Gene 19451 (Tetrahymena)
19451
Group:
Other
Family:
Ciliate-A7
Sequence
Protein domains of 19451.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 19451.AA | Ciliate-A7 | 354-674 | 33 | 8.10000000001e-151 | 507.34 | In-house | 1-360 (360) | Show / Hide |
Range on Protein: 354-674 Range on HMM: 1-360/360 Sequence Identity: 33% (125 aa) VIKEVIKPNNLSESDFKKEGGQYQLLLNEFMVSKMI-------------PKHKNILKPYYFEEYNEGACLVMPFAAFGDADMLSKWQHNNFKNIQMYSSE ..|......|......|....|||..........|. ...... ..|.|..........|.|..|.|..| ..|.|.|...|.|...| RMKQIFESSNSCIFEIKNSSNQYQIVKVKKHHEHMMYNLEGREQCCHHCQECYMLKNEYNFLKKMDHPHIIMLFEQFNDYNMDEFWHHRNCCCILMEQAE LHKLRCSSQSYEYQQPHIQEKIENQCEYLEKLIKEEIIQKQLGTCVNVIRVLAKQIGEALYLLHNKYDIAHNDIKPDNLYISEFNIKQNKYNFKLADFGY .......||.|.....|..||||||||| |||..|....||..||..|||...||||||||.|..|...|..||.|.|||||||. CDLFQYFSQHYPHKNLHHNEKIENQCEY----------------CVNQMRHCFRQIAQALHYLHNEKNIAHNDIKPENIFIFCNNNQQNQYCFKLADFGF AKKGQFQSHKES----------FEFFNRKNKRFFSPELLYLVDG--------------QLEANQTIVDQKKCDVYALGLSLYEILVGG--FFPFKDDLND |||.|||||.|| ........|..|.||....... | ..||...|.|||||.|.|.|...||... |.......|| AKKYQFQSHFESTLRQQIIEDQYKNWKYRCKQYFAPEIINCLNKCCDKNSAKNKKFISQQIDNQCEFDEKKCDVFAFGVSFFQILFQQNPFCCEACHQND PL-YIKYLNKTIS---IKDLMQWFYQYFS------------KVTSADQMIDLLSHMMDPNPSTRYSITQVLQHPWL |. |..|..||.| ... .||....|. .....|||.|||..|..||||.||.|.|.|||||. PYKYKHYFQKTYSKFWQWMQIQWMWNHFQKEIQDMIKNTDQQQQDIDQMKDLLNKMLCPNPSQRYCIKQILQHPWF |
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| Kinase | 19451.AA | Ciliate-E2-Unclassified | 487-674 | 23 | 5e-22 | 73.2 | In-house | 138-352 (352) | Show / Hide |
Range on Protein: 487-674 Range on HMM: 138-352/352 Sequence Identity: 23% (54 aa) NVIR-----VLAKQIGEAL-YLLHNKYDIAHNDIKPDNLYISEFNIKQNKYNFKLADFGYAKKGQFQSHKESFE-------------FFNRKNKRFF--- . .. ...|| ..| || |.. .| | ||||.|. ... . .|. |..||| .|| | .. .. .. . . .. QQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGK---NYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQY -SPELLYL-VDGQLEANQTIVDQKKCDVYALGLSLYEILVGGFFPFKDDLNDPLYIKYLNKTIS---IKDLMQWFYQ---YFSK-------VTSADQMID .||.| .. | .|||...|| |||.| | .||.| . .. ... .| | |...| .|.| .. .. .| TAPEVLQGQNYDHSKA-------YKCDIWSLGVILYEMLFGY-YPFYDNNCEQHQQLITQWI-NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKD LLS----HMMDPNPSTRYSITQVLQHPWL ... |.. ||. |... |.|.|||. FINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | 19451.AA | Ciliate-E2 | 487-674 | 19 | 1.4e-19 | 63.88 | In-house | 145-365 (365) | Show / Hide |
Range on Protein: 487-674
Range on HMM: 145-365/365
Sequence Identity: 19% (50 aa)
NVIRVLAKQIGE---------------ALYLLHNKYDIAHNDIKPDNLYISEFNIKQNKYNFKLADFGYAKKGQFQSHKES-----FEFFNRK-------
. |. . ||| . || ||.| | | ||||.|. . |..|||..|| . .. ... .. . |
KEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTP
-----------------NKRFFSPELLYLVD--GQLEANQTIVDQKKCDVYALGLSLYEILVGGFFPFKDDLNDPLYIKYLNKTISIKDLMQWFYQYF--
. . .|| | . .| .. .|||...|| ||| | | .|| . .. .. .. .
GYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ---QKQKGYDYKCDIWSLGVILYEMLFG-KPPF----------------QQQIKQCKIDFPCPEW
------------SKVTSADQMIDLLSH----MMDPNPSTRYS-ITQVLQHPWL
|. ....||.. |.. .|. |.. . |.|.|||.
QKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | 19451.AA | CAMK1 | 649-674 | 42 | 2e-14 | 38.26 | In-house | 251-276 (276) | Show / Hide |
Range on Protein: 649-674 Range on HMM: 251-276/276 Sequence Identity: 42% (11 aa) DLLSHMMDPNPSTRYSITQVLQHPWL |...||....|. ||...|.|.|||. DFIKHMLEVDPKKRYTCEQCLNHPWI |
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| Kinase | 19451.AA | WEE | 489-600 | 21 | 7.1e-14 | 43.0 | In-house | 113-229 (297) | Show / Hide |
Range on Protein: 489-600 Range on HMM: 113-229/297 Sequence Identity: 21% (28 aa) IRVLAKQIGEALYLLHNKYDIAHNDIKPDNLYISEFN----------------IKQNKYNFKLADFGYAKKGQ-----FQSHKESFEFFNRKNKRFFSPE |. . .| ..| .|.. .. |.||||.|..||. . .| ..|..||| ... ... |. . |. .|| IWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWW-FN-MMCKIGDFGHVTDMNSNNNNPHQEQEG-------DSRYMAPE LLYLVDGQLEANQTIVDQKKCDVYALGLSLYEI .| . . .. .| |...||. .||. ILQG-------YYHYTHLYKADIFSLGITIYEL |
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| Kinase | 19451.AA | S_TKc | 367-674 | 15 | 7.7e-14 | 26.02 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 367-674
Range on HMM: 1-231/231
Sequence Identity: 15% (53 aa)
SDFKKEGGQ---------YQLLLNEFMVSKMIPKHKNILKPYYFEEYNEGACLVMPFAAFGDADMLSKWQHNNFKNIQMYSSELHKLRCSSQSYEYQQPH
.. .. |. . .. . |.|. . ..|.| .| | ...| . .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------------------EHIRREIQILKK-HHPNI--VKLYDVFQD---------------
IQEKIENQCEYLEKLIK-----EEIIQKQLG------TCVNVIRVLAKQIGEALYLLHNKYDIAHNDIKPDNLYISEFNIKQNKYNFKLADFGYAKKGQF
.. . .| . ..|.|. . ..| ...|| .|| .|.. | | |.||.|. ..| . |..||| |..
-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--------HIKICDFGLARQL--
QSHKESFEFFNRKNKRFF------SPELLYLVDGQLEANQTIVDQKKCDVYALGLSLYEILVGGFFPFKDDLNDPLYIKYLNKTISIKDLMQWFYQYFSK
. | .||.| . .|||....| ||| |. | || .. . .| .
--------------TTFCGTPWYMAPEVL------------GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG------------------
VTSADQMIDLLSHMMDPNPSTRYSITQVLQ-------HPWL
....|....... .|. |... ..|| |||.
---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 19451.AA | CAMK | 586-674 | 21 | 2.3e-12 | 35.45 | In-house | 313-425 (425) | Show / Hide |
Range on Protein: 586-674 Range on HMM: 313-425/425 Sequence Identity: 21% (25 aa) KKCDVYALGLSLYEILVGGFFPFKDDLNDPLY--------IKYLNKTISIKDLM-QWFY----------QYFSKVTSA------DQMIDLLSHMMDPNPS .|||. ..| || |.. |..|| .| .. . .. | . | . ..| .. .... .. .||...|. ..|. PKCDMWSCGVILY-IMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPE TRYSITQVLQHPWL |..|.|.|.|||. KRMTIEQCLNHPWM |
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| Kinase | 19451.AA | ULK | 586-674 | 25 | 2.4e-12 | 39.51 | In-house | 235-329 (329) | Show / Hide |
Range on Protein: 586-674 Range on HMM: 235-329/329 Sequence Identity: 25% (25 aa) KKCDVYALGLSLYEILVGGFFPFKDDLNDPLYIKYLNKTIS--------IKDLMQWFYQYFSKVTSADQMIDLLSHMMDPNPSTRYSITQVLQHPWL .|||.. || .||.|.| ||. . ..|.....| | ||. |... .... ....||.. |. ... | |......|||. YKCDIWSLGCIFYEMLYGK-PPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF |
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| Kinase | 19451.AA | Pkinase | 586-674 | 19 | 4.6e-11 | 40.21 | Pfam | 191-293 (293) | Show / Hide |
Range on Protein: 586-674 Range on HMM: 191-293/293 Sequence Identity: 19% (21 aa) KKCDVYALGLSLYEILVGGFFPFKDD----LNDPLYIKYLNKTISIKDLMQWFY---QYFSKVTS----------ADQMIDLLSHMMDPNPSTRYSITQV .|.|....|. ||| | | .||... . . .. .. . . . ||. .. . ..|... . ...|. |....|. PKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI LQHPWL |||||. LQHPWF |
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| Kinase | 19451.AA | ULK | 586-674 | 27 | 1.9e-10 | 33.34 | In-house | 231-324 (324) | Show / Hide |
Range on Protein: 586-674 Range on HMM: 231-324/324 Sequence Identity: 27% (26 aa) KKCDVYALGLSLYEILVGGFFPFKDDLNDPL--YIKYLNK----TISIKDLMQWFYQYFSKVTSADQMIDLLSHMMDPNPSTRYSITQVLQHPWL .|||.. || .||.| | .|.. || .| .|. | ||. |. . . . ....||.. |. ... | |......|||. YKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF |
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| Kinase | 19451.AA | DCAMKL | 649-674 | 50 | 1.2e-09 | 25.59 | In-house | 254-279 (279) | Show / Hide |
Range on Protein: 649-674 Range on HMM: 254-279/279 Sequence Identity: 50% (13 aa) DLLSHMMDPNPSTRYSITQVLQHPWL || |||. .| ||. |..|||| DLISHMLQVDPEKRYTAEQIMQHPWV |
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| Kinase | 19451.AA | Ciliate-E9 | 487-539 | 33 | 2.5e-09 | 25.57 | In-house | 111-157 (298) | Show / Hide |
Range on Protein: 487-539 Range on HMM: 111-157/298 Sequence Identity: 33% (18 aa) NVIRVLAKQIGEALYLLHNKYDIAHNDIKPDNLYISEFNIKQNKYNFKLADFG ||... .||. .. .|.. | | |.||.|. | . .|| |. ||| NVAKYYFKQLIDSIEYMHQYQNICHRDLKPENMLIDK------NYNMKICDFG |
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| Kinase | 19451.AA | ULK | 487-543 | 32 | 1e-06 | 19.11 | In-house | 130-191 (329) | Show / Hide |
Range on Protein: 487-543 Range on HMM: 130-191/329 Sequence Identity: 32% (21 aa) NVIRVLAKQIGEALYLLHNKYDIAHNDIKPDNLYISEFNIK-------QNKYNFKLADFGYAKK . .. ||| ... || . | | ||||.| |.. ..| . .. .|.|||| ||. QEAIQFFKQILNGFKELHKH-NIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKH |
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| Kinase | 19451.AA | CAMK | 490-543 | 29 | 1e-06 | 16.69 | In-house | 182-245 (425) | Show / Hide |
Range on Protein: 490-543 Range on HMM: 182-245/425 Sequence Identity: 29% (19 aa) RVLAKQIGEALYLLHNKYDIAHNDIKPDNLYISEFNIKQNK-----------YNFKLADFGYAKK | . .|| .|. .|.. |.| |.||.|. ... | ... .| |..||| |.| RRYFRQICSAVHYCHSHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANK |
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| Kinase | 19451.AA | DCAMKL | 495-542 | 37 | 1e-06 | 16.09 | In-house | 123-167 (279) | Show / Hide |
Range on Protein: 495-542 Range on HMM: 123-167/279 Sequence Identity: 37% (18 aa) QIGEALYLLHNKYDIAHNDIKPDNLYISEFNIKQNKYNFKLADFGYAK ....||. || . | | |||| || . . . . ||.||| |. CLCKALKYLHEM-NIVHRDIKPENLLVCKHEDG--EKSLKLCDFGLAC |
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| Kinase | 19451.AA | Ciliate-E9 | 648-674 | 37 | 4e-06 | 15.33 | In-house | 272-298 (298) | Show / Hide |
Range on Protein: 648-674 Range on HMM: 272-298/298 Sequence Identity: 37% (10 aa) IDLLSHMMDPNPSTRYSITQVLQHPWL ||.. | . | | || .. |||. IDMMNWMLQQDPQNRISIQEIRMHPWM |
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| Kinase | 19451.AA | Pkinase | 487-553 | 28 | 7e-06 | 21.83 | Pfam | 108-171 (293) | Show / Hide |
Range on Protein: 487-553 Range on HMM: 108-171/293 Sequence Identity: 28% (20 aa) NVIRVLAKQIGEALYLLHNKYDIAHNDIKPDNLYIS-EFNIKQNKYNFKLADFGYAKK--GQFQSHKESF .... ..|| ..|. .|. | | |.||.|. |. . .|. .|..||| ||. .| .| WECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDA---CVKICDFGLAKQFDY-NNS-MTTF |
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| Kinase | 19451.AA | WEE | 649-674 | 46 | 1e-05 | 15.2 | In-house | 272-297 (297) | Show / Hide |
Range on Protein: 649-674 Range on HMM: 272-297/297 Sequence Identity: 46% (12 aa) DLLSHMMDPNPSTRYSITQVLQHPWL .|. ||.|.|. | .. | |||| | QLIKWMMHPDPEQRPTCQQLLQHPVL |
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| Kinase | 19451.AA | ULK | 487-543 | 32 | 1.9e-05 | 15.33 | In-house | 126-187 (324) | Show / Hide |
Range on Protein: 487-543 Range on HMM: 126-187/324 Sequence Identity: 32% (21 aa) NVIRVLAKQIGEALYLLHNKYDIAHNDIKPDNLYISEFNIK-------QNKYNFKLADFGYAKK . .. ||| ... ||.. | | ||||.|. |.. ..| . .. .|.|||| ||. QEAIQFFKQICNGFKELHKH-NIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKH |
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| TyrKc | 19451.AA | TyrKc | 342-674 | 13 | 0.000374 | -155.47 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 342-674 Range on HMM: 1-280/280 Sequence Identity: 13% (53 aa) ITNN---------------LTNNLQKSVIKEVIKPNNLSESDFKKEGGQYQLLLNEFMVSKMI-PKHKNILKPYYFEEYN-------EGACLVMPFAAFG || . .. |. .| . . . ...| . ... ..|.||.. | | ..|| ... | ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG D-ADMLSKWQHNNFKNIQMYSSELHKLRCSSQSYEYQQPHIQEKIENQCEYLEKLIKEEIIQKQLGTCVNVIRVLAKQIGEALYLLHNKYDIAHNDIKPD | | | | ... |. . || . || | . | |. DLKDYLRKHRPK------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAAR NLYISEFNIKQNKYNFKLADFGYAKKGQFQ-SHKESFEFFNRK---NKRF------FSPELLYLVDGQLEANQTIVDQ---KKCDVYALGLSLYEILVGG | ..| . | .||| .... .. || . | .... .|| . . | ||.. | ..||. | NCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-------------NYGKFTTKSDVWSFGVCMWEIFTYG FFPFKDD----LNDPLYIKYLNKTISIKDLMQWFYQY-----FSKVTSADQMIDLLSHMMDPNPSTRYSITQVLQHPWL | .. ... |.|. . . .. | |. | | .. . . .|. | . ... | . QQPYPGMIQQMMSNQEVIEYV-----KQGYRMPQPPNDYPMSF--VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF |
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| Kinase | 19451.AA | CAMK1 | 494-543 | 38 | 0.080649 | 1.0 | In-house | 115-162 (276) | Show / Hide |
Range on Protein: 494-543 Range on HMM: 115-162/276 Sequence Identity: 38% (21 aa) KQIGEALYLLHNKYDIAHNDIKPDN-LYISE-FN--IK-QNKYNFKLADFGYAKK ||| .|.. .| | .|.| |.|| | || .. .. || .|||| .|. KQILSAVEYMHSK-GIVHRDLKPENLLYYDKDEDSKIKRS------IADFGLSKI |
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| Kinase | 19451.AA | DCAMKL | 587-609 | 47 | 0.101912 | 0.5 | In-house | 199-220 (279) | Show / Hide |
Range on Protein: 587-609 Range on HMM: 199-220/279 Sequence Identity: 47% (11 aa) KCDVYALGLSLYEILVGGFFPFK |.|. |.| || .|. || ||. KVDIWAAGVILYILLC-GFPPFR |
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| Kinase | 19451.AA | Pkinase | 368-415 | 20 | 0.931009 | 3.76 | Pfam | 35-82 (293) | Show / Hide |
Range on Protein: 368-415 Range on HMM: 35-82/293 Sequence Identity: 20% (10 aa) DFKKEGGQYQLLL-NEFMVSKMIPKHKNILKPYYFEEYNEGACLVMPFA . .|.. ...... .| . |.. .|.||.. |.. |.. ..||... RHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYC |
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