Gene 9133 (Tetrahymena)
9133
Sequence
Protein domains of 9133.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 9133.AA | RCK | 15-290 | 35 | 5.6e-171 | 547.01 | In-house | 1-298 (298) | Show / Hide |
Range on Protein: 15-290 Range on HMM: 1-298/298 Sequence Identity: 35% (106 aa) YIVLN----------------DQGKKLAMKKLKRGNTFADLEEAKNDIEVRHLNKLK-NEHVIEVLDVIYNSTDRTGFIILPYFQMNLFEFLEN----GK |.... ..|...|.||.| ..|...||..|..|...|.||. ....|....||.............|..|||...... .| YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDFKERRK KLQEFQR--RHIVKQLFQVLSFIHSQNIFHRDLHPENIMITDEQEYSSDKSLFNIKLIDFGSSKCRQDNQ-FTDYVGVRWYRAPELLLSCQKYDEKVDIF .|.|.|| ..|..|..|.|...|....|||||.|||||.|..|.|..|.. ..||..|||......... .||||..|||||||.||.|..|....||. YLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNSPMDIW ALGCIIYEIYHKKPLFPGTSELAQLNELCVILGSPTQEIWSKGVEQAEKKGLDLGKHKKSNLKVIFCDMPQDMVELCELCLTWNPEKRISAAEALNHKSI |.|||.||.|...|||||.||..|....|...|.|....|..|...|..........|...||.......||..||.| .|.|.|.|||.|..||.|... AVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPNCSQDCIELMEKMLQWDPQKRITAQQALQHPYF |
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Kinase | 9133.AA | CMGC | 17-290 | 17 | 1.9e-85 | 280.64 | In-house | 33-513 (513) | Show / Hide |
Range on Protein: 17-290 Range on HMM: 33-513/513 Sequence Identity: 17% (86 aa) VLNDQGKKLAMKKLKRGNTFADLEEAK-----------NDIEVRHLNKLK----------------NEH-VIEVLDVIYNST---------------DRT .... ... |.||.| | | . |.|| |.. | .|. ... .. .|..| . .. HHHETNEIVAIKKIK--NPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNH GFIILPYFQMNLFEFLENGK---------KLQEFQ------------RRHIV------KQLFQVLS--FIHSQN--IFHRDLHPENIMITDEQEY----- ... | ...|.....| . .| | . .... .|... | ..||.. |.|||| ||||.|... |. LYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMM --------SSDKSLFNIKLIDFGSSKCRQDN-----------------------QFTDYVGVRWYRAPELLLSC---------QKYDEKVDIFALGCIIY .. ...|..|||... .. ..|.|| |||||||.||.. ..|....|. ..|||.. WKSEDWNPC--QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFA EIYHK--------KPLFPGTSE-----------LAQLNELCVILGSPT---------------QE-------------------------IWSKGVEQAE |.| . |||||| || . ||.. . .||.|| .| .||... .. EMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYI KKGLDLGKHKKSNLKVIFCD-----------------------------------MPQDMVELCELCLTWNPEKRISAAEALNHKSI ........... ..| .| . .... ..| . .|...|.|||.|..||.| . QSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF |
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Kinase | 9133.AA | MAK | 18-290 | 31 | 2.1e-62 | 197.28 | In-house | 50-352 (352) | Show / Hide |
Range on Protein: 18-290 Range on HMM: 50-352/352 Sequence Identity: 31% (95 aa) LNDQGKKLAMKKLKRGNTFADLEEAKNDIEVRHLNKLK-NEHVIEVLDVIYNSTDRTGFIILPYFQMNLFEFLENGKK--LQEFQRRHIVKQLFQVLSFI ..| | | | |. |. | ..||. | || | ||. . ... . || .| . . .... | . ||.. . .. . | | |. | | | |. IIDTGEKVAIKRMKK--KFYSWEECMNLREVKSLKKLNAHPNIVKLKEVIRDSENDHLYFVFEYMKENLYQMMKDRDRRHFPEPVIRNIMYQILQGLAFM HSQNIFHRDLHPENIMITD-----EQEYSSDKSL---FNIKLIDFG-SSKCRQDNQFTDYVGVRWYRAPELLLSCQKYDEKVDIFALGCIIYEIYHKKPL | . ||||. |||||.. |.|| ||. ||| | . .|||| ||||||| || . .| .|. |.||| |.| .|| HKHGFFHRDMKPENIMCMGPTQYFEKEYMNQIGYQDNELIKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTYYSSPIDMWAVGCIMAELYTFRPL FPGTSELAQLNELCVILGSPTQEI----------------WSKGVEQAEKKGLDLGKHKK---SNLKVIFCDMPQ-DMVELCELCLTWNPEKRISAAEAL |||.|| |. | .||.|. . | | | . .. . . . ..|| . | | .|| . .| |.|.|| |.... FPGSSEIDQIFKICQVLGTPKKDDDFVNTNHITAPPPGGFWPDGYQLAHMMNFRFPQCVPPSIMPLKHLIPNCSQSDAIELMKDMLQWDPNKRPTAQQCC NHKSI .. KYPYF |
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S_TKc | 9133.AA | S_TKc | 8-290 | 21 | 1.3e-55 | 191.99 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 8-290 Range on HMM: 1-231/231 Sequence Identity: 21% (65 aa) LQAHDNL--------YIVLNDQ-GKKLAMKKLKRGNTFADLEEAKNDIEVRHLNKLKNEHVIEVLDVIYNSTDRTGFIILPYFQM---NLFEFLENGKK- . .. . | . . |.. |.|..| . |.. | | . .... .||... .... | .||..... .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRH -----LQEFQRRHIVKQLFQVLSFIHSQNIFHRDLHPENIMITDEQEYSSDKSLFNIKLIDFGSSKCRQDNQFTDYVGVRWYRAPELLLSCQKYDE-KVD . | . |....|... | ..||..| |||| ||||.... .||..|||... | ..| .||.|||.| .|. |.| GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----------HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCD IFALGCIIYEIYHKKPLFPGTSELAQLNELCVILGSPTQEIWSKGVEQAEKKGLDLGKHKKSNLKVIFCDMPQDMVELCELCLTWNPEKRISAAEALN-- . ..|||.|| . .|.|| |.... ..| .... .. . ||...||||..| |||. WWSCGCILYEMLCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE -----HKSI | . WDIKCHPWF |
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Kinase | 9133.AA | Pkinase | 22-290 | 23 | 1.4e-54 | 192.4 | Pfam | 24-293 (293) | Show / Hide |
Range on Protein: 22-290 Range on HMM: 24-293/293 Sequence Identity: 23% (67 aa) GKKLAMKKLKRGNTFADLEEAKNDI---EVRHLNKLKNEHVIEVLDVIYNSTDRTGFIILPYFQM-----NLFEFLE--NGKKL--QEFQRRHIVKQLFQ ||. |.|..|. .. .. .... |.. ...|. ..... .|. .. .. ....| .. ||.... ..... .| . .....|... GKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILR VLSFIHSQNIFHRDLHPENIMITDEQEYSSDKSLFNIKLIDFGSSKC--RQDNQFTDYVGVRWYRAPELLLSCQKYDEKVDIFALGCIIYEIYHKKPLFP | ..||..| |||| ||||.| .. . .. .|..|||..|. |..|...| .||.|||.....|.|. |||....|||.|| . ..|.|| GLEYCHSMGIIHRDLKPENILIDNNGHIDA-----CVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFP GT----SELAQLNELCVILGSPTQEIWSKGVEQAEKKGLDLGKHKKSNLKVIFCDMPQDMVELCELCLTWNPEKRISAAEALNHKSI | . . |. .| |.| |. . |.. . . . . . ... ..... .... ||...|.||..|...|.|. . GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | 9133.AA | CDK | 47-290 | 26 | 1.4e-49 | 156.72 | In-house | 58-284 (284) | Show / Hide |
Range on Protein: 47-290 Range on HMM: 58-284/284 Sequence Identity: 26% (71 aa) EVRHLNKLKNEHVIEVLDVIYNS-TD--------RTGFIILPYFQMNLFEFLENGKKLQEFQRRHIVKQLFQVLSFIHSQNIFHRDLHPENIMITDEQEY |. | .| ..... ..||.. . .| .. ... .| . | .... ... .|| . |...||..| |||| | ||.|.. | EISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD---------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGE- SSDKSLFNIKLIDFGSSKCRQ--------DNQFTDYVGVRWYRAPELLLSCQKYD--EKVDIFALGCIIYEIYH---KKPLFPGTSELAQLNELCVILGS | .|. ||| .. . . .| | .||||||||| ...|. .|. ..|||..|.. .||||||.||. || . |.|. --VK-CGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGT PTQEIWSKGVEQAEKKGLDLGKHKKSNLKVIFCDMPQDMVELCELCLTWNPEKRISAAEALNHKSI || ..| .. . .| . .|. .|.||||| .||.|. PTEDNWPGVTKLPDY-------------------------DLLNKMLCYDPKKRISAEQALQHPYF |
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Kinase | 9133.AA | p38 | 101-290 | 31 | 1.1e-44 | 150.55 | In-house | 109-289 (289) | Show / Hide |
Range on Protein: 101-290 Range on HMM: 109-289/289 Sequence Identity: 31% (61 aa) RHIVKQLFQVLSFIHSQNIFHRDLHPENIMITDEQEYSSDKSLFNIKLIDFGSSKCRQDNQFTDYVGVRWYRAPELLLSCQKYDEKVDIFALGCIIYEIY . .| |. | .||| .| |||| | || .... | . ||| . .|. |.||. ||||||| .|. .|...||| .|||. |. QFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCEL---------RILDFGLAR-HCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELI HKKPLFPGTSELAQLNELCVILGSPTQEIWSKGVEQAEKKGLD-LGKHKKSNLKVIFCDMPQDMVELCELCLTWNPEKRISAAEALNHKSI ..||||. ..||... ..|.|..|.|.| ... . . . .... ... .| ..| | | |.|||.|.||. | . TGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF |
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Kinase | 9133.AA | ERK7 | 47-290 | 29 | 5.3e-44 | 148.2 | In-house | 48-292 (292) | Show / Hide |
Range on Protein: 47-290 Range on HMM: 48-292/292 Sequence Identity: 29% (76 aa) EVRHLNKLK-NEHVIEVLDVIYNSTDRTGFIILPYFQMNLFEFLENGKKLQEFQRRHIVKQLFQVLSFIHSQNIFHRDLHPENIMITDEQEYSSDKSLFN |. | .. . .| ...|| . || ... . | |. |.. .. |. ||.. . ..|| |. |||| | ||.. | EIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILL---------DSECM IKLIDFG-----SSKC---RQDNQFTDYVGVRWYRAPELLLSCQKYDEKVDIFALGCIIYEIYHKKPLFPGTSELAQLNELCVILGSPTQE-IWSKGVEQ .|. ||| ... |. |.|| ||||||| ||. ..| || .|||. |. .||.||||| . |.. ... |||| | . | . VKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHY AEKKGLDLGKHKKSNLKVIFCDMPQDMVELCELCLTWNPEKRISAAEALNHKSI | . ....|. |. .. . ..| ..| | ||.||..| .||.| . AWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV |
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Kinase | 9133.AA | CDC2 | 51-290 | 30 | 7e-43 | 129.28 | In-house | 54-301 (301) | Show / Hide |
Range on Protein: 51-290 Range on HMM: 54-301/301 Sequence Identity: 30% (79 aa) LNKLK-NEHVIEVLDVIYNSTDRTGFIILPYFQMNLFEFLE----NGKKLQEFQRRHIVKQLFQVLSFIHSQNIFHRDLHPENIMITDEQEYSSDKSLFN | .|| . .. |||.. . ... | |.| .... .|.... . . .|. | ..| |.. |.|||| | || | .. . LKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN--------- IKLIDFGSSK--CRQDNQFT--DYVGVRWYRAPELLLSCQKYDEKVDIFALGCIIYEI---YHKKPLFPGTSELAQLNELCVILGSPTQEIWSKGVEQAE ||. ||| .. . .. | | .||||||.|| |..|. ||. ..|||..|. .|||||.| || || |||.|. ..| ||.| IKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTW-PGVTQLP KKGLDLGKHKKSNLKVIFCD---------MPQDMVELCELCLTWNPEKRISAAEALNHKSI . .. |...|. |. . .... ..| . | .|.||||| |||.|. . DYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQHPYF |
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Kinase | 9133.AA | Ciliate-E2 | 51-290 | 21 | 1.5e-42 | 143.92 | In-house | 86-365 (365) | Show / Hide |
Range on Protein: 51-290 Range on HMM: 86-365/365 Sequence Identity: 21% (71 aa) LNKLKNEHVIEVLDVIYNSTDRTGFIILPYFQM-NLFEFLENG-----------KKLQEFQRRHIVKQLFQ---------------VLSFIHSQN-IFHR | .|.. ..|. .. .. .| . .... |.| .||....| |.. |.....| ||..| | ..||.| |.|| LEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHR DLHPENIMITDEQEYSSDKSLFNIKLIDFGSSK--------------CR-------------------QDNQFTDYVGVRWYRAPELLLSCQK------- |. ||||.. ||.|||| || | |.|.| ..| | ||| | . . DIKPENILF--------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQK -YDEKVDIFALGCIIYEIYHKKPLFPGTSELAQLNELCVILGSPTQEIWSKGVEQAEKKGLDLGKHKKSNLKVIFC-------------------DMPQD ||.|.||..||.|.|| .|| | .. . |. | . .|. GYDYKCDIWSLGVILYEMLFGKPPF---------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQE MVELCEL----CLTWNPEKRIS-AAEALNHKSI . |. .| .|||||. . ..|||. . CKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | 9133.AA | MAPK | 111-287 | 30 | 3.3e-37 | 126.12 | In-house | 130-325 (328) | Show / Hide |
Range on Protein: 111-287 Range on HMM: 130-325/328 Sequence Identity: 30% (63 aa) LSFIHSQNIFHRDLHPENIMITDEQEYSSDKSLFNIKLIDFGSSKCRQDNQF----------------TDYVGVRWYRAPELLLS--CQKYDEKVDIFAL | .||| |. |||| |.|| .. . . |. ||| . . .... |.|| |||||||..|. ..|...||. .. LKYIHSANVIHRDLKPSNILVNENCDL---------KICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSV GCIIYEIYH-KKPLFPGTSELAQLNELCVILGSPTQEIWSKGV--EQAEKKGLDL---GKHKKSNLKVIFCD----MPQDMVELCELCLTWNPEKRISAA ||| | . ||||||.. . |.| .||.|..| ... | | . | |..| ... .|.. . . | | |...|.|||... GCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQAIDLLEKMLVFDPDKRITVE EALNH |||.| EALQH |
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Kinase | 9133.AA | ERK | 149-287 | 34 | 8.6e-33 | 115.27 | In-house | 158-304 (307) | Show / Hide |
Range on Protein: 149-287 Range on HMM: 158-304/307 Sequence Identity: 34% (50 aa) IDFGSSKCR--QDNQFTDYVGVRWYRAPELLLSCQKYDEKVDIFALGCIIYEIYHKKPLFPGTSELAQLNELCVILGSP--TQEIWSKGVEQAEKKGLDL .|...... ..|..|.|| |||||||..|| |||....|| . |||. | . |||||| . . |.|. |.|.| ... .. |.| | | FDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNL GK--HKKSNLKVIFCDMP--QDMVELCELCLTWNPEKRISAAEALNH .. .. ... || . . ....| | |...|.|||...|.| | PNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVEECLEH |
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TyrKc | 9133.AA | TyrKc | 12-290 | 17 | 2.2e-08 | -87.07 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 12-290 Range on HMM: 1-280/280 Sequence Identity: 17% (57 aa) DNLYIVL-------------NDQGKKLAMKKLKRGNTFADLEEAKNDI--EVRHLNKL--KNEHVIEVLDVIYNS-----TDRTGFIILPYFQM-NLFEF | .| . . | |.|| . . |. | | . || ...... . |. . . .|.. | .| .. ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY LENGKK-LQEFQRRHIVKQLFQVLSFIHSQNIFHRDLHPENIMITDEQEYSSDKSLFNIKLIDFGSSKCRQDN--------QFT------DY--VGVRWY | . .. |. . .. | . ...||.|. |||| |....... .| ||| |. | . . .||. LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM RAPELLLSCQKYDEKVDIFALGCIIYEIYHK-KPLFPG-------TSELAQLNELCVILGSPTQ--EIWSKGVEQAEKKGLDLGKHKKSNLKVIFCDMPQ ||| . |. .| |... | ..||. .. || .|. .. . . | . | | .|. -APECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS------------------------FVCCPD DMVELCELCLTWNPEKRISAAEALNHKSI .| .. . | .||.| . .| |. . EMYQIMKQCWHEDPEDRPTFSEI--HECF |
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Kinase | 9133.AA | ERK | 113-132 | 55 | 3e-05 | 15.71 | In-house | 123-142 (307) | Show / Hide |
Range on Protein: 113-132 Range on HMM: 123-142/307 Sequence Identity: 55% (11 aa) FIHSQNIFHRDLHPENIMIT .|||.|..|||| | || .. YIHSANVIHRDLKPSNILVN |