Gene 28806 (Tetrahymena)

28806

Species: Tetrahymena
Alias: 28806, TTHERM_01026430, 202.m00065, 827, PreTt28806
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-A7

Sequence

Name Sequence Type Origin Length Description Download
28806.AA Protein None 710 None Fasta, JSON
28806.kin_dom Protein Kinase Domain None 264 None Fasta, JSON
28806.NA RNA None 2133 None Fasta, JSON

Protein domain

Protein domains of 28806.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 28806.AA Ciliate-A7 394-700 36 4.8e-145 488.17 In-house 1-360 (360) Show / Hide 
Range on Protein: 394-700
Range on HMM: 1-360/360
Sequence Identity: 36% (132 aa)

ALKLQLHPK------LKQTNQINQIGQDQ--NSSIISHNHKCDQFVQKC-MCEMLKDEWNVLQKMDHPHILKAFQ---LYENIEIEPNSFCCAIEMELAE
..|.   .       .|  .   ||.. .  ..  ..     .| .. |  |.|||.|.|.|.|||||||...|.   .|...|......||.|.||.||
RMKQIFESSNSCIFEIKNSSNQYQIVKVKKHHEHMMYNLEGREQCCHHCQECYMLKNEYNFLKKMDHPHIIMLFEQFNDYNMDEFWHHRNCCCILMEQAE

CNLHQLLAKVSQHKQFCLS------------FAKRILLEVTSALNYLHNNSNYTHNDIKADNVFIFCD-DTTGQYFTKLADLGTAREYSNENHNSSTL--
|.|.|.......||.....            ...... ....||.||||..|..|||||..|.||||. ....||..||||.|.|..|....|..|||  
CDLFQYFSQHYPHKNLHHNEKIENQCEYCVNQMRHCFRQIAQALHYLHNEKNIAHNDIKPENIFIFCNNNQQNQYCFKLADFGFAKKYQFQSHFESTLRQ

------FQNWKIRNPDYQPPEIITFLNE------AKNKE----QIDNVLGFDEKKADIFNLGTLFFAVLFQLRPFSCRGATQNDPL-YKLIFEKRYQEFW
      ..|||.|...|..||||..||.      ||||.    ||||. .|||||.|.|..|. ||..|||..||.|....||||. ||..|.|.|..||
QIIEDQYKNWKYRCKQYFAPEIINCLNKCCDKNSAKNKKFISQQIDNQCEFDEKKCDVFAFGVSFFQILFQQNPFCCEACHQNDPYKYKHYFQKTYSKFW

SQEKFQRMLNHWA---------TEQNEQDMYLMIQLITNMIQQDPSQRPTIQEVLQNPWF
.....|.|.||..         |.|..||...|..|...|....||||..|...||.|||
QWMQIQWMWNHFQKEIQDMIKNTDQQQQDIDQMKDLLNKMLCPNPSQRYCIKQILQHPWF
Kinase 28806.AA Ciliate-E2 444-700 18 1.1e-26 88.68 In-house 84-365 (365) Show / Hide 
Range on Protein: 444-700
Range on HMM: 84-365/365
Sequence Identity: 18% (58 aa)

NVLQKMDHPHILKAFQLYENIEIEPNSFCCAIEMELAEC-NLHQLLAKVSQHKQFC--------LSFAKRILLEVTS---------------ALNYLHNN
|.|....||.|.| .  ....    .  .. . ||...  .| ... . .. ....        .  .|.|  ....               ||.|||..
NILEQLNHPNIIKMYECFQEK----DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSK

SNYTHNDIKADNVFIFCDDTTGQYFTKLADLGTAREYSNENHNSS-----TLFQNWK----------------------IRNPDYQPPEIITFLNEAKNK
 |  | ||| .|...           |..|.|....|...| | .      .... |                      . .| |..|||.   .. .. 
NNIIHRDIKPENILF----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ-

EQIDNVLGF-DEKKADIFNLGTLFFAVLFQLRPFSCRGATQNDPLYKLIFEKRYQEF---WSQEKFQRMLNHWATE-QNEQDMYLMIQLITN----MIQQ
      ..    .|.||. || ...  ||  .||           .. | .. .. .   |  . .| .      .  ...    ...|| .    |.| 
-----QKQKGYDYKCDIWSLGVILYEMLFGKPPF-----------QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWKKWSQECKDLIKKFGKRMLQK

DPSQRPT-IQEVLQNPWF
||..|.| ....|..|||
DPEKRITGWEQILNHPWF
S_TKc 28806.AA S_TKc 366-700 17 2.8e-23 84.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 366-700
Range on HMM: 1-231/231
Sequence Identity: 17% (62 aa)

