Gene 9946 (Tetrahymena)
9946
Group:
Other
Family:
Ciliate-A8
Sequence
Protein domains of 9946.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 9946.AA | Ciliate-A8 | 35-172 | 48 | 1.5e-82 | 280.57 | In-house | 1-151 (151) | Show / Hide |
Range on Protein: 35-172 Range on HMM: 1-151/151 Sequence Identity: 48% (73 aa) IEIEKKIGEGFFAEVFQATQINEQRRVAIKKVKDLNKEQKFED-----EKKAMYKIKNQQYAIQIIGELTNKELGYNAIIMEICDC--------TLAEIF ....|....|.|..|.||..||.|..||||..|..|...|..| ...||.||||..|..|||.....||.|..||..|.||| .||.|. YKYQKVLEKGDFSYVVQAYSINHQCQVAIKIIKYMNQQNKINDKEFEKCIQAMQKIKNEKYILQIIECIQDKEQGFIAIVTEFCDCFDFYKKKENLASIL EKNIDNFTEEQFIALVYQLLKGLLVFQEKGIIHGDLKPENILYNQKKNKFL |.|...||.||..||.|||||.|||||||||||.|.||.||||...||.|. ENNLNKFTFEQIVALTYQLLKCLLVFQEKGIIHCDIKPQNILYSWSKNQFI |
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| Kinase | 9946.AA | Ciliate-E1 | 41-178 | 30 | 9.5e-25 | 77.7 | In-house | 1-155 (202) | Show / Hide |
Range on Protein: 41-178 Range on HMM: 1-155/202 Sequence Identity: 30% (47 aa) IGEGFFAEVFQATQINEQRRVAIKKVKDLN---KEQKFEDEKKAMY---KIKNQQYAIQIIGELTNKELGYNAIIMEICDCTLAEIFE------------ ||.| |. ||.| |.| . .. ..|. .. ....|.||.| | |.|...| |||| . ... .||.| |.|.| . .. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMKFKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQQCQ KNIDNFTEEQFIALVYQLLKGLLVFQEKGIIHGDLKPENILYNQKKNKFLIQIVKI .| .||..|......||..|| .. ..|||.|.||.|||.|.. ...... | QNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQ-GNYVYCDFGI |
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| Kinase | 9946.AA | CMGC | 35-167 | 18 | 5.1e-23 | 71.68 | In-house | 1-220 (513) | Show / Hide |
Range on Protein: 35-167 Range on HMM: 1-220/513 Sequence Identity: 18% (40 aa) IEIEKKIGEGFFAEVFQATQ--------------INEQRRVAIKKVK---DLNKEQ----------KFEDEKKAMYKIK----------------NQQYA || |||||| ...|.... .. ...|||||.| . . .. . .| | . ... . . YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI IQIIGELTNKE---------------LGYNAIIMEICDCTLAEIFEKNID--------NFTEEQ------------FIALV------YQLLKGLL--VFQ .... .. |. . . ...| .|..|... ..| . ...| . .. ||.|.|| VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH EKG--IIHGDLKPENILYNQK .. ||| |||||||| |.. SHWGNIIHRDLKPENILINHN |
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| Kinase | 9946.AA | CK1 | 35-163 | 15 | 6.3e-15 | 48.57 | In-house | 1-164 (339) | Show / Hide |
Range on Protein: 35-163 Range on HMM: 1-164/339 Sequence Identity: 15% (26 aa) IEIEKKIGEGFFA-EVFQA-----TQINEQ-----RRVAIKKVK-DLN--KEQKFEDEKKAMYKIKNQQYA------------------IQIIGELTNKE ...|||||| | ... . . .. . ..|.| . . . . |. |... ... ..... . ... .... WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED LGYNAIIMEICDCTLAEIFE--KNIDN-FTEEQFIALVYQLLKGLLVFQEKGIIHGDLKPENIL .|| ..|. . .| .... .. .. |. . . .|.|..| . ..|.|| |.||.|.. DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFC |
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| Kinase | 9946.AA | Ciliate-E2-Unclassified | 35-173 | 19 | 7.6e-15 | 47.95 | In-house | 1-189 (352) | Show / Hide |
Range on Protein: 35-173 Range on HMM: 1-189/352 Sequence Identity: 19% (38 aa) IEIEKKIGEGFFAEVFQATQINEQRRV-------AIKKVKDLNKEQKFEDEKKAMYKIKNQQ---------------------YAIQIIGELTNKELGYN .| |.||.| |..|... ..... . |...|......| ... | ..|.. . . . . ..|. | YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY- AIIMEICDCTLAEIFEKNIDN-----------------FTEEQFI-----ALVYQLLKGL-LVFQEKGIIHGDLKPENILYNQKK---NKFLI |.|| |. . . |. . |||.| . . .|.|.|| ....||| |.||||||..... . .| -IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKII |
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| Kinase | 9946.AA | S_TKc | 35-272 | 19 | 1.6e-13 | 21.58 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 35-272 Range on HMM: 1-231/231 Sequence Identity: 19% (53 aa) IEIEKKIGEGFFAEVFQATQINEQRRVAIKKVKDLNKEQKFEDEKKAMYKIKNQQYAIQIIGELTNKELGYNAIIMEICDC---TLAEIFEKNIDN---- || .|||.| |..|.... .. .|.||||..| .... | . . | . . ..... . .. ..|| || .| .. .|. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF -FTEEQFIALVYQLLKGLLVFQEKGIIHGDLKPENILYNQKKNKFLIQIVKI------KEWKFQVYGSRSSSQQ-------EALHNQR---------LML |.| . ..||....| ..|||| |||||||| .. .|| .. .. | |. . .| PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------HIKICDFGLARQL--------TTFCGTPWYMAPEVLGYGKCKCDWWSCGCIL LEFVLKRELTLSESLRLKENNSLFDVIQNLQNNPYIEFINQILAKMVCFESEQRLESMQLLQ-----RLNQYI |.. .. . . . .|..| |... .. |. ... |.|. ..|| .. ... YEMLC-GYPPFP------QMQMMFKKIG------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 9946.AA | Ciliate-E2 | 35-178 | 18 | 4.9e-13 | 41.08 | In-house | 1-197 (365) | Show / Hide |
Range on Protein: 35-178
Range on HMM: 1-197/365
Sequence Identity: 18% (38 aa)
IEIEKKIGEGFFAEVFQATQINEQRRVAIK---------------KVKDLNKEQKFEDEKKAMYKIKNQQ----------------------YAIQIIGE
... ||||.| |. |........|...||| |.| ..... ....... ..... . |...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC
LTNKELGYNAIIMEICDC-TLAE------IFEKNI----DNFTEEQFIALVYQLLK---------------GLLVFQEKG-IIHGDLKPENILYNQKKNK
.| . ..|| |. .| . ...... .|||.. . . .|.|. .| .|. ||| |.||||||.
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------
FLIQIVKI
.||
-----IKI
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| Kinase | 9946.AA | Ciliate-E2a | 123-170 | 40 | 4.2e-10 | 25.96 | In-house | 91-142 (275) | Show / Hide |
Range on Protein: 123-170 Range on HMM: 91-142/275 Sequence Identity: 40% (21 aa) KNIDNFTEE--QFIALVYQLL-KGLLVFQEKGIIHGDLKPENILYN-QKKNK |. ..|.|| . . ||| .||. .. ..|.| ||||||||.. .||. KQCKRFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNS |
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| Kinase | 9946.AA | GSK | 136-168 | 39 | 1.6e-09 | 24.64 | In-house | 121-153 (328) | Show / Hide |
Range on Protein: 136-168 Range on HMM: 121-153/328 Sequence Identity: 39% (13 aa) LVYQLLKGLLVFQEKGIIHGDLKPENILYNQKK ..||...|| ...|| | |.||.|||..... YMYQMFRGLAYLHSHGICHRDIKPQNILVDPDT |
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| Kinase | 9946.AA | GSK | 35-76 | 31 | 8.5e-09 | 22.37 | In-house | 1-51 (328) | Show / Hide |
Range on Protein: 35-76 Range on HMM: 1-51/328 Sequence Identity: 31% (16 aa) IEIEKKIGEGFFAEVFQATQI----NEQRR----VAIKKVKDLNKEQ-KFE .|. |.|| | | |.||. . .... |||||| .. . .| YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRE |
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| Kinase | 9946.AA | TyrKc | 35-268 | 16 | 1.1e-08 | -82.31 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 35-268
Range on HMM: 1-280/280
Sequence Identity: 16% (49 aa)
IEIEKKIGEGFFAEVFQATQINEQRRVAIKKVKDLNKEQKFEDEKKAMYKI-KNQQYAIQIIGELTNK-----ELGYNAIIMEICDC-TLAEIFEKNIDN
|. .||.|||.| ||...| . . ||.|..|. .. | .| . | |. .. . ....| | . . . |.|| .. | . |. ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK
FTEEQFIALVYQLLKGLLVFQEKGIIHGDLKPENILYNQKKNKFLIQIVKI------KEWKFQ--------VYGSRSSSQQEALHNQRLMLLEFVLKRE-
.. .... .| .| .|..|| || |.|.. .. .||| .... .| ...... .. | | .| ...
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF
----------------LTLSESLRLK-EN--NSLFDVIQNLQNNPYIEFINQ--------------ILAKMVCFE-SEQRLESMQLLQRL
.|. .. . | ..||..... . . . |. . | |.| .. ...
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | 9946.AA | CAMK1 | 36-64 | 37 | 1.1e-08 | 21.26 | In-house | 2-33 (276) | Show / Hide |
Range on Protein: 36-64 Range on HMM: 2-33/276 Sequence Identity: 37% (12 aa) EIEKKIGEGFFAEVFQATQINE---QRRVAIK |. |.||.| |.||...|... .. .||| EFGKEIGRGAFSEVYLCTHKETQTNGKQYAIK |
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| Kinase | 9946.AA | Pkinase | 35-67 | 33 | 8.2e-08 | 28.7 | Pfam | 1-33 (293) | Show / Hide |
Range on Protein: 35-67 Range on HMM: 1-33/293 Sequence Identity: 33% (11 aa) IEIEKKIGEGFFAEVFQATQINEQRRVAIKKVK ..|..|||.| |..|.... ......||.|..| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIK |
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| Kinase | 9946.AA | CDK | 108-167 | 30 | 9.1e-08 | 20.76 | In-house | 95-144 (284) | Show / Hide |
Range on Protein: 108-167 Range on HMM: 95-144/284 Sequence Identity: 30% (18 aa) IIMEICDCTLAEIFEKNIDNFTEEQFIALVYQLLKGLLVFQEKGIIHGDLKPENILYNQK ...| .| |... . . .|||.|| ...|.| |||| |||.| . MVFEYMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNN |
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| Kinase | 9946.AA | Ciliate-E2a | 36-74 | 33 | 1e-07 | 18.82 | In-house | 2-40 (275) | Show / Hide |
Range on Protein: 36-74 Range on HMM: 2-40/275 Sequence Identity: 33% (13 aa) EIEKKIGEGFFAEVFQATQINEQRRVAIKKVKDLNKEQK ...||||.|.|. |. |..... . |.||... . .|| KFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQK |
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| Kinase | 9946.AA | Pkinase_Tyr | 35-88 | 29 | 2.1e-07 | 25.73 | Pfam | 1-64 (270) | Show / Hide |
Range on Protein: 35-88 Range on HMM: 1-64/270 Sequence Identity: 29% (19 aa) IEIEKKIGEGFFAEVFQATQI----NEQRRVAIKKVKDLNKEQK-----FEDEKKAMYKI-KNQ |.. ||.||| | ||...| |.. ||.|..|. .. | | | | .. ... ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHP |
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| Kinase | 9946.AA | CDK | 36-67 | 32 | 2.4e-07 | 19.38 | In-house | 2-38 (284) | Show / Hide |
Range on Protein: 36-67 Range on HMM: 2-38/284 Sequence Identity: 32% (12 aa) EIEKKIGEGFFAEVFQATQINEQ-----RRVAIKKVK |. .||||| ...|. | . . . ||.||.. EKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIR |
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| Kinase | 9946.AA | CAMK1 | 149-175 | 51 | 5.2e-07 | 16.35 | In-house | 126-154 (276) | Show / Hide |
Range on Protein: 149-175 Range on HMM: 126-154/276 Sequence Identity: 51% (15 aa) EKGIIHGDLKPENILYNQKKNKFLIQ--I .||| | ||||||.|| |.. . | | SKGIVHRDLKPENLLYYDKDEDSKIKRSI |
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| Kinase | 9946.AA | Pkinase | 104-167 | 31 | 3e-06 | 23.0 | Pfam | 73-144 (293) | Show / Hide |
Range on Protein: 104-167 Range on HMM: 73-144/293 Sequence Identity: 31% (23 aa) GYNAIIMEICDCT--LAEIF-------EKNIDNFTEEQFIALVYQLLKGLLVFQEKGIIHGDLKPENILYNQK .. ..|| |... ... | .... |.|.. . .||.|.|| ..|||| ||||||||.... DHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNN |
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