Gene 20271 (Tetrahymena)

20271

Species: Tetrahymena
Alias: TTHERM_00455420, 3712.m00035, 414, 20271, PreTt20271, 53.m00173
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
20271.AA Protein None 408 None Fasta, JSON
20271.kin_dom Protein Kinase Domain None 259 None Fasta, JSON
20271.NA RNA None 1227 None Fasta, JSON

Protein domain

Protein domains of 20271.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 20271.AA AGC 65-323 33 8.10000000001e-169 440.68 In-house 1-395 (395) Show / Hide 
Range on Protein: 65-323
Range on HMM: 1-395/395
Sequence Identity: 33% (135 aa)

FRIIRVIGSGAFGKVYLVNKK------GTEEVYAMKVYD---KMTLYEKNVILSTIGE------------RNILKNMN----------SNFIVK-LHYAF
|....||| |.||||||| ||      .|...||||| .   |. . .|| .  |. |            ||||...|          . |||| |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QAAQN--LYLMMDFMV---------GG-ELYYHLK---KAKKFDEERTKFYIAQ-------VILAIECLHQ-NNIMYRD-LKLENILLGQDGYIKLTDFG
|  ..  ||. |..|          || ||..||.   | ..|||||..||.|.       ..||.| ||. ..| .|| ||.||||| .||.|||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKEGIKDK--------------------------------------------------DLTNTLCG--TAEYMAPEQIMNEGHNKMADFWQ--IGVLTY
|.|||..|.                                                  |.|.|.||  |.|||||| .    ..| .| |    |.| |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLYGTTPFFNEFRP-------NKDEIFNDII------QGKYTFP----------QYFKDDAKNFIRGLLQKDVKKRLGYN-------GFHELKKHAFF
|||.| .||... .        |..|.|. |.      . | .||          ..| ..||..|..||.|| .||||..       |. |.|.| .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 20271.AA Akt 65-323 48 4.7e-163 525.15 In-house 1-264 (264) Show / Hide 
Range on Protein: 65-323
Range on HMM: 1-264/264
Sequence Identity: 48% (130 aa)

FRIIRVIGSGAFGKVYLVNKKGTEEVY-AMKVYDKMTLYEKNVILSTIGERNILKNMNSNFIVKLHYAFQAAQNLYLMMDFMVGGELYYHLKKAKKFDEE
|....|.|.|.||||.|| || |...| ||||. |. ...|| .  |..|||||...|..|||.|||.|| ...||..||.. ||||.|||.....|.|.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

RTKFYIAQVILAIECLHQNNIMYRD-LKLENILLGQDGYIKLTDFGLSKEG-IKDKDLTNTLCGTAEYMAPEQIMNEGHNKMADFWQ-IGVLTYEMLYGT
|..||.|..|||||.||..||.||| ||.||||. .||.|.||||||.||. ||| | |.|.|||.||.|||.. . || |..|.|  .|...|||..| 
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

TPFFNEFRPNKDEIFNDIIQGKYTFP--QYFKDDAKNFIRGLLQKDVKKRLG--YNGFHELKKHAFF
 ||.|.   .... |  | .... ||   .. ...|..|.|||.|| |||||  .|. .|.| | .|
PPFYNQ---DHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 20271.AA AktR 65-323 47 2.5e-125 422.66 In-house 1-268 (268) Show / Hide 
Range on Protein: 65-323
Range on HMM: 1-268/268
Sequence Identity: 47% (128 aa)

FRIIRVIGSGAFGKVYLVNKK-GTEEVYAMKVYDKMTLYEKNVILSTIGERNILK-NMNSNFIVKLHYAFQAAQNLYLMMDFMVGGELYYHLKKAKKFDE
|......|.||||||||| ||  . ..||||. .| .. |.| .  || ||||..  .| .|||||||.||   .|.. |... ||||..|||| |||.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

ERTKFYIAQVILAIECLHQN-NIMYRDLKLENILLGQDGYIKLTDFGLSK-EGIK-DKDLTNTLCGTAEYMAPEQIMN-EGHNKMADFWQIGVLTYEMLY
|...||.||..||.| |||. ||.||||| |||||..||..|.||||||| .... . ......||| ||||||.|.. .||||..|.|..|.. |||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GTTPFFNEFRPNKDEIFNDIIQ-GKYTFPQYFKDDAKNFIR-GLLQKDVKKRLG--YNGFHELKKHAFF
| .||... . | . .. .|.|  | ..| || . .|..|  .||.|. .||||   ||. |.|.| .|
GCPPFYHKNQ-NQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 20271.AA SGK 65-323 44 4.2e-125 388.44 In-house 1-283 (283) Show / Hide 
Range on Protein: 65-323
Range on HMM: 1-283/283
Sequence Identity: 44% (126 aa)

FRIIRVIGSGAFGKVYLVNKKGT------------------EEVYAMKVYDKMTLY-------EKNVILSTIGER-NILKNMNSNFIVKLHYAFQAAQNL
|... ||| | |||||.| .|..                  . .|||||  | .          |.    .  || .|||||.. |||.|||||| .. |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLMMDFMVGGELYYHLKKAKKFDEERTKFYIAQVILAIECLHQNNIMYRDLKLENILLGQDGYIKLTDFGLSKEGIKDKDLTNTLCGTAEYMAPEQIMNE
|. ||.. |||. |||...|.| | | .|| |....|.| ||  .| ||||| |||||. .|...||||||.|||||..| | | ||| ||.||| .  .
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GHNKMADFWQIGVLTYEMLYGTTPFFNEFRPNKDEIFNDIIQGKYTFPQYFKDDAKNFIRGLLQKDVKKRLGYN-GFHELKKHAFF
.| .  | | .| . |||.||  ||..    || . .  || ..  .|...  ||.  | ||||||.||||| . .| | |.| ||
PHDRTVDWWCLGCVLYEMMYGLPPFYSR---NKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 20271.AA RSK 68-323 43 9.60000000001e-106 357.6 In-house 1-278 (278) Show / Hide 
Range on Protein: 68-323
Range on HMM: 1-278/278
Sequence Identity: 43% (120 aa)

IRVIGSGAFGKVYLVNKK---GTEEVYAMKVYDKMTLYEKNV-ILSTIGERNILKNMN-SNFIVKLHYAFQAAQNLYLMMDFMVGGELYYHLKKAKK---
..| | |..|||.|. |.    |. .||||| .| ..  ... .  |  |||||.  . . |||.||||||  . ||| |... ||||..||.| |    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDEERTKFYIAQVILAIECLHQNNIMYRDLKLENILLGQ---DGYIKLTDFGLSKEG-IKDKDLTNTLCGTAEYMAPEQIM----NEGHNKMADFWQIGV
|.|.. .||.|...||.|.|||  | .||||.||||. .   .| |||||||..|.. .... .|.| |.|.|||||| ..    ..||.| .| |  ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LTYEMLYGTTPFFNEFRP-NKDEIFNDIIQGK--YTFP--QYFKDDAKNFIRGLLQKDVKKRLG--YNGFHELKKHAFF
| |||| | .|| .  .  |..||.. | .||   |.|  ||  ..||..||..|..| .||||   ..  |.|.|..|
LMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 20271.AA PKA 65-323 43 4.7e-97 328.75 In-house 1-263 (263) Show / Hide 
Range on Protein: 65-323
Range on HMM: 1-263/263
Sequence Identity: 43% (115 aa)

FRIIRVIGSGAFGKVYLVNKKGTEEVYAMKVYDKMTLYEKNVILSTIGERNILKNMNSNFIV-KLHYAFQAAQNLYLMMDFMVGGELYYHLKKAKKFDEE
| ||...|.| ||.|.|. .|.... ||||. .| .    . .  .. |.|||.|... ||| |. . || ...||. |..  |||. ..| | ..|.. 
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

RTKFYIA-QVILAIECLHQNNIMYRDLKLENILLGQDGYIKLTDFGLSKEGIKDKDLTNTLCGTAEYMAPEQIMNE-GHNKMADFWQIGVLTYEMLYGTT
 .|||.| |..||.| ||. ||.||||| ||||. ..|.||.|||| .|. ..|   | ||||| ||.||| | .. ||.|  | |  |.| |||| | .
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKK-VDD--RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PFFNEFRPNKDEIFNDIIQGKYTFPQYFKDDA---KNFIRGLLQKDVKKRLG--YNGFHELKKHAFF
||... | .. .|.. |..||. ||..|  ||   | .|. |||.|..||.|   ||    |.| .|
PFYDHNR-DPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 20271.AA RSK-Unclassified 65-323 39 9.5e-97 304.43 In-house 1-283 (283) Show / Hide 
Range on Protein: 65-323
Range on HMM: 1-283/283
Sequence Identity: 39% (113 aa)

FRIIRVIGSGAFGKVYLVNKKGTEEVYAMKVYDKMTLYEKNVILSTIGERNILKNMNSNFIVKLHYAFQAAQNLYLMMDFMVGGELYYHLK--KAKKFDE
|  .| || | ||||||| ||.|. .|||||  |  .  .| |   . |.||.   |  |||.| ..||    ||| |..  ||... ||   | |.| |
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

ERTKFYIAQVILAIECLHQNNIMYRDLKLENILLGQDGYIKLTDFGLSKEG-------IK--------------DKDLTNTLCGTAEYMAPEQIMNEGHN
.. .||.. |..| | ||   . ||||| .||.| |.| ..||||.||...       .|              .   ||  ||| ||.||| |   || 
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

KMADFWQIGVLTYEMLYGTTPFFNEFRPNKDEIFNDIIQGKYTFP--QYFKDDAKNFIRGLLQKDVKKRLG-YNG-FHELKKHAFF
|  | |  |.. |||| | .|.  .   ||.|.|. | ...  ||  .|   ...  |. |||.   ||||   |   . |.| ||
KAVDWWTLGIVMYEMLFGCPPYYGN---NKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 20271.AA S_TKc 65-323 34 1.6e-90 307.96 SMART 1-231 (231) Show / Hide 
Range on Protein: 65-323
Range on HMM: 1-231/231
Sequence Identity: 34% (94 aa)

FRIIRVIGSGAFGKVYLVNKKGTEEVYAMKVYDKMTLYEKNVILSTIGERNILKNMNSNFIVKLHYAFQAAQNLYLMMDFMVG--GELYYHLKKAKK---
..|.|.||.|||||||.. .|.| ...|.|. .           ... |..|||. .  .||||...||  ..||. |... |  |.|. ..|| ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FDEERTKFYIAQVILAIECLHQNNIMYRDLKLENILLGQDGYIKLTDFGLSKEGIKDKDLTNTLCGTAEYMAPEQIMNEGHNK-MADFWQIGVLTYE
   |.| ...||..|...|.| .|...|..|||| ||||| .   ||..||||...        .|.||| .||||| .   |..|  .| | .|.. ||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MLYGTTPFFNEFRPNKDEIFNDIIQGKYTFPQYFKDDAKNFIRGLLQKDVKKRLGYNGFHE----LKKHAFF
||.| .||      . ...|. |            ..||.|||..|||| .||..     .     |.| .|
MLCGYPPFP-----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 20271.AA RSK 65-323 40 1.1e-87 297.66 In-house 1-271 (271) Show / Hide 
Range on Protein: 65-323
Range on HMM: 1-271/271
Sequence Identity: 40% (110 aa)

FRIIRVIGSGAFGKVYLVNKK---GTEEVYAMKVYDKMTLYEKNVILSTIGERNILKNMNSNFIVKLHYAFQAAQNLYLMMDFMVGGELYYHLKKAKKFD
. ....|| |.|.|||.. |.    |.  ||||. .| |.  |     .  ||.|| . .. |||||||.|| ....|. |||| ||.|  .| | | | 
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EERTKFYIAQVILAIECLHQNNIMYRDLKLENILLGQD----GYIKLTDFGLSKEGIKDKDLTNTLCGTAEYMAPEQIMNEGHNKMADFWQIGVLTYEML
|.  ||| | . || |.||.  | .|||| ||||.  .    | ||..|||..|. . .  .. | |.||.||||| ..  || . .|.|  ||| ||||
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEML

YGTTPFFNEFRPNKDEIFNDIIQGKYTF----PQYFKDDAKNFIRGLLQKDVKKRLGY--NGFHELKKHAFF
 |.||| |  |   ..|   |  |....    ...  | ||  .|..|  |  .|||   ||  . |.|..|
TGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 20271.AA AGC-Unique 65-323 35 2.9e-87 296.21 In-house 1-270 (270) Show / Hide 
Range on Protein: 65-323
Range on HMM: 1-270/270
Sequence Identity: 35% (98 aa)

FRIIRVIGSGAFGKVYLVNKK---GTEEVYAMKVYDKMTLYEKNVILSTIGERNILKNMNSNFIVKLHYAFQAAQNLYLMMDFMVGGELYYHLKKAKKFD
| | ..||.|..|.||.| .|    || .||||| .|  .  .  .  .  |. ||  |   |....||.||    | . ||.  ||..  |...| .| 
FEILKHIGVGSYGRVYAVRRKNGCDTEKFYAMKVMNKRDMSKHKQMVHHNTEWMILTTMHHPFFMRMHYSFQNKDHLFMCMDYVPGGDMFHHMQNAECFI

EERTKFYIAQVILAIECLHQNNIMYRDLKLENILLGQDGYIKLTDFGLSKEGIKDKDLTNT---------LCGTAEYMAPEQIMNEGHNKMADFWQIGVL
||  .|||. ||  |  || |.| .|| |.||||.. || |..||.|||| |.   |             .||| .||||| ..  .| | .| | .|..
EESAHFYICEVICSIHYLHENHIIHRDIKPENILIDNDGHIMITDYGLSKTGCDSVDAIQNGGEGGFATTFCGTRHYMAPEIHTEKKHGKSCDWWSVGIT

TYEMLYGTTPFFNEFRPNKDEIFNDIIQGKYTFPQYFKDDAKNFIRGLLQKDVKKRLG--YNGFHELKKHAFF
 ..|. .  ||      |. . .   ||..   |     |.. |.  |. .|  .|||   .|| | | | .|
YCDMRTDRSPFDAS---NRNDMYDSMIQKRPRMPMFLSPDEQDFVNKLIVRDPNQRLGNSPQGFEEIKSHDMF
Kinase 20271.AA Pkinase 65-323 29 3.9e-80 277.34 Pfam 1-293 (293) Show / Hide 
Range on Protein: 65-323
Range on HMM: 1-293/293
Sequence Identity: 29% (87 aa)

FRIIRVIGSGAFGKVYLVNKKGTEEVYAMKVYDKMTLYEKNVILSTI-GERNILKNMNSNFIVKLHYAFQAAQNLYLMMDFMVGG----ELYYHLK--KA
..|.|.||||.||.||.  .|||....|.|. .| .  ..  .  .   |  |.|..|. .||.|...|.  ...|. |... ||    .|. ...  . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KKF--DEERTKFYIAQVILAIECLHQNNIMYRDLKLENILLGQDGYI----KLTDFGLSKEG-IKDKDLTNTLCGTAEYMAPEQIM-NEGHNKMADFWQI
..|  .|.  |||. |.. ..| .|...|..||||.||||. ..|.|    |..||||.|   .  .  ..|.||| .||||| |. .... . .| | .
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVLTYEMLYGTTPFFNE----FRPNKDEIFNDIIQGKYTFPQYFK---------------------DDAKNFIRGLLQKDVKKRLGYNGFHELKKHAFF
|.. |||| | .|| ..       ....... | .... |. . .                     ...| ||...|.|| |||..   ......| .|
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPWF
Kinase 20271.AA p70 110-323 40 7.4e-80 271.62 In-house 75-299 (299) Show / Hide 
Range on Protein: 110-323
Range on HMM: 75-299/299
Sequence Identity: 40% (93 aa)

TIGERNILKNMNSNFIVKLHYAFQAAQNLYLMMDFMVGGELYYHLKKAKKFDEERTKFYIAQVILAIECLHQNNIMYRDLKLENILLGQDGYIKLTDFGL
|  |||||   .. ||..||||||    |||  ... ||||..||..   ..|. ..|| . .|.|.| |||  | ||||| ||..| | | ..||||||
TFAERNILEEVKHPFICDLHYAFQTNGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGL

SKEGIKDKDL----------TNTLCGTAEYMAPEQIMNEGHNKMADFWQIGVLTYEMLYGTTPFFNEFRPNKDEIFNDIIQGK--YTFPQYFKDDAKNFI
.|| |.|             | |.||| |||||| .|  |||.  | |  |.| | || |  ||  |   |. .. . |..||   . | |   ...  |
CKESIHDGAVDEEDPENVNATHTFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGE---NRKKTIDKILKGKQGLKLPPYLTHEMRDLI

RGLLQKDVKKRLG--YNGFHELKKHAFF
. || .....|.|   .   . ..|.||
KKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase 20271.AA TyrKc 65-323 22 1.5e-12 -19.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 65-323
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

FRIIRVIGSGAFGKVYL-VNKKGTEEVYAMKVYDKMTLYEKNVILSTIGERNILKNM--NSNFIVKLHYAFQAA-------QNLYLMMDFMVGGELYYHL
 . ....|.||||.||. . |   ..| | |.  . .      .   . | .|...   .   ||.|. .           . |.. | .| .| |  .|
ITLGKKLGEGAFGEVYKGTWK---IQV-AVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKAKK-FDEERTKFYIAQVILAIECLHQNNIMYRDLKLENILLGQDGYIKLTDFGLSKEGIKD------KDLTNT----LC---GTAEYMAPEQIMNEGH
.| .. .  .    .  |.    | ||..|.  |||   |.|.| .. .| .|||||...  |      ||   .     .        |||| |.    
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

NKMADFWQIGVLTYEML-YGTTPFFNEFR--PNKDEIFNDIIQG-KYTFPQY--------FKDDAKNFIRGLLQKDVKKRLGYNGFHELKKHAFF
.   | |  ||. .|.. || .|  ..     . .|..... ||     |..          |.  . ..   . | ..|     | |.  | .|
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP---TFSEI--HECF
Kinase 20271.AA S_TK_X 324-389 33 1.2e-10 42.56 SMART 1-79 (79) Show / Hide 
Range on Protein: 324-389
Range on HMM: 1-79/79
Sequence Identity: 33% (27 aa)

ADFDWDKLER--QEIEPQFKPPLR----SQVDLQNFNPRLVKNTMTDLGVKDN---KPHLKEEIESQ------FRGFTFVK
...|||||..  .|||| |||...    |. |. || |   ..| . | . |    . .  .| ..       |||||.| 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM-LTPDDPPLSNSMWQNE-METEIPPDPFRGFTYVF
Kinase 20271.AA p70 65-98 43 1.9e-08 26.88 In-house 1-37 (299) Show / Hide 
Range on Protein: 65-98
Range on HMM: 1-37/299
Sequence Identity: 43% (16 aa)

FRIIRVIGSGAFGKVYLVNKKG---TEEVYAMKVYDK
|  ..|.| |..|||..| |     |  .|||||  |
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRK
Kinase 20271.AA Pkinase_Tyr 65-81 41 0.000191 15.68 Pfam 1-17 (270) Show / Hide 
Range on Protein: 65-81
Range on HMM: 1-17/270
Sequence Identity: 41% (7 aa)

FRIIRVIGSGAFGKVYL
 ......|.||||.||.
ITFGKKLGEGAFGEVYK
Kinase 20271.AA Pkinase_Tyr 193-216 33 0.003504 11.4 Pfam 141-164 (270) Show / Hide 
Range on Protein: 193-216
Range on HMM: 141-164/270
Sequence Identity: 33% (8 aa)

NILLGQDGYIKLTDFGLSKEGIKD
|.|.. .. .| .||||..   .|
NCLVTENNVVKICDFGLARDIYND