Gene 3884 (Tetrahymena)

3884

Species: Tetrahymena
Alias: 3884, PreTt03884, TTHERM_00446150, 3704.m00105, 51.m00250, 475
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: CMGC
Family: SRPK

Sequence

Name Sequence Type Origin Length Description Download
3884.AA Protein None 912 None Fasta, JSON
3884.kin_dom Protein Kinase Domain None 512 None Fasta, JSON
3884.NA RNA None 2739 None Fasta, JSON

Protein domain

Protein domains of 3884.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 3884.AA SRPK 286-797 47 0.0 1085.86 In-house 1-554 (554) Show / Hide 
Range on Protein: 286-797
Range on HMM: 1-554/554
Sequence Identity: 47% (264 aa)

YVVIQKIGWGHFSTVWLAKDFKYDTYVALKIQKSAPHYLEAAFDEVEILQKVARMSKDPEWMKSLQKYYEGEKR--KSFNKDDCQVVQLLNSFVFKGPYG
|.||.|.||||||||||..|..||.|||.||.||||||.|.|.||...||.|......|.||..|..|||..||  |.|....|.|||||..|...||.|
YHVIRKLGWGHFSTVWLCWDMQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKEYYEDYKRDCKEFDPNRCHVVQLLDHFKHRGPNG

NHFCFVFEILGVNLLEVIKRYNYSGVPMHLCRKIAKQVLIGLDFLHRFCDVIHTDLKPENVLLQLTQDELKDI--------IENGQMTKNQLFKERLKVI
||.|.|||.||.|||..||.|||.|.|||....||.|||||||.|||.|..||||.|||||||...||..|..        ....||......... ...
NHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVLLCVNQDYIKRMAAEWTEWQKMGMQMPSSSMVQTAPQHQ

RKHLGVK--EEEEKPVEEKKPQQQQQAKPDQKTKKQQEDDDNDNDDEDGEDDDGNQKDEGDNTNLKELEQKLKQPGLTKKQKKNLRKKISMKKRKLQEQK
......|  ....|....|..|||.|....|..|.|.|||.|||.|...||.|..|............|.. .....|.|||||..||...|..| ||..
TQCQQQKMSKNKKKKMKKKQKQQQEQQEKNQQQKQQMEDDQNDNEDNNQEDNDNEQDNKNNQNQENNMENEQEEKENTNKQKKNQKKKEQHKDKKEQECQ

NAQQQPQE-------------------------------QQSTKESTKQENQAEENKPSQQKEMNTKDLFSQPDTKLLDKNKLMRGPQLDENFKLKIADL
|.|.|...                               |.|||...||..|.|..|.|...|....|...| ..|.|...| .|...||...|.|||||
NVQKQNNDPNFESQNDSQMEQETNSCNNQEHKQEKTMQCQDSTKQQNKQDQQKEGQKQSEESECESEDMQEQ-AGKFLVWWKNPRNADLDHKIKIKIADL

GNACWTFHHFATEIQTRQYRSPEVIIGSKYNTTADIWSLACMLFEMLTGDFLFEPRKGPTFSKNDDHLAQIEELCKKFPKSFAKRGEKSKKYFDNNGNLR
|||||..|||...||||||||||||||..|||.|||||.|||.||..|||.||||..|...|..|||.|.|.|||.|.|..||..|..|...|...|.||
GNACWVHHHFTEDIQTRQYRSPEVIIGAGYNTPADIWSTACMAFELATGDYLFEPHSGEDYSRDDDHIAHIIELCGKIPWHFALSGKYSREFFNKKGELR

RIPQLQYWPLKSVLVEKYRLKEKEAKAFEDFMMPMLHCMPEKRATAEQMLNHPWL
.||.|..|||..||.|||.....|||.||||.|||||..|||||||...|.||||
HIPKLKPWPLMNVLIEKYEWSHEEAKQFEDFLMPMLHYNPEKRATAKECLQHPWL
Kinase 3884.AA CMGC 286-797 14 2.6e-109 360.51 In-house 1-513 (513) Show / Hide 
Range on Protein: 286-797
Range on HMM: 1-513/513
Sequence Identity: 14% (102 aa)

YVVIQKIGWGHFSTVWLAKD--------------FKYDTYVALKIQKSAPHYLEAAF-------------DEVEILQKVARMSKDPEWMKSLQKYYEGEK
| .|.|||.|....|. ..|               ... .||.|. |... | | |              .|..||... .  .  .|           .
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NW-----------Q

R--KSFNKDDCQVVQLLNSFVFKGPYGN-------------HFCFVFEILGVNLLEVIKRYN--YSG------------------------VPMHLCRKI
|  ...||..  .|.|...|..|.. ||             |...||| .. .|...||...  | |                         .. ..| .
RRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-Y

AKQVLIGLD--FLHRFC-DVIHTDLKPENVLLQLTQDELKDIIENGQMTKNQLFKERLKVIRKHLGVKEEEEKPVEEKKPQQQQQAKPDQKTKKQQEDDD
..|.| ||.  ..|. . ..||.||||||.|.  . . .... .   . |     |                                            
MYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRM-M---W-KS----E--------------------------------------------

NDNDDEDGEDDDGNQKDEGDNTNLKELEQKLKQPGLTKKQKKNLRKKISMKKRKLQEQKNAQQQPQEQQSTKESTKQENQAEENKPSQQKEMNTKDLFSQ
                                                                                                    
----------------------------------------------------------------------------------------------------

PDTKLLDKNKLMRGPQLDENFKLKIADLGNACWTFHH------------------------FATEIQTRQYRSPEVIIGSK----------YNTTADIWS
      | .  ..    ..|..|||.| |.|.|. .|                        . ....|| ||.||...|.|          |.|. |.||
------D-W-NPC----QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWS

LACMLFEMLTG--------DFLFEPRKGP-----TFSKNDDHLAQIEELCKKFPKSFAKRGE-------KSKKYFDNNGNLRRIPQLQ------------
..|...||.||        . || .. .      . ... |.|..| ... ... .....|.       ....... ...........            
VGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWS

-------------YWPLKSVLVEKYRLKEK--------------------------------EAKAFEDFMMPMLHCMPEKRATAEQMLNHPWL
              |. .  . ...  . .                                . . . |... ||.. |.|| |||| |.||..
EFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 3884.AA S_TKc 286-797 13 1.4e-44 155.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 286-797
Range on HMM: 1-231/231
Sequence Identity: 13% (70 aa)

YVVIQKIGWGHFSTVWLAKDFKYDTYVALKIQKSAPHYLEAAFDEVEILQKVARMSKDPEWMKSLQKYYEGEKRKSFNKDDCQVVQLLNSFVFKGPYGNH
| ...||| | |..|..... | . .||.|| |                                 .  . | .   . .   .|.|. .|.      .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------------------------EHIRREIQILKK-HHPNIVKLYDVFQD-----DH

FCFVFEILGV---NLLEVIKRYNY----SGVPMHLCRKIAKQVLIGLDFLHRFCDVIHTDLKPENVLLQLTQDELKDIIENGQMTKNQLFKERLKVI---
...|.| ..    .|...||....    .. |   .|....|.. .|...|.   .|| ||||||.||                        ..|..   
LYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE----------------------HIKICDFG

-RKHLGVKEEEEKPVEEKKPQQQQQAKPDQKTKKQQEDDDNDNDDEDGEDDDGNQKDEGDNTNLKELEQKLKQPGLTKKQKKNLRKKISMKKRKLQEQKN
  ..|                                                                                               
LARQL-----------------------------------------------------------------------------------------------

AQQQPQEQQSTKESTKQENQAEENKPSQQKEMNTKDLFSQPDTKLLDKNKLMRGPQLDENFKLKIADLGNACWTFHHFATEIQTRQYRSPEVIIGSKYNT
                                                                               | . |. |..|||.   .|..
------------------------------------------------------------------------------TTFCGTPWYMAPEVL---GYGK

-TADIWSLACMLFEMLTGDFLFEPRKGPTFSKNDDHLAQIEELCKKFPKSFAKRGEKSKKYFDNNGNLRRIPQLQYWPLKSVLVEKYRLKEKEAKAFEDF
  .|.||. |.|.|||.|  .|.            ..... ....                                                 . . ||
CKCDWWSCGCILYEMLCGYPPFP------------QMQMMFKKIG------------------------------------------------SPEAKDF

MMPMLHCMPEKRATAEQMLN-------HPWL
.. .|.  |||| || . |.       |||.
IRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 3884.AA CLK 368-739 16 2.3e-40 118.22 In-house 67-289 (350) Show / Hide 
Range on Protein: 368-739
Range on HMM: 67-289/350
Sequence Identity: 16% (65 aa)

QVVQLLNSFVFKGPY-GNHFCFVFEILGVNLLEVIKRYN------YSGVPMHLCRKIAKQVLIGLDFLHRFCDVIHTDLKPENVLLQLT------QDELK
...... .|    .| ..|.| |||..| .. ...|  |      | . |..  |..|.| .  . |||     .|||||||| ..  .      .    
HCWKMNDWF----DYGHGHICIVFELYGLSIYDFMKSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDM-KLTHTDLKPENICFVDSRFTHFDCTFKY

DIIENGQMTKNQLFKERLKVIRKHLGVKEEEEKPVEEKKPQQQQQAKPDQKTKKQQEDDDNDNDDEDGEDDDGNQKDEGDNTNLKELEQKLKQPGLTKKQ
..  ...                                                                                             
NHKKKIN---------------------------------------------------------------------------------------------

KKNLRKKISMKKRKLQEQKNAQQQPQEQQSTKESTKQENQAEENKPSQQKEMNTKDLFSQPDTKLLDKNKLMRGPQLDENFKLKIADLGNAC---WTFHH
                                                                   .|.  .  .  .|.  .. | |.|        |
-----------------------------------------------------------------KKSNNCVCHYWHVKNTHICVIDFGSATKIRFDHEH

FATEIQTRQYRSPEVIIGSKYNTTADIWSLACMLFEMLTGDFLFEPRKGPTFSKNDDHLAQIEELCK-KFPKSFAKRGE---KSKKYFDNNG
  | ..||.|| |||| |  ...  |.|| .| |||  ||. ||     .| . | .||| .|...   .|.. ..|      ..||| .|.
HSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLF-----QTHD-NREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNR
Kinase 3884.AA Pkinase 369-797 14 2.3e-34 122.58 Pfam 62-293 (293) Show / Hide 
Range on Protein: 369-797
Range on HMM: 62-293/293
Sequence Identity: 14% (64 aa)

VVQLLNSFVFKGPYGNHFCFVFEIL-GV----NLLEVIK---RYNYSGVPMHLCRKIAKQVLIGLDFLHRFCDVIHTDLKPENVLLQLTQDELKDIIENG
.|.|. .|      ..| ..|.| . |      | ..|.   . ...  ... |.....|.| ||...|. . .|| ||||||.|.   ......     
IVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILID-NNGHIDA-----

QMTKNQLFKERLKVIRKHLGVKEEEEKPVEEKKPQQQQQAKPDQKTKKQQEDDDNDNDDEDGEDDDGNQKDEGDNTNLKELEQKLKQPGLTKKQKKNLRK
                                                                                                    
----------------------------------------------------------------------------------------------------

KISMKKRKLQEQKNAQQQPQEQQSTKESTKQENQAEENKPSQQKEMNTKDLFSQPDTKLLDKNKLMRGPQLDENFKLKIADLGNAC---WTFHHFATEIQ
                                                                           ..||.| | |.   .   . .| . 
---------------------------------------------------------------------------CVKICDFGLAKQFDY-NNS-MTTFC

-TRQYRSPEVII-GSKYNTTADIWSLACMLFEMLTGDFLFEPRKGPTFSKNDDHLAQIEELCKKFPKSFAKRGEKSKKYFDNNGNLRRIPQLQYWPLKSV
 |. |..||||  |..| . .|.||. |.|.|||.| ..|  .   . . .|.     . ...... .. .  ..|  . ..    .             
GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-------------

LVEKYRLKEKEAKAFEDFMMPMLHCMPEKRATAEQMLNHPWL
  .  ... .  ... ||.  .|.  |.|| |||| |.|||.
--F-HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 3884.AA DYRK 637-797 29 1.1e-26 95.0 In-house 146-320 (320) Show / Hide 
Range on Protein: 637-797
Range on HMM: 146-320/320
Sequence Identity: 29% (54 aa)

LKIADLGNACWTFHHFATEIQTRQYRSPEVIIGSKYNTTADIWSLACMLFEMLTGDFLFEPRKGPTFSKNDDHLAQIEELCKKFPKSFAKRG--EKSKKY
.|..| | .|   ... | || | ||.||||.| .|..  |.||| | | |..||  ||        . . | || | |.  ..|| . . |  .. .|.
IKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPG------ENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKF

FDN------------NG------NLRRIPQLQYWPLKSVLVE--KYRLKEKEAKAFEDFMMPMLHCMPEKRATAEQMLNHPWL
||.            |       .....| .     ..   .  ..|.. .. . | || . .|  .|.|| |..| |.|||.
FDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase 3884.AA Ciliate-E2-Unclassified 414-797 13 5.7e-23 76.54 In-house 140-352 (352) Show / Hide 
Range on Protein: 414-797
Range on HMM: 140-352/352
Sequence Identity: 13% (58 aa)

CR-----KIAKQVLIGLDFLHRFCDVIHTDLKPENVLLQLTQDELKDIIENGQMTKNQLFKERLKVIRKHLGVKEEEEKPVEEKKPQQQQQAKPDQKTKK
..     ....|.| ||..||.  ..|| |.||||.|..  .                                                          
AKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK---------------------------------------------------------

QQEDDDNDNDDEDGEDDDGNQKDEGDNTNLKELEQKLKQPGLTKKQKKNLRKKISMKKRKLQEQKNAQQQPQEQQSTKESTKQENQAEENKPSQQKEMNT
                                                                                                    
----------------------------------------------------------------------------------------------------

KDLFSQPDTKLLDKNKLMRGPQLDENFKLKIADLGNA------------------CWTFHHFATEIQTRQYR----SPEVIIGSKYNTT----ADIWSLA
                         |...||.|.|..                   | .... | ..| .|     .|||. | .|...    .||||| 
-------------------------NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLG

CMLFEMLTGDFLFEPRKGPT-----------FSKNDDHLAQIEELCKKFPKSFA-------KRGEKSKKYFDNNGNLRRIPQLQYWPLKSVLVEKYRLKE
. |.|||.| . |. ..              .    . . .... ..| .. .        |.  .. | | |                           
VILYEMLFGYYPFYDNNCEQHQQLITQWINNA----YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN---------------------------

KEAKAFEDFMMPMLHCMPEKRATAEQMLNHPWL
       |..  ||   |.|| |.|| |||||.
-------DLLQKMLKKNPNKRITFEQILNHPWF
Kinase 3884.AA DYRK 369-454 38 2.5e-22 80.4 In-house 63-147 (320) Show / Hide 
Range on Protein: 369-454
Range on HMM: 63-147/320
Sequence Identity: 38% (34 aa)

VVQLLNSFVFKGPYGNHFCFVFEILGVNLLEVIKRYNYSGV-PMHLCRKIAKQVLIGLDFLHRFCDVIHTDLKPENVLLQL--TQDELK
.|.....|...    ||.| ||| |  || |..|...  |. .. | ||.|.|.| .|.|||.  . || ||||||..|.    . ..|
CVHMYDYFYHR----NHLCIVFELLSMNLYEFLKNNHFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIK
Kinase 3884.AA DYRK1 286-446 33 3.8e-20 67.05 In-house 1-137 (321) Show / Hide 
Range on Protein: 286-446
Range on HMM: 1-137/321
Sequence Identity: 33% (54 aa)

YVVIQKIGWGHFSTVWLAKDFKYDTYVALKIQKSAPHYLEAAFDEVEILQKVARMSKDPEWMKSLQKYYEGEKRKSFNKDDCQVVQLLNSFVFKGPYGNH
| ..  || | |  |  | | .   |||.|| |    ... |  |. .|  . .  |.       .|||              .|.| . |.|.    ||
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKE-------MKYY--------------IVHLKRHFMFR----NH

FCFVFEILGVNLLEVIKRYNYSGVPMHLCRKIAKQVLIGLDFLHRF-CDVIHTDLKPENVLL
 | |||.|  || ....  .. || . | ||.|.|..  | |.     |.|| ||||||.||
LCLVFELLSYNLYDLLRNTHFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILL
Kinase 3884.AA DYRK2 369-446 43 4.4e-20 61.69 In-house 63-135 (318) Show / Hide 
Range on Protein: 369-446
Range on HMM: 63-135/318
Sequence Identity: 43% (34 aa)

VVQLLNSFVFKGPYGNHFCFVFEILGVNLLEVIKRYNYSGVPMHLCRKIAKQVLIGLDFLHRFCDVIHTDLKPENVLL
.| .|..|.|     ||.| .|| |..|| | ||. .. |  . | |. |...| .|.|||.  ..|| ||||||.||
CVHMLDYFYFR----NHHCITFELLSMNLYEYIKKNHFQGFSLQLVRRFAHSILQCLRFLHK-NNIIHCDLKPENILL
Kinase 3884.AA DyrkP 636-695 48 4.9e-19 58.71 In-house 146-205 (323) Show / Hide 
Range on Protein: 636-695
Range on HMM: 146-205/323
Sequence Identity: 48% (29 aa)

KLKIADLGNACWTFHHFATEIQTRQYRSPEVIIGSKYNTTADIWSLACMLFEMLTGDFLF
. || | | .|.   | .  .| | || |||||| ||    |.||| |.| |. ||  ||
QVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLF
Kinase 3884.AA DYRK2 637-695 43 6.1e-19 57.92 In-house 143-202 (318) Show / Hide 
Range on Protein: 637-695
Range on HMM: 143-202/318
Sequence Identity: 43% (26 aa)

LKIADLGNACWTFH-HFATEIQTRQYRSPEVIIGSKYNTTADIWSLACMLFEMLTGDFLF
.|..| |  |     .. | ||.| ||.||||.| ||..  |.||. | . |..||  ||
IKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF
Kinase 3884.AA DYRK1 636-736 37 6.8e-18 59.0 In-house 144-238 (321) Show / Hide 
Range on Protein: 636-736
Range on HMM: 144-238/321
Sequence Identity: 37% (38 aa)

KLKIADLGNACWTFHHFATEIQTRQYRSPEVIIGSKYNTTADIWSLACMLFEMLTGDFLFEPRKGPTFSKNDDHLAQIEELCKKFPKSFAKRGEKSKKYF
..|| | | .| . .     || | ||||||..| .|..  |.||| |.| || ||. ||      . |   | . .| |     || .  .. |..|||
AIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLF------SGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYF

D
.
E
Kinase 3884.AA YAK 369-460 39 3.4e-16 51.13 In-house 67-153 (347) Show / Hide 
Range on Protein: 369-460
Range on HMM: 67-153/347
Sequence Identity: 39% (37 aa)

VVQLLNSFVFKGPYGNHFCFVFEILGVNLLEVIKRYNYSGVPMHLCRKIAKQVLIGLDFLHRFCDVIHTDLKPENVLLQL-TQDELKDIIENG
.. .. .||.|    |||| |||.| .|| | .|  .. |  . | |   ||.| |.  |     .|| ||||||..|.   . |.| || .|
ILRMYDFFVHK----NHFCLVFEMLSNNLYEYLKQNKFCGFSFQLIRQWTKQILDGMCVLEN-KQIIHCDLKPENIMLCKPNKPEIK-IIDFG
Kinase 3884.AA PRP4 657-744 32 7e-13 43.55 In-house 167-248 (320) Show / Hide 
Range on Protein: 657-744
Range on HMM: 167-248/320
Sequence Identity: 32% (29 aa)

QTRQYRSPEVIIGSKYNTTADIWSLACMLFEMLTGDFLFEPRKGPTFSKNDDHLAQIEELCKKFPKSFAKRGEKSKKYFDNNGNLRRI
. | ||.||.||| .|    |.|| .| |.|. || ..|    | |   | . |  . ..  |.|.   ..|.   ..|| | |.  .
VSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFP---GKT---NNHMLKLFMDYKGKMPNKMIRKGQFKDNHFDQNCNFMYQ
Kinase 3884.AA CLK 286-338 36 7.4e-12 31.11 In-house 1-55 (350) Show / Hide 
Range on Protein: 286-338
Range on HMM: 1-55/350
Sequence Identity: 36% (20 aa)

YVVIQKIGWGHFSTVWLAKDFKY-DTYVALKIQKSAPHYLEAAFDEVE-ILQKVA
|... . | | |..|   .| |. ..|||||| ...  | |||  |.. |..|..
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKIN
Kinase 3884.AA YAK 637-687 45 1.3e-11 35.35 In-house 147-197 (347) Show / Hide 
Range on Protein: 637-687
Range on HMM: 147-197/347
Sequence Identity: 45% (23 aa)

LKIADLGNACWTFHHFATEIQTRQYRSPEVIIGSKYNTTADIWSLACMLFE
.|| | | .| .     | || | |||||.|..  | |  | ||| | . |
IKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAE
Kinase 3884.AA PRP4 369-445 33 1.6e-09 31.06 In-house 66-138 (320) Show / Hide 
Range on Protein: 369-445
Range on HMM: 66-138/320
Sequence Identity: 33% (26 aa)

VVQLLNSFVFKGPYGNHFCFVFEILGVNLLEVIKRY-NYSGVPMHLCRKIAKQVLIGLDFLHRFCDVIHTDLKPENVL
.|.. ..| ..    .| | ||| .  || ||.|.|    |  .   |  |.| .. |  | . |. .| |.|| |.|
CVRMFRHFNHR----QHMCLVFECMSMNLREVLKKYGKDVGLHLKAVRSYAQQLFLALKHLKK-CNILHADIKPDNIL
Kinase 3884.AA DYRK2 759-797 38 9.7e-09 24.2 In-house 280-318 (318) Show / Hide 
Range on Protein: 759-797
Range on HMM: 280-318/318
Sequence Identity: 38% (15 aa)

KYRLKEKEAKAFEDFMMPMLHCMPEKRATAEQMLNHPWL
|. ||. | . | || .  .. .|..| |..| |.|||.
KSVLKGCEDENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase 3884.AA DYRK 286-336 31 1.4e-08 28.45 In-house 1-51 (320) Show / Hide 
Range on Protein: 286-336
Range on HMM: 1-51/320
Sequence Identity: 31% (16 aa)

YVVIQKIGWGHFSTVWLAKDFKYDTYVALKIQKSAPHYLEAAFDEVEILQK
| ... || | |. |  ..| | . .||.|| .. . ..  | .|..||..
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEY
Kinase 3884.AA DyrkP 416-447 53 2e-08 23.12 In-house 110-140 (323) Show / Hide 
Range on Protein: 416-447
Range on HMM: 110-140/323
Sequence Identity: 53% (17 aa)

KIAKQVLIGLDFLHRFCDVIHTDLKPENVLLQ
|| .|.||.||..|    .|| ||||||.|..
KITQQILIALDYIHSLR-LIHCDLKPENILMK
Kinase 3884.AA DYRK2 286-343 31 5e-06 15.2 In-house 1-58 (318) Show / Hide 
Range on Protein: 286-343
Range on HMM: 1-58/318
Sequence Identity: 31% (18 aa)

YVVIQKIGWGHFSTVWLAKDFKYDTYVALKIQKSAPHYLEAAFDEVEILQKVARMSKD
| .   || | |  |  . | |....||.|.      ... |  |..||..  |  ||
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKD
Kinase 3884.AA PRP4 286-345 31 1.8e-05 16.11 In-house 1-61 (320) Show / Hide 
Range on Protein: 286-345
Range on HMM: 1-61/320
Sequence Identity: 31% (19 aa)

YVVIQKIGWGHFSTVWLAKDFKYDT-YVALKIQKSAPHYLEAAFDEVEILQKVARMSKDPE
| |....| | ||.|  ..|       || ||  . .        |.|||||      |..
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKN
Kinase 3884.AA CLK 761-797 32 3.5e-05 10.7 In-house 314-350 (350) Show / Hide 
Range on Protein: 761-797
Range on HMM: 314-350/350
Sequence Identity: 32% (12 aa)

RLKEKEAKAFEDFMMPMLHCMPEKRATAEQMLNHPWL
. |. |.  . | .  ||   | || |. . | ||. 
DCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase 3884.AA Ciliate-E2-Unclassified 286-320 27 0.00013 11.94 In-house 1-39 (352) Show / Hide 
Range on Protein: 286-320
Range on HMM: 1-39/352
Sequence Identity: 27% (11 aa)

YVVIQKIGWGHFSTVWLAKDFKYDTYV-----ALKIQKSA
| .|..|| | |..|..... | . ..     . |||. .
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYK
Kinase 3884.AA TyrKc 286-797 8 0.000151 -149.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 286-797
Range on HMM: 1-280/280
Sequence Identity: 8% (49 aa)

YVVIQKIGWGHFSTVWLAKDFKYDTYVALKIQKSAPHYLEAAFDEVEILQKV-------------ARMSK------DPEWMKSLQKYYEGEKRKSFNKDD
 . ..|.| |.| .|....     . || |  |.    .|.  .| .|. |.             .. ..      .| ..  .  | ..   |.. .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMI--VMEYMPHGDLKDYLRKH

CQVVQLLNSFVFKGPYGNHFCFVFEILGVNLLEVIKRYNYSGVPMHLCRKIAKQVLIGLDFLHRFCDVIHTDLKPENVLLQLTQDELKDIIENGQMTKNQ
                                          ..|    ... |.  | ..||.                                    
RPK---------------------------------------LCMKDLLSFCWQIACGMEYLHSK-----------------------------------

LFKERLKVIRKHLGVKEEEEKPVEEKKPQQQQQAKPDQKTKKQQEDDDNDNDDEDGEDDDGNQKDEGDNTNLKELEQKLKQPGLTKKQKKNLRKKISMKK
                                                                                                    
----------------------------------------------------------------------------------------------------

RKLQEQKNAQQQPQEQQSTKESTKQENQAEENKPSQQKEMNTKDLFSQPDTKLLDKNKLMRGPQ------------LDENFKLKIADLGNACWTFHH---
                                                               .            ..||.  ||.| | .    ..   
---------------------------------------------------------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQ

-FATEIQTR----QYR--------SPEVIIGSKYNTTADIWSLACMLFEMLTGDFLFEPRKGPTF--SKNDDHLAQIEEL--CKKFPK----SFAKRGEK
  ...  .     . .        .||.|  .|..|  |.||   ...|..|  .  .|  |...   .|.. ......    .. |     |       
GESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFT--YGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------

SKKYFDNNGNLRRIPQLQYWPLKSVLVEKYRLKEKEAKAFEDFMMPMLHC---MPEKRATAEQMLNHPWL
                                      . ..  . |. |    ||.| | ..   |  .
-----------------------------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase 3884.AA PRP4 769-797 34 0.000503 10.72 In-house 292-320 (320) Show / Hide 
Range on Protein: 769-797
Range on HMM: 292-320/320
Sequence Identity: 34% (10 aa)

AFEDFMMPMLHCMPEKRATAEQMLNHPWL
.| |..  .|   |.|| | .. | || .
QFKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase 3884.AA DyrkP 759-797 33 0.000666 7.98 In-house 286-323 (323) Show / Hide 
Range on Protein: 759-797
Range on HMM: 286-323/323
Sequence Identity: 33% (13 aa)

KYRLKEKEAKAFEDFMMPMLHCMPEKRATAEQMLNHPWL
. ||.  .   | ||.  .|     .| ||   |.|||.
RARLRT-DDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase 3884.AA Pkinase 286-316 35 0.001012 14.24 Pfam 1-31 (293) Show / Hide 
Range on Protein: 286-316
Range on HMM: 1-31/293
Sequence Identity: 35% (11 aa)

YVVIQKIGWGHFSTVWLAKDFKYDTYVALKI
|....||| | |..|..... ..   ||.||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKI
Kinase 3884.AA DYRK1 770-797 32 0.018322 3.89 In-house 294-321 (321) Show / Hide 
Range on Protein: 770-797
Range on HMM: 294-321/321
Sequence Identity: 32% (9 aa)

FEDFMMPMLHCMPEKRATAEQMLNHPWL
|.| .  ||.  |..| |  . | |...
FKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase 3884.AA YAK 770-797 32 0.050064 2.23 In-house 320-347 (347) Show / Hide 
Range on Protein: 770-797
Range on HMM: 320-347/347
Sequence Identity: 32% (9 aa)

FEDFMMPMLHCMPEKRATAEQMLNHPWL
| ||.  .|   | .| .. |   || .
FIDFINQLLQLNPRERWKPMQAMQHPFI