FEKSKMIGRTNSSYVYSLHDENNQVLHRALKLQLHPKLKQTNQINQIGQDQNSSIISHNHKCDQFVQKCMCEMLKDEWNVLQKMDHPHILKAFQLYENIE
.|. . ||.   . ||  .. .    . |.|                                        |... | ..|.| .||.| | .  ...  
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-------------------------------------EHIRREIQILKK-HHPNIVKLYDVFQD--

IEPNSFCCAIEMELAEC---NLHQLLAKVSQH---KQFCLSFAKRILLEVTSALNYLHNNSNYTHNDIKADNVFIFCDDTTGQYFTKLADLGTAREYSNE
      .  . ||...    .|.... |   |   ..|    |.... .. .||.|.|.. .  | |.| .|...           |..| | ||..   
-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-------HIKICDFGLARQL---

NHNSSTLFQNWKIRNPDYQPPEIITFLNEAKNKEQIDNVLGFDEKKADIFNLGTLFFAVLFQLRPFSCRGATQNDPLYKLIFEKRYQEFWSQEKFQRMLN
         .  .  |.| .||..                |.. .|.|.  .| ...  |    ||.     | . ..|.|                   
---------TTFCGTPWYMAPEVL----------------GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG------------------

HWATEQNEQDMYLMIQLITNMIQQDPSQRPTIQEVLQ-------NPWF
             ....| .. | ||..|||. |.||        |||
----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 28806.AA Ciliate-E2-Unclassified 366-700 20 3.4e-17 56.2 In-house 1-352 (352) Show / Hide 
Range on Protein: 366-700
Range on HMM: 1-352/352
Sequence Identity: 20% (81 aa)

FEKSKMIGRTNSSYVYSLHDENNQVLHRALKLQLHPKLKQTNQINQ-IGQDQNSSIISHNHKCDQFVQKCMCEMLKDEWNVLQKMDHPHILKAFQLYENI
... | ||. . . || . ..... .  |.|     . .  .||.. . .  |. ..  |.|   .. |     ...    |. ..||.|.|       .
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKY-NKIMQQ---ILLNHPHPFIVK------MF

EIEPNSFCCAIEMELAE-CNLHQLLAKVSQ--------------HKQFCLSFAK-----RILLEVTSALNYLHNNSNYTHNDIKADNVFIFCDDTTGQ-Y
... . ... | ||..|  .|.| . | ..               |.|    ||     ... .. ..|.||| . |  | ||| .|...   |  |. |
YCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILF---DNNGKNY

FTKLADLGTAREYSNENHNSSTLFQ-----------NWKIR-NPDYQ----PPEIITFLNEAKNKEQIDNVLGFDEKKADIFNLGTLFFAVLFQLRPFSC
  |..|.| ...| ..| |.   .|            | .  .| |.    .||..   |  . |           .|.||. || .... ||. .||..
YIKIIDFGISKKY-QQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA----------YKCDIWSLGVILYEMLFGYYPFYD

RGATQND-------------PLYKLIFEKRYQEFW---------SQEKFQRMLNHWATEQNEQDMYLMIQLITNMIQQDPSQRPTIQEVLQNPWF
.  .|..              ||. |..| .| ..         .... . ..|               .|.  |.. .|..|.|....|. |||
NNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFIN---------------DLLQKMLKKNPNKRITFEQILNHPWF
Kinase 28806.AA TKL 484-696 18 3.7e-16 54.67 In-house 126-362 (364) Show / Hide 
Range on Protein: 484-696
Range on HMM: 126-362/364
Sequence Identity: 18% (46 aa)

LHQLLAKVSQHKQFCLSFAKRILLEVTSALNYLHNNS-------NYTHNDIKADNVFIFCDDTT---------GQYFTKLADLGTAREYS---NENHNSS
||.|.          ..   |. |.. ...||||..        .  | |.| .|.... . |.          ... |..|.|..|. |   | |....
LHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMT

TLF----------QNWKIR-NPDYQPPEIITFLNEAKNK----EQIDNVLGFDEKKADIFNLGTLFFAVLFQLRPFS---CRGATQNDPLYKLIFEKRYQ
|            .. ... .| . .||..   .. ..|    | ... . ..| |.|..  | ... .|   ||..   ..    .|| ....|.....
TMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE-FCKGFEYSE-KCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDP-FEEMFMMVCD

EFWSQEKFQR---MLNHWATEQNEQDMYLMIQLITNMIQQDPSQRPTIQEVLQ
..   .   .   ..   .  .... .  |..|..   ..||..||. ||.|.
KGLRPPIPPIWQNHH-K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILK
Kinase 28806.AA CAMK 431-583 14 4e-14 41.2 In-house 70-292 (425) Show / Hide 
Range on Protein: 431-583
Range on HMM: 70-292/425
Sequence Identity: 14% (32 aa)

VQKCMCEMLKDEWNVLQK-------MDHPHILKAFQLYEN---------------IEIEPNSFCCAIE--MELAECN--LHQLLAKVSQHKQ--------
.. ....... | ....|       .|||.|.| .. ||.               .  ....... .   ||...    .  |. .. .|..        
RRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQF

-------FCLSFAKRILLEVTSALNYLHNNSNYTHNDIKADNVFIFCDDTTGQ------------YFTKLADLGTAREYSNEN-------HNSSTLFQNW
       |. . |.|.   . ||..|.|..    | |.| .|. .  ...  .            .  |..| | |...   .       ... . . . 
DIVERGRFTEREARRYFRQICSAVHYCHSHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HN

-------------KIRNPDYQP-PEII
                 | | . ||..
QWTTPTEGQKMKTFCGTPEYMAAPEVL
Kinase 28806.AA CAMKL 446-551 21 4e-12 34.85 In-house 66-174 (297) Show / Hide 
Range on Protein: 446-551
Range on HMM: 66-174/297
Sequence Identity: 21% (25 aa)

LQKMD---HPHILKAFQLYENIEI-EPNSFCCAIEMELAECN---LHQLLAKVSQHK-QFCLSFAKRILLEVTSALNYLHNNSNYTHNDIKADNVFIFCD
.....   ||.| | .. .|. |  . .  .. . ||...     |.. . |   ..  .  . |.|.   . ||.||.|..    | |||..|. . ..
MKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG-IVHRDIKPENILLDEN

DTTGQYFTKLADLG
.       |..| |
GNN---NIKIIDFG
Kinase 28806.AA CAMK 674-700 44 1.5e-11 32.76 In-house 399-425 (425) Show / Hide 
Range on Protein: 674-700
Range on HMM: 399-425/425
Sequence Identity: 44% (12 aa)

IQLITNMIQQDPSQRPTIQEVLQNPWF
..|| .| | ||..|.||...|. ||.
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 28806.AA CAMKL 674-700 40 4.1e-11 31.57 In-house 271-297 (297) Show / Hide 
Range on Protein: 674-700
Range on HMM: 271-297/297
Sequence Identity: 40% (11 aa)

IQLITNMIQQDPSQRPTIQEVLQNPWF
..||  | | .|..||||..... ||.
RDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase 28806.AA Ciliate-E2a 674-700 40 1.2e-09 24.63 In-house 249-275 (275) Show / Hide 
Range on Protein: 674-700
Range on HMM: 249-275/275
Sequence Identity: 40% (11 aa)

IQLITNMIQQDPSQRPTIQEVLQNPWF
..|.  | . ||..|.|.|. |..|||
KDLMKKMLEKDPKKRITAQQALNHPWF
Kinase 28806.AA CMGC 664-700 32 2.2e-08 22.67 In-house 477-513 (513) Show / Hide 
Range on Protein: 664-700
Range on HMM: 477-513/513
Sequence Identity: 32% (12 aa)

EQNEQDMYLMIQLITNMIQQDPSQRPTIQEVLQNPWF
......  . | |. .| | ||..|.|... || |.|
FKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 28806.AA NEK 673-700 39 2.9e-08 25.6 In-house 259-286 (286) Show / Hide 
Range on Protein: 673-700
Range on HMM: 259-286/286
Sequence Identity: 39% (11 aa)

MIQLITNMIQQDPSQRPTIQEVLQNPWF
. .||..|.| ||.|||.....|..|  
LQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase 28806.AA Pkinase 673-700 39 3.1e-08 30.21 Pfam 266-293 (293) Show / Hide 
Range on Protein: 673-700
Range on HMM: 266-293/293
Sequence Identity: 39% (11 aa)

MIQLITNMIQQDPSQRPTIQEVLQNPWF
....|......||..|||....|| |||
CKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase 28806.AA Pkinase 442-565 20 3.2e-08 30.13 Pfam 50-168 (293) Show / Hide 
Range on Protein: 442-565
Range on HMM: 50-168/293
Sequence Identity: 20% (27 aa)

EWNVLQKMDHPHILKAFQLYENIEIEPNSFCCAIEMELAECN--LHQLLAKVS--QHKQF--CLSFAKRILLEVTSALNYLHNNSNYTHNDIKADNVFIF
|  ......||.|.. .  .|.     .. .. . ||..|.   .  | . .|  .|. |      .|...... ..|.|.|.. .  | |.| .|..| 
EIQIMKRLNHPNIVRLYDWFED-----KDHIY-MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM-GIIHRDLKPENILID

CDDTTGQYFTKLADLGTAREYSNENHNSST
 .....  . |..| | |. .. . .|| .
NNGHIDA-CVKICDFGLAKQFD-Y-NNS-M
Kinase 28806.AA WEE 503-563 23 4.1e-08 23.39 In-house 114-189 (297) Show / Hide 
Range on Protein: 503-563
Range on HMM: 114-189/297
Sequence Identity: 23% (18 aa)

KRILLEVTSALNYLHNNSNYTHNDIKADNVFIFCDDTTGQY---------------FTKLADLGTAREYSNENHNS
. ||...  .|...|.| .  |.||| .|.||  ..   |                  |..|.| . . . .|.|.
WQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHVTDMNSNNNNP
Kinase 28806.AA CMGC 446-559 13 4.5e-08 21.63 In-house 75-257 (513) Show / Hide 
Range on Protein: 446-559
Range on HMM: 75-257/513
Sequence Identity: 13% (25 aa)

LQKM-----------------DHPHILKAFQLYENIEIEPNSF-----------CCAIEMELAECNLHQLLAKVSQ------------------------
|...                 .|..|.| .  .   . ..| .           .  . .|. ...|.|.. . ..                        
LKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPH

-HKQFCLSFAKRILLEVTSALN--YLHNNS-NYTHNDIKADNVFIFCDDTT---------------GQYFTKLADLGTAREYSNE
  | | .   . .   .  .|.  |.| .  |  | |.|  |. |  . .                 ..  |..| | || |...
NIKYFMI-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPH
Kinase 28806.AA WEE 675-700 53 4.5e-07 19.86 In-house 272-297 (297) Show / Hide 
Range on Protein: 675-700
Range on HMM: 272-297/297
Sequence Identity: 53% (14 aa)

QLITNMIQQDPSQRPTIQEVLQNPWF
||| .|.. ||.||||.|. ||.|  
QLIKWMMHPDPEQRPTCQQLLQHPVL
Kinase 28806.AA NEK 437-566 23 1.5e-05 15.98 In-house 48-184 (286) Show / Hide 
Range on Protein: 437-566
Range on HMM: 48-184/286
Sequence Identity: 23% (34 aa)

EMLK-DEWNVLQKMDHPHILKAFQLYENIEIEP-NSFCCAIEMELAE--CNLHQL---LAKVS-QHKQFCLSFAKRILLEVTSALNYLHNNS----NYTH
...   | ..|....||.| |    |. .. |  |..|  |.|| .|   .|.|.   . |   ..| |  .   ...    .||.|.|...    .  |
QNAQNNEVRILKQLKHPNIVK---YYDSFIEEQNNCLC--IVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILH

NDIKADNVFIFCDDTTGQY-FTKLADLGTAREYSNENHNSST-L
 |||  |.|.  ...  .| . |. |.| ... ....   .| .
RDIKPQNIFLTKNNN--DYHNVKIGDFGISKVLNHTTDMAYTTQ
Kinase 28806.AA Ciliate-E2a 486-560 24 0.000808 7.15 In-house 85-164 (275) Show / Hide 
Range on Protein: 486-560
Range on HMM: 85-164/275
Sequence Identity: 24% (20 aa)

QLLAKVSQHKQFCLS--FAKRILLEVTS-ALNYLHNNSNYTHNDIKADNVFIF-CDDTT-GQYFTKLADLGTAREYS-NEN
.|. | .|.|.|      ...|.   .. .|.|.|.. |. | |.| .|...  |. .   .   |..| |.|. .. .|.
ELYDKIKQCKRFFEEIQEICDIMQQLLWQGLHYMHQR-NIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEK
Kinase 28806.AA Ciliate-E2a 439-463 36 0.00343 5.27 In-house 46-70 (275) Show / Hide 
Range on Protein: 439-463
Range on HMM: 46-70/275
Sequence Identity: 36% (9 aa)

LKDEWNVLQKMDHPHILKAFQLYEN
...| | ....|||.|.| .  ||.
FMNEINIMRQLDHPNIIKLYEVYED