Gene 6284 (Tetrahymena)

6284

Species: Tetrahymena
Alias: 6284, 58.m00256, 3719.m00110, TTHERM_00483500, 373, PreTt06284
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: AGC
Family: AktR

Sequence

Name Sequence Type Origin Length Description Download
6284.AA Protein None 742 None Fasta, JSON
6284.kin_dom Protein Kinase Domain None 257 None Fasta, JSON
6284.NA RNA None 2229 None Fasta, JSON

Protein domain

Protein domains of 6284.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank 6284.AA Ank 277-309 45 2.4e-09 38.0 Pfam 1-33 (33) Show / Hide 
Range on Protein: 277-309
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

QGQTPLILACLENKQDVAALLIESGANINAQDQ
 |.||| |||. .  .|. .|.. ||..|||| 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank 6284.AA Ank 244-276 27 3e-06 26.95 Pfam 1-33 (33) Show / Hide 
Range on Protein: 244-276
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

EGWTPLHYFAYFGNTPLCNLLIQKDINLDSVNI
.|.||||. .. |.|  . .|.|.  ... .. 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank 6284.AA Ank 310-343 23 0.339561 8.57 Pfam 1-33 (33) Show / Hide 
Range on Protein: 310-343
Range on HMM: 1-33/33
Sequence Identity: 23% (8 aa)

YLNTPLHYCFLNGDKDLLDIILKKPYLDINLRNN
. .||||.  ..|... .   |.    |.|....
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Kinase 6284.AA AktR 414-670 48 5.8e-156 524.43 In-house 1-268 (268) Show / Hide 
Range on Protein: 414-670
Range on HMM: 1-268/268
Sequence Identity: 48% (131 aa)

YIVHGLIGKGAFAEVFLVEER-KTGKQFALKMLHKQKIIEQNMYKYAITERNILQ-LVDHPFIVKMHKAFQTKDKLFFLLENGKRGDILQHLKFEKKFSE
. |. ..|||||..|.||... ...||.|.||..|.||||.|.....||||||.. ...||||||.|..||||.||||..|. ..|...||||..|||||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

SKAQFYAAEVLLALEYLHNH-DIIYRDLKAQNILIAEDGHVRITDFGLSK-EGVREYDQGARSFCGSVAYMPPEILRN-QGHGKSIDLYLLGIFIFEMLT
..|.||.|..||||||||.| .||||||| .|||. |||||.|||||||| .....||. |.||||...||.||.... .||.||.|.. .||||.||.|
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GQPPFYG-KDEQNILFIREHNLQQYLNESAQISQFYFKDCQ-KLANQNPRFRPT-----PDQIKRHPFF
|.||||  ...|....|.... |.. ......|.......| || ..||. |..     ...||.||.|
GCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase 6284.AA AGC 414-670 28 8.9e-146 379.73 In-house 1-395 (395) Show / Hide 
Range on Protein: 414-670
Range on HMM: 1-395/395
Sequence Identity: 28% (114 aa)

YIVHGLIGKGAFAEVFLVEER------KTGKQFALKMLHKQK-IIEQN--MYKYAITE------------RNILQLVD----------HPFIVK-MHKAF
. .. .||||.| .|.||...       |||..|.|.| |.. |.. .  | ....||            ||||....          |||||| .| .|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTKDK--LFFLLENGK---------RG-DILQHLK---FEKKFSESKAQFYAAE-------VLLALEYLHN-HDIIYRD-LKAQNILIAEDGHVRITDFG
|.||.  |.|..|  .          | . ..||.    |..|.|. |.|||||       ..|||||||. ..||.|| ||  |||. ||||...||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKEGVREYDQG-------------------------------------------------ARSFCG--SVAYMPPEILRNQGHGKSIDLY--LLGIFIF
|.|||......|                                                 . .|||  .  ||.||||    .||. | .  .||....
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLTGQPPFYGKD---------EQNILFIREHNLQ----QYLNES----------AQISQFYFKDCQKLANQNPRFRPT----------PDQIKRHPFF
|||||.|||||..          .. .| .  | .    . .              ..|.     ..|| . .|. |..           ..||.||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase 6284.AA Akt 419-619 46 1.5e-104 335.1 In-house 6-209 (264) Show / Hide 
Range on Protein: 419-619
Range on HMM: 6-209/264
Sequence Identity: 46% (95 aa)

LIGKGAFAEVFLVEERKTGKQF-ALKMLHKQKIIEQNMYKYAITERNILQLVDHPFIVKMHKAFQTKDKLFFLLENGKRGDILQHLKFEKKFSESKAQFY
..|||.|. ||||.. .|.| . |.|.| |..||..|  ....||||||| ..|||||..| .|||.|||.| ..  . |.. .||. ...|||..| ||
VLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSEDRARFY

AAEVLLALEYLHNHDIIYRD-LKAQNILIAEDGHVRITDFGLSKEGVREYDQGARSFCGSVAYMPPEILRNQGHGKSIDLYL-LGIFIFEMLTGQPPFYG
.||. ||.|.||...||||| ||  |||. .|||...|||||.||..  ... . .|||. .|..|||| ..||.|. | .  ||....||..|.|||| 
CAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYN

KDEQ
.| .
QDHH
Kinase 6284.AA RSK-Unclassified 414-623 41 1e-101 320.34 In-house 1-231 (283) Show / Hide 
Range on Protein: 414-623
Range on HMM: 1-231/283
Sequence Identity: 41% (97 aa)

YIVHGLIGKGAFAEVFLVEERKTGKQFALKMLHKQKIIEQNMYKYAITERNILQLVDHPFIVKMHKAFQTKDKLFFLLENGKRGDILQHLK--FEKKFSE
.|.|.|||.| | .|.||....| . .|.| |||.|.| .|  ||..||.||. . .|||||..  .|||.|.|.  .|    ||. .||    ||.|.|
FIKHRLIGQGDFGKVYLVRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFCE

SKAQFYAAEVLLALEYLHNHDIIYRDLKAQNILIAEDGHVRITDFGLSKEG--------------------VREYDQGARSFCGSVAYMPPEILRNQGHG
 ...|||.|| .||||||  |.||||||  ||.   .|||. |||.||...                    . .   ...||||...|. ||..|  ||.
DDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSIQAKDSKKPVMKGSAQSTYVDTKICDHGFRTNSFCGTEEYLAPEMIRRCGHT

KSIDLYLLGIFIFEMLTGQPPFYGKDEQNILF
| .| ..||| ..||| | ||.|| . .| .|
KAVDWWTLGIVMYEMLFGCPPYYG-NNKNETF
Kinase 6284.AA SGK 414-619 41 1.7e-93 289.1 In-house 1-231 (283) Show / Hide 
Range on Protein: 414-619
Range on HMM: 1-231/283
Sequence Identity: 41% (96 aa)

YIVHGLIGKGAFAEVFLVEERKT------------------GKQFALKMLHKQKII-------EQNMYKYAITER-NILQLVDHPFIVKMHKAFQTKDKL
 .   .|||| | .|..|.  ..                  .| .|.| | || ||         .  |.  .|| .||... |||||. | |||||.||
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FFLLENGKRGDILQHLKFEKKFSESKAQFYAAEVLLALEYLHNHDIIYRDLKAQNILIAEDGHVRITDFGLSKEGVREYDQGARSFCGSVAYMPPEILRN
.| ..    |.   ||. ||.|.|..| |||||. .||||||  ||||||||  |||   .||...|||||.|||. . |    .|||...|. ||.|| 
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDT-TFTFCGTPEYLAPEVLRK

QGHGKSIDLYLLGIFIFEMLTGQPPFYGKDEQ
|.|... | ..||.. .||..| |||| .. |
QPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQ
Kinase 6284.AA RSK 417-620 41 8.1e-87 294.74 In-house 1-218 (278) Show / Hide 
Range on Protein: 417-620
Range on HMM: 1-218/278
Sequence Identity: 41% (90 aa)

HGLIGKGAFAEVFLVEER---KTGKQFALKMLHKQKIIEQNM-YKYAITERNILQLVD-HPFIVKMHKAFQTKDKLFFLLENGKRGDILQHLKFEKK---
. . |.|.. .|||. .    .||...| | |.| ||.  .   ... ||||||...  |||||. | ||||..||.  .|  . |. . ||. ||    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSESKAQFYAAEVLLALEYLHNHDIIYRDLKAQNILIAE---DGHVRITDFGLSKEGVREYDQGARSFCGSVAYMPPEILR----NQGHGKSIDLYLLGI
|||. |.||.||. ||.|.|| ..||.||||  ||| ..   .||...||||..|... .. | . .||....||.||.|.    . ||.|. |.. ||.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

FIFEMLTGQPPFYGKDEQN
 ..|||||.|||.| ...|
LMYEMLTGCPPFQG-PNDN
Kinase 6284.AA S_TKc 414-670 31 2.2e-82 280.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 414-670
Range on HMM: 1-231/231
Sequence Identity: 31% (86 aa)

YIVHGLIGKGAFAEVFLVEERKTGKQFALKMLHKQKIIEQNMYKYAITERNILQLVDHPFIVKMHKAFQTKDKLFFLLENGKR--GDILQHLKFEKK---
| .. .||||||..|... ..|||...|.|...          . .. |..||.  .||.|||.. .||. |.|.. .|      || ....|  ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSESKAQFYAAEVLLALEYLHNHDIIYRDLKAQNILIAEDGHVRITDFGLSKEGVREYDQGARSFCGSVAYMPPEILRNQGHGK-SIDLYLLGIFIF
   |.|  |.||......||||.|.| ||.|||| .|||. |  |. |.||||...         ..|||.  ||.||.|   |.|| ..| . .|. ..
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLTGQPPFYGKDEQNILFIREHNLQQYLNESAQISQFYFKDCQKLANQNPRFRPTPDQIKR-------HPFF
|||.|.|||.  ..| .. .               |.      .|. . .|. |||  .. .       ||.|
EMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 6284.AA RSK 414-619 36 1.6e-80 273.82 In-house 1-211 (271) Show / Hide 
Range on Protein: 414-619
Range on HMM: 1-211/271
Sequence Identity: 36% (78 aa)

YIVHGLIGKGAFAEVFLVEER---KTGKQFALKMLHKQKIIEQNMYKYAITERNILQLVDHPFIVKMHKAFQTKDKLFFLLENGKRGDILQHLKFEKKFS
|..|  ||.|.| .|...       |....| | . | ..       .. .||.||  ..|||||| | .||.  |..  ..  . ||.. .|  .| ||
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR-VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

ESKAQFYAAEVLLALEYLHNHDIIYRDLKAQNILIAED----GHVRITDFGLSKEGVREYDQGARSFCGSVAYMPPEILRNQGHGKSIDLYLLGIFIFEM
|... ||.||..||.|||| ..|..||||. |||....    ||..|.|||..|. .| .. .. .||....|| ||.|. |||... | ...|.  .||
EREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQ-LRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEM

LTGQPPFYGKDEQ
||| .||..|. .
LTGCTPFQNKPRD
Kinase 6284.AA Ciliate-E2-Unclassified 414-670 25 2.8e-76 259.72 In-house 1-352 (352) Show / Hide 
Range on Protein: 414-670
Range on HMM: 1-352/352
Sequence Identity: 25% (90 aa)

YIVHGLIGKGAFAEVFLVEERKTGKQFALKMLHKQKIIEQNMYKY---------AITERN-------------ILQLVDHPFIVKMHKAFQTKDKLFFLL
|...  ||.|.|..|......|.....|.|...|..|. |. ...         .. ...             ||.  .|||||||. .||.|..... .
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

ENGKRGDILQHLKFEKK-----------------FSESKAQ-----FYAAEVLLALEYLHNHD-IIYRDLKAQNILIAEDG---HVRITDFGLSK-----
|  . || .|..|  ||                 |.| .|.     ||.|..|..|||||    ||.||.| .|||. ..|   ...|.|||.||     
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

---EGVRE-------YDQGARSFCGSVAYM----PPEILRNQGHG----KSIDLYLLGIFIFEMLTGQPPFYGKDEQN---------------ILFIREH
   .  .        ..| . .|||.  ||    .||.|..|...    ...| . ||. ..|||.|..|||....                 .|.   .
NNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

NLQQYLNESAQ-----ISQFYFKDCQK-----LANQNPRFRPTPDQIKRHPFF
. ... ... .     ....  ||. .     . . ||  |.|..||. ||.|
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 6284.AA PKC 414-618 41 5.2e-75 242.55 In-house 1-205 (262) Show / Hide 
Range on Protein: 414-618
Range on HMM: 1-205/262
Sequence Identity: 41% (85 aa)

YIVHGLIGKGAFAEVFLVEERKTGKQFALKMLHKQKIIEQNMYKYAITERNILQLVD-HPFIVKMHKAFQTKDKLFFLLENGKRGDILQHLKFEKKFSES
   .  .||| |. |.|.| ..| . .| | | |  ||.      . ||. .| |   ||| ...|  |||.|.||| .|  . ||   |    ..|.|.
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

KAQFYAAEVLLALEYLHNHDIIYRDLKAQNILIAEDGHVRITDFGLSKEGVREYDQGARSFCGSVAYMPPEILRNQGHGKSIDLYLLGIFIFEMLTGQPP
.| |||||...|| .||...|||||||  |.|. ..||..|.|||..||....  . ...|||   |. ||||. |  |||.|   .|.  .||. ||.|
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNG-DTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSP

FYGKDE
| |.||
FHGEDE
Kinase 6284.AA Pkinase 414-670 27 1.5e-73 255.41 Pfam 1-293 (293) Show / Hide 
Range on Protein: 414-670
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

YIVHGLIGKGAFAEVFLVEERKTGKQFALKMLHKQKIIEQNMYKYAI-TERNILQLVDHPFIVKMHKAFQTKDKLFFLLENGKRG----DILQHLK--FE
| ... ||.|.|..|..  ...|||..|.| . |... ..  .  .  .|  |.. ..||.||... .|..||.. . .|    |    |   ...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KKF--SESKAQFYAAEVLLALEYLHNHDIIYRDLKAQNILIAEDGHV----RITDFGLSKEG-VREYDQGARSFCGSVAYMPPEILR-NQGHGKSIDLYL
..|  ||  ..||. ..| .|||.|.. ||.|||| .|||| ..||.    .|.||||.|      .   . .|||.  ||.||..| .|..|...| . 
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGIFIFEMLTGQPPFYGK----DEQNILFIREHNLQ-------QYLNESAQISQFYF-----------KDCQKLA----NQNPRFRPTPDQIKRHPFF
.|. ..|||.|.|||.|.    .  . ... . ...       .....    . |..           ..|...     ...|  |||..||. ||.|
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 6284.AA Ciliate-E2 414-670 23 5.3e-70 238.87 In-house 1-365 (365) Show / Hide 
Range on Protein: 414-670
Range on HMM: 1-365/365
Sequence Identity: 23% (87 aa)

YIVHGLIGKGAFAEVFLVEERKTGKQFA-----------------------LKMLHKQKIIEQNMYKYAI----------TERNILQLVDHPFIVKMHKA
|... .||.|.|. |.... .|..||||                       .|...|..|..... .. .           |.|||....||.|.||. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TKDKLFFLLENGKRGDILQHLKFE-----------KKFSESKAQ---------------FYAAEVLLALEYLHNHD-IIYRDLKAQNILIAEDGHV
||  ....... .|  . || ....|             |.|.| ...               ||.|...|||||||.   ||.||.| .|||.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

RITDFGLSKEGVREYD------------------------------QGARSFCGSVAYMPPEILRNQG---------HGKSIDLYLLGIFIFEMLTGQPP
 |.||||||.   ...                              . ....||.  ||.||||....         .....|.. ||. ..|||.|.||
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FYGKDEQNILFIREHNLQQYLN------------ESAQISQFYFKDCQK----LANQNPRFRPT-PDQIKRHPFF
|     |..    . ..... .            .  ..||     ..|    . . .|  |.| ..||. ||.|
F-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 6284.AA TyrKc 414-670 21 3.1e-13 -8.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 414-670
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

YIVHGLIGKGAFAEVFLVEERKTGKQFALKMLHKQKIIEQNMYKYAITERNILQLV--DHPFIVKMHKAFQTK-------DKLFFLLENGKRGDILQHLK
      .| ||| ||.. . .    | | |||.. .       .  . | .|.  .  .|| ||... .  ..       . |. ..|  . || ...|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

FEKK-FSESKAQFYAAEVLLALEYLHNHDIIYRDLKAQNILIAEDGHVRITDFGLSKEGVRE--------YDQG----ARSFCGSVAYMPPEILRNQGHG
  .. .. ..   ..  .    |||| . .| ||| | |.|..|...|.|.|||||...  .        |        . .   .  |.|| ..     
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

KSIDLYLLGIFIFEMLT-GQPPFYG-----KDEQNILFIREHN--LQQYLN----ESAQISQFYFKDCQKLANQNPRFRPTPDQIKRHPFF
   | .  |. ..|..| ||.| .|     .. | ..   ..   . |  |     .   ..  ..  ..  . .|  |||  .|  | .|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 6284.AA Pkinase_Tyr 524-560 45 1.9e-08 29.21 Pfam 123-159 (270) Show / Hide 
Range on Protein: 524-560
Range on HMM: 123-159/270
Sequence Identity: 45% (17 aa)

ALEYLHNHDIIYRDLKAQNILIAEDGHVRITDFGLSK
..|||... .| ||| | |.|..|...|.|.||||..
GMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase 6284.AA RSK 654-670 36 0.001003 9.45 In-house 250-271 (271) Show / Hide 
Range on Protein: 654-670
Range on HMM: 250-271/271
Sequence Identity: 36% (8 aa)

NPRFRPTP-----DQIKRHPFF
.|  |..       |||.||.|
DPHNRLGAGPNGVEQIKQHPWF
Kinase 6284.AA Akt 662-670 66 0.001192 7.45 In-house 256-264 (264) Show / Hide 
Range on Protein: 662-670
Range on HMM: 256-264/264
Sequence Identity: 66% (6 aa)

DQIKRHPFF
..|||||.|
QEIKRHPWF
Kinase 6284.AA RSK-Unclassified 662-670 88 0.001619 6.34 In-house 275-283 (283) Show / Hide 
Range on Protein: 662-670
Range on HMM: 275-283/283
Sequence Identity: 88% (8 aa)

DQIKRHPFF
| |||||||
DDIKRHPFF
Kinase 6284.AA SGK 663-670 75 0.001801 6.06 In-house 276-283 (283) Show / Hide 
Range on Protein: 663-670
Range on HMM: 276-283/283
Sequence Identity: 75% (6 aa)

QIKRHPFF
.||.||||
EIKNHPFF
Kinase 6284.AA RSK 654-670 31 0.002811 8.27 In-house 257-278 (278) Show / Hide 
Range on Protein: 654-670
Range on HMM: 257-278/278
Sequence Identity: 31% (7 aa)

NPRFRPT-----PDQIKRHPFF
.|  |..      ..||.||.|
DPHKRLGCGPQDAEEIKQHPWF
Kinase 6284.AA PKC 662-670 55 0.049874 2.17 In-house 254-262 (262) Show / Hide 
Range on Protein: 662-670
Range on HMM: 254-262/262
Sequence Identity: 55% (5 aa)

DQIKRHPFF
. |..||||
QDIREHPFF