Gene 25761 (Tetrahymena)

25761

Species: Tetrahymena
Alias: 54.m00217, 3823.m01129, PreTt25761, 25761, TTHERM_00463090, 185
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: AktR

Sequence

Name Sequence Type Origin Length Description Download
25761.AA Protein None 1706 None Fasta, JSON
25761.kin_dom Protein Kinase Domain None 259 None Fasta, JSON
25761.NA RNA None 5121 None Fasta, JSON

Protein domain

Protein domains of 25761.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 25761.AA AktR 964-1222 51 3e-170 571.88 In-house 1-268 (268) Show / Hide 
Range on Protein: 964-1222
Range on HMM: 1-268/268
Sequence Identity: 51% (138 aa)

FHLIRCIGLGGFSRVYLVQKK-DTGKMFALKLIDKKFIIENKKEVIVQNERNIMA-SIAHPFLLKLEYSFESKSYLGFCMEYCAGGELFYHLRRIKRMSE
||...|.| |.|..||||||| |..|..|.|.|.||.|||.... ....|||||.  . |||. ||.|.|..|..| |.||||.|||||.||...|..||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

EMARFYFVEICLGIDYLHKR-HIIYRDIKPENILLDLDGHVRIGDFGLSK--PDMDINEHAYSFCGSPEYMAPEMLMK-VGHTYTVDFYCLGALLYELVT
|.|||||..|.|...|||.. .|||||.||||||||.||||.|.||||||  ..|. .|.||||||.||||||||..| .||...||....|...||.||
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GLPPFYSHDTDAIYQRILSED-LDFPDHVELSIELKNLLK-GLLAKHPQNRLG-IKNGIRDILAHSWF
|.||||....  ..|.|.... . ||.....| ..|.|.. .|| |.|..||| ..||. .|  | ||
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 25761.AA AGC 964-1222 31 8.9e-168 437.92 In-house 1-395 (395) Show / Hide 
Range on Protein: 964-1222
Range on HMM: 1-395/395
Sequence Identity: 31% (124 aa)

FHLIRCIGLGGFSRVYLVQKK------DTGKMFALKLIDKKF-IIENK--KEVIVQNE------------RNIMASIA----------HPFLLK-LEYSF
|.....|| |.|..||||.||      ||||..|.| ..||  |...|  ..  ...|            |||.. .           |||. | | |||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ESKSY--LGFCMEYCA---------GG-ELFYHLR---RIKRMSEEMARFYFVE-------ICLGIDYLHK-RHIIYRD-IKPENILLDLDGHVRIGDFG
..|..  | |.|||.          || |||.||.   . .|..||.||||. |       |.|...|||. ..||.|| .|||||||| |||... |||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKPDMDIN--------------------------------------------------EHAYSFCG--SPEYMAPEMLMKVGHTYTVDFYC--LGALLY
|.|  |. .                                                  . ...|||  .|||||||.|    .....| ..  ||.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ELVTGLPPFYSHDTD----------AIYQRIL------SEDLDFPDH--------VELSIELKNLLKGLLAKHPQNRLGIKN------GIRDILAHSWF
|..||.||||.....           ..|.|.      .... ||..        ...| |.|.|.|.|| |.| .||| ..      |. .| .| ||
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 25761.AA Akt 964-1222 45 8.4e-127 407.4 In-house 1-264 (264) Show / Hide 
Range on Protein: 964-1222
Range on HMM: 1-264/264
Sequence Identity: 45% (121 aa)

FHLIRCIGLGGFSRVYLVQKKDTGKMF-ALKLIDKKFIIENKKEVIVQNERNIMASIAHPFLLKLEYSFESKSYLGFCMEYCAGGELFYHLRRIKRMSEE
| .....| | | .|.||.||||.|.. |.| . |. ||....   .. ||||   . |||. .| ||| .. .| |.|.|| ||||||||.| .|.||.
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

MARFYFVEICLGIDYLHKRHIIYRD-IKPENILLDLDGHVRIGDFGLSKPD-MDINEHAYSFCGSPEYMAPEMLMKVGHTYTVDFYC-LGALLYELVTGL
 ||||  || |.|..||.. |||||  ||||||.| |||... ||||.| . .  .. ...|||.|||.|||.| ..||| .||..  ||...||. .|.
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

PPFYSHDTDAIYQRILSEDLDFPDHVELSIELKNLLKGLLAKHPQNRLG-IKNGIRDILAHSWF
||||. | .  .. |..... |||   .| | |.|..||| | | .|||  .|....| .| ||
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase 25761.AA SGK 964-1222 41 9.69999999999e-127 393.59 In-house 1-283 (283) Show / Hide 
Range on Protein: 964-1222
Range on HMM: 1-283/283
Sequence Identity: 41% (117 aa)

FHLIRCIGLGGFSRVYLVQKKDT------------------GKMFALKLIDKKFII-------ENKKEVIVQNER-NIMASIAHPFLLKLEYSFESKSYL
|...  || |.| .||.|..||.                  .|..|.|.. |. ||        .|... .. || .|.  . |||. .| |.|  | .|
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

GFCMEYCAGGELFYHLRRIKRMSEEMARFYFVEICLGIDYLHKRHIIYRDIKPENILLDLDGHVRIGDFGLSKPDMDINEHAYSFCGSPEYMAPEMLMKV
 | |.|  |||.||||.| |. .|  ||||  || . ..|||.  ||||| |||||||| .||... ||||.| ..  |.   .|||.|||.|||.| | 
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

GHTYTVDFYCLGALLYELVTGLPPFYSHDTDAIYQRILSEDLDFPDHVELSIELKNLLKGLLAKHPQNRLGIKNGIRDILAHSWF
.|  ||| .|||..|||. .||||||| ..   |. |....| .|  .  | . . |..|||.| |..||| |.. ..|  | .|
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQM--SNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase 25761.AA RSK-Unclassified 964-1222 39 9.40000000001e-103 323.63 In-house 1-283 (283) Show / Hide 
Range on Protein: 964-1222
Range on HMM: 1-283/283
Sequence Identity: 39% (112 aa)

FHLIRCIGLGGFSRVYLVQKKDTGKMFALKLIDKKFIIENKKEVIVQNERNIMASIAHPFLLKLEYSFESKSYLGFCMEYCAGGELFYHLR--RIKRMSE
|  .| || | | .||||.|||| ...|.|   |. .|  .|   |  |.||||   |||  .| .|| .. ||  ||||| ||..| ||   . |...|
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

EMARFYFVEICLGIDYLHKRHIIYRDIKPENILLDLDGHVRIGDFGLSKPD---------------------MDINEHAYSFCGSPEYMAPEMLMKVGHT
. .|||  |. .   ||||| .|||| ||.||.|. .|||.  ||.||.                       .|    . ||||. ||.||||.   |||
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

YTVDFYCLGALLYELVTGLPPFYSHDTDAIYQRILSEDLDFPDHVELSIELKNLLKGLLAKHPQNRLGIKNG-IRDILAHSWF
  || . || ..||.  |.||.|   .. ... |. ... ||.  ..| . . |.| || . |  ||| | |   || .|  |
KAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPHDSYISNNCRDLIKKLLQRNPAKRLGCKMGDADDIKRHPFF
Kinase 25761.AA RSK 967-1222 38 3.8e-102 345.67 In-house 1-278 (278) Show / Hide 
Range on Protein: 967-1222
Range on HMM: 1-278/278
Sequence Identity: 38% (108 aa)

IRCIGLGGFSRVYLVQKK---DTGKMFALKLIDKKFIIENKKEVIVQN-ERNIMASIA-HPFLLKLEYSFESKSYLGFCMEYCAGGELFYHLRRIKR---
..  | ||.  |.|..|.   |||. .| | ..|. |. ..| .     ||||.. .  |||. .| |.|. ...|  .|||| |||||.||.. |.   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

MSEEMARFYFVEICLGIDYLHKRHIIYRDIKPENILLDL---DGHVRIGDFGLSKP-DMDINEHAYSFCGSPEYMAPEMLM----KVGHTYTVDFYCLGA
.||. |.||. || | ...||...||.||.||||||.|    .||... |||..|  . | |. ...||.. ||||||||.    ..||.  .| . ||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LLYELVTGLPPFYS---HDTDAIYQRILSED--LDFPDHVELSIELKNLLKGLLAKHPQNRLGI-KNGIRDILAHSWF
|.||. || |||..    . . | .||.. .  |..|   .|| | |.|....| ..|..|||  .... .|..|.||
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 25761.AA PKA 964-1222 41 5.4e-95 321.9 In-house 1-263 (263) Show / Hide 
Range on Protein: 964-1222
Range on HMM: 1-263/263
Sequence Identity: 41% (111 aa)

FHLIRCIGLGGFSRVYLVQKKDTGKMFALKLIDKKFIIENKKEVIVQNERNIMASIAHPFLL-KLEYSFESKSYLGFCMEYCAGGELFYHLRRIKRMSEE
| .|. .| | | ||.|...|..|. .|.| ..|  |.  | .  | ||.||. .| |||.  |....|   .|| . |||..|||.|..||. .| |. 
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

MARFYFV-EICLGIDYLHKRHIIYRDIKPENILLDLDGHVRIGDFGLSKPDMDINEHAYSFCGSPEYMAPEMLMKV-GHTYTVDFYCLGALLYELVTGLP
.|.||   .|.| ..|||. .||||| ||||||.| .||. |.||| .|    . .  .. || |||.|||..    ||   ||  .|| | ||...| |
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAK---KVDDRTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PFYSH--DTDAIYQRILSEDLDFPDHVELSI-ELKNLLKGLLAKHPQNRLG-IKNGIRDILAHSWF
||| |  |. .||..|.. ...|| |.      .| |.| ||.. .  |.|  |||..||  | ||
PFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase 25761.AA S_TKc 964-1222 33 8.4e-95 322.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 964-1222
Range on HMM: 1-231/231
Sequence Identity: 33% (90 aa)

FHLIRCIGLGGFSRVYLVQKKDTGKMFALKLIDKKFIIENKKEVIVQNERNIMASIAHPFLLKLEYSFESKSYLGFCMEYCAG--GELFYHLRRIKR---
....| || |.|..||....|.||. .|.| |.            ...|..|. .  ||.. || ..|.. ..| ..|||| |  |.|| .... .|   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---MSEEMARFYFVEICLGIDYLHKRHIIYRDIKPENILLDLDGHVRIGDFGLSKPDMDINEHAYSFCGSPEYMAPEMLMKVGHTY-TVDFYCLGALLYE
   ..| .||||. .||....|.|...||.||.||||||||   |. |.||||..         ..|||.|.|||||.|   |...  .| . .| .|||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LVTGLPPFYSHDTDAIYQRILSEDLDFPDHVELSIELKNLLKGLLAKHPQNRLGIKNGIR---DILAHSWF
...| |||.  . ......|.            | |.|......| | |..|...    .   || .| ||
MLCGYPPFP--QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 25761.AA RSK 964-1222 37 6e-88 298.5 In-house 1-271 (271) Show / Hide 
Range on Protein: 964-1222
Range on HMM: 1-271/271
Sequence Identity: 37% (102 aa)

FHLIRCIGLGGFSRVYLVQKK---DTGKMFALKLIDKKFIIENKKEVIVQNERNIMASIAHPFLLKLEYSFESKSYLGFCMEYCAGGELFYHLRRIKRMS
. |..||| | || ||...|.   ||.. .| | |.|. .    . |   .||.|.. . |||  || |.|..  ..   |. ..||.|| .| . | .|
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EEMARFYFVEICLGIDYLHKRHIIYRDIKPENILLDLD----GHVRIGDFGLSKPDMDINEHAYSFCGSPEYMAPEMLMKVGHTYTVDFYCLGALLYELV
|. ..||  || |  .|||.  |..|| ||||||.| .    ||..| |||..|   | |. ...||.. .|||||.|.. ||.  .|.. .|.|.||  
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEML

TGLPPFYSHDTDAIYQRILSEDLDF-----PDHVELSIELKNLLKGLLAKHPQNRLGI-KNGIRDILAHSWF
|| .||.. . |   . |.  .|       .    .| | | || ..|   |.||||   ||. .|. |.||
TGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase 25761.AA Ciliate-E2 964-1222 26 6.1e-87 295.14 In-house 1-365 (365) Show / Hide 
Range on Protein: 964-1222
Range on HMM: 1-365/365
Sequence Identity: 26% (101 aa)

FHLIRCIGLGGFS-----RVYLVQK------------------KDTGKMFALKLIDKKFIIENKKEVIVQ----------NERNIMASIAHPFLLKLEYS
. .|..|| |.|.     .|..|||                  |...|..|.| . |. |.. |.|  .           ||.||. .. ||...|. ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--SKSYLGFCMEYCAGGELFYHLR-------------------RIKRMSEEMAR-------FYFVEICLGIDYLHKRH-IIYRDIKPENILLDLDGHV
|.  ..... . |||| ||.||....                    ||..... ..       ||...|.|.. |||... ||.|||||||||.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

RIGDFGLSK----------------PDMDIN----------------EHAYSFCGSPEYMAPEMLMKVG---------HTYTVDFYCLGALLYELVTGLP
 | ||||||                  |. .                . ....||.|.|||||.|.. .         ..| .|...|| .|||...| |
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFYSHDTDAIYQRILSEDLDFP----------------DHVELSIELKNLLKG----LLAKHPQNRLGIKNGIRDILAHSWF
||        .| |.  ..|||                .. ..| | |.|.|     .| | |..|..   |. .|| | ||
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT---GWEQILNHPWF
Kinase 25761.AA Pkinase 964-1222 33 2.4e-84 291.29 Pfam 1-293 (293) Show / Hide 
Range on Protein: 964-1222
Range on HMM: 1-293/293
Sequence Identity: 33% (101 aa)

FHLIRCIGLGGFSRVYLVQKKDTGKMFALKLIDKKFIIENKKEVIVQ-NERNIMASIAHPFLLKLEYSFESKSYLGFCMEYCAGG----ELFYHLR--RI
.|..|.|| |.|..||. ..|.|||..|.| |.|. . ..|..  .  .|  ||... ||. ..| ..||.|... ..|||| ||    .|| ...  | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KRM--SEEMARFYFVEICLGIDYLHKRHIIYRDIKPENILLDLDGHV----RIGDFGLSKPD-MDINEHAYSFCGSPEYMAPEMLM-KVGHTYTVDFYCL
...  ||. ..||. .|. |..|.|.. ||.||.||||||.| .||.    .|.||||.|      |. ...|||.|.||||| ..   .... || . .
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GALLYELVTGLPPFYSH------DTDAIYQRILSEDLDFPDHVELS-------------------IELKNLLKGLLAKHPQNRLGIKNGIRDILAHSWF
| .|||...| |||..|      | .....||.. .|.|.   . |                    |.| ..|..|.| |. |..    ...|| | ||
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT----AEQILQHPWF
Kinase 25761.AA Ciliate-E2-Unclassified 964-1222 27 7.4e-84 284.9 In-house 1-352 (352) Show / Hide 
Range on Protein: 964-1222
Range on HMM: 1-352/352
Sequence Identity: 27% (98 aa)

FHLIRCIGLGGFSRVYLVQKKDTGKMFALKLIDKKFIIENKKEVIV---------QNERN-------------IMASIAHPFLLKLEYSFESKSYLGFCM
...|..|| |||. ||..|.|.... .|.| . |. |.  |.   .          |...             |. .. |||..|..| |..| .. . |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYCAGGELFYHLRRI-----------------KRMSEEMAR-----FYFVEICLGIDYLHKRH-IIYRDIKPENILLDLDG---HVRIGDFGLSK-PDMD
||| ||.|.....                   |. .|. |.     ||| .|..|..|||. . ||.|||||||||.| .|   ...| |||.|| .. .
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

--------------INEHAYSFCGSPEYM----APEMLMKVGHT----YTVDFYCLGALLYELVTGLPPFYSHDTDA----------------IYQRILS
              .......|||.|.||    |||.|.. ..     | .|...|| .|||...| .|||. . .                 .|| |. 
NNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQ

EDLDFPDHVE------LSIELKNLLKGLLAKHPQNRLGIKNGIRDILAHSWF
 ...|| . .      .| | |.... || | ...... . .. .|| | ||
KNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 25761.AA TyrKc 964-1216 20 3.6e-12 -25.96 SMART 1-280 (280) Show / Hide 
Range on Protein: 964-1216
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

FHLIRCIGLGGFSRVYLVQKKDTGKMFALKLIDKKFIIENKKEVIVQNERNIMASI--AHPFLLKLEYSFESK-------SYLGFCMEYCAGGELFYHLR
 .|.. .| | | .||. . |    . | | . .        .    .| .|| ..   || ...|     ..         |   |||...| |  .||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RIKR-MSEEMARFYFVEICLGIDYLHKRHIIYRDIKPENILLDLDGHVRIGDFGLSKPDMDINEH--------AYSFCG--SPE------YMAPEMLMKV
. ..  . .    . . |. | .|||....| ||.   |.|.. ...|.|.|||||.   || ..         |.  .  .         |||| ... 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSR---DIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

GHTYTVDFYCLGALLYELVT-GLPPFYS-----HDTDAIYQRILSE-DLDFPDH------VELSIELKNLLKGLLAKHPQNRLGIKNGIRDI
  |   | .  | ...|. | | .| .       . . ..... .   .. |..      |. . |. .. |   .  | .|   .. ....
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 25761.AA Pkinase_Tyr 1041-1110 29 1.1e-05 19.89 Pfam 86-159 (270) Show / Hide 
Range on Protein: 1041-1110
Range on HMM: 86-159/270
Sequence Identity: 29% (22 aa)

MEYCAGGELFYHLRR----IKRMSEEMARFYFVEICLGIDYLHKRHIIYRDIKPENILLDLDGHVRIGDFGLSK
|||...| |  .||.     .. . ..   . ..|. | .||. ...| ||.   |.|.. ...|.|.||||..
MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR