Gene 15446 (Tetrahymena)
15446
Group:
Other
Family:
Ciliate-C6
Sequence
Protein domains of 15446.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 15446.AA | Ciliate-C6 | 15-285 | 67 | 3.2e-203 | 681.43 | In-house | 1-306 (306) | Show / Hide |
Range on Protein: 15-285 Range on HMM: 1-306/306 Sequence Identity: 67% (207 aa) LDYRDSLGSGSYGQVFKVKNKYKDIIKNPDILQDMPNYYACKQIHMFQDG--ENQSSQIFHEIEVLEKLKKYENVIKLQNYMTE-ERSMYIILDLAESTL ..|||||||||.|||.|.|||.|.||||.||||.||.||||||||| |.. |||.|||||||||||||||||||||.|||. | .|..||.|||||||| INYRDSLGSGSFGQVYKCKNKHKQIIKNMDILQQMPDYYACKQIHMTQQMSFENQMSQIFHEIEVLEKLKKYENVIKMQNYFIEPNRQTYIVLDLAESTL QDEINSKQAN------------------LEKFDESEIVKFLIQIGKTLALIQIEEQIAHRDIKPSNILIKDK--NFYLSDFGCAEKLFESEGARNN-LVM ||.|..|||| .|.|||.|||.|..|||||||.|..|..|||||||||||||.|. |.||||||||..||.||..||| ..| QDCIQMKQANVNNFYFKQEINIFSFNYKYEHFDENEIVQFCKQIGKTLADIYNECNIAHRDIKPSNILIMDDENNYYLSDFGCAQQLFQSEFTRNNDIHM GTLKWMSPELKEMKK----------NQAVDYFKSDIFSFGMLLLYMLTLSDISSVNSDEFTKSQKIRIMKNYCKDIS-NEIILLTSKMLETNPDNRPDAA ||||||||||.|||| ||..||||.||||.||.|||||||||||.||.|||.|.||||||||.||||| .|||.|.|||||||||.|||.. GTLKWMSPELREMKKQYNQHQDDNSNQQIDYFKCDIFSLGMILLYMLTLSDISQVNCDEFMKNQKIRIMKNMCKDISYKEIIKLVSKMLETNPDHRPDMS IIINTI |.|.|| ILIQTI |
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Kinase | 15446.AA | S_TKc | 15-293 | 22 | 4.1e-31 | 110.62 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 15-293 Range on HMM: 1-231/231 Sequence Identity: 22% (64 aa) LDYRDSLGSGSYGQVFKVKNKYKDIIKNPDILQDMPNYYACKQIHMFQDGENQSSQIFHEIEVLEKLKKYENVIKLQNYMTEERSMYIILDLAES---TL . . .|.|..|.|.|...| ..|.|.|. .| ||..|.| . .|..|| .. . ..|....... .| YEILRKIGKGAFGKVYKCRHKK------------TGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDL QDEINSKQANL--EKFDESEIVKFLIQIGKTLALIQIEEQIAHRDIKPSNILIKDKNFYLSDFGCAEKLFESEGARNNLVMGTLKWMSPELKEMKKNQAV | | ... . .|.| .. ... || . |. . .| |||.||.|||. . . ..||| | .| . . ||. .|.||. FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-HIKICDFGLARQL--------TTFCGTPWYMAPEVL------GY DYFKSDIFSFGMLLLYMLT----LSDISSVNSDEFTKSQKIRIMKNYCKDISNEIILLTSKMLETNPDNRPDAAIIINTIQDIE-NDFK ...|.|. |.| .| ||. . .... .||. | | . . .|.|. .|..|| | . . .|| . GKCKCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | 15446.AA | Pkinase | 15-285 | 19 | 3.3e-29 | 104.35 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 15-285 Range on HMM: 1-293/293 Sequence Identity: 19% (62 aa) LDYRDSLGSGSYGQVFKVKNKYKDIIKNPDILQDMPNYYACKQIHMFQDGENQSSQIFH--EIEVLEKLKKYENVIKLQNYMTEERSMYIILDLAES--- . .||||.|.|.| ..| . .|.|.| . ... . .. ||... .| . .|...| ........|......| YHIGRKIGSGSFGCVYKCHHKGTGK------------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY --TLQDEIN-SKQANLEKFDESEIVKFLIQIGKTLALIQIEEQIAHRDIKPSNILIK-DKNF----YLSDFGCAEKLFESEGARNNLVMGTLKWMSPELK | | | ... .. |.| |. ... || . |. . . | |||.||.||||. . . ..|||.|... . . .. . ||. .|.||. VMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV- EMKKN-QAVDYFKSDIFSFGMLLLYMLTLSDISSVNSDEFTKSQK-----IRIMKNYCKDIS-------------------------------NEIILLT . . . |.|..|.| .| .||. .. ... .. |. .|.. . | . . ---IRGGQYYGPKVDMWSCGCILYEMLC---------GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFI SKMLETNPDNRPDAAIIINT--I ...|. .| || |. | . . KWCLCKDPKKRPTAEQILQHPWF |
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Kinase | 15446.AA | STE | 15-228 | 22 | 8.4e-29 | 98.89 | In-house | 1-263 (359) | Show / Hide |
Range on Protein: 15-228 Range on HMM: 1-263/359 Sequence Identity: 22% (62 aa) LDYRDSLGSGSYGQVFKVKNKYKDIIKNPDILQ----DMPNYYACKQIHMFQDG---------------ENQSSQIFHEIEVLEKLKK-YENVIKLQNYM .. . .|.|..|.|.| .|. ...| . . .. ...| ||... .. ... || .||... |... .|..| . WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY TEER-------SMYIILDLAE-STLQDEIN---SKQANLE-------KFDESEIVKFLIQIGKT-LALIQIEEQIAHRDIKPSNILIKDKNFYLSDFGCA | . .|.. . . .| | |. ... .| .|.||.| ... || | |... | ||||||.|||. |.|||.. FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL----VKLCDFGVC EKLFES--------------EGA-RNNLVMGTLKWMSPELKEMKKNQ-AVDY-FKSDIFSFGMLLLYMLT .| .| .. ..| . || ||.|| . .. .| .|.|| |.| ... |.| GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMAT |
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Kinase | 15446.AA | Ciliate-E2 | 15-283 | 20 | 7e-24 | 78.84 | In-house | 1-361 (365) | Show / Hide |
Range on Protein: 15-283 Range on HMM: 1-361/365 Sequence Identity: 20% (76 aa) LDYRDSLGSGSYGQVFKVKNKYKD----IIKNPDILQDMPN----YYACKQIHMFQDGENQSSQIFHEIEVLEKLK---------------KYENVIKLQ . .|.|..|.|.|.|.. .. |... .| .. ... |.. | . .|| ||. || .. ... . |.||. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY NYMT--EERSMYIILDLAES-TLQD--EINSKQANLE-----KFDESEIVKFLIQIGK---------------TLALIQIEEQIAHRDIKPSNILIKDKN . . ..|....... .|.| ..|.|. | | .|.| || .. || . | . . | ||||||.|||. ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---- FYLSDFGCAE---------------KLFESEG----------------ARNNLVMGTLKWMSPELKEMKK-----NQAVDYFKSDIFSFGMLLLYMLTL- ..||| . |.. . | . ||. |.|| ..|| .| .|.||.|.|..| .||. IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK ---SDISSVNSDEFTKSQKIRIMKNYCK--------DISNEIILLTSK----MLETNPDNRPD-AAIIIN .. . .| . ... .. |. ..|.| . | .| ||. .|..|.. . |.| PPFQQQIKQCKIDFPCPEWQKD-TQ-CIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN |
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Kinase | 15446.AA | TKL | 21-285 | 15 | 9.4e-24 | 82.41 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 21-285 Range on HMM: 1-364/364 Sequence Identity: 15% (60 aa) LGSGSYGQVFKVKNKYKDIIKNPDILQDMP----NYYACKQIHMFQ-DGENQSSQI---------------------FHEIEVLEKLKK--YENVIKLQN .|||..|.|.| | . . | | . | |.... . | .. .|| |.|.|.. ... .|.... IGSGGFGEVYKGKWRGWGG-KC-------PSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMG YMTEERS-------------MYIILDLA-ESTLQDEINSKQANLEKFDESEIVKFLIQIGKTLALIQIEE-------QIAHRDIKPSNILIKDKN----- | ..... ..|. ... .| . .. . .... ..| . .. .. .|.|||.|..|||..... YCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSN ----------FYLSDFGCAEKLFESEG------------------ARNNLVMGTLKWMSPEL--KEMKKNQAV---------DYF-KSDIFSFGMLLLYM ..||| . ...|.. ... . ||. ||.||. ..|. ...| .|. |.|..|||..| . YMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEI LTLSDISSVNSDEFTKSQK------IRIMKNY--------------------CKDISNEIILLTSKMLETNPDNRPDAAIIINTI || . .|. ... . .|... |.|. ... | . ...|..|| . |. .. LTRCR---PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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Kinase | 15446.AA | ULK | 13-228 | 23 | 9.4e-23 | 77.6 | In-house | 1-247 (324) | Show / Hide |
Range on Protein: 13-228 Range on HMM: 1-247/324 Sequence Identity: 23% (62 aa) YELDYRDSLGSGSYG-QVFKVKNKYKDIIKNPDILQDMPNYYACKQIHMFQDGENQSS--------QIFHEIEVLEKLK--KYEN--VIKLQN-YMTEE- |.|. . ||.||.| .|.| .|| .. |.|||.| ... .... .. ||... ||| | .| ..|| ..| YCLNHC--LGKGSFGVKVYKGRNKKTNT---------QNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNH RSMYIILDLAES-TLQDEINSKQA-----NLEKFDESEIVKFLIQIGKTLALIQI-EEQIAHRDIKPSNILIKDKNFY-------------LSDFGCAEK |||... . .|.. |. .. . .. |.|...|..|| .. . ...| ||||||.||||.... . ..||| | . NNIYIIMEYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQI--CNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKH LFE-SEGARNN-------LVMGTLKWMSPELKEMK-KNQAVDYFKSDIFSFGMLLLYMLT ... .. . . .. || |.|.. . . ... . .|.||.|.|... .||. VDNNNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY |
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Kinase | 15446.AA | ULK | 13-228 | 23 | 4.4e-22 | 73.93 | In-house | 1-251 (329) | Show / Hide |
Range on Protein: 13-228 Range on HMM: 1-251/329 Sequence Identity: 23% (61 aa) YELDYRDSLGSGSYGQVFKVKNKYKDIIKNPDILQDMPNYYACKQIHMF-QDGENQSSQ-------IFHEIEVLEKLK-------KYENVIKLQN-YMTE |.|. . ||.||.|.|. | ...... | .. ..|||.| . .. .|. .. . ||... ||| . .|..|| ..| YCLNHC--LGKGSFGKVY----KGRNKKTK-D-YVN--EKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETS E-RSMYIILDLAES-TLQDEINSKQA------NLEKFDESEIVKFLIQIGKTLALIQI-EEQIAHRDIKPSNILIKDKNFY-------------LSDFGC |||... . .|.. |. .. . .. |.|...|..|| .. . ...| ||||||.||||.... . ..||| NHNNIYIIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQI--LNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGF AEKLFES--EGARNNLVM------GTLKWMSPELKEMK-KNQAVDYFKSDIFSFGMLLLYMLT | .. .. | . . || |.|.. . . ... . .|.||.|.|... .||. AKHVDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLY |
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Kinase | 15446.AA | CAMK | 20-228 | 18 | 1.1e-20 | 62.67 | In-house | 1-329 (425) | Show / Hide |
Range on Protein: 20-228 Range on HMM: 1-329/425 Sequence Identity: 18% (62 aa) SLGSGSYGQVFKVKNK-YKDIIKNPDILQDMPNYYACKQIHM----------------FQDGENQS----------SQIFHEIEVLEKLKK------YEN ||.||.|.|.....| . .. |. . . .|.| | .. .... ....|||.. ||.. .| TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN VIKLQNYMTE-------------------ERSMYIIL---DLAEST-----LQDEINSKQANLEK-----------FDESEIVKFLIQIGKTLALIQIEE .||| .. .. ||... .... | | | .. . |. |.|.| .. || .. . IIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN QIAHRDIKPSNILIKDKNF---------------Y---LSDFGCAEKLFESEGARNN----------------------LVMGTLKWMS-PELKEMKK-- |.|||.|| |||. |.| . ..||| | |....|. ... . ||. |. ||. . |. -IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC ------NQAVDY--FKSDIFSFGMLLLYMLT .. .| .|.|. | | .| ||. NMQNATDEEKPYYGPKCDMWSCGVILYIMLC |
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Kinase | 15446.AA | CMGC | 15-173 | 16 | 5.2e-20 | 61.6 | In-house | 1-249 (513) | Show / Hide |
Range on Protein: 15-173 Range on HMM: 1-249/513 Sequence Identity: 16% (42 aa) LDYRDSLGSGSYGQVFKVKNKYKDIIK---NPDILQDMPNYYACKQIH---MFQD------GENQSSQIFHEIEVLEKLK---------------KYEN- . . .|.|.||.|.| ..| . | . . ...| | | . . ... .. .. ||. |..|. | .| YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQ-AHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN VIKLQNYMTEER-----------------SMYIILDLAESTLQDEINSKQA-----NLEKFDESE------------IVKFL------IQIGKTLA--LI ..||... . . ..|.. .. . .| . | ..| . ...| . | .|. || . |. . IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC QIEE-QIAHRDIKPSNILIKDKNF---------------------YLSDFG .| |||.||.|||| ... . ||| HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFG |
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Kinase | 15446.AA | NAK | 15-173 | 22 | 6.5e-14 | 42.74 | In-house | 1-171 (299) | Show / Hide |
Range on Protein: 15-173 Range on HMM: 1-171/299 Sequence Identity: 22% (39 aa) LDYRDSLGSGSYGQVFKVKNKYKDIIKNPDILQDMPNYYACKQIHMFQDGENQSSQIFHEIEVLEKLKKYENVIKLQN-YMTEERS------MYIILDLA . . |..| ...|..|.. | ... | .. || | . ...|.. .. .|||...||.. .|.... ...|... ..... . YTVEKYLAEGGFSYVYLVQDNYINHPDN---PNSNGEKYALKRM-ICHSDEQDLNACKREIEMMKKLQHHNNIVQYIDSHINERDDSNGTWEVFLLMEYC ES-TLQDEINSKQ-ANLEKFDESEIVKFLIQIGKTLALIQIEEQ---IAHRDIKPSNILIK----DKNFYLSDFG . .|.|..|... .. .| | ||.... .. . .. . . |.|||||. |||.. |.|. | ||| CHGSLWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGNYKLCDFG |
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Kinase | 15446.AA | TyrKc | 15-285 | 15 | 9.8e-12 | -32.91 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 15-285 Range on HMM: 1-280/280 Sequence Identity: 15% (48 aa) LDYRDSLGSGSYGQVFKVKNKYKDIIKNPDILQDMPNYYACKQIHMFQDGENQSSQIFHEIEVLEKL-KKYENVIKLQNYMTEE-------RSMYIILDL . . ||.| .|.|.| . | | | .. . .|.... || .. .|...| . |.. ..|.. . ITLGKKLGEGAFGEVYKGTWK---------------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY AE-----STLQDEINSKQANLEKFDESEIVKFLIQIGKTLALIQIEEQIAHRDIKPSNILIKDKN-FYLSDFGCAEKLFES-------EGARNN---LVM .. . |.. . . .. ..| .|| . . . .. |||. |.|..... |||| . .. . . | MPHGDLKDYLRKHRPK-------LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK --GTLKWMSPELKEMKKNQAVDYFKSDIFSFGMLLLYMLTLSDISSVN------SDEFTKSQKIRIMKNYCKDI---------SNEIILLTSKMLETNPD ..||.|| | . .|||..||| .. ..|. . . |.. . . . . . . |. . .. . .|. TMLPIRWMAPECI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPE NRPDAAIIINTI .|| . |. . DRPTFSEIHECF |
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Kinase | 15446.AA | STE20 | 147-200 | 35 | 1.6e-10 | 35.01 | In-house | 135-193 (288) | Show / Hide |
Range on Protein: 147-200 Range on HMM: 135-193/288 Sequence Identity: 35% (21 aa) EEQIAHRDIKPSNILIKDK-NFYLSDFGCAEKLFE----SEGARNNLVMGTLKWMSPEL ...| ||||| |||. .. . |.||| . .| . ... . | . || ||.||. SNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEV |
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Kinase | 15446.AA | STE20 | 15-89 | 22 | 1e-06 | 20.33 | In-house | 1-68 (288) | Show / Hide |
Range on Protein: 15-89 Range on HMM: 1-68/288 Sequence Identity: 22% (17 aa) LDYRDSLGSGSYGQVFKVKNKYKDIIKNPDILQDMPNYYACKQIHMFQDGE--NQSSQIFHEIEVLEKLKKYENVIK . . .|.||||.|.|. .| . . | .| |.. . .. . .. |. || .. ..| .|..| YELLEKIGQGSYGKVYKAYHKPTGEYCN--------QRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVK |
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Kinase | 15446.AA | NAK | 257-285 | 27 | 5.7e-05 | 12.43 | In-house | 271-299 (299) | Show / Hide |
Range on Protein: 257-285 Range on HMM: 271-299/299 Sequence Identity: 27% (8 aa) SNEIILLTSKMLETNPDNRPDAAIIINTI |.... | ..||...|..||. . ..| . SQQMHDLIRYMLTPDPEQRPNIYQVLNQL |
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Kinase | 15446.AA | CAMK | 254-283 | 28 | 0.11908 | 0.28 | In-house | 384-421 (425) | Show / Hide |
Range on Protein: 254-283 Range on HMM: 384-421/425 Sequence Identity: 28% (11 aa) KDISNE--------IILLTSKMLETNPDNRPDAAIIIN .|||.| . | .|||...|..|. .. . | DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLN |