Gene 26273 (Tetrahymena)

26273

Species: Tetrahymena
Alias: 122.m00075, TTHERM_00752050, 26273, 913, PreTt26273
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C8

Sequence

Name Sequence Type Origin Length Description Download
26273.AA Protein None 1633 None Fasta, JSON
26273.kin_dom Protein Kinase Domain None 215 None Fasta, JSON
26273.kin_dom2 Protein Kinase Domain None 208 None Fasta, JSON
26273.NA RNA None 4902 None Fasta, JSON

Protein domain

Protein domains of 26273.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 26273.AA C8 94-305 59 9.5e-117 394.16 In-house 1-226 (226) Show / Hide 
Range on Protein: 94-305
Range on HMM: 1-226/226
Sequence Identity: 59% (135 aa)

FQNFEYLNSGAYALVLKAQNIKSNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMDEDVEVDKNGNKKP---KEKSFFVTEME
|.||.||..|||..||||.|.|.||...|||..|..|.  ..|||..||||..|.|.|.||.||.|||||.| |..| .|..|.|    .|||.|| |||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

LCEQNLKQLFDYLRNTQLP-SQEIKEIIAIQMLEGLNTLHTKNIMHRDIKPHNFLVCPSQTYGFTIKICDLGFASAITKSKTHYPSKK----GTEAYFAP
|||||||||.|..||.|.. |.|.||||||||..|.|..| ||||||||||||||||..|.|||.||.||.||||...|.| |. |||    || |||||
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFAP

EVENG------ESRIQSDLFSLGLVL
|.|..      ..||||||||.||||
EIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 26273.AA Ciliate-C8 103-305 52 2.4e-112 379.56 In-house 1-238 (238) Show / Hide 
Range on Protein: 103-305
Range on HMM: 1-238/238
Sequence Identity: 52% (126 aa)

GAYALVLKAQNIKSNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMDEDVEVDKNGNKKP---KEK---SFFVTEMELCEQN-
||...||||||.|.||.|||||..|..|.  ...|...||||....|.|..|.|.|||||||| |... |..||.|    .||   |||| |||.|.|| 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

-LKQLFDYLRNTQLP-SQEIKEIIAIQMLEGLNTLHTKNIMHRDIKPHNFLVCPSQTYGFTIKICD------LGFASAITKSKTHYPSKK--GTEAY---
 |||.||..|..|.. ||..||||||||....|.|| .|||||||||||||||..|.|..|||.||      .||||...|.|.|| |||  ||..|   
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

--------FAPEVENGESRIQSDLFS-------LGLVL
        ||||||.. ||||||.||       .||||
YFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 26273.AA C2 103-318 38 4.4e-67 228.18 In-house 1-245 (245) Show / Hide 
Range on Protein: 103-318
Range on HMM: 1-245/245
Sequence Identity: 38% (94 aa)

GAYALVLKAQNIKSNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMDEDVEV----------DKNG--NKKPKEKSFFVTEME
|| .||||| | |.|| ||||   | | . ..| ... |||....... . ....||..|||  .. |           ...   . | . |.|.| |.|
GAFGLVLKAFNKKQNRHVALKIQECQSND-INGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

LCEQNLKQLFDYLRNTQ-LPSQEIKEIIAIQMLEGLNTLHTKNIMHRDIKPHNFLVCPSQTYGFTIKICD----------LGFASAITKSKT-HYPSK-K
 |. |||| |. .|. .  |.|..|.|.||||. . | || ..| |||||| |||.  .|    |||.||          . |||.. ..|.  . || |
FCQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFK

GTEAY----FAPEVENGESRIQSDLFS-LGLVLLELDNLNVLNQNW
.|..|    |||||. .  . .||||| .|.||||||| .  . . 
WTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 26273.AA Pkinase 94-308 23 7.1e-33 117.32 Pfam 1-205 (293) Show / Hide 
Range on Protein: 94-308
Range on HMM: 1-205/293
Sequence Identity: 23% (53 aa)

FQNFEYLNSGAYALVLKAQNIKSNRMVALKFLTCTSKEGLKGIESLK-KEYELLQKFSQSDFLVNVYDCFYLMDEDVEVDKNGNKKPKEKSFFVTEMELC
..  . . ||... | |.........||.| .   ...  | .. ..  | ...... .... |  ||.|.                | .  .|.|   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED---------------KDHIYMVMEYCEG

-EQNLKQLFDYLR---NTQL--PSQEIKEIIAIQMLEGLNTLHTKNIMHRDIKPHNFLVCPSQTYGFTIKICDLGFASAI-TKSKTHYPSKKGTEAYFAP
 .  .  ||||..   .. .  . .|.| ..  |.|.||. .| ..|.|||.|| |.|.    . . ..|||| |.|  . . ... . .  ||  | ||
GLY-VMDLFDYISTWRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAP

EV--ENGESRIQSDLFSLGLVLLEL
||  .. .    .| .|.|..| |.
EVIRGGQYYGPKVDMWSCGCILYEM
Kinase 26273.AA CMGC 94-273 15 1.2e-28 90.54 In-house 1-285 (513) Show / Hide 
Range on Protein: 94-273
Range on HMM: 1-285/513
Sequence Identity: 15% (46 aa)

FQNFEYLNSGAYALVLKAQN--------------IKSNRMVALKFLTCTSKEGLKGI---------ESLKKEYELLQKFS---------------QSDF-
... ... .|.|. | |...              ...|..||.| .     .   .           .   | ..|....               . .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVNVYDCFY--LMDEDVEVDKNGNKKPKEKSFFVTEMELCEQNLKQLFDYLR-------NTQLPSQE------------IKEII-----AIQMLEGLN--
.|. ||.||   .| . . ||.   .. .   .   .|.....|.|. .  .       .  |.  .            || ..     . |.|.||.  
IVKLYDIFYHKNSDGNEYEDKHII-SQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLK

TLHTKN--IMHRDIKPHNFLVCPSQTY----------------GFTIKICDLGFASAITKS------------------------KTHY
 .| ..  |.|||.|| | |...  ..                 ...|||| |.| .. .                          |||
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHY
Kinase 26273.AA S_TKc 94-371 21 1.6e-27 98.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 94-371
Range on HMM: 1-231/231
Sequence Identity: 21% (64 aa)

FQNFEYLNSGAYALVLKAQNIKSNRMVALKFLTCTSKEGLKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMDEDVEVDKNGNKKPKEKSFFVTEMELCE
..  . . .||.. | |....|..| ||.| .           |....| ..|.|  . ...|. ||.|.                 .. ..|  ||.|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD----------------DHLYMV--MEYCD

QNLKQLFDYLRNTQ-------LPSQEIKEIIAIQMLEGLNTLHTKNIMHRDIKPHNFLVCPSQTYGFTIKICDLGFASAITKSKTHYPSKKGTEAYFAPE
..|  ||||... .       .|  ... ... |....|. .| ..|.|||.|| | |..       .||||| |.|  .        .  ||  | |||
GDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPE

VENGESRIQSDLFSLGLVLLELDNLNVLNQNWIGFEIKREIYQGEGIASKYQIDRNSNIYKIVEICLKPNYLERTTSGDLLS--------ELI
|  | ..  .|  |.| .| |.     . .    ... . |               .    ... ||. .  .| |  ..|         . .
VL-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 26273.AA STE 94-308 19 1e-24 84.26 In-house 1-261 (359) Show / Hide 
Range on Protein: 94-308
Range on HMM: 1-261/359
Sequence Identity: 19% (56 aa)

FQNFEYLNSGAYALVLKAQNIK---------------SNRMVALKFLT---CTSKEGL------------KGIESLKKEYELLQKFSQ-SDFLVNVYDCF
... | . .||.  | || |.|               .....| | .    |..|.              . .....|| ....|... ... |. |.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

YLMDEDVEVDKNGNKKPKEKSFFVTEMELCE-QNLKQLFDYLRNTQLPS-----------QEIKEIIAIQMLEG-LNTLHTKNIMHRDIKPHNFLVCPSQ
.  ...           |...     ||...   | .. .    .. |             ..  .|. | |.| |. || ..|.|||||| | |.    
FKEGHN----------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----

TYGFTIKICDLGFASAITKSKT----------------HYPSKKGTEAYFAPEVENG-ESR------IQSDLFSLGLVLLEL
     .|.|| |... .|.| .                .  .  ||  . |||| .. ..       ...|  |||....|.
-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase 26273.AA CAMK 99-305 15 4.4e-24 73.86 In-house 1-324 (425) Show / Hide 
Range on Protein: 99-305
Range on HMM: 1-324/425
Sequence Identity: 15% (51 aa)

YLNSGAYALVLKAQNIKSN------------RMVALKFLTCTSKEG-------------------------LKGIESLKKEYELLQKFS------QSDFL
 | .|... | ........            . || |..  .   .                          |  .....|.|...| .      .   .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNVYDCFY-------LMDEDVEVDKNGNKKP----------KEKSFFVT-EMELCEQN--LKQLFDYLR-NTQ---------------LPSQEIKEIIAI
.. |. .                       .          ... ..|.  ||.|.    .  ||||.. ...               .. .| . ..  
IKLYEVYEDPHYFKNT-------------NDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFR-

QMLEGLNTLHTKNIMHRDIKPHNFLVCPSQTYG-------------FTIKICDLGFASAITKSKTHYPS-----------------------KKGTEAYF
|...... .| .||.|||.|| | |.. . .               ..|||.| |||  .....  .                           || .| 
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM

A-PEVENG-------------ESRI--QSDLFSLGLVL
| ||| ||             .  .  ..|  |.| .|
AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 26273.AA Ciliate-E3 94-309 26 6.2e-24 71.74 In-house 1-202 (202) Show / Hide 
Range on Protein: 94-309
Range on HMM: 1-202/202
Sequence Identity: 26% (58 aa)

FQNFEYLNSGAYALVLKAQNIKSNRMVALKFLTCTSKEG---LKGIESLKKEYELLQKFSQSDFLVNVYDCFYLMDEDVEVDKNGNKKPKEKSFFVTEME
.     |. | . .| || .   |. || | ..|. .     .     . .|  . |..  | ..| ..| .|  .               |. |.  .|
YTVQQILGCGQFGRVYKAFDFQNNQDVAIKAIICQNQQNEGVGEQFQKTQQEFQNCQQI-NSQNVVKCHDQYYDQQ--------------NKMIFIV-QE

LCEQNLKQLFDYLRNTQLPSQEIKEIIAIQMLEGLNTLHTKNIMHRDIKPHNFLVCPSQTYG-FTIKICDLGFASAITKSKTHYPSK-KGTEAYFA-PEV
.|.    .|  |..   .  ..|.. |.||...|.  .| ||| | |||| |.||  .. ..  .|||||.| .    | |.|   .  |.  ..| ||.
YCSN--GDLYHYIKQQNKTQNIIYD-ICIQIIQGMIAIHEKNIIHSDIKPDNILV--DKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQ

EN-GESRIQSDLFSLGLVLLELD
   .     ||. |.| |...| 
NDQQQISKESDYYSVGAVFCQLC
Kinase 26273.AA Ciliate-E1 100-299 21 1.8e-23 73.49 In-house 1-202 (202) Show / Hide 
Range on Protein: 100-299
Range on HMM: 1-202/202
Sequence Identity: 21% (47 aa)

LNSGAYALVLKAQNIKSN-RMVALKFLTCTSKEGLKGIESLKKEYE-LLQKFSQSDFLVNVYDCFYLMDEDVEVDKNGNKKPKEKSFFVTEMELCEQNLK
. .| ...|.|| ....| . ||.|.  |  ..    .....|||  ... | . . .....|....               ..  ...  .|.|...||
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKI---------------DQNYICIIIFECCCCSLK

QLFD----------YLRNTQLPSQEIKEIIAIQMLEGLNTLHTKNIMHRDIKPHNFLVCPSQTYGFTIKICDLGFASAITKSKTHYPSKKGTEAYFA-PE
. ..          . .| .  ... |. |..|...||. || .||.||||||.| |.. .  | ..    |.| .. . ......  .||   |.. ||
DYLQNHNRLEYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC----DFGISKFLKNNQNQQCQYKGYTHYYYPPE

VEN------GES---RIQSDLF
. |       ..    ..||..
QYNCPEQEHNKNQKINYKSDIY
Kinase 26273.AA Ciliate-E2 189-308 25 2.6e-23 76.85 In-house 113-289 (365) Show / Hide 
Range on Protein: 189-308
Range on HMM: 113-289/365
Sequence Identity: 25% (49 aa)

MELCEQNLKQLFDYLRNTQLPSQEI---------KEI--IAIQMLE---------------GLNTLHTKN-IMHRDIKPHNFLVCPSQTYGFTIKICDLG
||.|..  . ||||..| .. ....         |||  |  | |.               .|. || || |.|||||| | |.         |||.|.|
MEYCQG--GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFG

FASAITKSKT---------HYPSKK-----------------------GTEAYFAPEVENGESR----------IQSDLFSLGLVLLEL
..  ....            |.  |                       ||  | |||. ||..            ..|..||| .| |.
LSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 26273.AA TKL 217-308 22 3.9e-20 69.21 In-house 137-282 (364) Show / Hide 
Range on Protein: 217-308
Range on HMM: 137-282/364
Sequence Identity: 22% (33 aa)

IAIQMLEGLNTLHT--------KNIMHRDIKPHNFLVCPSQT----------YGFTIKICDLGFASAITKSKT-------------------HYPSKKGT
.|...  |.| ||.        ..| |||.|..| ||    |          .  ..||||.|..  ...|.                    .  .. ||
WALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT

EAYFAPEV-----------------ENGESRIQSDLFSLGLVLLEL
 .. ||||                 ...|   ..| .| |.|| |.
PRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI
Kinase 26273.AA TyrKc 94-370 20 1.8e-09 -69.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 94-370
Range on HMM: 1-280/280
Sequence Identity: 20% (63 aa)

FQNFEYLNSGAYALVLKAQNIKSNRMVALKFLTCTSKEGLKGIESLKKEYELLQKF-SQSDFLVNVYDCFYLMDEDVEVDKNGNKKPK---EKSFFVTEM
 .  . | .||.  | |.. .   ..|| | |   .      .| . .| ... |.  . . .|. | .     .                |  . |  |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-----------FMYIEPLMIV--M

ELCEQNLKQLFDYLRNTQL-PSQEIKEIIAIQMLEGLNTLHTKNIMHRDIKPHNFLVCPSQTYGFTIKICDLGFASAITKS------KTHYPSKK--GTE
|...     | ||||...   . . .  ...|  .| . || ||. |||.   | ||   .    |.||.| | . .|.        |  | .|.  |. 
EYMPH--GDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

-----AYFAPEVE-NGESRIQSDLFSLGLVLLELDNL-NVLNQN-----WIGFEIKREIYQGEGIASKYQIDR---------NSNIYKIVEICLKPNYLE
        |||.   |.  ..|| .| | .. |.  .      .        .|. . . ||.      | .           . .|.| . | . .  .
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRM---PQPPNDYPMSFVCCPDEMYQIMKQCWHEDPED

RTTSGDLLSEL
| |  .. ...
RPTFSEIHECF
Kinase 26273.AA Ciliate-E2 94-168 12 3e-06 17.68 In-house 1-107 (365) Show / Hide 
Range on Protein: 94-168
Range on HMM: 1-107/365
Sequence Identity: 12% (14 aa)

FQNFEYLNSGAYALVLKAQNIKSNRMVALKFLTCTS----------------KEGL--KGIESLKKEYELLQ---------------KFSQSDFLVNVYD
.   . . .|... | |....| ....|.|. . .                 .. .  ..||..|.|  ...               .. ....... |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

CFYLMDED
||. .|..
CFQEKDDN
Kinase 26273.AA C8 457-663 49 1.6e-101 343.57 In-house 1-226 (226) Show / Hide 
Range on Protein: 457-663
Range on HMM: 1-226/226
Sequence Identity: 49% (112 aa)

AKNFQILNFGSFGMVLSTKKVKFNNKEIVLKIQKIVNEQEIQNEIRIMQQLKTPLVVQLYDNYVIEQATAPERYVVFELEKCS-----------CQDNQ-
 .|||.|.||..||||..|.|| .|.|||||.||..|.|.|||...||.....|.|.|.||.||.|.....|.|.|||.||||           |. .. 
FNNFQYLSFGAYGMVLKAKNVK-DNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEM

-----QQATNLLLRQGKEKEFSDEEKLDIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQL-EIKLCDFGLSAQLEQNCEQIETLDM--VGNWAYMA
     . .   . |. |...||.|.|. ||||.||.||||||.||.||||||.|||||||.|.. ||||||||...|...|...|.. .|  .|.|||.|
ELCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNTCGTWAYFA

PEILAKNDDQNKIYSKKSDSYSVGLLL
|||..|.|.|.|.|...||..||||.|
PEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 26273.AA Ciliate-C8 466-663 40 1e-94 320.97 In-house 1-238 (238) Show / Hide 
Range on Protein: 466-663
Range on HMM: 1-238/238
Sequence Identity: 40% (97 aa)

GSFGMVLST------KKVKFNNKEIVLKIQKIVNEQEIQNEIRIMQQLKTPLVVQLYDNYVIEQATAPER-----------------YVVFELEKCSCQD
|.|||||..      .||.....|.|.||||...|.||.....|||....|.|||.||..........|.                 ..|.|.|||. . 
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQN-

NQQQATNLLLR-QGKEKEFSDEEKLDIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLD-GNQLEIKLCD------FGLSAQLEQNCE---------QIET
   .  ... | . |....|...|. ||||.||||||.|||||.||||||.|||||.| ..|..|||||      ||...||..|..         ....
--CNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQY

LDM--VGNWAYMAPEILAK-NDDQNKIYSKKSDSYSVGLLL
..|  .|||.|.|||...| ...|..|.|||||||||||.|
IEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 26273.AA C2 466-676 28 1.8e-41 139.47 In-house 1-245 (245) Show / Hide 
Range on Protein: 466-676
Range on HMM: 1-245/245
Sequence Identity: 28% (74 aa)

GSFGMVLSTKKVKFNNKEIVLKIQKIVN-----EQEIQNEIRIMQQLK-TPLVVQLYD-NYVIEQATAP------------ER----------YVVFELE
|.||.|| .   |  |....||||..       ..|.|.|..||.|..  |.....|.  |. ..                |.           ||.|.|
GAFGLVLKAFN-KKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQE

KCSCQDNQQQATNLLLRQGKEK-EFSDEEKLDIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQL-EIKLCD----------FGLSAQLEQNCEQIE
.|..        . . |. |.. ......|  .|||..||.||.|.|.|.||||||.|||. .| ...  |||||          |  .  |. | ..| 
FCQGN-----LKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIH

TLDMVGNWAY----MAPEILAKNDDQNKIYSKKSDSYS-VGLLLSLLDNYLILKEQT
.  ...  .|    .|||.      . .|| |.|| .| ||. |  |||  .   . 
FSKFKWTQQYYQHIFAPEV------YQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 26273.AA Ciliate-E1 463-657 25 3.7e-26 82.32 In-house 1-202 (202) Show / Hide 
Range on Protein: 463-657
Range on HMM: 1-202/202
Sequence Identity: 25% (54 aa)

LNFGSFGMVLSTKKVKFNNKEIVLKIQKIV---N----EQEIQNEIRIMQQLKTPL-VVQLYDNYVIEQATAPERYVVFELEKCSCQDNQQQA-----TN
.  |||..|.  |. . |.... .||...    |    ..||.... ||. .|.   ..|..| . |.|.       .. .|.|.|......        
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNY----ICIIIFECCCCSLKDYLQNHNRLEY

LLLRQGKEKEFSDEEKLDIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLEIKLCDFGLSA-----QLEQNCEQIETLDMVGNWAYMAPEILAKND
  . | ....|....|. |..| || ....| .|||||||||.| |.. . ... .   |||.|      |..|  .  .|  .  .. |. |  .  . 
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYC--DFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCP--EQ-EH

DQNKIYSKKSDSY
..|.....||| |
NKNQKINYKSDIY
Kinase 26273.AA TKL 565-663 25 8.5e-26 89.87 In-house 134-279 (364) Show / Hide 
Range on Protein: 565-663
Range on HMM: 134-279/364
Sequence Identity: 25% (37 aa)

KLDIAIQVIDSVNYIHCFN--------IIHRDIKPDNFLVCLDGN-----------QLEIKLCDFGLSAQLEQNCEQIETLDM-----------------
....|...   .|| |  |        |||||.|..| ||  ...           .  .|.||||||  ..|. ..  |  .                 
RCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQ

VGNWAYMAPEILAKNDDQNK-----------IYSKKSDSYSVGLLL
.|. ..||||.| .... ..            ||.|.| || |..|
CGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL
Kinase 26273.AA Pkinase 457-663 25 3.2e-25 90.27 Pfam 1-202 (293) Show / Hide 
Range on Protein: 457-663
Range on HMM: 1-202/293
Sequence Identity: 25% (58 aa)

AKNFQILNFGSFGMVLSTKKVKFNNKEIVLKIQKIVNEQEIQN-------EIRIMQQLKTPLVVQLYDNYVIEQATAPERYVVFELEKCS--CQDNQ---
 .  ...  |||| |   .... ..|. ..|| | ..| . ..       ||.||. |. | .|.||| .       .. |.|.|.  .   ..|     
YHIGRKIGSGSFGCVYKCHHKG-TGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYI

-QQATNLLLRQGKEKEF--SDEEKLDIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQL--EIKLCDFGLSAQLEQNCEQIETLDMVGNWAYMAPEI
            ... |  |..|  ... |..  ..|.|  .|||||.||.|.|.  . ...   .|.|||||..|.. .  .  . . .|   |||||.
ST---------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEV

LAKNDDQNKIYSKKSDSYSVGLLL
.      .. |..|.| .|.|..|
IR----GGQYYGPKVDMWSCGCIL
Kinase 26273.AA CAMK 571-663 23 9.2e-25 76.1 In-house 187-324 (425) Show / Hide 
Range on Protein: 571-663
Range on HMM: 187-324/425
Sequence Identity: 23% (33 aa)

QVIDSVNYIHCFNIIHRDIKPDNFLVCLDG--------------NQLEIKLCDFGLSAQLEQNCEQI---------------------ETLDMVGNWAYM
|... |.|.|  ||.|||.||.| |.. ..              |.  ||..|||........ ..                         ...|  .||
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM

A-PEILAKN---------DDQNKIYSKKSDSYSVGLLL
| ||.| ..         |.... |..|.|  |.| .|
AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase 26273.AA STE 568-663 32 3.4e-24 82.4 In-house 156-258 (359) Show / Hide 
Range on Protein: 568-663
Range on HMM: 156-258/359
Sequence Identity: 32% (36 aa)

IAIQVIDS-VNYIHCFNIIHRDIKPDNFLVCLDGNQLEIKLCDFGLSAQLEQNCE--------------QIETLDMVGNWAYMAPEILAKNDDQ-NKIYS
|. |..    .|.|  .||||||||.| |.        .||||||...||....               | ..  .||   .||||.. .|.   .| |.
ICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYD

KKSDSYSVGLLL
 |.| .|.|...
TKCDIWSLGCTI
Kinase 26273.AA Ciliate-E2 554-663 26 9.8e-23 74.86 In-house 138-286 (365) Show / Hide 
Range on Protein: 554-663
Range on HMM: 138-286/365
Sequence Identity: 26% (42 aa)

QGKEKEFSDEEKLDIAIQVID---------------SVNYIHCFN-IIHRDIKPDNFLVCLDGNQLEIKLCDFGLSAQLEQN---------CEQIETLD-
. . | |...| ..|  |...                ..|.|  | ||||||||.| |.        ||..||||| .. ..         |. .     
K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KN

--------------------MVGNWAYMAPEILAKNDDQN----KIYSKKSDSYSVGLLL
                     .|.  ||||||| . ...|    | |..|.| .|.| .|
DTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL
Kinase 26273.AA S_TKc 460-735 23 2.1e-22 81.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 460-735
Range on HMM: 1-231/231
Sequence Identity: 23% (69 aa)

FQILNF---GSFGMVLSTKKVKFNNKEIVLKIQKIVNEQEIQNEIRIMQQLKTPLVVQLYDNYVIEQATAPERYVVFELEKC---SCQDNQQQATNLLLR
..||.    |.|| |   ...|  ...  .|| |    . |..||.|... . | .|.||| ..       . |.|.|.      .  |       .. .
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFD-------YIKK

QGKEKE---FSDEEKLDIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLEIKLCDFGLSAQLEQNCEQIETLDMVGNWAYMAPEILAKNDDQNKIY
.|...    |.  .   .. |... ..|.|  .|||||.||.| |..      .||.|||||..||           ..|   |||||.|         |
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL--------GY

SK-KSDSYSVG-LLLSLLDNYLILKEQTGATFMNMTSKQYEEPFKKQKINIKENTEIFKFIKQLVVWERVKRDSLSIIVE----QNSNKFK
.| |.| .|.| .|  .|  |     |  ..| ..                    |   ||... ...  || .   . .     ..  . 
GKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 26273.AA Ciliate-E3 556-667 44 8.2e-21 61.87 In-house 96-202 (202) Show / Hide 
Range on Protein: 556-667
Range on HMM: 96-202/202
Sequence Identity: 44% (50 aa)

KEKEFSDEEKLDIAIQVIDSVNYIHCFNIIHRDIKPDNFLVCLDGNQLEIKLCDFGLSAQLEQNCEQIETLDMVGNWAYMAPEILAKNDDQNKIYSKKSD
|. . . .. .||.||.| ..  ||  |||| ||||||.||    ||| || ||||.| || .|   . |..      | |||.    .||..| || ||
KQQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILVDKNNNQLIIKICDFGESKQLRKNKGHTHTQYQGWTPFYAAPEQ----NDQQQI-SKESD

SYSVGLLLSLLD
 ||||  . .| 
YYSVGAVFCQLC
Kinase 26273.AA CMGC 457-619 15 6.4e-19 57.94 In-house 1-257 (513) Show / Hide 
Range on Protein: 457-619
Range on HMM: 1-257/513
Sequence Identity: 15% (41 aa)

AKNFQILNFGSFGMVLSTKK-------------VKFNNKEIVLKIQKIVNEQEIQ---------------NEIRIMQQLK-----------------TPL
 .. . .  |..|.| . .               . .|... .|. | .   |.|                ||.|...|.                  . 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VVQLYDNYVIEQATAPE-----------RYVVFELEKCSCQDNQQQATNLLLRQG-KEKEFSDEE------------KLDIA------IQVIDSVN--YI
.|.||| .. .. . .|           ... .  | . .   |    |  . || . ...|. .            .  .        |.. ...  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HCFN--IIHRDIKPDNFLVCLDGNQ-----------------LEIKLCDFGLSAQLEQN
|  .  |||||.|| | |.. ..                    ..|.|||||. .....
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPH
Kinase 26273.AA CAMK 462-535 14 1.7e-05 12.88 In-house 1-141 (425) Show / Hide 
Range on Protein: 462-535
Range on HMM: 1-141/425
Sequence Identity: 14% (21 aa)

ILNFGSFGMVLSTKKVKFNN-----------KEIVLKI---QKIV----------------------------NEQEIQNEIRIMQQ-------LKTPLV
.|  |||| |   .  . ..           ..   ||   .|.                             .......||.||..       |. | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQLYDNYV----------------IEQATAPERYVVF---EL
..||. |                 .   .  . | |.   |.
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEY
Kinase 26273.AA Ciliate-E2 457-519 20 0.000186 11.19 In-house 1-101 (365) Show / Hide 
Range on Protein: 457-519
Range on HMM: 1-101/365
Sequence Identity: 20% (21 aa)

AKNFQILNFGSFG-----MVLSTKKV-----------------KFNNKEIVLKIQK------IVNEQEIQNEIR----------IMQQLKTPLVVQLYDN
 |  ... .|.||      | ...|                  |...|.. .||.|      | .|. | .||.          |..||. | ....|. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

Y
.
F
Kinase 26273.AA STE 457-520 17 0.000667 9.81 In-house 1-100 (359) Show / Hide 
Range on Protein: 457-520
Range on HMM: 1-100/359
Sequence Identity: 17% (17 aa)

AKNFQILNFGSFGMVLSTKKVK-----FNNKE---------IVLKIQKIVN--------------------EQEIQNEIRIMQQLK--TPLVVQLYDNYV
 .. ...  |.|| |   ...|      ....         .  |. .. |                    .|.|..||.||....   | .|. |. |.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF