Gene 18266 (Tetrahymena)

18266

Species: Tetrahymena
Alias: 3742.m00017, PreTt18266, TTHERM_00755890, 1072, 123.m00085, 18266
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-A4

Sequence

Name Sequence Type Origin Length Description Download
18266.AA Protein None 914 None Fasta, JSON
18266.kin_dom Protein Kinase Domain None 145 None Fasta, JSON
18266.NA RNA None 2745 None Fasta, JSON

Protein domain

Protein domains of 18266.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 18266.AA Ciliate-A4 470-585 51 5.1e-78 254.06 In-house 140-255 (284) Show / Hide 
Range on Protein: 470-585
Range on HMM: 140-255/284
Sequence Identity: 51% (60 aa)

PIAVKKLKTIEEFARELYLMETLQSIYMPQLFFYDETQKKLFMEMGLCSLEDLKKYSEQTDFCLTDQQTFSILNQLLVAIELFIDQKAFHSDIKPSNIVI
|.|.||.||.|||.||||.|.|.|..|||.||.||..|..||||||||||.|||..|||...|..|..|.|||..|..|||.....||............
PVACKKIKTQEEFIRELYIMQTVQCEYMPKLFYYDIDQQILFMEMGLCSLYDLKQDSEQNNYCFSDEFTYSILINLIQAIESMLSNKAYNQQEQKHQPLF

RSKLNESNKIQLQLMI
.|.....||||||.|.
HSDIKPQNKIQLQIML
Kinase 18266.AA Ciliate-E2-Unclassified 445-597 17 1e-15 51.02 In-house 1-200 (352) Show / Hide 
Range on Protein: 445-597
Range on HMM: 1-200/352
Sequence Identity: 17% (35 aa)

FRYITSIGEGSFGTVDLYEFTPLKFPIAVKKLKTIEEFARELY------------------------------LMETLQSIYMPQLFFYDETQKKLFMEM
.. |  ||.|.||.| . .    |.  | | .| | .... ..                              ..  .....   .|........... |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

GLCSLEDLKKYSEQTDF----------------CLTDQQTF-----SILNQLLVAIELFIDQK-AFHSDIKPSNIVIRSKLNESNKIQLQLMIIDYGGAS
 .|   ||..| ..  .                ..|.||.       .. |.|...|  . ..   | ||||.||.. .. .      ... |||.| ..
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK-----NYYIKIIDFGISK

FDIED
. ...
KYQQN
Kinase 18266.AA Ciliate-A4 445-466 77 1.5e-14 43.59 In-house 36-57 (284) Show / Hide 
Range on Protein: 445-466
Range on HMM: 36-57/284
Sequence Identity: 77% (17 aa)

FRYITSIGEGSFGTVDLYEFTP
|.|.||||||||||||||.|..
FYYYTSIGEGSFGTVDLYFFEI
Kinase 18266.AA Ciliate-E2 445-609 15 1.4e-13 43.02 In-house 1-256 (365) Show / Hide 
Range on Protein: 445-609
Range on HMM: 1-256/365
Sequence Identity: 15% (42 aa)

FRYITSIGEGSFG-----TVDLY--------------------EFTPLKFPIAVKKLKTIEEFARELYLM----------------ETLQSIYMPQLF--
.  |  ||.|.||     .|..                     ...  .. . ..| . ||.. .|...|                |.|.. .  ...  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FYDETQKKLFMEMGLCSLEDLKKYSEQTDFC----------LTDQQTFSILNQLLV---------------AIELFIDQK-AFHSDIKPSNIVIRSKLNE
|.......... | .|.  ||..| .. . .          .|...   |  |.|                |.|    ..  .| ||||.||..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

SNKIQLQLMIIDYGGASFDIEDYW-----------------------------------IYYTPAFVCP
       . ||| | . .  .|.                                    |..|| ...|
-------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAP
Kinase 18266.AA S_TKc 445-741 12 4.5e-09 -43.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 445-741
Range on HMM: 1-231/231
Sequence Identity: 12% (42 aa)

FRYITSIGEGSFGTVDLYEFTPLKFPIAVKKLKTIEEFARELYLMETLQSIYMPQLFFYDETQKKLFMEMGLCSL--EDLKKYSEQTDF-----CLTDQQ
.. .  ||.|.||.| .   .  .   |.|..|  | . ||. ...  .  .  .|. . .. ..|.| | .|.    ||..| ..         ..  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H

TFSILNQLLVAIELFIDQKAFHSDIKPSNIVIRSKLNESNKIQLQLMIIDYGGASFDIEDYWIYYTPAFVCPKLWEKLLSSDSC----------------
. ... |.. |.|   ...  | |.||.|| . .          ...|.| | | .    . .  || .. | .      . ..                
ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----------HIKICDFGLARQL---TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILYEML

-----FSKDISKEKSAYIQELDSIEENYEQECDTNNIEKSKLENSTNLGEIDRRQSMENSLTLKTNNSNDKSTLASKTSQNFPSYQQQDSIQMLTDQKQP
     |.     .  . .. .                                                                          . |. 
CGYPPFP-----QMQMMFKKIG-----------------------------------------------------------------------SPEAKDF

ISRVFNDN----LSSYQKSQNF--DKKSKIF
|.. .. .    ..  .  |.    |.   |
IRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 18266.AA Ciliate-C4 540-589 34 6.7e-07 17.77 In-house 144-194 (361) Show / Hide 
Range on Protein: 540-589
Range on HMM: 144-194/361
Sequence Identity: 34% (18 aa)

SILNQLLVAIELFIDQKAFHSDIKPSNIVIRSK--LNESNKIQLQLMIIDYG
..  ..  |. .  ..|  |.||||.||.. .|   . || || |. .||.|
KFIQHICHALWHLHQNKWVHCDIKPENILVKYKSDFGGSNNIQ-QVKLIDFG
Kinase 18266.AA STE 445-581 15 7e-06 16.81 In-house 1-188 (359) Show / Hide 
Range on Protein: 445-581
Range on HMM: 1-188/359
Sequence Identity: 15% (30 aa)

FRYITSIGEGSFG-TVDLYEFT-----PLKFP---------IAVKKLK----------------------TIEEFARELYLMETLQ--SIYMPQLF--FY
.. |  ||.|.|| ..  .        . ..          .|.|...                       .... .|. .|  ..  . .  . .  ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DE-------TQKKLFMEMGLC-SLEDLKKYSEQTDFCLT----------DQQTFSILNQLLVA-IELFIDQKAFHSDIKPSNIVIRSKLNESNKIQL
.|       ..  ..||     ||.|. |    . . |.           .|   |. |.| .  ..  ...  | ||||.|| .         . |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------VKL
Kinase 18266.AA urch 451-474 45 7e-06 18.74 In-house 1-24 (217) Show / Hide 
Range on Protein: 451-474
Range on HMM: 1-24/217
Sequence Identity: 45% (11 aa)

IGEGSFGTVDLYEFTPLKFPIAVK
|| |..|.| ||.... | |.|.|
IGRGTYGRVHLYRHRQTKQPVAIK
Kinase 18266.AA Ciliate-E3 502-569 29 8e-06 14.54 In-house 71-136 (202) Show / Hide 
Range on Protein: 502-569
Range on HMM: 71-136/202
Sequence Identity: 29% (20 aa)

FYDETQKKLFMEMGLCSLEDLKKYSEQTDFCLTDQQTFSILNQLLVAIELFIDQKAFHSDIKPSNIVI
.||.  | .|  . .||  ||. |    .  .| . .  |  |..  .     ..  ||||||.|| .
YYDQQNKMIFIVQEYCSNGDLYHYIK--QQNKTQNIIYDICIQIIQGMIAIHEKNIIHSDIKPDNILV
Kinase 18266.AA Ciliate-A4 586-597 75 1.1e-05 14.2 In-house 273-284 (284) Show / Hide 
Range on Protein: 586-597
Range on HMM: 273-284/284
Sequence Identity: 75% (9 aa)

IDYGGASFDIED
||.|||||..||
IDFGGASFQLED
Kinase 18266.AA SGK 445-459 53 1.6e-05 12.47 In-house 1-15 (283) Show / Hide 
Range on Protein: 445-459
Range on HMM: 1-15/283
Sequence Identity: 53% (8 aa)

FRYITSIGEGSFGTV
|.... ||.|||| |
FDFLKVIGKGSFGKV
Kinase 18266.AA MELK 445-574 24 2.8e-05 13.63 In-house 1-135 (254) Show / Hide 
Range on Protein: 445-574
Range on HMM: 1-135/254
Sequence Identity: 24% (33 aa)

FRYITSIGEGSFGTVDLYEFTPLKFPIAVKKL------KTIEEFARELYLMETLQSIYMPQLFFYDETQKKLFMEMGLCSLEDLKKYSEQTDFCLTDQQT
.     || | |. | |         .|.| .      . .     |.  .  |.   . ||. | ||..|.|| |  |.  ..  |  . |  | ...|
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGHDLPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQD-RLEEEET

FSILNQLLVAIELFIDQKAFHSDIKPSNIVIRSKLN
  .. |.. ||     |   | |.|| |...  ...
RHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHH
Kinase 18266.AA AGC 445-459 53 3.8e-05 7.68 In-house 1-15 (395) Show / Hide 
Range on Protein: 445-459
Range on HMM: 1-15/395
Sequence Identity: 53% (8 aa)

FRYITSIGEGSFGTV
|. .. ||.||||.|
FEFLKVIGKGSFGKV
Kinase 18266.AA TyrKc 445-637 13 0.000144 -148.76 SMART 1-280 (280) Show / Hide 
Range on Protein: 445-637
Range on HMM: 1-280/280
Sequence Identity: 13% (40 aa)

FRYITSIGEGSFGTVDLYEFTPLKFPIAVKKLK--TIEEFARELYLMETL--QSIYMPQLFFYDETQ-------KKLFMEMGLCSLEDLKKYSEQTD-FC
 . .  .||| ||.| . . .    . |||.||  ..|.| ||. .|  |  .     .|. .  .|       . |.. | .... |||.|   .    
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

LTDQQTFSILNQLLVAIELFIDQKAFHSDIKPSNIVIRSKL-----------NESNK--------IQL-----QLM------------------------
|. ..  |.  |     |   ...  | |.   |. . ...           .  ..                .                          
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

--------------IIDYGG------ASFDIEDYWIYY---TPAFV--------CPKLWEKLLSSDSCFSKDISK--EKSAYIQEL
                 | |        ...  |        .           ||.   .. .  .|   | ..    |. ....
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMK--QCWHEDPEDRPTFSEIHECF