Gene 15513 (Tetrahymena)

15513

Species: Tetrahymena
Alias: TTHERM_00450990, 52.m00291, 15513, PreTt15513, 3811.m01042, 232
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: RCK

Sequence

Name Sequence Type Origin Length Description Download
15513.AA Protein None 831 None Fasta, JSON
15513.kin_dom Protein Kinase Domain None 285 None Fasta, JSON
15513.NA RNA None 2496 None Fasta, JSON

Protein domain

Protein domains of 15513.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 15513.AA RCK 4-288 55 2.7e-221 709.36 In-house 1-298 (298) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-298/298
Sequence Identity: 55% (167 aa)

YIHLDVIGKGSFGEVVKAQNKETKEIVAIKTMKQKFVTWEECMNLRELKSLRKLV-NKNIVKLKEVLRVQN--QLSFVFEYCDTDIYKLYENQKKLGQR-
|.... .|.|..|.|.|||||||.||||||.||||| .|||||||||.||||||  ..||.|||||.|...  ||.|||||.|...|......|. ... 
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMKQKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKE-RRKY

LPETQ--LRSIFYQLAQSLSYMHKHGYFHRDLKPENILYSNK--------DGYVKLTDFGLAREIRSRPPYTDYVATRWYRAPELILRATNYNSPVDIFA
|||.|  ...|.||..|.|..|||||.||||||||||.....        ....|..||||.|||||.||||||| ||||||||..||.|.||||.||.|
LPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIWA

LGCIMAELYMFKPLFNGSSELDQLQKMTSVLGTPSKLDWPEGYRLAGLKGITFPSYPAIPLNQVITDCPYEAVQLIAECLKWDPQKRPTASKILQHQYF
.||||.||||..|||.||||.||..|...|.|||.| |||.||.||  ....||.....||.|.|..|......|. ..|.||||||.||...|||.||
VGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF
Kinase 15513.AA MAK 4-288 43 2.8e-154 494.83 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-352/352
Sequence Identity: 43% (153 aa)

YIHLDVIGKGSFGEVVKAQN------------------------------KETKEIVAIKTMKQKFVTWEECMNLRELKSLRKLV-NKNIVKLKEVLR--
|. .  .| |..|.|..|.                               ..| |.||||.||.|| .||||||||| |||.||  . ||||||||.|  
YQMIKQLGDGTYGCVMLAKRQFPLSNILGKQHDIRGTLMDQPKNGHQNYIIDTGEKVAIKRMKKKFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDS

VQNQLSFVFEYCDTDIYKLYENQKK-LGQRLPETQLRSIFYQLAQSLSYMHKHGYFHRDLKPENILYSNK----------------DGYVKLTDFGLARE
  ..| |||||     | .    .. .   .||. .|.| ||  | | .|||||.||||.|||||. .                  .  .|. |||||||
ENDHLYFVFEYMKENLYQMMKDRDRRH---FPEPVIRNIMYQILQGLAFMHKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLARE

IRSRPPYTDYVATRWYRAPELILRATNYNSPVDIFALGCIMAELYMFKPLFNGSSELDQLQKMTSVLGTPSKLD----------------WPEGYRLAGL
|||.||||||| ||||||||  || |.|.||.|. |.||||||||.|.||| |||| ||. | ..||||| | |                ||.||.||  
IRSKPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPLFPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHM

KGITFPSYPA---IPLNQVITDCPY-EAVQLIAECLKWDPQKRPTASKILQHQYF
 . .||   .   .|| ..|  |   .|..|. ..|.|||.|||||.  ... ||
MNFRFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCCKYPYF
Kinase 15513.AA CMGC 4-288 24 2.3e-129 427.6 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-513/513
Sequence Identity: 24% (126 aa)

YIHLDVIGKGSFGEVVKAQN--------------KETKEIVAIKTMKQKFVTWEEC----------MNLRELKSLRKL----------------VNKN-I
|  ...||.|..|.|.|...              .||.|||||| .|..| .....          . |||.| |..|                 ..| |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VKLKEVLRVQN-----------------QLSFVFEYCDTDIYKLYENQKKL-----GQRLPETQ------------LRSIF------YQLAQSLS--YMH
|||.....  |                 .| .||||.|.| |.. .|....     .. |.| .             ....      ||. ..|   |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

KHG--YFHRDLKPENILYSNK-------------------DGYVKLTDFGLAR--EIRSRP--------------------PYTDYVATRWYRAPELILR
.|.   .|||||||||| ...                   .| .|. ||||||  ...|..                    |||.||.||||||||..|.
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

A---------TNYNSPVDIFALGCIMAELYM--------FKPLFNGSSE-----------LDQLQKMTSVLGTPS---------------KLDWPE----
.         ..|..|.|. ..|||.||.|.         |||| |.||           .|||.|.  |||||.               . .||.    
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

---------------------GYRLAGLKGITFPSYPAIPLNQVITD-----------------------------------CPYEAVQLIAECLKWDPQ
                     ..|..  ....|| .| .|..... .                                   |. .|. |.  .|..||.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

KRPTASKILQHQYF
||.||. .||| ||
KRITAEQALQHPYF
Kinase 15513.AA CDK 4-288 32 3.3e-98 314.81 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-284/284
Sequence Identity: 32% (106 aa)

YIHLDVIGKGSFGEVVKAQNKETK-----EIVAIKTMK------QKFVTWEECMNLRELKSLRKLVNKNIVKLKEVLRVQ-----------NQLSFVFEY
|  |. || |..|.| ||..|.|.     .|||.|  .      ..  .   .  .|| . |..| ..|||||..|               | |..||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

CDTDIYKLYENQKKLGQRLPETQLRSIFYQLAQSLSYMHKHGYFHRDLKPENILYSNKD----GYVKLTDFGLAREIRS-------RPPYTDYVATRWYR
.|.| .|. .              .....|| . |.|.|...  |||||| |||..|.     | .|..||||||.  .       . .||  | |.|||
MDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYR

APELILRATNYN--SPVDIFALGCIMAELYM---FKPLFNGSSELDQLQKMTSVLGTPSKLDWPEGYRLAGLKGITFPSYPAIPLNQVITDCPYEAVQLI
|||| | ...|.   |.|. ..|||.||...    |||| |.||.||| |   ..|||.  .||.   | .                          .|.
APELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLL

AECLKWDPQKRPTASKILQHQYF
  .|  ||.|| .|.  |||.||
NKMLCYDPKKRISAEQALQHPYF
Kinase 15513.AA S_TKc 4-288 33 2.1e-94 320.86 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-231/231
Sequence Identity: 33% (99 aa)

YIHLDVIGKGSFGEVVKAQNKETKEIVAIKTMKQKFVTWEECMNLRELKSLRKLVNKNIVKLKEVLRVQNQLSFVFEYCDT---DIYKLYENQKKLGQR-
|  |..||||.||.| |...|.|..||||| .|        .. .||.. |.|   .|||||..| .  . | .|.||||.   | ... ..... | | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LPETQLRSIFYQLAQSLSYMHKHGYFHRDLKPENILYSNKDGYVKLTDFGLAREIRSRPPYTDYVATRWYRAPELILRATNYNS-PVDIFALGCIMAEL
 .|| . |...||... | |.|.||  |||||||||| ..    .|..||||||..      | .. |.||.|||..     |.  ..|. ..|||..|.
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

YMFKPLFNGSSELDQLQKMTSVLGTPSKLDWPEGYRLAGLKGITFPSYPAIPLNQVITDCPYEAVQLIAECLKWDPQKRPTASKILQ-------HQYF
.  .|.|       |.|.|  ..|                                    . || ..|  ||..||.||||| ..||       |..|
LCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 15513.AA Pkinase 4-288 30 1.9e-91 314.91 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-293/293
Sequence Identity: 30% (94 aa)

YIHLDVIGKGSFGEVVKAQNKETKEIVAIKTMKQKFVTWEECMNLR---ELKSLRKLVNKNIVKLKEVLRVQNQLSFVFEYCDTDIYKLYENQ----KKL
|  . .||.||||.| |...| | .|||.|..| .   .......|   |.. ...|  .|||.|... .  . . .|.|||. . | . .       . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWR

GQRL--PETQLRSIFYQLAQSLSYMHKHGYFHRDLKPENILYSNKDGYV----KLTDFGLARE--IRSRPPYTDYVATRWYRAPELILRATNYNSPVDIF
. ..  .| ......||... | |.|..|  ||||||||||.. ..|..    |..|||||.   . . . .|... |.||.|||.|. .. | ..||..
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

ALGCIMAELYMFKPLFNGS----SELDQLQKMTSVLGTPSKLDWPEGYRLAGLKGITFPSYPAIPLNQVITDCPYEAVQLIAECLKWDPQKRPTASKILQ
..|||..|..  .|.| |.    . .||.|..  ..|.| . |||. ..    . ...   . . .  . .  . |. ..|  ||..||.|||||  |||
SCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQ

HQYF
| .|
HPWF
Kinase 15513.AA CDC2 4-288 36 5.6e-91 279.8 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-301/301
Sequence Identity: 36% (112 aa)

YIHLDVIGKGSFGEVVKAQNKETKEIVAIKTMKQKFVTWEE---CMNLRELKSLRKLV-NKNIVKLKEVLRVQNQLSFVFEYCDTDIYKLYENQKKLGQR
|  .  ||.|..|.| |.....|..|||.|  . .  . ..      .||.  | .|   .|||||..|.   | |  ||||.| |  |. ..... .. 
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LPETQLRSIFYQLAQSLSYMHKHGYFHRDLKPENILYSNKDGYVKLTDFGLAREIRS-RPPYT--DYVATRWYRAPELILRATNYNSPVDIFALGCIMAE
.|.  ..|..||. | ... | .. .|||||| |||  .|.| .|. |||||| .     .||    | |.||||||. |..  |. |||. ..|||.||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILI-DKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAE

L---YMFKPLFNGSSELDQLQKMTSVLGTPSKLDWPEGYRLAGLKGITFPSYPAIPLNQVITD---------CPYEAVQLIAECLKWDPQKRPTASKILQ
.    ..|||| | || ||| |.  .||||.  .||. . |   |  ||| .... | ... .         .. |...|. . |  ||||| .| ..||
MFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKN-TFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQ

HQYF
| ||
HPYF
Kinase 15513.AA CDK5 4-288 35 3.2e-75 237.02 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-287/287
Sequence Identity: 35% (106 aa)

YIHLDVIGKGSFGEVVKAQNKETKEIVAIKTMKQKFVTWEE-----CMNLRELKSLRKLVNKNIVKLKEVLRVQNQLSFVFEYCDTDIYKLYENQKKLGQ
|  .. || | .| | ||.||||.||||.|  .      .|     .  .||   |. |  |||| |  |.   . |  |||.|| |. |  .. .    
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLD----SEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNG---

RLPETQLRSIFYQLAQSLSYMHKHGYFHRDLKPENILYSNKDGYVKLTDFGLARE--IRSRPPYTDYVATRWYRAPELILRATNYNSPVDIFALGCIMAE
 .     .|. ||| . |.. |.|   |||||| | |  || |  || ||||||   |  |  |.  | | |||.|   . .  |. ..|.   |||.||
EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLI-NKNGELKLADFGLARAFGIPVR-CYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAE

LY-MFKPLFNGSSELDQLQKMTSVLGTPSKLDWPEGYRLAGLK--GITFPSYPAIP-LNQVITDCPYEAVQLIAECLKWDPQKRPTASKILQHQYF
.    .||| |... ||| .   ..|||.   ||    |   |     .|.||| . . |..     .   |  . |. .|..| .| . |.|.||
MANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase 15513.AA CDKL 4-222 45 1.3e-71 244.05 In-house 1-218 (286) Show / Hide 
Range on Protein: 4-222
Range on HMM: 1-218/286
Sequence Identity: 45% (101 aa)

YIHLDVIGKGSFGEVVKAQNKETKEIVAIKTMKQ-KFVTWEECMNLRELKSLRKLVNKNIVKLKEVLRVQNQLSFVFEYCDTDIYKLYENQKKLGQRLPE
|  | ..| || | | |  |||| .|||||  |  .    .    .||.| |. |  .||| |.|| |  . |  ||||||  .  . |  .  |  ..|
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEE-YPNG--VDE

TQLRSIFYQLAQSLSYMHKHGYFHRDLKPENILYSNKDGYVKLTDFGLAREIRSRPP--YTDYVATRWYRAPELILRATNYNSPVDIFALGCIMAELYMF
 ..|.. .|. ..... |||   ||| |||||| . |.| ||| |||.|| . . |   ||||||||||||||| .  | | .|||| |.||.|||. . 
HVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFAR-MLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMIDG

KPLFNGSSELDQLQKMTSVLGT
 ||. |.|..||| .   .||.
QPLWPGQSDIDQLYHIQKCLGP
Kinase 15513.AA MAPK 4-288 32 2.9e-70 239.72 In-house 1-328 (328) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-328/328
Sequence Identity: 32% (107 aa)

YIHLDVIGKGSFGEVVKAQNKE------TKEIVAIKTMKQKFVTWEECMN-LRELKSLRKL-VNKNIVKLKEVLRV-----QNQLS------FVFEYCDT
|  |  ||.|..| |..|  |.      ....|||| . . | .   |   .||.| || .   .||.||.....      || |.      .|.|...|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DIYKLYENQKKLGQRLPETQLRSIFYQLAQS--LSYMHKHGYFHRDLKPENILYSNKDGYVKLTDFGLAREIRSRPPY---------------TDYVATR
| ... . |.     | .   ....||.     | |.|  .  ||||||.|||  |... .|. |||||| | .   .               |.|||||
DLHQIIKSQQ----PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNIL-VNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATR

WYRAPELILR--ATNYNSPVDIFALGCIMAELYM-FKPLFNGSSELDQLQKMTSVLGTPSKLDW---P-EGYRLAGLKGIT-FPSYPAIPLNQVITD---
||||||..|   ...|.  ||. ..|||.||..   |||| |.. .||......||||||. ..   .        ...   .| ||..|. ... .   
WYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF

-CPYEAVQLIAECLKWDPQKRPTASKILQHQYF
 .  .|. |.   | .||.|| |.   ||| ||
NANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 15513.AA CDK4 4-288 35 1.3e-65 224.01 In-house 1-290 (290) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-290/290
Sequence Identity: 35% (106 aa)

YIHLDVIGKGSFGEVVKAQNKETKEIVAIKTMKQKFVTWEE-----CMNLRELKSLRKLVNK---NIVKLKEV---LRVQN---QLSFVFEYCDTDIYKL
|  .  ||.| .| | .|   .|  .|| |    .  . ||        .||   .|.|  .   |||||..|   ...      .  ||| || |   .
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQV--RIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTY

YENQKKLGQRLPETQLRSIFYQLAQSLSYMHKHGYFHRDLKPENILYSNKDGYVKLTDFGLAREIRSRPPYTDYVATRWYRAPELILRATNYNSPVDIFA
 ..  . |  .|. . . .  ||   . . | |   ||||||.|||  . || |||.||||||.  .    |  | | ||||||  | .. ||.|||. .
LDKCPPPG--MPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILV-TSDGHVKLADFGLARIYSFQMALTPVVVTLWYRAPEVLLQSY-YNTPVDMWS

LGCIMAELYMFKPLFNGSSELDQLQKMTSVLGTPSKLDWPEGYRLAGLKGITFPSYPAIPLNQVITDCPYEAVQLIAECLKWDPQKRPTASKILQHQYF
.|||.||.|  .||| |.|| |||.|   | |.|   |||    |.      ||.. . |.  . ..    . .|. ..| ....||..| . ||| ||
VGCIFAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLP---WDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase 15513.AA PITSLRE 48-288 38 3.8e-56 192.85 In-house 48-295 (295) Show / Hide 
Range on Protein: 48-288
Range on HMM: 48-295/295
Sequence Identity: 38% (96 aa)

LRELK-SLRKLVNKNIVKLKEVL--RVQNQLSFVFEYCDTDIYKLYENQKKLGQRLPETQLRSIFYQLAQSLSYMHKHGYFHRDLKPENILYSNKDGYVK
||| .  |. |   |||..||..     .    |.|| . |.  | || |.  |.  . .  .   ||    ..||..   |||||  |.|||.| |  |
LREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHK-GILK

LTDFGLAREIRSR-PPYTDYVATRWYRAPELILRATNYNSPVDIFALGCIMAELYMFKPLFNGSSELDQLQKMTSVLGTPSKLDWPEGYRLAGLKGIT-F
. |||||||  |   |||  | | ||||||| | .  |  |||.   |||.||. . ||||.|.||.||...    .|||.   ||    | . | .. |
ICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNF

PSYPAIPLNQVIT---DCPYEAVQLIAECLKWDPQKRPTASKILQHQYF
| ||   |.. .         .  |    |  .|..| |||. |.| .|
PHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase 15513.AA TyrKc 4-288 24 1.5e-15 28.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-288
Range on HMM: 1-280/280
Sequence Identity: 24% (79 aa)

YIHLDVIGKGSFGEVVKAQNKETKEIVAIKTMKQKFVTWEECMNLRELKSLRKL--VNKNIVKLKEVLRVQ-------NQLSFVFEYC---DTDIYKLYE
   ....| | ||||.|.. |   . ||.|..|       . . .||.. ..||   ..|||.|  | . |        .|  |.||.   | . | | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY-LRK

NQKKLGQRLPETQLRSIFYQLAQSLSYMHKHGYFHRDLKPENILYSNKDGYVKLTDFGLAREIRSR-------PPYT------DY--VATRWYRAPELIL
...|    |.  .| |. .| |.  .| |.... ||||   |.|....   || .||||.|.| .          |.          .  ||. ||| | 
HRPK----LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-

RATNYNSPVDIFALGCIMAELYMF-KPLFNG---SSELDQLQKMTSVLGTPSKLDWPEG----YRLAGLKGITFPSYPAIPLNQVITDCPYEAVQLIAEC
.   ...  |... |  | |.. . ..   |          | .   . .   .. |.                              || |  |.. .|
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------FVCCPDEMYQIMKQC

LKWDPQKRPTASKILQHQYF
 . || .||| | |  |..|
WHEDPEDRPTFSEI--HECF
Kinase 15513.AA Pkinase_Tyr 4-154 29 2.5e-14 49.17 Pfam 1-161 (270) Show / Hide 
Range on Protein: 4-154
Range on HMM: 1-161/270
Sequence Identity: 29% (48 aa)

YIHLDVIGKGSFGEVVKAQNK----ETKEIVAIKTMKQKFVTWE--ECMNLRELKSLRKL-VNKNIVKLKEVLR-VQNQ--LSFVFEYCDT-DIYKLYEN
 . . ..|.|.||||.|.  |    .||  ||.|..|..    .    . .||.| ...|  ..|||.|  |    . .  .  |.||.   | ..   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

QKKLGQRLPETQLRSIFYQLAQSLSYMHKHGYFHRDLKPENILYSNKDGYVKLTDFGLAREI
..  .|.|.  .| .. .| |. ..| . ... ||||   |.| .. .. || .|||||| |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-NNVVKICDFGLARDI
Kinase 15513.AA PITSLRE 4-36 42 1.7e-09 30.98 In-house 1-33 (295) Show / Hide 
Range on Protein: 4-36
Range on HMM: 1-33/295
Sequence Identity: 42% (14 aa)

YIHLDVIGKGSFGEVVKAQNKETKEIVAIKTMK
.  |..|. | .|.| .|..|.| ||||.| .|
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLK
Kinase 15513.AA CDKL 259-288 33 1.1e-08 25.83 In-house 257-286 (286) Show / Hide 
Range on Protein: 259-288
Range on HMM: 257-286/286
Sequence Identity: 33% (10 aa)

YEAVQLIAECLKWDPQKRPTASKILQHQYF
..|  ..  ||. || .|.|... ..| ||
KKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase 15513.AA Pkinase_Tyr 256-288 39 0.121017 6.19 Pfam 240-270 (270) Show / Hide 
Range on Protein: 256-288
Range on HMM: 240-270/270
Sequence Identity: 39% (13 aa)

DCPYEAVQLIAECLKWDPQKRPTASKILQHQYF
.|| |  .|. .| ..||..||| | |  |. .
NCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL