Gene 22826 (Tetrahymena)

22826

Species: Tetrahymena
Alias: TTHERM_00937670, 22826, PreTt22826, 872, 169.m00066
External Links: Tetrahymena Genome Database (TGD)
Annotation: Secondary Group: Other, Secondary Family: Ciliate_C8_Cterm, Secondary Subfamily: C2,

Classification

Group: Other
Family: Ciliate-C8
Subfamily: C2

Sequence

Name Sequence Type Origin Length Description Download
22826.AA Protein None 1182 None Fasta, JSON
22826.kin_dom Protein Kinase Domain None 205 None Fasta, JSON
22826.kin_dom2 Protein Kinase Domain None 214 None Fasta, JSON
22826.NA RNA None 3549 None Fasta, JSON

Protein domain

Protein domains of 22826.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 22826.AA C2 45-272 36 3.3e-104 352.49 In-house 1-245 (245) Show / Hide 
Range on Protein: 45-272
Range on HMM: 1-245/245
Sequence Identity: 36% (97 aa)

GSFALVIKAFNKNSQRQVALKIVLCNQNEPSEEESVLKEYNLLLKIKNCPYLVDVYNHFYVYEEKIIIEDSDDEEQIAEKPK--KQNEKLKSFLVLELEF
|.|.||.|||||...|.|||||. |..|.......|.|||... ...|.||...|||.||....|...||.|..|...|...  ||....|.|.|.|.||
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CKSKDYFAILYLNFNKKVDPKADYYEQYHSVQTHQKQYPDKQMKEILAIQILDGISFLHQKSFLHRDIKPNNILLQFDNQNNPIIKICD----------L
|...                    ..||......|..||..|||.|.|||..|.|..||.....||||||.|.|.|||.|..|.||.||          .
CQGN--------------------LKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDF

AFASFISPSQSQIHT------------------------KQSDLFQ-VGIVLLELDNIEKFDFLK
.|||......|.||.                        |.||||. ||.|||||||.. ... .
DFASKLKYNKSRIHFSKFKWTQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 22826.AA Ciliate-C8 45-259 29 6.4e-69 235.28 In-house 1-238 (238) Show / Hide 
Range on Protein: 45-259
Range on HMM: 1-238/238
Sequence Identity: 29% (78 aa)

GSFALVIKAFNKNSQRQVALKIVLC-NQNEPSEEESVLKEYNLLLKIKNCPYLVDVYNHFYVYEEKIIIEDSDDEEQIAEKPK-KQNEKLKSFLVLELEF
|.|..|.|| ||...|.||||.. | |...  ..|.. ||| .. .  ..|..|.||..||. ||.   .|.......... | |.     || |.|.|.
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKK-----SFFVMEMEK

CKSKDYFAILYLNFNKKVDPKADYYEQYHSVQTHQKQYPDKQMKEILAIQILDGISFLHQKSFLHRDIKPNNILLQFDNQNNPIIKICD------LAFAS
|...                  . ..||.  . ....||..|||||.|||..|....||.. ..||||||.|.|..||.|..|.||.||      ..|||
CQQN------------------CNLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFAS

FISPSQS---------QIHT----------------------KQSDLFQ-------VGIVL
... ..|         .. .                      .|||.|.       ||.||
QLPKNKSHYHSKKFKGTDQYIEMYFCGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 22826.AA C8 168-247 41 4.8e-27 90.96 In-house 107-186 (226) Show / Hide 
Range on Protein: 168-247
Range on HMM: 107-186/226
Sequence Identity: 41% (33 aa)

EQYHSVQTHQKQYPDKQMKEILAIQILDGISFLHQKSFLHRDIKPNNILLQFDNQNNPIIKICDLAFASFISPSQSQIHT
.|.   . ...|...|.||||.|||..||....|.| ..||||||.|.|...|......||.||..|||..| ..|.|..
KQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQS
Pkinase 22826.AA Pkinase 36-231 20 4.6e-21 75.57 Pfam 1-155 (293) Show / Hide 
Range on Protein: 36-231
Range on HMM: 1-155/293
Sequence Identity: 20% (41 aa)

YNDFEYLGNGSFALVIKAFNKNSQRQVALKIVLCNQNEPSEEESVLK--EYNLLLKIKNCPYLVDVYNHFYVYEEKIIIEDSDDEEQIAEKPKKQNEKLK
|   . .| |||. | |. .|.....||.||.    ........ ..  |  ..... |.|. |  |  |.                            |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED---------------------------K

SFLVLELEFCKSK----DYFAILYLNFNKKVDPKADYYEQYHSVQTHQKQY--PDKQMKEILAIQILDGISFLHQKSFLHRDIKPNNILLQFDNQNNPII
. . . .|.|       | |...                        .. .  .... | ..  ||| |. ..|.....|||.|| |||.  ........
DHIYMVMEYCEGGLYVMDLFDYIST--------------------WRHGCFYFSEWECKFYMY-QILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACV

KICD
||||
KICD
Kinase 22826.AA Ciliate-E1 42-244 23 5.7e-20 61.99 In-house 1-165 (202) Show / Hide 
Range on Protein: 42-244
Range on HMM: 1-165/202
Sequence Identity: 23% (48 aa)

LGNGSFALVIKAFNKNSQ-RQVALKIVLCNQN-EPSEEESVLKEYNLLLKIKNCPYLVDVYNHFYVYEEKIIIEDSDDEEQIAEKPKKQNEKLKSFLVLE
.|||||..|.||...|.. .|||.||..|..| .  ......|||....|.|.  |...... ... . .|.|.  .  ..  ..  .....        
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNR--------

LEFCKSKDYFAILYLNFNKKVDPKADYYEQYHSVQTHQKQYPDKQMKEILAIQILDGISFLHQKSFLHRDIKPNNILLQFDNQNNPIIKICDLAFASFIS
                             .|   .  .... . | |. ...|..||.. |||. ..|||||| |||    |..  . ..||.. ..|. 
---------------------------L-EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILI---NNQ-GNYVYCDFGISKFLK

PSQSQ
 .| |
NNQNQ
Kinase 22826.AA C8 36-146 27 1.3e-16 54.28 In-house 1-105 (226) Show / Hide 
Range on Protein: 36-146
Range on HMM: 1-105/226
Sequence Identity: 27% (31 aa)

YNDFEYLGNGSFALVIKAFNKNSQRQVALKIVLCNQN-EPSEEESVLKEYNLLLKIKNCPYLVDVYNHFYVYEEKIIIEDSDDEEQIAEKPKKQNEKLKS
 |.|.|| .|....|.|| | ...|...||.  | .. .  ..||. ||| ......    .| .|. ||  .|..  |. . |  .         . ||
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQ-------TEEKS

FLVLELEFCKSK
. | |.| |...
CFVMEMELCEQN
Kinase 22826.AA Ciliate-E2 185-262 17 2.9e-16 52.34 In-house 151-289 (365) Show / Hide 
Range on Protein: 185-262
Range on HMM: 151-289/365
Sequence Identity: 17% (26 aa)

MKEIL----------AIQILDGISFLHQKS-FLHRDIKPNNILLQFDNQNNPIIKICDLAFAS-------------------------------------
||.||          . .|.... .||.|   .||||||.|||.         |||.|. ..                                      
MKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQ

-----------FISP----SQS-------QIHTKQSDLFQVGIVLLEL
           . .|    ...       . .....|.. .|..| |.
NMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM
Kinase 22826.AA CMGC 36-104 13 1.9e-15 46.36 In-house 1-108 (513) Show / Hide 
Range on Protein: 36-104
Range on HMM: 1-108/513
Sequence Identity: 13% (15 aa)

YNDFEYLGNGSFALVIKAFN--------------KNSQRQVALKIVLCNQNEPSEEE----------SVLKEYNLLLKIK----------------NCPY
|   ...| |... | |...              ......||.|..  .. .. ..           . | |  .| ...                . ..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LVDVYNHFY
.|  |..||
IVKLYDIFY
Kinase 22826.AA CAMK 192-244 30 9.9e-15 43.2 In-house 187-252 (425) Show / Hide 
Range on Protein: 192-244
Range on HMM: 187-252/425
Sequence Identity: 30% (20 aa)

QILDGISFLHQKSFLHRDIKPNNILLQFDNQNNP-------------IIKICDLAFASFISPSQSQ
||.... ..|..   |||.|| ||||. .| ...              |||.|  || .. |....
QICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENN
Kinase 22826.AA CMGC 174-249 21 7.9e-14 40.91 In-house 162-265 (513) Show / Hide 
Range on Protein: 174-249
Range on HMM: 162-265/513
Sequence Identity: 21% (23 aa)

QTH------------QKQYPDKQMKEILAIQILDGIS--FLHQKS--FLHRDIKPNNILLQFDNQN----------------NPIIKICDLAFASFISPS
. |             | ..  . .   . ||| |.   ..|..   ..|||.|| |||.  ....                | ..||||  .| ...| 
E-HENKHPHRRPPHNIKYFMI-HIR--YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPH

QSQIHTKQ
.......|
SDHHFQQQ
Kinase 22826.AA CDK 189-217 41 8.9e-13 37.05 In-house 113-141 (284) Show / Hide 
Range on Protein: 189-217
Range on HMM: 113-141/284
Sequence Identity: 41% (12 aa)

LAIQILDGISFLHQKSFLHRDIKPNNILL
.  |.|.|....|.. ..|||.||.|||.
YMWQLLRGLHYCHSNWIMHRDLKPQNILI
Kinase 22826.AA S_TKc 36-344 17 2e-12 5.36 SMART 1-231 (231) Show / Hide 
Range on Protein: 36-344
Range on HMM: 1-231/231
Sequence Identity: 17% (59 aa)

YNDFEYLGNGSFALVIKAFNKNSQRQVALKIVLCNQNEPSEEESVLKEYNLLLKIKNCPYLVDVYNHFYVYEEKIIIEDSDDEEQIAEKPKKQNEKLKSF
|   . .| |.|. | |. .|...|.||.||.          |....| ..| |  ..|..|  | .|.                             ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD----------------------------DH

LVLELEFCKS--KDYFAILYLNFNKKVDPKADYYEQYHSVQTHQKQYPDKQMKEILAIQILDGISFLHQKSFLHRDIKPNNILLQFDNQNNPIIKICDLA
| . .|.|     | | ..  .  .. .                ...|  . . ... ||.... ..|.. ..|||.|| ||||         |||||  
LYMVMEYCDGDLGDLFDYIKKRGRHGLR----------------FPFPE-HARFYMY-QICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFG

FASFISPSQSQI------------HTK-QSDLFQVGIVLLELDNIEK-FDFLKTTDDERYALRNGQIFPTYFLDRKSNIFQIAQTFLNPNFKERQSAQKF
.| ..    ...            ..|  .|   .|..| |.   .  |.      ..   ...                              ..|  |
LARQL---TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG---------------------------SPEAKDF

LEQLLWKDPQ--YQNIELSS----IIIMPQL
....| |||.  .   |.      | ..| .
IRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 22826.AA STE 36-112 16 6.1e-12 38.58 In-house 1-114 (359) Show / Hide 
Range on Protein: 36-112
Range on HMM: 1-114/359
Sequence Identity: 16% (19 aa)

YNDFEYLGNGSFALVIKAFNK------NSQRQ---------VALKIVLCNQNEP---------------SEEESVLKEYNLLLKIKN-CPYLVDVYNHFY
. . | .|.|.|  | || |.       ....         .| |..  .....               .|....||| ... | .. .|. |  | ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VY------EEKIII
.       .... |
KEGHNHKNDDELWI
Kinase 22826.AA STE 190-231 44 1e-11 37.78 In-house 157-190 (359) Show / Hide 
Range on Protein: 190-231
Range on HMM: 157-190/359
Sequence Identity: 44% (19 aa)

AIQILDG-ISFLHQKSFLHRDIKPNNILLQFDNQNNPIIKICD
. ||| |  ..||..   |||||| ||||         .|.||
CRQILKGLLYYLHSHHIIHRDIKPANILL---------VKLCD
Kinase 22826.AA CDC2 189-217 51 4.8e-11 29.66 In-house 108-136 (301) Show / Hide 
Range on Protein: 189-217
Range on HMM: 108-136/301
Sequence Identity: 51% (15 aa)

LAIQILDGISFLHQKSFLHRDIKPNNILL
...|||.|..|.||.  .|||.|| |||.
YMYQILQGVHFCHQRRIMHRDLKPQNILI
Kinase 22826.AA CAMK 41-112 14 2.4e-10 28.8 In-house 1-134 (425) Show / Hide 
Range on Protein: 41-112
Range on HMM: 1-134/425
Sequence Identity: 14% (19 aa)

YLGNGSFALVIKAFNKNSQ------------RQVALKIVLCNQNE--------------------------PSEEESVLKEYNLLLKIK------NCPYL
 || |||. | ....||..            ..|| ||.  ..                            |. ...|..|.... |..      . | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VDVYNHFY----------------VYEE---KIII
.  | ..                 |. .   ....
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYM
Kinase 22826.AA CDK 36-104 25 1.3e-09 26.72 In-house 1-77 (284) Show / Hide 
Range on Protein: 36-104
Range on HMM: 1-77/284
Sequence Identity: 25% (20 aa)

YNDFEYLGNGSFALVIKAFNKNSQ-----RQVALKIVLCNQNEPSEEE------SVLKEYNLLLKIKNCPYLVDVYNHFY
|   | .| |... | || .|...     . |||| .   ..   |||      . . | .|| ..  .|. | ..  ..
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEG-REEEKEGFPITAIREISLLKEL--HPNIVKLHDVCH
Kinase 22826.AA TyrKc 36-323 12 5.9e-09 -77.84 SMART 1-280 (280) Show / Hide 
Range on Protein: 36-323
Range on HMM: 1-280/280
Sequence Identity: 12% (44 aa)

YNDFEYLGNGSFALVIKAFNKNSQRQVALKIVLCNQNEPSEEESVLKEYNLLLKI-KNCPYLVDVY-------------NHFYVYEE-------KIIIED
    . ||.| |  | |.  |   .||| | .  .      .|  ..| ... |. .. | .|  |                ..  |       |  . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SDDEEQIAEKPKKQNEKLKSFLVLELEFCKSKDYFAILYLNFNKKVDPKADYYEQYHSVQTHQKQYPDKQMKEILAIQILDGISFLHQKSFLHRDIKPNN
. ..                                                                 . .   ..|| .| ..||.| . |||.   |
HRPK--------------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARN

ILLQFDNQNNPIIKICDLAFASFISPS------QSQIHTK---QSD------------LFQV-----------GIVLLELDNIEKFDFL------KTTDD
.|.  ..    ..||.|   . .|         .. ...|   ...            ..             |... |.    .          .. ..
CLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE

ERYALRNGQIFPTYFLD-------RKSNIFQIAQTFLNPNFKERQSAQKFLEQL
 .  ...|   |    |         . ..|| ..  . . ..| . .   |..
VIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 22826.AA Ciliate-E2 36-104 16 3e-06 17.28 In-house 1-102 (365) Show / Hide 
Range on Protein: 36-104
Range on HMM: 1-102/365
Sequence Identity: 16% (17 aa)

YNDFEYLGNGSFALVIKAFNKNSQR------------------QVALKIVLCNQNEPSEEESVLKEYNLL---------------LKIKNCPYLVDVYNH
|.  . .|.|.|. | |. ... |.                  .|. ||.  ....... |....| ...               |.. |.|...  | .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FY
|.
FQ
Kinase 22826.AA CDC2 36-65 33 3.1e-05 11.49 In-house 1-30 (301) Show / Hide 
Range on Protein: 36-65
Range on HMM: 1-30/301
Sequence Identity: 33% (10 aa)

YNDFEYLGNGSFALVIKAFNKNSQRQVALK
|   | .| |..  |.|. .. ....||||
YQKIEKIGEGTYGVVYKCKDMQTNQIVALK
Kinase 22826.AA C8 248-259 75 0.00023 11.19 In-house 215-226 (226) Show / Hide 
Range on Protein: 248-259
Range on HMM: 215-226/226
Sequence Identity: 75% (9 aa)

KQSDLFQVGIVL
.|||||.||.||
IQSDLFSVGLVL
Kinase 22826.AA C2 422-613 35 3.7e-99 335.74 In-house 1-245 (245) Show / Hide 
Range on Protein: 422-613
Range on HMM: 1-245/245
Sequence Identity: 35% (87 aa)

GGKGLIIGAYNLKDKRDCVLKIQKVQS-----KSRIIKEISILKCCQ-MPLIVKLYDFFYLNVVQKED------------------------FVVYELEK
|..||...|.| |..|...||||..||     .....||..|...|| ||.|.|.|..|||.| .|||                        |||||.|.
GAFGLVLKAFNKKQNRHVALKIQECQSNDINGMHEVQKEYGIMRQCQNMPYIIKVYNYFYLTVNKKEDEDEDNDEEEKEQENIKKQKNEKKIFVVYEQEF

CDCDLKAYLEKKQNDQ-QFTQEVKEEIAIQMMDSVNYIHKHNIIHRDIKPQNFLVQESNSSIPAIKLSD----------FDEADFLRLDEEYGYDSNGNW
|...||.|........ ...|..|...|||||||.||.|...|.||||||.|||.|.....||.|||.|          ||.|..|...... ..|...|
CQGNLKQYFNRCRKQNSYPCQQMKMIMAIQMMDSINYLHRFDIVHRDIKPSNFLYQFDQQGIPTIKLCDYHIQYQKKCDFDFASKLKYNKSRIHFSKFKW

ILQQYFAP------------NCDGCGTFGYWAPEQIYEKQSTIEC
. |.|...            |.| ..|.||...|.....|.||.|
TQQYYQHIFAPEVYQNIYKKNSDLFSTVGYVLLELDNMQQYTICC
Kinase 22826.AA Ciliate-C8 422-622 34 4.8e-88 298.81 In-house 1-238 (238) Show / Hide 
Range on Protein: 422-622
Range on HMM: 1-238/238
Sequence Identity: 34% (83 aa)

GGKGLIIG-------AYNLKDKRDCVLKIQKVQSKSRIIKEISILKCCQMPLIVKLYDFFYLN-VVQKED-----------------FVVYELEKCD--C
|..|....       ... ...|.||.||||.|....|.....| ..||||..|..||.|||. . .|||                 |.|.|.|||.  |
GAFGMVLKAQNKKQNRKVALKFRECVNKIQKNQMEHEIKEYEMIMQFCQMPFVVQVYDCFYLMEENKKEDDDGNDKIVQTQEKIKKSFFVMEMEKCQQNC

DLKAYLEKKQNDQ-QFTQEVKEEIAIQMMDSVNYIHKHNIIHRDIKPQNFLVQESNSSIPAIKLSD------FDEADFLRLDEEYGYDSN---GNWILQQ
.|| |... ...| ...|. ||.|||||.|||||.| .||.||||||.||||.......| |||.|      |. |..|. .... ....     .....
NLKQYFDRCRKKQSYPSQQMKEIIAIQMIDSVNYLHCFNIMHRDIKPHNFLVCFDQQYQPTIKLCDFKKQCDFGFASQLPKNKSHYHSKKFKGTDQYIEM

YFAPNCDGCGTFGYWAPEQIYE------KQSTIECDVFSLGISL
||      ||..||.|||....      .. ....|..|.|. |
YF------CGNWGYFAPEVEKKQSRIQSDIFSKKSDSYSVGLVL
Kinase 22826.AA C8 413-622 35 2.4e-77 263.29 In-house 1-226 (226) Show / Hide 
Range on Protein: 413-622
Range on HMM: 1-226/226
Sequence Identity: 35% (85 aa)

SKSFYLISQGGKGLIIGAYNLKDKRDCVLKIQKVQSKSRIIKEISILKCCQMPLIVKLYDFFYLN-VVQKEDFVVYELEKCD-----------CDLKA--
...|...|.|..|... |.|.||.|..|||.||.|.|..| ...|| |...||.....|||.... ....|...|.|.|||.           |...   
FNNFQYLSFGAYGMVLKAKNVKDNREIVLKFQKCQNKQDIQNIESIMKEYEMPQVFQQYDFYVNEYDCFYEMYEVFEEEKCSNEKIVQTEEKSCFVMEME

---------YLEKKQNDQQFTQEVKEEIAIQMMDSVNYIHKHNIIHRDIKPQNFLVQESNSSIPAIKLSDFDEADFLRLDEEYGYDSNGNWILQQYFAPN
         |.|.....|||..| ||.|||||.|.||||| .||.||||||.||||.........|||.||..|.... ...  .. . |          
LCEQNLKQLYDERRNKQQQFSKEMKEIIAIQMIDGVNYIHCKNIMHRDIKPHNFLVCLDQNYGFEIKLCDFGFASQVSKNKSHIQSKKMNT---------

CDGCGTFGYWAPEQIYE-----KQSTIECDVFSLGISL
   |||..|.|||....     ||..|. |.||.|. |
---CGTWAYFAPEIEKKQDNQYKQYRIQSDLFSVGLVL
Kinase 22826.AA CDC2 425-560 26 9.9e-22 63.09 In-house 13-147 (301) Show / Hide 
Range on Protein: 425-560
Range on HMM: 13-147/301
Sequence Identity: 26% (38 aa)

GLIIGAYNLKDKRDCVLKIQKVQSKSRI-------IKEISILKCCQ-MPLIVKLYDFFYLNVVQKEDFVVYELEKCDCDLKAYLE-KKQNDQQFTQEVKE
| .. . ...... ..||  .. . . .       |.|||.||  .  | |||| | ..     .  . | |   .|.||| |.. ... ........  
GVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ----NKLYMVFEY--LDMDLKKYMDMSIPKNKHMPPQLVK

EIAIQMMDSVNYIHKHNIIHRDIKPQNFLVQESNSSIPAIKLSDF
....|. . |.. | . |.|||.|||| |. .. .    ||..||
SYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN----IKIADF
Kinase 22826.AA CAMK 439-620 20 2.2e-21 65.04 In-house 55-322 (425) Show / Hide 
Range on Protein: 439-620
Range on HMM: 55-322/425
Sequence Identity: 20% (56 aa)

CVLKIQKV-----------QSKSRIIKEISILKCCQ-------MPLIVKLYDFFY-----------------------LNVVQKEDFVVYELEKCDC---
|  ||.|            ... .. .||.|.| .|        | |.|||...                        .  | .        | |.    
CY-KIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVME------IMEYCSGGEL

--DLKAYLEKKQN------------DQQFTQEVKEEIAIQMMDSVNYIHKHNIIHRDIKPQNFLVQESNSSIP------------A-IKLSDFDEADFLR
  ||  |. .. .            .  || .    .  |. . |.|.|.|||.|||.|| | |....|.. .            . ||..||  | ...
FDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFD

LDEEYGYDSNGNWILQQYFA---------PNCDGCGTFGYWA-PEQIYEKQ--------------STIECDVFSLGI
 .|.. ..| ..    .            .  . ||| .| | || .  |.               . .||. |.|.
PGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGV
Kinase 22826.AA Ciliate-E1 419-560 23 2.9e-21 66.22 In-house 1-158 (202) Show / Hide 
Range on Protein: 419-560
Range on HMM: 1-158/202
Sequence Identity: 23% (37 aa)

ISQGGKGLIIGAYNLKDK----RDCVLKIQKVQSKSRIIKEISILKCCQMPLIVKLYDFFYLNVVQKED--FVVYELEKCDCDLKAYLE----------K
|..|. .... |.. ...     . . ...  ...  . .||   .. .. .. . | . .... ....  . .  .|.|.| || ||.          .
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQC

KQNDQQFTQEVKEEIAIQMMDSVNYIHKHNIIHRDIKPQNFLVQESNSSIPA-IKLSDF
.||..|||.. |..|..|. | ....| .||||||||||| |.  ..  . . . .|.|
QQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKF
Kinase 22826.AA Ciliate-E2 441-620 23 6.2e-20 65.11 In-house 52-284 (365) Show / Hide 
Range on Protein: 441-620
Range on HMM: 52-284/365
Sequence Identity: 23% (59 aa)

LKIQKVQSKSRIIKEISILKCCQ----------------MPLIVKLYDFFYLNVVQKEDFVVYELEKCDC-DLKAYLE---KKQNDQ-----QFTQEVKE
.||.| . .  | .||.|... .                 | |.|.|..|.    .... . . .| |.  ||. |..   ||.| .     .|| .   
MKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQE---KDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIK

EIAIQMMD---------------SVNYIHKHN-IIHRDIKPQNFLVQESNSSIPAIKLSDFDEADFLRLD----------EEYGYDSNGNWILQQYFAPN
.|  |  .                ..|.|. | ||||||||.| |.         ||..||  . ..  |          ..| . .| . . . |..  
YIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD--

CDG----------CGTFGYWAPEQIYEKQ---------STIECDVFSLGI
             ||| || ||| .  |.          . .||..|||.
--QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV
Kinase 22826.AA Pkinase 440-622 25 7.1e-20 71.35 Pfam 31-202 (293) Show / Hide 
Range on Protein: 440-622
Range on HMM: 31-202/293
Sequence Identity: 25% (50 aa)

VLKIQKVQSKSRIIK----EISILKCCQMPLIVKLYDFFYLNVVQKEDFVVYELEKCDC-----DLKAYLEKKQNDQQF--TQEVKEEIAIQMMDSVNYI
..| ..  |. ....    ||.|.| .. | ||.|||.|.      .| .   .| |..     ||..|..  ...  |  . ..   .. |.   ..|.
IIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-----KDHIYMVMEYCEGGLYVMDLFDYIST-WRHGCFYFSEWECKFYMYQILRGLEYC

HKHNIIHRDIKPQNFLVQESNSSI-PAIKLSDFDEADFLRLDEEYGYDSNGNWILQQYFAPNCDGCGTFGYWAPEQIY-EKQSTIECDVFSLGISL
|...|||||.||.|.|.  .|  | . .|..||  | ...                    .. . ||| .| ||| |   .  . ..|..|.|. |
HSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD----------------Y-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCIL
Kinase 22826.AA CMGC 428-560 18 2e-19 59.67 In-house 31-248 (513) Show / Hide 
Range on Protein: 428-560
Range on HMM: 31-248/513
Sequence Identity: 18% (40 aa)

IGAYNLKDKRDCVLKIQK-VQSKS--------------RIIKEISILKCCQ-----------------MPLIVKLYDFFYLNVVQKED------------
. | . .... . .|. | .. .               |.. ||.|||. .                  . ||||||.|| .  ....            
Q-AHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFN

FVVYELEKCDCDLKAYLEKKQ------NDQQFTQEV------------KEEIA------IQMMDSVN--YIHKHN--IIHRDIKPQNFLVQESNSSI---
 .    | .|.||. |....|      . . ... .            .  .        |.  ...  |.|.|.  |||||.||.| |. . . .|   
HLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRM

-------------PAIKLSDF
               .|. ||
MWKSEDWNPCQKNGRLKICDF
Kinase 22826.AA S_TKc 413-697 24 1.4e-18 68.99 SMART 1-231 (231) Show / Hide 
Range on Protein: 413-697
Range on HMM: 1-231/231
Sequence Identity: 24% (72 aa)

SKSFYLISQGGKGLIIGAYNLKDKRDCVLKIQKVQSKSRIIKEISILKCCQMPLIVKLYDFFYLNVVQKEDFVVYELEKCDC---DLKAYLEKKQN---D
 .   .| .|. |    ... |..| . .|| |     .|..||.|||  . | ||||||.|.       |..   .| ||    ||. |..|..    .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

QQFTQEVKEEIAIQMMDSVNYIHKHNIIHRDIKPQNFLVQESNSSIPAIKLSDFDEADFLRLDEEYGYDSNGNWILQQYFAPNCDGCGTFGYWAPEQIYE
..|.  .   .. |. . ..|.|.|.|||||.||.| |. |       ||..||  | .|                          |||  | ||| .  
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-----------------------TTFCGTPWYMAPEVL--

KQSTI-ECDVFSLGISL-SLLDNFQKLQPVYHYECLKIGKQFVEPFEPYKGQLDLINRQTKIYQKAIMYSLVYDKYKRKDLPQILD----NFKQNYF
 . .  .||. |.|. |  .|      .   ... .|. .                   ..     |.  |..|  ||    ..|       .  .|
-GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 22826.AA CDK 453-560 29 1.8e-14 42.59 In-house 56-157 (284) Show / Hide 
Range on Protein: 453-560
Range on HMM: 56-157/284
Sequence Identity: 29% (35 aa)

IKEISILKCCQMPLIVKLYDFFYLNVVQ--------KEDFVVYELEKCDCDLKAYLEKKQNDQQFTQEVKEEIAIQMMDSVNYIHKHNIIHRDIKPQNFL
| |||.|| .  | ||||.| .. .           .  . | |   .| ||| |..           .|  .  |... ..|.|...|.|||.|||| |
IREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY--MDHDLKKYMD-----------IK-CYMWQLLRGLHYCHSNWIMHRDLKPQNIL

VQESNSSIPA--IKLSDF
. .  .      .|. ||
INNNGEVK-CGRLKIADF
Kinase 22826.AA STE 526-560 48 1.1e-10 34.13 In-house 166-191 (359) Show / Hide 
Range on Protein: 526-560
Range on HMM: 166-191/359
Sequence Identity: 48% (17 aa)

NYIHKHNIIHRDIKPQNFLVQESNSSIPAIKLSDF
.|.|.|.||||||||.| |.         .||.||
YYLHSHHIIHRDIKPANILL---------VKLCDF
Kinase 22826.AA STE 416-475 20 0.001059 9.09 In-house 1-100 (359) Show / Hide 
Range on Protein: 416-475
Range on HMM: 1-100/359
Sequence Identity: 20% (20 aa)

FYLISQGGK---GLIIGAYNLK---------------DKRDCVLKIQKVQS--------------------KSRIIKEISILKCCQ--MPLIVKLYDFFY
. .|.. ||   |    |.| |                .. .  |. ....                    . .|.|||.|.|.|.   | ||| |. ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
Kinase 22826.AA STE 593-622 33 0.004422 6.87 In-house 224-258 (359) Show / Hide 
Range on Protein: 593-622
Range on HMM: 224-258/359
Sequence Identity: 33% (12 aa)

CGTFGYWAPEQIYE------KQSTIECDVFSLGISL
.||  . ||| |        |. .. ||. |||. .
VGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI