Gene 18245 (Tetrahymena)

18245

Species: Tetrahymena
Alias: PreTt18245, 513.m00003, 50, TTHERM_01620830, 18245
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C7

Sequence

Name Sequence Type Origin Length Description Download
18245.AA Protein None 559 None Fasta, JSON
18245.kin_dom Protein Kinase Domain None 175 None Fasta, JSON
18245.NA RNA None 1680 None Fasta, JSON

Protein domain

Protein domains of 18245.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 18245.AA Ciliate-C7 98-260 64 2.8e-107 344.88 In-house 1-164 (164) Show / Hide 
Range on Protein: 98-260
Range on HMM: 1-164/164
Sequence Identity: 64% (105 aa)

FKYIGEGKQGLVFLAKELSTNRRFAIKGLHVKDSQGKIFQETFNQAQQEINMLQKCKGSSYVVNLLKKIEGKEFIYLVLNECQ-GTLSELIKKSPNEKLN
|...|.|.||||.|||. .||.|.||||..|.|.||.|.|...||.|||||.|..||.|.|||.||...||..|||||||||| |||...|....|..||
FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN

ELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADSLTKTSGYGMNQYL
|.||||||||||.||..|||..|. ||||||||||||||||||.|.|||| ||. |.| .||| 
EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM
Pkinase 18245.AA Pkinase 95-269 26 3.3e-24 86.66 Pfam 1-181 (293) Show / Hide 
Range on Protein: 95-269
Range on HMM: 1-181/293
Sequence Identity: 26% (49 aa)

FSDFKYIGEGKQGLVFLAKELSTNRRFAIKGLHVKDSQGKIFQETFNQAQQEINMLQKCKGSSYVVNLLKKIEGKEFIYLVLNECQG-----TLSELIKK
.   . ||.|  | |..... .|....|.| . ...   .  |. ..   .|| ..... .. ..| |.   | |  ||.|.  |.|      |...|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

SPNEKL--NELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNA----VVSDLGLADSLTKTSGYGMNQYLGNLLFQAPE
. . ..   |  ...|.. |..|| ..||...|  ||| .||||| ||.      ..| |||  .   ..  |. . | . . |||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPE
Kinase 18245.AA Ciliate-E1 101-283 19 5.2e-23 71.98 In-house 1-202 (202) Show / Hide 
Range on Protein: 101-283
Range on HMM: 1-202/202
Sequence Identity: 19% (41 aa)

IGEGKQGLVFLAKELSTN-RRFAIKGLHVKDSQGKIFQETFNQAQQEIN-MLQKCKGSSYVVNLLKKIEGKE--FIYLVLNECQGTLSELIK--------
||.| ...|| ||  ..| .  |.|   .   .... |..|.. ..|.. ...  |.  |...... |. ..  ........|. .| . ..        
IGNGSFSIVFKAKQQNNNYNQVAQK---IINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYW

---KSPNEKLNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADSLTKTSGYGMNQYLGNLLFQAPECY--------DPKKFQ
   .. . .....  .. .... .||  .|... |  |.|..||||. .|| | .|.|... | . . . ...      .. ||.|        ...|  
QQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKIN

DYSDEY
  || |
YKSDIY
Kinase 18245.AA CAMK 100-269 15 7.4e-23 69.86 In-house 1-290 (425) Show / Hide 
Range on Protein: 100-269
Range on HMM: 1-290/425
Sequence Identity: 15% (46 aa)

YIGEGKQGLVFLAKELSTN------------RRFAIKGLHVKDSQGKI----------------------FQETFNQAQQEINMLQKCKG------SSYV
 .|.|  | |.|... .|.            ...||| .  |  ..|                        ...  . ..||....|..|         .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNLLKKIEG-------------------KEFIYLVL---NECQGT-----LSELIKKSPN-------------EKLNELSAIKYAKDIAEGLLHIHSQKC
..|.  .|                    ....|.|.     |.|      | . |.. ..              ...|  | .| . |.... ..||.. 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

ISNDLKMDNILIDYN-----------------GNAVVSDLGLADSLTKTSGYG----------------------MNQYLGNLLFQA-PE
.  ||| .|||.|.|                 .|  ..| |.|  ... ...                       |. . | . . | ||
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPE
Kinase 18245.AA Ciliate-E2-Unclassified 95-272 18 3e-22 73.97 In-house 1-239 (352) Show / Hide 
Range on Protein: 95-272
Range on HMM: 1-239/352
Sequence Identity: 18% (45 aa)

FSDFKYIGEGKQGLVFLAKELSTNRRFAIKGLHVKDSQG-KIFQETFNQAQQEINMLQKCK------------------GSSYVVNLLKKIEGKEFIYLV
.   | ||.| .| |..... ...  .|.| .... ..  |. ..   .  .|.. ... |                   . ..|...   . |. ||.|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

LNEC-QGTLSELIKKSPN---------------EKLNELSAI-----KYAKDIAEGLLHIHSQK-CISNDLKMDNILIDYNG---NAVVSDLGLADSLTK
.  | .|.|.. |||...               ... |  |.     .|.. | .|| ..|... .|  |.| .|||.| ||   .  ..|.|..  . .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

TSGYG--------------MNQYLGNLLFQ----APECYD
 ...               |..  |.. ..    |||...
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ
Kinase 18245.AA STE 95-269 19 1e-20 69.99 In-house 1-232 (359) Show / Hide 
Range on Protein: 95-269
Range on HMM: 1-232/359
Sequence Identity: 19% (46 aa)

FSDFKYIGEGKQGLVFLAKEL------STNRR---------FAIKGLHVKDSQ-----------GKIFQETFNQAQQEINMLQKCKG-SSYVVNLLKKIE
. . . ||.|  | |..|.        .|..          .||| .......            ....| ..| ..||....||.  . ..|. .   .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

GK-------EFIYLVLNECQ-GTLSELIK-K-SPNEKLN----------ELSAIKYAKDIAEG-LLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLAD
 .       . .....  .  |.|...|| | .... ||          |   ......| .| | ..||.. |  |.| .|||.     .  .| |.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

SLTK---------------TSGYGMNQYLGNLLFQAPE
.||.               |..   |   |   . |||
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase 18245.AA Ciliate-E2 95-280 20 3.6e-20 65.9 In-house 1-274 (365) Show / Hide 
Range on Protein: 95-280
Range on HMM: 1-274/365
Sequence Identity: 20% (56 aa)

FSDFKYIGEGKQGLVFLAKELSTNRRFAIK-------------GLHVKDSQGKIFQET-FNQAQQEINMLQKCK---------------GSSYVVNLLKK
.   | ||.| .| |...|  .....||||             .  .|    ||...   .|  |||..... .                . .....   
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

IE--GKEFIYLVLNECQG-TLSELIK---KSPNEKLN------ELSAIKYAKDIAE---------------GLLHIHSQK-CISNDLKMDNILIDYNGNA
 .   .. ||||.  ||| .| ..||   |. |....      |  .... | |..               .| ..||.. .|  |.| .|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

VVSDLGLADSLT----------------------KTSGY--------GMNQYLGNLLFQAPECYDPKK------FQDYS
 ..|.||.  ..                      .|.||          |...|.. ..||| .  ||      ...|.
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYD
Kinase 18245.AA AGC 95-245 23 3.7e-20 47.38 In-house 1-202 (395) Show / Hide 
Range on Protein: 95-245
Range on HMM: 1-202/395
Sequence Identity: 23% (47 aa)

FSDFKYIGEGKQGLVFLAKEL------STNRRFAIKGLHVKD--------SQGKIFQE-TFNQ----AQQEINMLQKCKG---------SSYVVN-LLKK
|   | ||.|  | |.|...       .|.. .|.| |  |.         . ..  | .  |     ..| |.|.||..         . ..|. |   
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHW-KQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYS

IEGKEF--IYLVLNECQ----------G-TLSELIKKS-PNEKLNELSAIKYAKD-------IAEGLLHIHS-QKCISND-LKMDNILIDYNGNAVVSDL
 . |.   .|.|.  ..          |  |   ...   . ...|  |  ||         |. .| ..|| .. |  | || .|||.| .|.   .| 
FQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDF

GLA
||.
GLC
Kinase 18245.AA STE20 95-251 23 6.6e-18 62.27 In-house 1-174 (288) Show / Hide 
Range on Protein: 95-251
Range on HMM: 1-174/288
Sequence Identity: 23% (43 aa)

FSDFKYIGEGKQGLVFLAKELSTNRR----FAIKGLHVKDS---QGKIFQETFNQAQQEINMLQKCKGSSYVVNLLKKIEGK----EFIYLVLNECQG-T
. ... ||.|  | |..| . .|..      ||| . ...    |     . ..  |.||.....|| . ..|. .     .    . ...|   |.| .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-----DEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGS

LSELIK---KSPNE----KLNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADSLTK----T
|....|   |  .     ..||       ... .|| ..||...|  |.| ||||.. .|..  .| |.. .|||    |
LTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDT
Kinase 18245.AA S_TKc 95-370 20 1.1e-17 66.06 SMART 1-231 (231) Show / Hide 
Range on Protein: 95-370
Range on HMM: 1-231/231
Sequence Identity: 20% (63 aa)

FSDFKYIGEGKQGLVFLAKELSTNRRFAIKGLHVKDSQGKIFQETFNQAQQEINMLQKCKGSSYVVNLLKKIEGKEFIYLVLNECQG---TLSELIKKSP
.   . ||.|  | |..... .|.|..||| ..             .....||..|.|  .  ..|.|.  ..  ...|.|.  | |   .| ..||| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

NEK----LNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADSLTKTSGYGMNQYLGNLLFQAPECYDPKKFQDYSDEYQKLG
 ..    ..|  | .|.. |...| ..||.. |  ||| .|||.|   .  ..| |||  |        . . | . . |||                  
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----------------

LNISTKPTIKLVIQFDK-----------MFNKYKGYLIYLMVQDFKTDLMFKKHLTLNYSNQFEQFTYKNQLKFIINGLTQFKPEDR----NLS------
             ...|           ..  . ||  .        ..|||| .               ..| .|... |. ||.|     |       
-------------GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIK

-NSWM
   |.
CHPWF
Kinase 18245.AA CAMKL 99-245 26 3.1e-17 51.43 In-house 5-176 (297) Show / Hide 
Range on Protein: 99-245
Range on HMM: 5-176/297
Sequence Identity: 26% (46 aa)

KYIGEGKQGLVFLAKE-LSTNRRFAIKGLHVKDSQGKIFQETFNQAQ-------------QEINMLQKCK--GSSYVVNLLKKIEGKEF------IYLVL
| .|.|  | | ||.  . |... ||| .. |    ||  ......              .||. ... .  .   .. |.  || .|.      ||||.
KTLGKGSFGKVKLATHIRTTGEKVAIKIIDKK----KIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

NECQGT---LSELIKKSPNEK--LNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNG--NAVVSDLGLA
  |.|    | . |.| .. .  . |  | .| . | ... ..||.. .  |.| .|||.|.||  |. ..| |..
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS
Kinase 18245.AA IRE 167-244 27 9.4e-15 47.17 In-house 63-170 (292) Show / Hide 
Range on Protein: 167-244
Range on HMM: 63-170/292
Sequence Identity: 27% (30 aa)

EGKEFIYLVLNECQGTLSELIKK--------------SPNEKLN--------ELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDY--------NGN
|...|.|| |  |||.|.... .                |...|        ..  .. .|....|| | |||. . .|||  ||||..        |. 
EDDQFVYLALELCQGSLQDYVEQKKRNNFINSSNNSNNNNKNNNNNNNQWQIHIRMWQLIKQCMNGLQHLHSQNIVHRDLKPHNILIHMNRPNQHGENNR

AVVSDLGL
.. ||.||
FMISDFGL
Kinase 18245.AA TyrKc 95-331 18 1e-06 -116.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 95-331
Range on HMM: 1-280/280
Sequence Identity: 18% (55 aa)

FSDFKYIGEGKQGLVFLAKELSTNRRFAIKGLHVKDSQGKIFQETFNQAQQEINMLQKC-KGSSYVVNLLKKIEGK-------EFIYLVLNECQ-GTLSE
 .  | .|||  | |....     .  |.| |.         .| |    .|.... |  .    .|.|.  .  .       | ...|.  .  | | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDF---MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

LIKKSPNEKLNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADSLTKT------SGYGMNQY--LGNLLF----QAPECYDP
 ..|. .. |.    .... .||.|  ..||..||  ||   |.|.. |. . .|| ||.  ..        . | . .    |. ..     |||| . 
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

KKF---------------------QDYSDEYQKLGLNISTKPTIKLVIQFDKMFNKYK----------GYLIYLMVQDFKT---------DLMFKKHL
.||                     | |... |.    .| .  |..| | . |                 .  .| |  .          ..  .. .
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF