AA WD40 924-962 27 1.8e-11 35.62 Pfam 19-57 (39) Show / Hide 
Range on Protein: 924-962
Range on HMM: 19-57/39
Sequence Identity: 27% (11 aa)

KLNHSTLKGHDKGVFCVKLIDD-QGMVLSGGEDKKLKVWD
.   .|. || ..| |..  .| . ...||..|.....||
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 MEKKalpha.AA WD40 923-962 27 1.8e-09 38.72 SMART 1-46 (46) Show / Hide 
Range on Protein: 923-962
Range on HMM: 1-46/46
Sequence Identity: 27% (13 aa)

NKLNHSTLKGHDK--GVFCVKLIDDQ------GMVLSGGEDKKLKVWD
.    .|.|||..  .| ||.  .|        ...||. |.....||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 MEKKalpha.AA WD40 1007-1049 13 1.3e-05 18.74 Pfam 1-39 (39) Show / Hide 
Range on Protein: 1007-1049
Range on HMM: 1-39/39
Sequence Identity: 13% (6 aa)

SRYLFSLKGHSGCIKSVDYQRQSGSDVSRVFTASADFTCKIFS
.  . .. ||.. . ....      . ......|.| |..|..
WKCKHTF-GHTHWVTCCAWHPD---MGHYLASGSRDGTIRIWD
WD40 MEKKalpha.AA WD40 1006-1049 22 7.1e-05 23.44 SMART 1-46 (46) Show / Hide 
Range on Protein: 1006-1049
Range on HMM: 1-46/46
Sequence Identity: 22% (11 aa)

NSRYLFSLKGHSG--CIKSVDYQRQSGS--DVSRVFTASADFTCKIFS
. . ....|||.|   . .|..   .||  . ......| | |..|..
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 MEKKalpha.AA WD40 1053-1092 32 1.6e-09 30.03 Pfam 1-39 (39) Show / Hide 
Range on Protein: 1053-1092
Range on HMM: 1-39/39
Sequence Identity: 32% (13 aa)

KKTLFTYTNHQEAVTCINYLGDVENKCITSSLDKTIQLWD
.| . |.  |. .|||. .  |  . ....| |.|| .||
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 MEKKalpha.AA WD40 1052-1092 31 1.9e-08 35.29 SMART 1-46 (46) Show / Hide 
Range on Protein: 1052-1092
Range on HMM: 1-46/46
Sequence Identity: 31% (15 aa)

TKKTLFTYTNHQE--AVTCINYLGDV-----ENKCITSSLDKTIQLWD
| | ..|.. |.   .|||. .  |      .|  ...| |.|| .||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 MEKKalpha.AA WD40 1096-1141 28 2.7e-12 37.99 Pfam 1-39 (39) Show / Hide 
Range on Protein: 1096-1141
Range on HMM: 1-39/39
Sequence Identity: 28% (13 aa)

GSCLSTLRGHTGGIYCVKTDQVATHGNGYNHLVVSASVDKTSNVWD
. |..|. |||....|.. ..       . |...|.| |.|  .||
WKCKHTF-GHTHWVTCCAWHPD------MGHYLASGSRDGTIRIWD
WD40 MEKKalpha.AA WD40 1095-1141 32 1.8e-08 35.38 SMART 1-46 (46) Show / Hide 
Range on Protein: 1095-1141
Range on HMM: 1-46/46
Sequence Identity: 32% (16 aa)

TGSCLSTLRGHTG--GIYCVKTDQVATHGNGYNHLVVSASVDKTSNVWD
| .|..|..||||  ...||. ..   .. .|.....|.| |.|  .||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSD-DYPNYLASGS-DGTIRIWD
WD40 MEKKalpha.AA WD40 1145-1181 35 1.4e-10 33.04 Pfam 1-39 (39) Show / Hide 
Range on Protein: 1145-1181
Range on HMM: 1-39/39
Sequence Identity: 35% (14 aa)

SSKVRSFTQHTEDVLCCYVFDQ---KVVTGSCDGTIKLWD
.  ...|  ||  | || . .     ...||.||||..||
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 MEKKalpha.AA WD40 1144-1181 29 3e-08 34.65 SMART 1-46 (46) Show / Hide 
Range on Protein: 1144-1181
Range on HMM: 1-46/46
Sequence Identity: 29% (14 aa)

SSSKVRSFTQHTE--DVLCCYVFDQ--------KVVTGSCDGTIKLWD
. . |..|. ||   .|.|. . .          ...|| ||||..||
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 MEKKalpha.AA WD40 1184-1225 25 0.001002 19.29 SMART 1-46 (46) Show / Hide 
Range on Protein: 1184-1225
Range on HMM: 1-46/46
Sequence Identity: 25% (13 aa)

TGKTISTFIPSETRQKN--YVWTVQFDQS--------KIISSGKTGIIRIWD
| | ..||       ..  .|..|.....         ..|..  | |||||
T-KCVHTFK----GHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD
WD40 MEKKalpha.AA WD40 1199-1225 26 0.001634 12.73 Pfam 10-39 (39) Show / Hide 
Range on Protein: 1199-1225
Range on HMM: 10-39/39
Sequence Identity: 26% (8 aa)

KNYVWTVQFDQS---KIISSGKTGIIRIWD
.. |. . ....    ..|..  | |||||
THWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 MEKKalpha.AA WD40 1229-1265 20 7.1e-08 25.29 Pfam 1-39 (39) Show / Hide 
Range on Protein: 1229-1265
Range on HMM: 1-39/39
Sequence Identity: 20% (8 aa)

ERDSRSIGGHHETIFSLQFNNQ---KLITGSLDKLVKIWS
    ... ||  .. .. ..      |..|| |. ..||.
WKCKHTF-GHTHWVTCCAWHPDMGHYLASGSRDGTIRIWD
WD40 MEKKalpha.AA WD40 1228-1265 16 3e-06 28.24 SMART 1-46 (46) Show / Hide 
Range on Protein: 1228-1265
Range on HMM: 1-46/46
Sequence Identity: 16% (8 aa)

NERDSRSIGGHHE--TIFSLQFNNQ--------KLITGSLDKLVKIWS
. .  ... ||     . .....           |..|| |. ..||.
T-KCVHTFKGHTGNSWVTCVCWHPDGGSDDYPNYLASGS-DGTIRIWD