Gene 7080 (Tetrahymena)
7080
Sequence
Protein domains of 7080.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 7080.AA | CK1-Unclassified | 27-259 | 55 | 4.7e-192 | 572.08 | In-house | 1-244 (244) | Show / Hide |
Range on Protein: 27-259 Range on HMM: 1-244/244 Sequence Identity: 55% (136 aa) FRLEEKIGQGSFGMIFKCINMETQEVFAIKLEKRNQRHSSMLVREIKVMMEMKNDK-------GFAKMQTYGKD--EEYNYVVMSYLGRNIDSLLKKCGG .|..|||||||||.|.|||||.|.|..||||||.|.. ...|..|.|.|....|.. |..||...|.. ..||..||..||.....|...|.. YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK-HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNR KFSTQTVVNLADQMISRLEALHNKNLIHRDIKPENYVIG-YGSNFTVVHLIDFGLAKYYK--DSDGNHIPFIEKKGMIGTARYASINAHLGHEQSRRDDL ||| .|| ..|||||.|.| |||||.|||||||.|...| .| | ..|..|||||.|.|. |..|.|||. |.|...|||||||||||||.|||||||| KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDL EALGYVLLYFAKGKLPWQNIYADTKDEKYEKIKAMKQQYTLEQLC |.|||||.||.||.||||||.|..|.||||||. ||.....|||| ESLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC |
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Kinase | 7080.AA | CK1 | 27-285 | 48 | 3.5e-175 | 588.27 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 27-285 Range on HMM: 1-271/271 Sequence Identity: 48% (133 aa) FRLEEKIGQGSFGMIFKCINMETQEVF---AIKLEKRNQRHSSMLVREIKVMMEMKN------DKGFAKMQTYGKD--EEYNYVVMSYLGRNIDSLLKKC .|...||||||||.|...||| |.... ||||||....|. .|..|.|....... ..|...| ..|.. ..||..||..||.. ..|...| YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSKHP-QLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFC GGKFSTQTVVNLADQMISRLEALHNKNLIHRDIKPENYVIG-YGSNFTVVHLIDFGLAKYYKD-SDGNHIPFIEKKGMIGTARYASINAHLGHEQSRRDD ..||| .||...|||||.|.| .||||.|||||||.|...| || . ..|..|||||||.|.| ....|||. |.|...|||||||||.|||.||||||| NRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD LEALGYVLLYFAKGKLPWQNIYADTKDEKYEKIKAMKQQYTLEQLCEN-LPNEFVQYFQHVKSLEFEEAPNYA .|.|||||.||..|.||||...|.||..|||||. .|.....||||.. .||||..|......|.|||.|.|. MESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
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Kinase | 7080.AA | CK1 | 27-287 | 31 | 1.5e-122 | 413.43 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 27-287 Range on HMM: 1-339/339 Sequence Identity: 31% (108 aa) FRLEEKIGQGSFG-MIFKC-----INMETQ-----EVFAIKLEKRNQRHS-SMLVREIKVMMEMKND-------------------KGFAKMQTYGKDEE .....|||.|.|| .|.|. ..|... | .|.|.|....... ..| .|......... ... .| |.. |. WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED --YNYVVMSYLGRNIDSLLK---KCGGKFSTQTVVNLADQMISRLEALHNKNLIHRDIKPENYVIGY------GSNFT--------VVHLIDFGLAK-YY |||.||. ||.|...|.| |..||| |....|.||...|| .|... |||||||.|...|. | . . .|..||||.|. | DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKH-HHEWNNEHRQVYMIDFGMARRKY KDSDGN------------HIPFIE---KKGMIG-TARYASINAHLGHEQSRRDDLEALGYVLLYFAKGK--LPWQNIYADTK-------DEKYEKIKAMK .|.||. |.|. | |||..| ||||.|||.|||.||.|||||....|.|... ||. |||||. . .| ..|||.|. .| RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKK QQYTLEQLCEN-----LPNEFVQYFQHVKSLEFEEAPNYAML ..... ||.. .| || .......||.....|.|.|. MSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | 7080.AA | CK1-D | 27-287 | 46 | 5.2e-99 | 335.23 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 27-287 Range on HMM: 1-261/261 Sequence Identity: 46% (123 aa) FRLEEKIGQGSFGMIFKCINMETQEVFAIKLEKRNQRHSSMLVREIKVMMEMKNDKGFAKMQTYGKDEEYNYVVMSYLGRNIDSLLKKCGGKFSTQTVVN .|. ||| |||| |. |..| | ||||| .| . . | |. |. | ... .|.. .|| .|| || .. | |. ||| .||. YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHI-ESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLM LADQMISRLEALHNKNLIHRDIKPENYVIGYGSNFTVVHLIDFGLAKYYKDSD-GNHIPFIEKKGMIGTARYASINAHLGHEQSRRDDLEALGYVLLYFA ||||||.|.| .| .| |||||||.|...| | .|..||||||| |.|. |||. |.| . ||||||||| |.| |||||||||.|||||.||. LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN KGKLPWQNIYADTKDEKYEKIKAMKQQYTLEQLCENLPNEFVQYFQHVKSLEFEEAPNYAML .| |||| . | || .|||.| | . ...||. .|.||.||. ....|.|.. |.|. | RGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | 7080.AA | CK1-A | 27-287 | 50 | 8.7e-98 | 331.18 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 27-287 Range on HMM: 1-261/261 Sequence Identity: 50% (131 aa) FRLEEKIGQGSFGMIFKCINMETQEVFAIKLEKRNQRHSSMLVREIKVMMEMKNDKGFAKMQTYGKDEEYNYVVMSYLGRNIDSLLKKCGGKFSTQTVVN .|| ||| |||| |. ||.. | |||.|... || |. | || .. |. .|. ||.. .|| .|| || .. | | .|. .||. YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARH-PQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLM LADQMISRLEALHNKNLIHRDIKPENYVIGYGSNFTVVHLIDFGLAKYYKDSDG-NHIPFIEKKGMIGTARYASINAHLGHEQSRRDDLEALGYVLLYFA ||||||.|.| .|.|| |||||||.|...| | ..|||||||| |.|| |||. | | ..||||||||||||| |||||||.|..|||..|| LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN KGKLPWQNIYADTKDEKYEKIKAMKQQYTLEQLCENLPNEFVQYFQHVKSLEFEEAPNYAML .|||||| . | || ||||| | ..|||| | || |......| |||.|.| | RGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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Kinase | 7080.AA | CK1-G | 27-287 | 43 | 9.3e-91 | 307.83 | In-house | 1-266 (266) | Show / Hide |
Range on Protein: 27-287 Range on HMM: 1-266/266 Sequence Identity: 43% (116 aa) FRLEEKIGQGSFGMIFKCINMETQEVFAIKLEKRNQRHSSMLVREIKVMMEMKNDK-GFAKMQTYGKDEEYNYVVMSYLGRNIDSLLKKCGGKFSTQTVV .| ||| |.|| .| || . | |||.| . | | | . . | . .| || || || | |. ||| ||. YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSR-APQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRKFSVKTVC NLADQMISRLEALHNKNLIHRDIKPENYVIGYGSNFT--VVHLIDFGLAKYYKDSDGN-HIPFIEKKGMIGTARYASINAHLGHEQSRRDDLEALGYVLL .| |||.|.|..| ..|| ||.||.|. || || . |.|.||||.|| | | . . |||. |.| . ||||| ||| ||| |||||||.|||| . . MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFM YFAKGKLPWQNIYADTKDEKYEKIKAMKQQYTLEQLCEN--LPNEFVQYFQHVKSLEFEEAPNYAML || |.|||| ||. |.|.|| |.. | ||.| .| .| .| . | .|.|.| | | | YFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL |
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Kinase | 7080.AA | TTBKL | 27-291 | 29 | 1e-65 | 220.84 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 27-291 Range on HMM: 1-288/288 Sequence Identity: 29% (88 aa) FRLEEKIGQGSFGMIFKCINMET-QEVFAIKLEKRN-QRHSSMLVREIKVMMEMK--NDKGFAKMQTYGKDEEYNYVVMSYLGRNIDSLLKKCGGK--FS .. ...||.| || ... ..|.. ....| | ||. . .| . |..|.|.. . . |.|. .|| . ||..||. .|.|.. | |. | || WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS TQTVVNLADQMISRLEALHNKNLIHRDIKPENYVIGYGSN----FTVVHLIDFGLAKYYKDSDG--------NHIPFIEKK------GMIGTARYASINA .|.. .. | . | .| . ||||.|| |...|| .. .|.|||||.|. |...|| | . ... . || ||.|.|. DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM HLGHEQSRRDDLEALGYVLLYFAKGKLPWQNIYADTKDEKYEKIKAMKQQYTLEQLCEN------LPNEFVQYFQHVKSLEFEEAPNYAMLKKLF |.. ||.| ||| .. |.. ....| |||.|. |. ..| .||.. ..|.|. . .| || ..|..||.. . |.| |. ..| HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNM------EDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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Kinase | 7080.AA | Worm6 | 27-287 | 27 | 2.4e-61 | 210.14 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 27-287 Range on HMM: 1-279/279 Sequence Identity: 27% (78 aa) FRLEEKIGQGSFGMIFKCINMETQE--VFAIKLEKR-NQRHSSMLVREIKVMMEMKNDK--GFAKMQTYG-KDEE-YNYVVMSYLGRNIDSLLKKC-GGK . ...|||.|.|| ..|. . .. . ||.|.||. .....|| .|. |... |. | .| |. .| .|.. .||.|| .|.| | | . ..| WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK FSTQTVVNLADQMISRLEALHNKNLIHRDIKPENYVIGY-----GSNFTVVHLIDFGLAK--YYKDSDGNHIPFI-EKKGMIGTARYASINAHLGHEQSR || | .| |.. ..| ||| ||||.|| |. || . . ..|||... .|.. .. .. .. | || |||....| | ||.| FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR RDDLEALGYVLLYFAKGKLPWQNIYADTKDE-KYEKIKAMKQQYTLEQLCENLPN-EFVQYFQHVKSLEFEEAPNYAML .||.| |... . .|.|||... .. .| .... .. . ... .. | ||. .. . .. ....|.|. . KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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Kinase | 7080.AA | TTBK | 27-287 | 35 | 9e-61 | 208.22 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 27-287 Range on HMM: 1-257/257 Sequence Identity: 35% (94 aa) FRLEEKIGQGSFGMIFKCINMETQ-EVFAIKLEKRNQRHSSMLVREIKVMMEMKNDKGFAKMQTYGKDEEYNYVVMSYLGRNIDSL-LKKCGGKFSTQTV . |||.| || |. .| .. | |||.|. .| | |. |. . . . . | ....||.||. .|.| | | |.|| | WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPK-QVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTT VNLADQMISRLEALHNKNLIHRDIKPENYVIG-YGSNFTVVHLIDFGLAKYYKDSDGNHIPFIEKKGMIGTARYASINAHLGHEQSRRDDLEALGYVLLY . | |.. .|. |. |||||| |. .| |. . ..||||| | . |. | | | ||.||||||||. | |.||| | |.| LRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE FAKGKLPWQNIYADTKDEKYEKIKAMKQQYTLEQLCENLPNEFVQYFQHVKSLEFEEAPNYAML |..| ||| | || ... ||..| . | ...| || |. .|.|||..|. |.|... FVQGQLPWRKI----KDK--DQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | 7080.AA | Pkinase | 27-247 | 22 | 1.4e-30 | 109.24 | Pfam | 1-231 (293) | Show / Hide |
Range on Protein: 27-247 Range on HMM: 1-231/293 Sequence Identity: 22% (55 aa) FRLEEKIGQGSFGMIFKCINMETQEVFAIKLEKRNQRHSSMLVR-----EIKVMMEMKNDKGFAKMQTYGKDEEYNYVVMSYLGR-----NIDSLLK-KC .....|||.|||| .||.. |....|.| |. ..|..... ||..| ... . .. . . |.|| |.. .... . YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTWR GGKF--STQTVVNLADQMISRLEALHNKNLIHRDIKPENYVIGYGSNFTV---VHLIDFGLAKYYKDSDGNHIPFIEKKGMIGTARYASINAHL-GHEQS .|.| | ... . . |... || .|... ||||.|||| | .| .. |...|||||| .. . . .. || .|.. .. | . . HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFD------Y-NNSMTTFCGTPWYMAPEVIRGGQYYG RRDDLEALGYVLLYFAKGKLPWQNI----YADTKDEKYEKIK .. | ..| .| ... |..|... .........|. PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIM |
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Kinase | 7080.AA | VRK | 89-233 | 36 | 1.1e-29 | 92.61 | In-house | 96-242 (284) | Show / Hide |
Range on Protein: 89-233 Range on HMM: 96-242/284 Sequence Identity: 36% (54 aa) TYGKDEEYNYVVMSYLGRNIDSLLK-KCGGKFSTQTVVNLADQMISRLEALHNKNLIHRDIKPENYVIGYGSNFTVVHLIDFGLAKYYKDSDGNHIPFIE .. ..| | . || .|| . .... .|..|| || || .|. || || .. | ||| .| |. | | |.|.||| |.. .|.| ...| HDFNGEKYRFMVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYCP-NGKHRQYKE --KKGMIGTARYASINAHLGHEQSRRDDLEALGYVLLYFAKGKLPWQN ... || . |. ||.| ||| ||| ||| ... . |.||| . DPRRCHNGTCEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMD |
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Kinase | 7080.AA | S_TKc | 27-279 | 21 | 5.6e-17 | 63.66 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 27-279 Range on HMM: 1-231/231 Sequence Identity: 21% (57 aa) FRLEEKIGQGSFGMIFKCINMETQEVFAIKLEKRNQRHSSMLVREIKVMMEMKNDKGFAKMQTYGKDEEYNYVVMSYLGR---NIDSLLKKCGGK----- ... .|||.|.|| .||.. .|....||| | .. |||..... . . |. . | .. |.|| |.. . ...||.|.. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP FSTQTVVNLADQMISRLEALHNKNLIHRDIKPENYVIGYGSNFTVVHLIDFGLAKYYKDSDGNHIPFIEKKGMIGTARYASINAHLGHEQSR-RDDLEAL |. .. .. |... || .|... ||||.|||| . .. ..|||||. . . ..|| | . .. . | .. FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC GYVLLYFAKGKLPWQNIYADTKDEKYEKIKAMKQQYTLEQLCENLPN-----EFVQYFQHVKSLEFE | .| .. |. |.. . .. ..||. ...... |. | |. ...|. .. GCILYEMLCGYPPFP-----QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF |
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Kinase | 7080.AA | TyrKc | 27-291 | 18 | 3.6e-08 | -90.57 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 27-291 Range on HMM: 1-280/280 Sequence Identity: 18% (57 aa) FRLEEKIGQGSFGMIFKCINMETQEVFAIKLEKRNQRHSSMLVREIKVMMEM-KNDKGFAKMQTYGKDE-------EYNYVVMSYL-GRNIDSLLKKCGG .|..|.| | || ..|.. . |.| | . .. ||...|.. .. . .. . .. | ..|| | . . .. |.|... ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP KFSTQTVVNLADQMISRLEALHNKNLIHRDIKPENYVIGYGSNFTVVHLIDFGLAKYYKDSD-----GNHIPFIEKKGMI--GTARYASINAHLGHEQSR |..... .. . | . | || ||.||||. | .| . .| ||||... .| | . . |.|| | .. KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP---------- RDDLEAL-GY------------VLLY--FAKGKLPWQNIYA--DTKDEKYEKIKAMKQQYTLEQLCENL-----PNEFVQYFQHVKSLEFEEAPNYAMLK |.. . |... | |. |. .. . .| .|..|. . . .. . | | | . . |. |. . .. ----ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH KLF ..| ECF |
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Kinase | 7080.AA | VRK | 27-44 | 50 | 1.8e-05 | 13.99 | In-house | 1-18 (284) | Show / Hide |
Range on Protein: 27-44 Range on HMM: 1-18/284 Sequence Identity: 50% (9 aa) FRLEEKIGQGSFGMIFKC .|| .|||| ||.|... WRLGKPIGQGGFGCIYLA |