Gene 28107 (Tetrahymena)

28107

Species: Tetrahymena
Alias: TTHERM_01332120, 28107, 330.m00020, 730, PreTt28107
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: ERK

Sequence

Name Sequence Type Origin Length Description Download
28107.AA Protein None 421 None Fasta, JSON
28107.kin_dom Protein Kinase Domain None 279 None Fasta, JSON
28107.NA RNA None 1266 None Fasta, JSON

Protein domain

Protein domains of 28107.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 28107.AA ERK 47-325 49 6.2e-185 620.66 In-house 8-307 (307) Show / Hide 
Range on Protein: 47-325
Range on HMM: 8-307/307
Sequence Identity: 49% (148 aa)

GQGTFGVVVACQDKEKEFFDEDSDFVAIKKIERAFEHTQYAIRTIREIKLQRMLA-HEN------LLLPKSREQMNDIYLVEPLMTSDLRAIINSQNEIN
|.|..|||....|||. .|||....|||||||.||.|..|..||.|||||.|... |||      ...|.|.||.||||.||.||..||. |||||.|..
GHGAYGVVCSAIDKEY-CFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIYCVEELMETDLHQIINSQQELS

EEHIQFLMYQIIRGLKYMHSAQIVHRDLKPKNVLSNEQGDLKICDFGFAR----HIQKN---RVNDLSEYVTARWYRAPEILLSYKKYDIAVDMWSCGII
..|.|..||||..||||.|||...||||||.|.| |...||||||||.||    ..|.|   ..|...|||..||||||||.||..||. |.|.||||.|
DDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCI

MAELLKRQPIIRGASTDDQMRQILQLIGSP-DEYQVKDP---EYKKLLSYFPY--CPGKNFKLIFPNAS--SQCLDLLKKLLQIDPSQRITAEQALAHPF
.||.|.|.|...|.....|...|.|.||.| .|......   ...|.....|.  .|.|... |||||.  .|..|||.|.|..||..|||.|..|.||.
FAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEHPY

F
|
F
Kinase 28107.AA MAPK 47-325 42 1.1e-153 516.82 In-house 8-328 (328) Show / Hide 
Range on Protein: 47-325
Range on HMM: 8-328/328
Sequence Identity: 42% (136 aa)

GQGTFGVVVACQDKEKEFFDEDSDFVAIKKIERAFEHTQYAIRTIREIKLQRML-AHEN------LLLP------KSREQMNDIYLVEPLMTSDLRAIIN
||| .|||... ||........ ..||||||.|.|...... ||.|||||.|..  |||       . |      .|.|..||||.|..|| .||..||.
GQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIK

SQNEINEEHIQFLMYQIIRG--LKYMHSAQIVHRDLKPKNVLSNEQGDLKICDFGFARHIQKN---RVN----------DLSEYVTARWYRAPEILLS--
||.. ...|||..||||.||  |||.|||...|||||| |.| || .|||||||| ||.|  .   . .          ...|||. ||||||||.|.  
SQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWI

YKKYDIAVDMWSCGIIMAELLK-RQPIIRGASTDDQMRQILQLIGSPDEYQVKDPE-Y---KKLLSYF---PYCPGKNFKLIFPN----ASSQCLDLLKK
...|. ||||||.| |.||.|. |.|. .| .. ||. .|....|.|.|  ..  . .   ..... .   |..|.|... .|||    |..|..|||.|
WMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEK

LLQIDPSQRITAEQALAHPFF
.|..||..|||.|.||.||.|
MLVFDPDKRITVEEALQHPYF
Kinase 28107.AA CMGC 42-325 25 8.20000000001e-116 382.27 In-house 1-513 (513) Show / Hide 
Range on Protein: 42-325
Range on HMM: 1-513/513
Sequence Identity: 25% (132 aa)

LQIKA--GQGTFGVVVACQDKEKEFF--------DEDSDFVAIKKIERAFEHTQYAI----------RTIREIKLQRMLA-----------------HEN
 .|    |.||.|||. |.||. ..          |.  .|||||| ..| ..  |           |..||||. ..|                  |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

LL------LPK---SREQ---------MNDIYLVEPLMTSDLRAIINSQN---------EINEEH------------IQFLM------YQIIRGLK--YM
..       .|   . |.         .|..|||  .|  ||  .| ...         . .| |            |...|      |||.||||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAQ--IVHRDLKPKNVLSNEQGDL--------------------KICDFGFARHIQKNR--------------------VNDLSEYVTARWYRAPEILL
||.   |.|||||| |.| |....|                    ||||||.||.. ..                     .  ...||  ||||||||||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

SYKKYD---------IAVDMWSCGIIMAELLKR--------QPIIR-----------GASTDDQMRQILQLIGSP-------------DEYQVKDPEYKK
..|.|.          ..||||.| |.||.. .        .|.             |.|. ||. .| ...|.|             .... ..|...|
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

LLSY-----------------------------FPYCPGKNFKLIFPN-----------------------------------ASSQCLDLLKKLLQIDP
|. |                             || .|.|..| .||.                                   ...|..|||||.||.||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

SQRITAEQALAHPFF
..||||||||.||.|
DKRITAEQALQHPYF
Kinase 28107.AA p38 39-325 40 3.6e-98 332.43 In-house 1-289 (289) Show / Hide 
Range on Protein: 39-325
Range on HMM: 1-289/289
Sequence Identity: 40% (121 aa)

IQNLQIKAGQGTFGVVVACQDKEKEFFDEDSDFVAIKKIERAFEHTQYAIRTIREIKLQRMLAHENLLL------P--KSREQMNDIYLVEPLMTSDLRA
 ||||   |.| .| | .  |.. .   .   .|||||. | |. . .| || ||..| ... ||| .       |  .|.....|.|.| ..| .||  
YQNLQP-VGSGAYGQVCKAEDRRTG---QKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNN

IINSQNEINEEHIQFLMYQIIRGLKYMHSAQIVHRDLKPKNVLSNEQGDLKICDFGFARHIQKNRVNDLSEYVTARWYRAPEILLSYKKYDIAVDMWSCG
|. .|  ....||||| |||.||||| ||| |.|||||| |.  ||  .|.| ||| ||       ... .||  ||||||||.|.  .|. .||.|| |
IMKCQR-LSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLAR----HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVG

IIMAELLKRQPIIRGASTDDQMRQILQLIGSPDEY---QVKDPEYKKLLSYFPYCPGKNFKLIFPNASSQCLDLLKKLLQIDPSQRITAEQALAHPFF
 |||||. ...  .|    ||...|....|.|||.    ... | .  .   |  | ..|. .|..|. | .||| |.|..|| .|||||.|..||.|
CIMAELITGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase 28107.AA ERK7 41-325 38 5.2e-83 282.08 In-house 2-292 (292) Show / Hide 
Range on Protein: 41-325
Range on HMM: 2-292/292
Sequence Identity: 38% (114 aa)

NLQIKAGQGTFGVVVACQDKEKEFFDEDSDFVAIKKIERAFEHTQYAIRTIREIKLQRMLA-HENL--LLPKSREQMN-DIYLVEPLMTSDLRAIINSQN
... . |.| .|.|    ||         . ||.|||  ||     | || ||| . . .  |.|.  |.   | . . |||||   | .|| |.|   |
EIRKRLGKGAYGIVWKAYDKRTK------QVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGN

EINEEHIQFLMYQIIRGLKYMHSAQIVHRDLKPKNVLSNEQGDLKICDFGFARHIQKNR-----VNDLSEYVTARWYRAPEILLSYKKYDIAVDMWSCGI
 . . | |. |||..| .|||||....|||||| |.| . .  .|.|||| || | . .       .| |||  ||||||||||. ..|  .||||| | 
ILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGC

IMAELLKRQPIIRGASTDDQMRQILQLIGSPDEYQVKD--PEYK-KLLSYFPYCPGKNFKLIFPNASSQCLDLLKKLLQIDPSQRITAEQALAHPFF
|..|.|. .|.  | || .|. .||..|. | .  ...  ..|  ..|.  .  . | .. ..|... . .||||.||.  | .|.||||||.||. 
ILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase 28107.AA ERK1 40-325 42 1.2e-78 267.59 In-house 2-289 (289) Show / Hide 
Range on Protein: 40-325
Range on HMM: 2-289/289
Sequence Identity: 42% (127 aa)

QNLQIKAGQGTFGVVVACQDKEKEFFDEDSDFVAIKKIERAFEHTQYAIRTIREIKLQRMLAHENL------LLPKSREQMNDIYLVEPLMTSDLRAIIN
 |||   |.| .|.|.. .|. ..      . ||||||   |||  |  ||.||||.     |||.      .  .. ||| |.|.|  ||  ||  .. 
TNLQY-IGEGAYGMVCSAYDTVHK------QRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRADTIEQMRDVYIVQCLMETDLYKLLK

SQNEINEEHIQFLMYQIIRGLKYMHSAQIVHRDLKPKNVLSNEQGDLKICDFGFAR--HIQKNRVNDLSEYVTARWYRAPEILLSYKKYDIAVDMWSCGI
.| ..  .|| . .|||.|||||.||| ..|||||| |.| |   |||||||| ||    ..     | |||  ||||||||.|  | |  ..|.|| | 
TQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGC

IMAELLKRQPIIRGASTDDQMRQILQLIGSPDEYQVKDPEYKKLLSYFPYCPGKN---FKLIFPNASSQCLDLLKKLLQIDPSQRITAEQALAHPFF
|.||.|   ||  |    ||.  || ..||| .  ..    .|  .|    | |.   .. .||.| |. |||| |.|   | .||| |.|||||. 
ILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase 28107.AA CDK 45-325 34 1.4e-78 251.01 In-house 6-284 (284) Show / Hide 
Range on Protein: 45-325
Range on HMM: 6-284/284
Sequence Identity: 34% (109 aa)

KAGQGTFGVVVACQDKE---KEFFDEDSDFVAIKKIERAF-----EHTQYAIRTIREIKLQRMLAHENLLL----PKSREQM--------NDIYLVEPLM
| |.||.|||  ..||.   |    .  ..||.|||         | .   | .||||.| . | |.|         . . .        | .|.| . |
KIGEGTYGVVYKARDKQTGRK----KTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYM

TSDLRAIINSQNEINEEHIQFLMYQIIRGLKYMHSAQIVHRDLKPKNVLSNEQGD-----LKICDFGFARHIQKN-----RVNDLSEYVTARWYRAPEIL
  ||  ..          |. .|.|..||| |.||  |.|||||| | | |..|      ||| |||.||  . .      .. ..  |  .||||||.|
DHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELL

LSYKKYD--IAVDMWSCGIIMAELLK---RQPIIRGASTDDQMRQILQLIGSPDEYQVKDPEYKKLLSYFPYCPGKNFKLIFPNASSQCLDLLKKLLQID
|  |.|.   ..||||.| |.||..    |.|.  | |  ||.  | ...|.|.| .   |. .||  |                     ||| |.|. |
LGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNW--PGVTKLPDY---------------------DLLNKMLCYD

PSQRITAEQALAHPFF
|..||.||||| ||.|
PKKRISAEQALQHPYF
Kinase 28107.AA S_TKc 40-325 29 4.2e-78 266.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 40-325
Range on HMM: 1-231/231
Sequence Identity: 29% (88 aa)

QNLQIKAGQGTFGVVVACQDKEKEFFDEDSDFVAIKKIERAFEHTQYAIRTIREIKLQRMLAHENLLLPKSREQMNDIYLVEPLMTS---DLRAIINSQN
  .  | |.|.||.|  |..|.      .   ||||.|          ....|||.. ..  |.|.   .   | ...|.|  ..     ||. .| ...
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRG

E------INEEHIQFLMYQIIRGLKYMHSAQIVHRDLKPKNVLSNEQGDLKICDFGFARHIQKNRVNDLSEYVTARWYRAPEILLSYKKYDI-AVDMWSC
       ..| |..|.||||...|.|.|| .|.|||||| |.| .|   .||||||.||..        . ..  .||.|||.|    .|.  ..|.|||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSC

GIIMAELLKRQPIIRGASTDDQMRQILQLIGSPDEYQVKDPEYKKLLSYFPYCPGKNFKLIFPNASSQCLDLLKKLLQIDPSQRITAEQALA-------H
|.|..|.| ..|  .      || .....||                                  |....|...|.|| ||..|.|| .||.       |
GCILYEMLCGYPPFP------QMQMMFKKIG----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

PFF
|.|
PWF
Kinase 28107.AA ERK5 41-325 39 2e-77 263.53 In-house 2-295 (295) Show / Hide 
Range on Protein: 41-325
Range on HMM: 2-295/295
Sequence Identity: 39% (118 aa)

NLQIKAGQGTFGVVVACQDKEKEFFDEDSDFVAIKKIERAFEHTQYAIRTIREIKLQRMLAHEN------LLLPKS-REQMNDIYLVEPLMTSDLRAIIN
.   | |.| .||| .   .         . ||||||  ||.    | ||.||.|. |   |.|      .| ||     | |.| |  || |||  || 
KIIEKIGNGAYGVVCSARRRKN------GQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIH

SQNEINEEHIQFLMYQIIRGLKYMHSAQIVHRDLKPKNVLSNEQGDLKICDFGFARHIQK----NRVNDLSEYVTARWYRAPEILLSYKKYDIAVDMWSC
|.  .  ||| . .|||.||||||||||..|||||| |.| ||  .||| ||| || .      ..   . |||  |||||||...| . |  |.|.|| 
SNQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSV

GIIMAELLKRQPIIRGASTDDQMRQILQLIGSPDEYQVKDPEYKKLLSYFPY----CPGKNFKLIFPNASSQCLDLLKKLLQIDPSQRITAEQALAHPFF
| |. |.. |. .  |    .|.. |.. .| |    ..     ..  ||         |... ..| |  | |||| ..|  .||.|||. .|| ||| 
GCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase 28107.AA Pkinase 47-325 31 1.7e-72 251.97 Pfam 8-293 (293) Show / Hide 
Range on Protein: 47-325
Range on HMM: 8-293/293
Sequence Identity: 31% (96 aa)

GQGTFGVVVACQDKEKEFFDEDSDFVAIKKIERAFEHTQYAIRTIR--EIKLQRMLAHENLLLPKSREQ-MNDIYLVEPLMTS-----DLRAIIN--SQN
|.|.||.|  |..|  .        ||.|.|..  |. .  .. .|  ||.. ..| |.| .  .   .  ..||.| ...       || ..|   ...
GSGSFGCVYKCHHKGTGK------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHG

EI--NEEHIQFLMYQIIRGLKYMHSAQIVHRDLKPKNVLSNEQGDL----KICDFGFARHI-QKNRVNDLSEYVTARWYRAPEILLSYKKYDIAVDMWSC
 .   |....| ||||.|||.|.||  |.|||||| |.| ...|..    ||||||.|...   | .  .. ..  .||.|||.......|. .||||||
CFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIIMAELLKRQPIIRGA----STDDQMRQILQLIG---SPDEYQVKDPEYKKLLSYFPYCPGKNFKLIFPNASSQCLDLLKKLLQIDPSQRITAEQALAH
|.|..|.| ..|. .|.    . .|||  | .  |   . |...  .. | . ... . .  . ...  .|.|. |.|..|..|. ||..|.||||.| |
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PFF
|.|
PWF
Kinase 28107.AA CDC2 40-325 34 4e-68 208.29 In-house 2-301 (301) Show / Hide 
Range on Protein: 40-325
Range on HMM: 2-301/301
Sequence Identity: 34% (107 aa)

QNLQIKAGQGTFGVVVACQDKEKEFFDEDSDFVAIKKIERAFEHTQ--YAIRTIREIKLQRMLA-HENLLLPKSRE---QMNDIYLVEPLMTSDLRAIIN
| .. | | ||.|||  |.|..          ||.|||    |         .|||| .   |  |.|.   | ..   | | .|.|   .  ||.    
QKIE-KIGEGTYGVVYKCKDMQTNQ------IVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIV--KLHDVIHQ-NKLYMVFEYLDMDLKKYMD

----SQNEINEEHIQFLMYQIIRGLKYMHSAQIVHRDLKPKNVLSNEQGDLKICDFGFARHIQKNRVNDL--SEYVTARWYRAPEILLSYKKYDIAVDMW
    .. .. .. .. .||||..|. . |. .|.|||||| | | ...|..|| ||| || .. .  . .   | || .|||||||||  |.|...||||
MSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVT-LWYRAPEILLGCKRYSTPVDMW

SCGIIMAEL---LKRQPIIRGASTDDQMRQILQLIGSPDEYQVKDPEYKKLL---SYFPYCPGKNFKLIFPN---------ASSQCLDLLKKLLQIDPSQ
| | |.||.     . |.  | |  ||  .| . .|.|.|     |. ..|    . ||  . .... |.||         .  ...|||...||.||..
SIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTW--PGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQK

RITAEQALAHPFF
||.|..||.||.|
RISAKEALQHPYF
Kinase 28107.AA MAPK-Unclassified 41-194 37 1.7e-45 157.47 In-house 2-162 (575) Show / Hide 
Range on Protein: 41-194
Range on HMM: 2-162/575
Sequence Identity: 37% (63 aa)

NLQIKAGQGTFGVVVACQDKEKEFFDEDS--DFVAIKKIERAFEHTQYAIRTIREIKLQRMLAHENL------LLPKSREQ--MNDIYLVEPLMTS---D
 .|   |.| .|.|.       .. |  .    |||||. ..|.  . . |. ||| ..| | |.|.      . .|. .     |||.|  .| .   |
EYQKNIGSGAYGQVC-------RAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFD

LRAIINSQN-EINEEHIQFLMYQIIRGLKYMHSAQIVHRDLKPKNVLSNEQGDLKICDFGFARHIQKN
|  || |     ...||| ..||| |||||.||| |.|||||| |.| |. . ..||||| .| |  |
LHQIIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSRSIEDN
Kinase 28107.AA MAPK-Unclassified 198-325 30 6e-41 142.36 In-house 404-575 (575) Show / Hide 
Range on Protein: 198-325
Range on HMM: 404-575/575
Sequence Identity: 30% (52 aa)

DLSEYVTARWYRAPEILLSYKKYDIAVDMWSCGIIMAELLKR-----------QPIIRGAS--------------------TDDQMRQILQLIGSPDE--
....||  ||||||||.|| . || .||.|| | | ||.. .           .|.  | .                      ||   |.   |.|.|  
HMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMPPEED

-YQVKDPEYKKLLSYFPYCPGKNFK-LIFPNAS---------SQCLDLLKKLLQIDPSQRITAEQALAHPFF
   ....  .|... |   .   |. |.|..|.          .|.|...|.||..|. ||||.||| ||.|
CNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase 28107.AA TyrKc 40-325 19 7.1e-12 -30.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 40-325
Range on HMM: 1-280/280
Sequence Identity: 19% (66 aa)

QNLQIKAGQGTFGVVVACQDKEKEFFDEDSDFVAIKKIERAFEHTQYAIRTIREIKLQRML--AHENLL------LPKSREQM---NDIYLVEPLMTS-D
  |  | | | ||.|. .. |           ||.|..             .||... ..|   |.|..      . ..|        ...|  .|   |
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGD

LRAII-NSQNEINEEHIQFLMYQIIRGLKYMHSAQIVHRDLKPKNVLSNEQGDLKICDFGFARHIQKN-------RVND-----LSEY-VTARWYRAPEI
|.  . ....... ..    ..|| .|  | || ...||||   |.| .|..  ||.||| .| |           . .      . . .  ||. ||| 
LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APEC

LLSYKKYDIAVDMWSCGIIMAEL---------------LKRQPIIRGASTDDQMRQILQ----LIGSPDEYQVKDPEYKKLLSYFPYCPGKNFKLIFPNA
.  |.|. .. | || |. | |.               .. | .|.   . . |.|                                        |. .
I-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------------FVCC

SSQCLDLLKKLLQIDPSQRITAEQALAHPFF
..   .. |.  . ||..| | ..   | .|
PDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 28107.AA Pkinase_Tyr 148-237 34 1.3e-05 19.62 Pfam 118-208 (270) Show / Hide 
Range on Protein: 148-237
Range on HMM: 118-208/270
Sequence Identity: 34% (32 aa)

YQIIRGLKYMHSAQIVHRDLKPKNVLSNEQGDLKICDFGFARHI----QKNRVNDLSEYVTARWYRAPEILLSYKKYDIAVDMWSCGIIMAELL
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WQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSDVWSFGVLMWEIF