Gene 8793 (Tetrahymena)
8793
Sequence
Protein domains of 8793.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 8793.AA | CK1-Unclassified | 34-269 | 49 | 5.6e-172 | 511.81 | In-house | 1-244 (244) | Show / Hide |
Range on Protein: 34-269 Range on HMM: 1-244/244 Sequence Identity: 49% (121 aa) LEVIEKIGQGSFGDIFKVWDSKRARWAAMKFEKKDKKNRYSLIKKEAQIMIQVKGSK-------YFAVLYDSRFSELSTYNFIEMSFLGPNLESLKKRMN .|||||||||||.|.|...... ...|.|.|||..| ......||.|| .... . ... .| . | ..||.. |..|||.||.|.. .| YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSK--HPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCN GKFNLRTVLLIANQMISGLQVLHEKGIIHRDIKPENFVIG-SEGYHHQVYIIDFGLSKYYI--DENKNHIEQKTNKGLVGTARYTSINSHLGLEQSRRDD .||.|.|||.||.|||. ...||.|..|||||||.||..| ....|||||||||||||.|| |....||... ||.|.|||||.|||.|||.||||||| RKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDD MESLAYLLLYFAKGTLVWQNLQFKEKEERFKKIAELKQTTPHEHMC .|||.|.|.||.||.|.|||.....|.|...||.|.|..||.|..| LESLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC |
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Kinase | 8793.AA | CK1 | 34-295 | 44 | 3.7e-149 | 501.81 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 34-295 Range on HMM: 1-271/271 Sequence Identity: 44% (123 aa) LEVIEKIGQGSFGDIFKVWDSKRARWA---AMKFEKKDKKNRYSLIKKEAQIMIQVKG------SKYFAVLYDSRFSELSTYNFIEMSFLGPNLESLKKR .|..||||||||||..... ... |.|.||...| . ....||.|. . .| ..... .| . . | . ||.. |..|||.||.|.. YRVGRKIGQGSFGDIYLGINM-TNGEENHVAIKLEKNKSK-HP-QLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNF MNGKFNLRTVLLIANQMISGLQVLHEKGIIHRDIKPENFVIGS-EGYHHQVYIIDFGLSKYYID-ENKNHIEQKTNKGLVGTARYTSINSHLGLEQSRRD .|.|| |.|||.|| |||. ....|.|..|||||||.||..| . .||||||||||.|.|.| ....||....||.|.|||||.|||.|||.|||||| CNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRD DMESLAYLLLYFAKGTLVWQNLQFKEKEERFKKIAELKQTTPHEHMCRG-LPKQFHEFLNLVKSLTFEQTPEYD |||||.| |.||..|.| ||.|....|.... ||.| |..||.|..|.| .|..|...|| ...| ||..| |. DMESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
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Kinase | 8793.AA | CK1 | 34-297 | 32 | 5.1e-110 | 371.81 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 34-297 Range on HMM: 1-339/339 Sequence Identity: 32% (110 aa) LEVIEKIGQGSFG-DIFKV-----WDSKRA-----RWAAMKFEKKDKKNRYSLIKKEAQIMIQVKGS-------------------KYFAVLYDSRFSEL .|..|||.|.|| .|.|| .|.|. ..||| |.|. . .... ..|.|.. . .| . . ..|. . | WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED STYNFIEMSFLGPNLESLKK--RM-NGKFNLRTVLLIANQMISGLQVLHEKGIIHRDIKPENFVIGS-------------EGYHHQVYIIDFGLSK-YYI ||.. |. ||||||.|.| || |.||...|.| || ||...|...|..|.|||||||.||..| .. |.|||.||||... |. DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR DENKN------------HIEQKT---NKGLVG-TARYTSINSHLGLEQSRRDDMESLAYLLLYFAKGT--LVWQNLQFKEK-------EERFKKIAELKQ | ... |..... .||..| ||||.|||.||| ||.||||..|..|.|... ||| | |||. ..| .. ..|.| | DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM TTPHEHMCRG-----LPKQFHEFLNLVKSLTFEQTPEYDRY || . | . .|..| .... ..||... .|.|. STPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | 8793.AA | CK1-A | 35-297 | 39 | 1.6e-77 | 263.89 | In-house | 2-261 (261) | Show / Hide |
Range on Protein: 35-297 Range on HMM: 2-261/261 Sequence Identity: 39% (105 aa) EVIEKIGQGSFGDIFKVWDSKRARWAAMKFEKKDKKNRYSLIKKEAQIMIQVKGSKYFAVLYDSRFSELSTYNFIEMSFLGPNLESLKKRMNGKFNLRTV .. ||| ||||||. . |.| |. .| |. . ||.. ...| . . . . || . | ||| || | . .| ..|| RLVRKIGSGSFGDIYLGINITNGEEVAIKMES--NKARHPQLIYEAKVYRILQGCVGIPHMR--WYGCEKDYNVMVMDLLGPSLEDLFNFCKRRFTMKTV LLIANQMISGLQVLHEKGIIHRDIKPENFVIGSEGYHHQVYIIDFGLSKYYID-ENKNHIEQKTNKGLVGTARYTSINSHLGLEQSRRDDMESLAYLLLY |..| |||. . .|||. |||||||.||..| . ....|||||.| | | . . ||. .. | |.||||| ||| |||.||||||||||..| ..| LMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMY FAKGTLVWQNLQFKEKEERFKKIAELKQTTPHEHMCRGLPKQFHEFLNLVKSLTFEQTPEYDRY | .|.| || .. . |. .. || | | .|| |..|.| | .| ..| ...| ||..|.| FNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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Kinase | 8793.AA | CK1-D | 35-297 | 39 | 5.4e-74 | 252.14 | In-house | 2-261 (261) | Show / Hide |
Range on Protein: 35-297 Range on HMM: 2-261/261 Sequence Identity: 39% (104 aa) EVIEKIGQGSFGDIFKVWDSKRARWAAMKFEKKDKKNRYSLIKKEAQIMIQVKGSKYFAVLYDSRFSELSTYNFIEMSFLGPNLESLKKRMNGKFNLRTV . ||| ||||||. . . |.| | | . .. |... ..| . . . || . | ||| || | . || |.|| RIGRKIGSGSFGDIYHGTNIQTNEEVAIKLEC--IKTKHPQLHIESKFYKMMQGGIGIPEIR--WCGQEGDYNVMVMDLLGPSLEDLFNYCHRKFSLKTV LLIANQMISGLQVLHEKGIIHRDIKPENFVIGSEGYHHQVYIIDFGLSKYYIDEN-KNHIEQKTNKGLVGTARYTSINSHLGLEQSRRDDMESLAYLLLY |..|.|||. .. .| . |||||||.||..| . ||||||||.| | | . . || . || | ||||| ||| |.|.|||||||.||| |.|.| LMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMY FAKGTLVWQNLQFKEKEERFKKIAELKQTTPHEHMCRGLPKQFHEFLNLVKSLTFEQTPEYDRY |..|.| || |. | ... .|.| | |. . .|.|.|..| ...| ...| |.. |.| FNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | 8793.AA | TTBKL | 35-301 | 29 | 1.1e-67 | 227.58 | In-house | 2-288 (288) | Show / Hide |
Range on Protein: 35-301 Range on HMM: 2-288/288 Sequence Identity: 29% (86 aa) EVIEKIGQGSFGDIFKVWDSKR-ARWAAMKFEKKDKKNRYSLIKKEAQIMIQVK--GSKYFAVLYDSRFSELSTYNFIEMSFLGPNLESLKKRMNGK--F .....||.| || ...|||.|. |||| ||. . . | .|.|.... . ||..|. ...| . |||. |. .|||| |.|.|. | | MIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCS--GKRKDYNFMVMTLCGPNLQDLRKMMPNKKRF NLRTVLLIANQMISGLQVLHEKGIIHRDIKPENFVIGSEGY----HHQVYIIDFGLSKYYIDENKNH-----------IEQKT---NKGLVGTARYTSIN . .|.. |. | . .|. .|..|.||||.|| |...| .. . ||.||||... |...... .... .. || ||.|.| SDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPN SHLGLEQSRRDDMESLAYLLLYFAKGTLVWQNLQFKEKEERFKKIAELKQTTPHEHMCRG------LPKQFHEFLNLVKSLTFEQTPEYDRYRSLF |...||.| ||. |. | . ....| | |.|. |. .|...|. . .| .. . .|..| .| ..||.. ..| |. . .| MHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKM------EIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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Kinase | 8793.AA | CK1-G | 106-297 | 45 | 8.3e-67 | 225.44 | In-house | 70-266 (266) | Show / Hide |
Range on Protein: 106-297 Range on HMM: 70-266/266 Sequence Identity: 45% (90 aa) YNFIEMSFLGPNLESLKKRMNGKFNLRTVLLIANQMISGLQVLHEKGIIHRDIKPENFVIG--SEGYHHQVYIIDFGLSKYYID-ENKNHIEQKTNKGLV || . | ||| || | . || ..||...| |||. .. .|.. | ||.||.|| || |. .| ..|||||. | ||| | | || | | YNIMVMDLLGPSLEDLFDWCDRKFSVKTVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLT GTARYTSINSHLGLEQSRRDDMESLAYLLLYFAKGTLVWQNLQFKEKEERFKKIAELKQTTPHEHMCRG--LPKQFHEFLNLVKSLTFEQTPEYDRY ||||| ||| ||| |||||||||.| . .|| | | || | ||..|| . |. |. | .| . .|.|| .| | .| |. .| || GTARYMSINTHLGREQSRRDDMEALGHMFMYFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL |
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Kinase | 8793.AA | Worm6 | 35-297 | 29 | 1.2e-61 | 211.15 | In-house | 2-279 (279) | Show / Hide |
Range on Protein: 35-297 Range on HMM: 2-279/279 Sequence Identity: 29% (83 aa) EVIEKIGQGSFGDIFKVWDSKRAR--WAAMKFEKKDKKNRYSLIKKEAQIMIQVKGSK--YFAVLYDS-RFSELST-YNFIEMSFLGPNLESLKKRM-NG .| .|||.|.||...|| |... . ||| ||. ... . | |. .. || .| .| . | .. . .|.| | ..|.||. |.| .. KVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDN--RGFNYIVMTLVGKNLWDLRKNRPDR KFNLRTVLLIANQMISGLQVLHEKGIIHRDIKPENFVIGS-----EGYHHQVYIIDFGLSK--YYIDENKNHIEQK-TNKGLVGTARYTSINSHLGLEQS || ..| | || |.. ....|| | ||||.|| || || . ||..|..|||... .|..... . .. |. | .|| || ....| | ||. KFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQC RRDDMESLAYLLLYFAKGTLVWQNLQFKEKEE-RFKKIAELKQTTPHEHMCRGLPK-QFHEFLNLVKSLTFEQTPEYDRY |.||.|| |... . .|.| |... . .| ..|.. .. . . . .. || .| . . . .. .. .|.|. RKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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Kinase | 8793.AA | TTBK | 106-297 | 34 | 5.9e-40 | 138.89 | In-house | 70-257 (257) | Show / Hide |
Range on Protein: 106-297 Range on HMM: 70-257/257 Sequence Identity: 34% (66 aa) YNFIEMSFLGPNLESL-KKRMNGKFNLRTVLLIANQMISGLQVLHEKGIIHRDIKPENFVIGSEGYH-HQVYIIDFGLSKYYIDENKNHIEQKTNKGLVG .|.. |. .| || | | |.|.| | | . |.. ... |. | |||||| || .| . ..|..|||| |. . | | FNYMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRG TARYTSINSHLGLEQSRRDDMESLAYLLLYFAKGTLVWQNLQFKEKEERFKKIAELKQTTPHEHMCRGLPKQFHEFLNLVKSLTFEQTPEYDRY |.|| |||.|. | |.||. || |.| |..| | | . | |.. . |.|. | . .|..|| |.. .|||..| .|.| TVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPWRKI--KDKDQ----VGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | 8793.AA | Dual | 35-233 | 27 | 1.8e-29 | 96.18 | In-house | 2-215 (282) | Show / Hide |
Range on Protein: 35-233 Range on HMM: 2-215/282 Sequence Identity: 27% (59 aa) EVIEKIGQGSFGDIFKVWDSKR----ARWAAMKFEKKDKKNRYSLIKKEAQIMIQVKG---------SKYFAVLYDSRFSELSTYNFIEMSFLGPNL-ES |. .| | |.|. .| .... ..| | ... .. | |.|.|... . | | .. | ..| ... || || | | KVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQEI LKKRMNGKFNLRTVLLIANQMISGLQVLHEKGIIHRDIKPENFVIGSEGYHHQVYIIDFGLSKYYID-ENKNHIEQKTNKGLVGTARYTSINSHLGLEQS ..| ..| .. . .| ||. .| || | .||.||| || .| . || ||.. . ||| ||| | .. |..|| .. . .| RRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQKDQG RRDDMESLAYLLLY | ||.|. |.. . RKDDLECWIYMVFD |
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Kinase | 8793.AA | Pkinase | 34-256 | 22 | 1.3e-23 | 84.58 | Pfam | 1-230 (293) | Show / Hide |
Range on Protein: 34-256 Range on HMM: 1-230/293 Sequence Identity: 22% (55 aa) LEVIEKIGQGSFGDIFKVWDSKRARWAAMKFEKKDKKNR---YSLIK-KEAQIMIQV---KGSKYFAVLYDSRFSELSTYNFIEMSFLGPNLE--SLK-- .....|||.|||| .| . . . |.| ||.... ..... |.||| . ... . .| ... . | ... |. .|. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY --KRMNGKF--NLRTVLLIANQMISGLQVLHEKGIIHRDIKPENFVIGSEGYH-HQVYIIDFGLSK-YYIDENKNHIEQKTNKGLVGTARYTSINSHL-G ...|.| ... .. |...||. .|..||||||.||||. | ..|. | |.||||.| .. . . .....|| .| . .. | ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGG LEQSRRDDMESLAYLLLYFAKGTLVWQNL----QFKEKEERFKKI . ... || |. .| ... | . ... .. .....| QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRI |
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Kinase | 8793.AA | S_TKc | 34-301 | 19 | 1.2e-15 | 52.67 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 34-301 Range on HMM: 1-231/231 Sequence Identity: 19% (56 aa) LEVIEKIGQGSFGDIFKVWDSKRARWAAMKFEKKDKKNRYSLIKKEAQIMIQVKGSKYFAVLYDSRFSELSTYNFIEMSFLGPNLESLKKRMNGK----- |...|||.|.|| .|... | | |.| | |..| ||. . . .. |||. . .. .. | ... .| .|.... . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGL ---FNLRTVLLIANQMISGLQVLHEKGIIHRDIKPENFVIGSEGYHHQVYIIDFGLSKYYIDENKNHIEQKTNKGLVGTARYTSINSHLGLEQSR-RDDM |. .. .. |....|. .|..||||||.|||| . . .. |.||||.. . . ..|| | . .. . |. RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDW ESLAYLLLYFAKGTLVWQNLQFKEKEERFKKIAELKQTTPHEHMCRGLPKQFHEFLNLVKSLTFEQ-----TPEYDRY-------RSLF |. .| .. | .. . .. |||| .|...... . | | WSCGCILYEMLCGYPPFP-----QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 8793.AA | TyrKc | 34-286 | 18 | 8.1e-08 | -96.27 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 34-286 Range on HMM: 1-280/280 Sequence Identity: 18% (56 aa) LEVIEKIGQGSFGDIFK-VWDSKRARWAAMKFEKKDKKNRYSLIKKEAQIMIQV--KGSKYFAVLYDSRFSE------LSTYNFIEMSFLGPNLESLKKR .. ..|.| | || ..| .|. . | | |.|. . .||.|| .. . . . . .. . | .| .. |.|. ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH MNGKFNLRTVLLIANQMISGLQVLHEKGIIHRDIKPENFVIGSEGYHHQVYIIDFGLSKYYIDE-----NKNHIEQKTNKGLV--GTARYTSINSHLGLE . ..... | .. | .| . ||.|..||||. | .|... .| | |||||.. |. .| . .|. || | ... RPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP------- QSRRDDMESLAYL-------------LLY--FAKGTLVWQN-----LQFKEKEERFKKIAELKQTTP---------HEHMCRGLPKQFHE-------FLN |.. | ... | | . . . .| |. |. ..| .. | . . || | . -------ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE LVKSL ... . IHECF |
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Kinase | 8793.AA | TTBK | 35-70 | 32 | 5.1e-05 | 13.7 | In-house | 2-38 (257) | Show / Hide |
Range on Protein: 35-70 Range on HMM: 2-38/257 Sequence Identity: 32% (12 aa) EVIEKIGQGSFGDIFKVWDSKRA-RWAAMKFEKKDKK |. |||.| || |. | |.| |. ... KVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQP |
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Kinase | 8793.AA | Dual | 273-301 | 24 | 0.005102 | 5.84 | In-house | 254-282 (282) | Show / Hide |
Range on Protein: 273-301 Range on HMM: 254-282/282 Sequence Identity: 24% (7 aa) PKQFHEFLNLVKSLTFEQTPEYDRYRSLF |... . .| .. .. ||.|| | PRRLKPLVSYVNGYQYDSTPDYDYFRNCL |
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Kinase | 8793.AA | CK1-G | 35-49 | 53 | 0.019219 | 3.99 | In-house | 2-16 (266) | Show / Hide |
Range on Protein: 35-49 Range on HMM: 2-16/266 Sequence Identity: 53% (8 aa) EVIEKIGQGSFGDIF | ||| |.|| .| RVGKKIGCGNFGELF |