Gene 2016 (Tetrahymena)

2016

Species: Tetrahymena
Alias: TTHERM_01333220, PreTt02016, 2016, 331.m00019, 727
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CAMK
Family: CDPK

Sequence

Name Sequence Type Origin Length Description Download
2016.AA Protein None 493 None Fasta, JSON
2016.kin_dom Protein Kinase Domain None 259 None Fasta, JSON
2016.NA RNA None 1482 None Fasta, JSON

Protein domain

Protein domains of 2016.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 2016.AA CDPK 47-305 62 1.8e-204 632.76 In-house 1-271 (271) Show / Hide 
Range on Protein: 47-305
Range on HMM: 1-271/271
Sequence Identity: 62% (169 aa)

YKLGGVLGVGAFSQVRKVTNR-KTKAVR-AMKIINKRSLTNSEDQQKFINEVEILRLLDHPHILKIYEQYQDNNNYYIILE--MCTGGELFAKIIEKGSF
||...||| |.|.|||||... ||. .| |||||.|... ..|.||.|.||.|||. ||||.|.||||.|||..||||..|  .||||||| .|||||.|
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRVKDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYIIEKGHF

SEKEASYIMNQIVSAVFYAHNHKIVHRDLKPENILLDITSDGT---YNIKIVDWGTSKIFEQD-----EVMVEKFGTPYYIAPEVLKKSYNEKCDVWSCG
.||||.|||.||.|||.|.|...||||||||||||.|. .|..   ||||..||||||.|.|.     ..| ...|||||||||||.|.||||||.||||
TEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVLQKKYNEKCDIWSCG

VILYILLSGTPPFGGKNELEIMANVEKGQYSLEGDNLKHVSEEAKDLIRQMLEYNPKNRLSASQVLEHKWF
|||||||.|.|||.|||. |||..|.||.||.||.. .|.|.|||||||.||.|.||.|.||.|.|.|.||
VILYILLCGYPPFYGKNDQEIMEKVKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase 2016.AA Ciliate-E2a 47-305 40 3.7e-138 409.24 In-house 1-275 (275) Show / Hide 
Range on Protein: 47-305
Range on HMM: 1-275/275
Sequence Identity: 40% (112 aa)

YKLGGVLGVGAFSQVRKVTNRKTKAVRAMKIINKRSLTNSEDQQKFINEVEILRLLDHPHILKIYEQYQDNNNYYIILEMCTGGELFAKIIEKGSFSEK-
||.  ..| |.| .|.... ..|.  .|||...|.   . .....|.||. |.| ||||.|.|.|| |.|.||||...| | ||||. ||.....| |. 
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI

-EASYIMNQIVS-AVFYAHNHKIVHRDLKPENILLD-ITSDG--TYNIKIVDWGTSKIF--EQDEVMVEKFGTPYYIA------PEV-LKKSYNEKCDVW
 |.. || |. . .. | |. .|.||||||||||.. . ...  . .|||.|.|... .   . ..|  | |||.|.|      .|| ..|.| .|||.|
QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMW

SCGVILYILLSGTPPFGGKNELEIMANVEKGQYSLEGDN-LKHVSEEAKDLIRQMLEYNPKNRLSASQVLEHKWF
|||||.||||.|.||| ||.. ||  ...| ...... . .. .| |.|||...|||..||.|..| | |.|.||
SCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 2016.AA CAMK1 47-305 43 1.2e-137 402.76 In-house 1-276 (276) Show / Hide 
Range on Protein: 47-305
Range on HMM: 1-276/276
Sequence Identity: 43% (121 aa)

YKLGGVLGVGAFSQVRKVTNRKT---KAVRAMKIIN-KRSLTNSEDQ--QKFINEVEILRL---LDHPHILKIYEQYQDNNNYYIILEMCTGGELFAKII
|..| ..| ||||.|...|...|   .   |.|.|. |... ....|  ... ||.||..    .|||.| |.|| |...| .|...| .|||||| .|.
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

EKGSFSEKEASYIMNQIVSAVFYAHNHKIVHRDLKPENILLDITSDGTYNIK--IVDWGTSKIFEQDE-VMVEKFGTPYYIAPEVLK----KSYNEKCDV
|||...||.|. || ||.||| | | . ||||||||||.|.  . |    ||  | | | ||||..|| .|   .|||.|.|||||.    | |  .||.
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLY-YDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDM

WSCGVILYILLSGTPPFGGKN-ELEIMANVEKGQYSLEGDNLKHVSEE-AKDLIRQMLEYNPKNRLSASQVLEHKWF
||.|||.|||| | ||| ..| . |... . |..|    .   ..|.. |||.|..||| .||.|....|.|.|.|.
WSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase 2016.AA CAMK 52-305 28 7.79999999999e-130 420.81 In-house 1-425 (425) Show / Hide 
Range on Protein: 52-305
Range on HMM: 1-425/425
Sequence Identity: 28% (120 aa)

VLGVGAFSQVRKVTNRKTK------------AVRAMKIINKRSLTNSE-------------------------DQQKFINEVEILRL-------LDHPHI
.|| |.|..|.......|.               |.|||.|. |....                         |.... .|.||...       ||||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LKIYEQYQD-------------------NNNYYIIL---EMCTGGEL----FAKIIEKGS---------------FSEKEASYIMNQIVSAVFYAHNHKI
.|.|| |.|                   ....|...   |.|.||||    | .|.|.|.               |.|.||.... ||.||| | |.|.|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPENILLDITSDGT-------------YNIKIVDWGTSKIFEQ------------------------DEVMVEKFGTPYYIA-PEVLKKS-----
|||||||||||||  .|..             .||||.|.| ...|..                        .. | . .|||.|.| ||||...     
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

----------YNEKCDVWSCGVILYILLSGTPPFGGK-------------NELEIMANVEKGQYSLEGDNLKH------------VSEE--------AKD
          |..|||.|||||||||.|.|.||| |.             |. |.. .. ||.|. . . ...            .|.|        .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LIRQMLEYNPKNRLSASQVLEHKWF
|||.||...|..|....|.|.|.|.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 2016.AA S_TKc 47-305 36 1.6e-108 367.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 47-305
Range on HMM: 1-231/231
Sequence Identity: 36% (100 aa)

YKLGGVLGVGAFSQVRKVTNRKTKAVRAMKIINKRSLTNSEDQQKFINEVEILRLLDHPHILKIYEQYQDNNNYYIILEMCTG--GELFAKIIEKGS---
|... ..| |||..|.|....||. . |.|||.          .....|..||.  .||.| |.|. .|| ...|...|.| |  |.||  | ..|.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FSEKEASYIMNQIVSAVFYAHNHKIVHRDLKPENILLDITSDGTYNIKIVDWGTSKIFEQDEVMVEKFGTPYYIAPEVLKKSYNE-KCDVWSCGVIL
   |.| .| ..| ||..|. | |.|.|.||||||||||||       .||| | | ....          |||.|.|||||  .|.  |||.||||.||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCIL

YILLSGTPPFGGKNELEIMANVEKGQYSLEGDNLKHVSEEAKDLIRQMLEYNPKNRLSASQVLE-------HKWF
|..|.| |||   .. ... ..               |.||||.||..|...|..|..| ..|.       | ||
YEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 2016.AA RSK 47-305 38 9.9e-100 337.63 In-house 1-278 (278) Show / Hide 
Range on Protein: 47-305
Range on HMM: 1-278/278
Sequence Identity: 38% (107 aa)

YKLGGVLGVGAFSQVRKVTNRKTKAVRAMKIINKRSLTNSE-DQQKFINEVEILRLLD-HPHILKIYEQYQDNNNYYIILEMCTGGELFAKIIEKGS---
 |. | .|.|.....||.|...|. . |||...|. . ... |.     |..|| .   || | . .. .|..   |.|.| | ||||| .. ....   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEKEASYIMNQIVSAVFYAHNHKIVHRDLKPENILLDITSDGTYNIKIVDWGTSKIFEQD-EVMVEKF-GTPYYIAPEVLK----KS-YNEKCDVWSCG
|||.||...| .||.|| . | ..|.||||||||||.|  | .   ||..| | .|.|  | . .  .| .|  |.|||.||    .. ... ||.|| |
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

VILYILLSGTPPFGG---KNELEIMANVEKGQYSLEGDNLKHVSEEAKDLIRQMLEYNPKNRLS-----ASQVLEHKWF
|..| .|.| ||| |   .|  |||....||..||...| . .|.|||||||.||. .|..||.     |.....|.||
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase 2016.AA CAMK-Unique 47-305 26 1.5e-99 329.29 In-house 1-363 (363) Show / Hide 
Range on Protein: 47-305
Range on HMM: 1-363/363
Sequence Identity: 26% (98 aa)

YKLGGVLGVGAFSQVRKVTNRKTKAVRAMKIINK-RSLTNSEDQQ----------------KFINEVEILRLLDHPHILKIYEQ----YQDNN-------
||.. ..| |.|. |.....|.|.  .|.|...| .   .. .||                |. .|..|....|||.|.|.|.     ..| .       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------NYYIILEMCTGGELFAKIIE--------------------KGSFSE--KEASYIMNQIVSAVFYAHNHKIVHRDLKPENILLDITSDG----
        ..||..| |.||.||..|..                    .|.|||   ... || ...||| |.|. .|||||||.|||..    .     
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------TYNIKIVDWGTSKIFEQDEVMV---EKFGTPYYIAP--------------EVLK-KSYNEKC----DVWSCGVILYILLSGTPPFGGKNEL-
         ..||. |.| .. ... ..     .  |||.|.||              ||..   | ..|    | ||.|||.|..|.| ||| . .|  
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

-------EIMANVEKGQY-SLEGDNLKH---VSEEAKDLIRQMLEYNPKNRLSASQVLEHKWF
       || ..  ||.| ... .       .|.||||.. . ... |. |.||.. ||| |.
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase 2016.AA Ciliate-E2 47-305 28 1.3e-97 330.64 In-house 1-365 (365) Show / Hide 
Range on Protein: 47-305
Range on HMM: 1-365/365
Sequence Identity: 28% (108 aa)

YKLGGVLGVGAFSQVRKVTNRKTKA-----------------------VRAMKIINKRSLTNSEDQQKFINEVE----------ILRLLDHPHILKIYEQ
||.  ..| |.|..|.|....|..                          ||||..|. . . .  .. ..|..          ||..|.||.|.|.|| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YQ--DNNNYYIILEMCTGGELFAKIIEK-----------GSFSEKEASYIMNQIVS---------------AVFYAHNHK-IVHRDLKPENILLDITSDG
.|  |.||.|...| | ||.||  |...           ..|.|||..||| ||..               |. | |. . |.|||.||||||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

TYNIKIVDWGTSKIFEQD-----------EVMVEK----------------------FGTPYYIAPEVLK-KS---------YNEKCDVWSCGVILYILL
   |||.|.|.||.. .|           . |  |                       |||.| |||.|. |.         |..|||.||.|||||..|
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

SGTPPFGGKNELEIMANVEKGQYSLEGD--------------NLKHVSEEAKDLIRQ----MLEYNPKNRLS-ASQVLEHKWF
.| |||        . . .......                 . |..|.|.||||..    ||...|..|.. ..|.|.|.||
FGKPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 2016.AA CAMKL 47-305 33 2.2e-97 311.36 In-house 1-297 (297) Show / Hide 
Range on Protein: 47-305
Range on HMM: 1-297/297
Sequence Identity: 33% (102 aa)

YKLGGVLGVGAFSQVRKVTN-RKTKAVRAMKIINKRSLT-NSEDQQKFIN-----------EVEILRLLD---HPHILKIYEQYQDNNN------YYIIL
|..| .|| |.|..|.  |. | |.   |.|||.|. .. .   ......           |..|...|.   ||.| |.|| ... ..      .|...
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EMCTGGE--LFAKIIEK----GSFSEKEASYIMNQIVSAVFYAHNHKIVHRDLKPENILLDITSDGTYNIKIVDWGTSKIFE-Q----DEVMVEKFGTPY
| | |||  || .|...    |...|.||  .  |||||| | |.|.|||||.||||||||   .   ||||.| | | ... .    .. . .  |.| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

YIAPEVLKK---SYN-EKCDVWSCGVILYILLSGTPPFGGKN---------ELEIMANVEKGQYSLEGDNLKHVSEEAKDLIRQMLEYNPKNRLSASQVL
| |||....   .|.  | |.|||||||| .. |. || . .         .|. . ..  ...    .  .||| ...||||.||. ||. | .. |..
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYP----PIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIM

EHKWF
.|.|.
NHPWM
Kinase 2016.AA RAD53 47-305 34 9.1e-94 279.66 In-house 1-305 (305) Show / Hide 
Range on Protein: 47-305
Range on HMM: 1-305/305
Sequence Identity: 34% (106 aa)

YKLGGVLGVGAFSQVRKVTNRKTKAVRAMKIINK-----RSLTNSEDQQKFINEVEILRLLDHPHILKIYEQYQD-NNNYYIILEMCTGGELFAKII-EK
| ....|| |.|..|... ..||  . |.|||.|     |. ... .   . ||||||. | || | .||. ...   .||..||  |||||| ||.  |
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK

GS---FSEKEASYIMNQIVSAVFYAHNHKIVHRDLKPENILLDITSDGT--------------YNIKIVDWGTSKIFEQDEVMVEKFGTPYYIAPEVLKK
.    |.| .. |.  |.. || | |.  |.||||||||||........                ||| | | ||. . ...|    ||| | ||||. .
RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITS

S----------------YNEKCDVWSCGVILYILLSGTPPFG-GKNE----LEIMANVEK-GQYSLEGDNLKHVSEEAKDLIRQMLEYNPKNRLSASQVL
.                |. |.|.|| |.||||.|.|.|||. .. .      .   . . | |. .    . .||||||||..||  .|..|... ..|
KGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEAL

EHKWF
 | |.
NHPWM
Kinase 2016.AA Pkinase 47-305 34 1.4e-92 318.67 Pfam 1-293 (293) Show / Hide 
Range on Protein: 47-305
Range on HMM: 1-293/293
Sequence Identity: 34% (101 aa)

YKLGGVLGVGAFSQVRKVTNRKTKAVRAMKIINKRSLTNSEDQQKFI-NEVEILRLLDHPHILKIYEQYQDNNNYYIILEMCTGG----ELFAKII--EK
|..|...| |.|..|.| ....|  . |.|||.||.   ..||...  .|..|.. |.||.|...|. ..|....|...| | ||    .||. |   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GSF--SEKEASYIMNQIVSAVFYAHNHKIVHRDLKPENILLDITSDGTY--NIKIVDWGTSKI--FEQDEVMVEKFGTPYYIAPEVLK--KSYNEKCDVW
|.|  ||.|.  .| ||.... | |...|.||||||||||.|  ..|.    .|| |.| .|      .. |    |||.|.||||..  . |  |.|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SCGVILYILLSGTPPFGGK------NELEIMANVEKGQYSLEGDNLKHVS-----------------EEAKDLIRQMLEYNPKNRLSASQVLEHKWF
|||.|||..|.| ||| |.      ......... ..... . ...  .|                 ||.||.|. .|...|| |..| |.|.|.||
SCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 2016.AA Ciliate-E2-Unclassified 47-305 28 3.9e-83 282.49 In-house 1-352 (352) Show / Hide 
Range on Protein: 47-305
Range on HMM: 1-352/352
Sequence Identity: 28% (101 aa)

YKLGGVLGVGAFSQVRKVTNRKTKAVRAMKIINKRSLTNSEDQQKF---------INEVE-------------ILRLLDHPHILKIYEQYQDNNNYYIIL
||.. ..| |.|..|.|. ..|.| . |||...|    ..  ...          .|. .             ||. ..||.|.| ... || .| ||..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EMCTGGELFAKIIEKGS-----------------FSEKEAS-----YIMNQIVSAV-FYAHNHKIVHRDLKPENILLDITSDGTYNIKIVDWGTSKIFE-
| | ||.|.  | ....                 |.|..|.     ... ||...  .. |...|.|||.||||||.|      |.||| |.| ||  . 
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-NYYIKIIDFGISKKYQQ

---------------QDEVMVEKFGTPYYI----APEVLKK-SYN----EKCDVWSCGVILYILLSGTPPFGGKNELE----------------IMANVE
               ... |  . |||.|.    |||||..  |.    .|||.||.||||| .| |..||...|. .                .  |  
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

KGQYSLEGDNL----KHVSEEAKDLIR----QMLEYNPKNRLSASQVLEHKWF
.....    .     ||.|.||||.|.    .||..||..|....|.|.| ||
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase 2016.AA TyrKc 47-305 23 2.6e-16 40.9 SMART 1-280 (280) Show / Hide 
Range on Protein: 47-305
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

YKLGGVLGVGAFSQVRKVTNRKTKAVRAMKIINKRSLTNSEDQQKFINEVEILRLL--DHPHILKIYEQYQDN-------NNYYIILEMCTGGELFAKII
 .|| .|| ||| .|.| | .      | | ... .      .. |..| .|.. |  .||.|...|    .          ..|..| . .| |   . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

EKGS-FSEKEASYIMNQIVSAVFYAHNHKIVHRDLKPENILLDITSDGTYNIKIVDWGTSKIFEQD-------EVMVEKF--GTP-----YYIAPEVLKK
...  .. |.  ... || .   | | ....||||   |.|..        .|| | | |.  . |       .. . |   |.         |||....
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

S-YNEKCDVWSCGVILY-ILLSGTPPFGG-----KNELEIMANVEKGQYSLEGDNLK-----HVSEEAKDLIRQMLEYNPKNRLSASQVLEHKWF
. ...| |||| || .. |.  | .|  |     ..  |....|..| .    .|       . ..|  ....|  ...|..| . |..  |. |
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 2016.AA Pkinase_Tyr 47-171 25 3.2e-09 31.85 Pfam 1-137 (270) Show / Hide 
Range on Protein: 47-171
Range on HMM: 1-137/270
Sequence Identity: 25% (35 aa)

YKLGGVLGVGAFSQVRKVTNR-----KTKAVRAMKIINKRSLTNSED--QQKFINEVEILRLL-DHPHILKIYEQYQ-DNNN--YYIILEMCTGGELFAK
 ..| .|| ||| .|.| | .     ..  | | |...    . .|.  ...|..|..|.. | .||.|.. |     .     .||..| . .| |   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPV-AVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

IIE----KGSFSEKEASYIMNQIVSAVFYAHNHKIVHRDL
  .    |.... |.   .  || ..  | ......||||
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase 2016.AA Pkinase_Tyr 216-263 30 1.408443 2.58 Pfam 182-233 (270) Show / Hide 
Range on Protein: 216-263
Range on HMM: 182-233/270
Sequence Identity: 30% (16 aa)

APEVLKKS-YNEKCDVWSCGVILYILLS-GTPP-FGGKNELEIMANV-EKGQ
|||... . ...| |||| || .. ... |  | . |    |... . |.|.
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGY
Efhand 2016.AA efhand 355-383 34 9e-06 25.56 Pfam 1-29 (29) Show / Hide 
Range on Protein: 355-383
Range on HMM: 1-29/29
Sequence Identity: 34% (10 aa)

QLNKIFKALDKNGDGILTKNEIFEGYRQF
.|...|| .||.||| ....|  |.....
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 2016.AA EFh 355-383 24 7.9e-05 23.29 SMART 1-29 (29) Show / Hide 
Range on Protein: 355-383
Range on HMM: 1-29/29
Sequence Identity: 24% (7 aa)

QLNKIFKALDKNGDGILTKNEIFEGYRQF
.....|. .||.||| ....|  .. . .
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 2016.AA efhand 392-420 27 1.5e-05 24.68 Pfam 1-29 (29) Show / Hide 
Range on Protein: 392-420
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

EVNKIMNQVDIDKSGAIDYTEFILATMEK
|........| |..| ||. ||. . ...
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 2016.AA EFh 392-420 27 9.5e-05 23.02 SMART 1-29 (29) Show / Hide 
Range on Protein: 392-420
Range on HMM: 1-29/29
Sequence Identity: 27% (8 aa)

EVNKIMNQVDIDKSGAIDYTEFILATMEK
|...... .| |..| ||. ||. . ...
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
EFh 2016.AA EFh 427-455 37 2e-06 28.41 SMART 1-29 (29) Show / Hide 
Range on Protein: 427-455
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

KLLESFLLFDQDGNGFITAEELKQVLGNH
.. | | .||.||.|.|. ||.|... . 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL
Efhand 2016.AA efhand 427-455 37 2e-06 27.73 Pfam 1-29 (29) Show / Hide 
Range on Protein: 427-455
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

KLLESFLLFDQDGNGFITAEELKQVLGNH
.| | | .||.||.|.|. ||..... . 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
Efhand 2016.AA efhand 463-491 48 6e-07 29.84 Pfam 1-29 (29) Show / Hide 
Range on Protein: 463-491
Range on HMM: 1-29/29
Sequence Identity: 48% (14 aa)

IWLDLIGETDANGDGKISFEEFTEMMMKY
 . ... | |..|||.|.|||| |||.| 
ELKEMFKEFDKDGDGYIDFEEFCEMMKKL
EFh 2016.AA EFh 463-491 37 2e-06 28.27 SMART 1-29 (29) Show / Hide 
Range on Protein: 463-491
Range on HMM: 1-29/29
Sequence Identity: 37% (11 aa)

IWLDLIGETDANGDGKISFEEFTEMMMKY
 . ... . |..|||.|.|||| .||.. 
EFKEMFRMFDKDGDGYIDFEEFKDMMKSL