Gene MkcF (Slime mold)
MkcF
Sequence
Protein domains of MkcF.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| SH3 | MkcF.AA | SH3 | 2-57 | 34 | 2.9e-13 | 51.33 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 2-57 Range on HMM: 1-58/58 Sequence Identity: 34% (20 aa) LYLVATGDYKGPSENHLSFTKGQRIEFLERTENGFIKGKLD--GKVGIFPSSLITIET | .| ||.. ....|||.||. |. ||....| ||... |..|.|||. ... . PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID |
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| SH3_2 | MkcF.AA | SH3_2 | 3-56 | 20 | 4e-10 | 38.33 | Pfam | 1-68 (68) | Show / Hide |
Range on Protein: 3-56 Range on HMM: 1-68/68 Sequence Identity: 20% (14 aa) YLVATGDYKG-PSENH-----LSFTKGQRIEFL---ERTENGFIKG-KL--DGKV--GIFPSSLITIE | ... ||.. ...|. |.|.||. |. . .. ...... .|.. | |||. . . YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC |
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| SH3_1 | MkcF.AA | SH3_1 | 5-50 | 36 | 1e-06 | 25.48 | Pfam | 1-49 (49) | Show / Hide |
Range on Protein: 5-50 Range on HMM: 1-49/49 Sequence Identity: 36% (18 aa) VATGDYKGPSENHLSFTKGQRIEFLERTEN-GFIKGKLD--GKVGIFPS || ||.. ....|||.|| |. .|.... . ||... |..|.||| VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS |
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| Kinase | MkcF.AA | MKC | 401-646 | 49 | 3.5e-191 | 641.44 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 401-646 Range on HMM: 1-260/260 Sequence Identity: 49% (129 aa) IKFTHMVGRGQYGKVYDALY-------DKKRVCVKVVNYSTPKEQHNVLQEIGFLTQCDHPNILKYNCSVLYGS-DLFIVSEFIQGGTLEQASASSHVFK .||.|.||.|..|.||.|.| ||.||..|.....|.|.|.|.|.|||||..|.||||.||.||..... ....|.||.||||||.||..||.|. YKFLHQVGKGGFGTVYCAKYNNPHSTYDKCRVAIKKMPHVTKKHQRNNLNEIGFLNYCNHPNIVKYHCSHMKHDDEIWMVMEFMQGGTLEEASQNSHKFC ETQVGFIGLELLKAISYLHEKKLIHRDIKAANVMVSTDGEVKLIDFGLCASVEK-GGSQHMVGSPYYMSPEMIRGEECSYPSDIWSFGICILELLFKKPP |........|.|....||||....|||.|.||.|..||||.||||||||..|.. ....||.|||..||||||.....|||.||||||||.||.....|| ESCIAYVCKEMLQGLMYLHEHNIVHRDLKSANIMMNTDGEIKLIDFGLCIDVSHEKEEIHMCGSPFWMSPEMIQQKQHSYPCDIWSFGICLLEMANGRPP HRDSRMKAMFYNAINGIDFP-----KIRCSIDLKDMLWQCFESNPEKRSTVDKLMRHPFF |..|||||||..|.||..|| ....|....|.||||....|.||.|...|..|||. HHKSRMKAMFMVATNGCKFPKEFDDPCHWSDCFHDFLWQCLQMDPHKRPTAEQLLKHPFI |
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| Kinase | MkcF.AA | STE20 | 401-646 | 34 | 3.6e-108 | 365.68 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 401-646 Range on HMM: 1-288/288 Sequence Identity: 34% (99 aa) IKFTHMVGRGQYGKVYDALYDK---KR----VCVKVVNYSTP----KEQHNVLQEIGFLTQCDHPNILKYNCSVLYG----SDLFIVSEFIQGGTLEQAS .... .|.| ||||| | |.| . |..|..|.... .|......|| .. ||.|||| || .| |.. ..|.|| |. .||.| .. YELLEKIGQGSYGKVYKA-YHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM ASS---------HVFKETQVGFIGLELLKAISYLHEKKLIHRDIKAANVMVSTDGEVKLIDFGLCASVEK-------GGSQHMVGSPYYMSPEMIRG--- . |...| |. .| |.|.. .|||... |||||||.|.....||||||.|||.||...| . ...||.||.|.||.|.. KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEG --EECSYPSDIWSFGICILELLFKKPPHRD-SRMKAMFYNAINGIDFP------KIRCSIDLKDMLWQCFESNPEKRSTVDKLMRHPFF . | .||||.||...|.. .||..| ..|.|||. . |. ..| . ..| ...|....| . .|||| |...|..|||. PDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI |
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| Kinase | MkcF.AA | STE | 401-646 | 23 | 2.4e-91 | 309.76 | In-house | 1-359 (359) | Show / Hide |
Range on Protein: 401-646
Range on HMM: 1-359/359
Sequence Identity: 23% (86 aa)
IKFTHMVGRGQYGKVYDALYD-----------------KKRVCVKVVNYSTP-----------------KEQHNVLQEIGFLTQCD--HPNILKYNCSVL
.. ..|.| .|.|| |.. .... .|..|... .|. ..|.|| .. .|. |||| || .. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
YG-------SDLFIVSEFIQGGTLEQASASS--------------HVFKETQVGFIGLELLKA-ISYLHEKKLIHRDIKAANVMVSTDGEVKLIDFGLCA
.. ..|.|. |.. ||.|.. . |.|.|.|...| ..||. .|||... ||||||.||... |||.|||.|.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG
SVEK------------------GGSQHMVGSPYYMSPEMIRGEE------CSYPSDIWSFGICILELLFKKPPHRD-SRMKAMFYNAING----------
.... . ....||.| .|.||.|.... ... .||||.|..|.|.. |||. | . |.|||. ..|.
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC
---IDFPKI---------------------RCSIDLKDMLWQCFESNPEKRSTVDKLMR--HPFF
. |.. ..| ..|| . .|.. .|.|| |...|.. |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
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| Kinase | MkcF.AA | S_TKc | 401-646 | 26 | 5.2e-73 | 249.79 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 401-646 Range on HMM: 1-231/231 Sequence Identity: 26% (69 aa) IKFTHMVGRGQYGKVYDALYDK--KRVCVKVVNYSTPKEQHNVLQEIGFLTQCDHPNILKYNCSVLYGSDLFIVSEFIQG--GTLEQASASSHV------ .. .|.| .|||| . | ..| .|... ....|| | . .|||| |. . ..|..| |.. | |.| . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP FKETQVGFIGLELLKAISYLHEKKLIHRDIKAANVMVSTDGEVKLIDFGLCASVEKGGSQHMVGSPYYMSPEMIRGEECSY-PSDIWSFGICILELLFKK | | .. |. ....|. |.|... ||||.| .|..... ..|..||||.. . ...|.|.||.||.. .. ..|.||.|... |.| . FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGY PPHRDSRMKAMFYNAINGIDFPKIRCSIDLKDMLWQCFESNPEKRSTVDKLMR-------HPFF || . |..|| . | ..||.. .|.. .|||| |. .... ||.| PPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | MkcF.AA | Pkinase | 401-646 | 23 | 2e-63 | 221.85 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 401-646 Range on HMM: 1-293/293 Sequence Identity: 23% (70 aa) IKFTHMVGRGQYGKVYDALYDKKR--VCVKVVNYSTPKE---QHNVL-QEIGFLTQCDHPNILKYNCSVLYGSDLFIVSEFIQGG----TLEQASA--SS ... .|.| .|.|| . . . |.||...... |. |.... .|| . ..||||... ... ..... .| |. .|| | .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH HVF--KETQVGFIGLELLKAISYLHEKKLIHRDIKAANVMVSTDGEV----KLIDFGLCA---SVEKGGSQHMVGSPYYMSPEMIR-GEECSYPSDIWSF .| | .. |. ...|... |.|... ||||.| .|.... .|.. |..||||.. .. .. .|.|.||.|| || |.. ....|.||. GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC GICILELLFKKPPHRDS------RMKAMFYNAIN---GIDFPKIRC------------------SIDLKDMLWQCFESNPEKRSTVDKLMRHPFF |. . |.|...|| ... ....|... |.|. .. | ..|| . |.. .|.|| | . .. ||.| GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | MkcF.AA | Ciliate-E2 | 401-646 | 21 | 2e-55 | 188.71 | In-house | 1-365 (365) | Show / Hide |
Range on Protein: 401-646
Range on HMM: 1-365/365
Sequence Identity: 21% (83 aa)
IKFTHMVGRGQYGKVYDA-------LY------------------DKKRVCVKVVNYSTPKEQHN---VLQEIG----------FLTQCDHPNILKYNCS
.|| . |.|..|.|| . .. ..| . .|... . ... . ...|| | | .||||.|. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC
VL--YGSDLFIVSEFIQGGTLEQ-----ASASSHV------FKETQVGFIGLELLK---------------AISYLHEKK-LIHRDIKAANVMVSTDGEV
. ...| |..|||.|.. . | |.| ....| ..|. |. |||.|. |||||| |... .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I
KLIDFGLCASVEKG------GSQHM---------------------------VGSPYYMSPEMIRGEE---------CSYPSDIWSFGICILELLFKKPP
|.|||||. . . ..|. .|.|.||.||...|.. .| .||||.|... |.||.|||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP
HRDSRMKAMFYNAING--IDFP-----------------KIRCSIDLKDMLWQ----CFESNPEKRST-VDKLMRHPFF
.. | |||| . .| . ||.. . ... .|||| | .... ||.|
F---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | MkcF.AA | YSK | 402-646 | 34 | 3.8e-54 | 161.25 | In-house | 2-257 (257) | Show / Hide |
Range on Protein: 402-646 Range on HMM: 2-257/257 Sequence Identity: 34% (89 aa) KFTHMVGRGQYGKVYDALYDK--KRVCVKVVNYSTPKEQ-HNVLQEIGFLTQCDHPNILKYNCSVLYGSDLFIVSEFIQGGTLEQASASS--HVFKETQV . . .|||..| || . . . | .|... . . ||| || ||| |.| || | | .. | |. |. || . . .. | |... TKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKYI GFIGLELLKAISYLHEKKLIHRDIKAANVMVSTDGEVKLIDFGLCASVE--KGGSQHMVGSPYYMSPEMIRGEECSYPS--DIWSFGICILELLFKKPPH ..| |.||. .|||. . |||||||||| .| .|.||| ||| . . . .||.||.| || | | .| . |||| || .|.. ||. AIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPPY RDSR-MKAMFYNAINGIDFPKIRC---SIDLKDMLWQCFESNPEKRSTVDKLMRHPFF | |..|| | || | .|. | . .||.| . . | | | CDYHPMRVMF--LIPKNNPPKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI |
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| Kinase | MkcF.AA | PAKA | 402-646 | 32 | 1.2e-51 | 177.9 | In-house | 2-260 (260) | Show / Hide |
Range on Protein: 402-646 Range on HMM: 2-260/260 Sequence Identity: 32% (85 aa) KFTHMVGRGQYGKVYDALYDKKR----VCVKVVNYSTPKEQHNVLQEIGFLTQCDHPNILKYNCSVLYGSDLFIVSEFIQGGTL----EQASASSHV-FK ||. .| | |.|| | | | .|. | ... ... ||. . .| |.|| .| | |. ..|..| |. .|| | .| . . .. KFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYMD ETQVGFIGLELLKAISYLHEKKLIHRDIKAANVMVSTDGEVKLIDFGLCASVEKGGSQH--MVGSPYYMSPEMIRGEECSYPSDIWSFGICILELLFKKP | |.... | |......|.|. |||||| |. . .||.||. ||| || .. .. ||| ||.|.|| ||. . .. |||| || ..|.. | EGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGEP PH-RDSRMKAMFYNAINGIDFPKIR----CSIDLKDMLWQCFESNPEKRSTVDKLMRHPFF |. .. .||.. | ||. |.|. | ...| | .| . ....| ....|..|||. PYLNEPPLRAMYLIATNGK--PDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL |
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| Kinase | MkcF.AA | CAMK | 406-646 | 16 | 1.2e-51 | 164.25 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 406-646
Range on HMM: 1-425/425
Sequence Identity: 16% (70 aa)
MVGRGQYGKVYDALY--DK------------KRVCVKVVNYS----------------------------TPKEQHNVLQEIGFLTQC-------DHPNI
|||..|||. . .. ..| .|... . .|| ..||..|| . .. |||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
LKYNCSVL-----------------YGS---DLFIVS---EFIQGG----TLEQASASS---------------HVFKETQVGFIGLELLKAISYLHEKK
.| . . ....| |...|| | . . . |.| .. .. .. |. |.|...
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
LIHRDIKAANVMVSTD-----------------GEVKLIDFGLCASVEKGGSQH-------------------------MVGSPYYMS-PEMIRG-----
.|||.| |...... . .|.||||. . ...| ... ..|.|.||. ||...|
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
---------EECSYPSDIWSFGICILELLFKKPPHRDS-------------RMKAMFYNAINGI-DFPKIR-----------------------CSIDLK
. .....|.|| |. .| .|| ... .. .| . ..| ||| .| . |
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK
DMLWQCFESNPEKRSTVDKLMRHPFF
|.. .. . .|||| |.. ..||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
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| Kinase | MkcF.AA | Ciliate-E2-Unclassified | 401-646 | 22 | 1.3e-50 | 173.81 | In-house | 1-352 (352) | Show / Hide |
Range on Protein: 401-646 Range on HMM: 1-352/352 Sequence Identity: 22% (79 aa) IKFTHMVGRGQYGKVYDALYDKKRVCV--------------KVVNYS--------TPKEQH--------NVLQEIGFLTQCDHPNILKYNCSVLYGSDLF |. . |.|..|||| . .|. . | .... . ... .|. | ...||.|.|. .. YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQ--ILLNHPHPFIVKMFYCFQDKQNIY IVSEFIQGGTLEQASASS-----------------HVFKETQVG-----FIGLELLKAISYLHEKK-LIHRDIKAANVMVSTDG---EVKLIDFGLCASV || |...||.|.| .. . | | |. |. ..|....|||.|. |||||| |.... .| ..|.||||.. IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY E-----KGG-------------SQHMVGSPYYM----SPEMIRGEECS----YPSDIWSFGICILELLFKKPPHRDSRMKA---------------MFYN . . . .....|.|.|| .||...|.. . | .||||.|... |.|| ..| | . ..|. QQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQ AING--IDFPK-------IRCSIDLKDMLW----QCFESNPEKRSTVDKLMRHPFF |. |.||| . | ||.. .... ||.|| | .... ||.| NIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | MkcF.AA | SLK | 402-646 | 30 | 4.2e-47 | 156.88 | In-house | 2-259 (259) | Show / Hide |
Range on Protein: 402-646 Range on HMM: 2-259/259 Sequence Identity: 30% (79 aa) KFTHMVGRGQYGKVYDALYDKKRV--CVKVVNYSTPKEQHNVLQEIGFLTQCDHPNILKYNCSVLYGSDLFIVSEFIQGGTLEQASAS-SHVFKETQVGF . .| | .|||| | ..| |... | . . || |..|.||||.| . | .|... || .|| ... |. .| |. . EIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQY IGLELLKAISYLHEKKLIHRDIKAANVMVSTDGEVKLIDFGLCASVEKGGSQH--MVGSPYYMSPEMIRGEECS-----YPSDIWSFGICILELLFKKPP .. ... |. .||..|.||||.|| |... ||.|.| ||| | .. .. .| ||.| ||.. | | .||||.|| ..|. || VCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEPP HRD-SRMKAMFYNAINGIDFPKI----RCSIDLKDMLWQCFESNPEKRSTVDKLMRHPFF | . . |. .. |. . |.. . | . ||.| .| . .|..| | ..||.|... HHEMNPMRVLL--KIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV |
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| Kinase | MkcF.AA | TKL | 407-644 | 18 | 3.3e-45 | 156.53 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 407-644
Range on HMM: 1-364/364
Sequence Identity: 18% (69 aa)
VGRGQYGKVYDALYDK----------KRVCVKVVNYS------------------------TPKEQHNVLQEIGFLTQ---CDHPNILKYNCSVLYGSD-
.|.| .|.|| . . | | ||. . |. ... .|. . . ..||||... .......
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------LFIVSEFIQGGT-LEQASASSHVFKETQVGFIGLELLKAISYLHE--------KKLIHRDIKAANVMVSTDGE--------------V
|.|| |...||. |.. | . |. ....||| ...||||.| .|..| ... .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC
KLIDFGLCASVEKGGSQHM---------------------VGSPYYMSPEMIRGE----------------ECSYPSDIWSFGICILELLFKKPPHRDSR
|. ||||. .... |.. . .|.|..|.||..||. | | .|..||||.. |.| ..| .|
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP
MK---------AMFYNAINGIDFPKIR--------------CSIDLKDMLWQCFESNPEKRSTVDKLMRHP
. .||. ... | | | ..|. . .| ...|||| . .... .
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | MkcF.AA | TyrKc | 401-646 | 21 | 1.9e-17 | 59.48 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 401-646 Range on HMM: 1-280/280 Sequence Identity: 21% (62 aa) IKFTHMVGRGQYGKVYDALYDKKRVCVKVVNYSTPKEQHNVLQEIGFLTQC--DHPNILKYNCSVLYG-------SDLFIVSEFIQGGTLEQA-SASSHV |.. .. |.|..|.|| . .. | ||... .. . ..|. ... .||||.. .. . |.|| |. .| | . .. . ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK FKETQVGFIGLELLKAISYLHEKKLIHRDIKAANVMVSTDGEVKLIDFGLCASVEKG------GSQHMV----GSP-----YYMSPEMIRGEECSYPSDI .. . . . . .|||.|..||||. | |..|. .. || ||||. .. . .. .. |. |.|| |. ... ||. LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV WSFGICILELL-FKKPPHRD-----SRMKAMFYNAING--IDFPKI-------RCSIDLKDMLWQCFESNPEKRSTVDKLMRHPFF ||||.|. |.. . ..|. . . .. . .| . |. .|. .. .. || . .||.| | . | .| WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | MkcF.AA | Pkinase_Tyr | 505-586 | 34 | 5.6e-13 | 44.58 | Pfam | 122-208 (270) | Show / Hide |
Range on Protein: 505-586 Range on HMM: 122-208/270 Sequence Identity: 34% (30 aa) KAISYLHEKKLIHRDIKAANVMVSTDGEVKLIDFGLCASVEKGGSQ-HMVG---SPY-YMSPEMIRGEECSYPSDIWSFGICILELL |. .||..|..||||. | |..|. .. || ||||. ... . .. | | |.|| |. ... ||.||||... |.. KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIF |
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| Kinase | MkcF.AA | Pkinase_Tyr | 401-481 | 24 | 6.9e-13 | 44.28 | Pfam | 1-94 (270) | Show / Hide |
Range on Protein: 401-481 Range on HMM: 1-94/270 Sequence Identity: 24% (23 aa) IKFTHMVGRGQYGKVYDALYD------KKRVCVKVV-NYSTPKE--QHNVLQEIGFLTQC-DHPNILKYNCSVL-YGSD--LFIVSEFIQGGTL |.| .. |.|..|.|| . .. | | ||.. ....... . ..|. ..| .||||... .. | ..|| |. ..| | ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL |
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