Gene 19991 (Tetrahymena)
19991
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 19991.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 19991.AA | Ciliate-C7 | 45-245 | 63 | 1.5e-110 | 355.57 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 45-245
Range on HMM: 1-164/164
Sequence Identity: 63% (128 aa)
FRFLGQGAQGLVLLAKDLKTQMRYAIKGVQVRDLQGNLDDEVYSKVGQEIDILKQCRGSPYVVSLLDSFEGKQFMYLILNECQAQIQINNQTHFTKNSQC
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FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQG----------------
MVQKGTLTEIIESQLNKRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVCKLLTNLNKTLHYIQFTADFGLADKLTVKSGYSPNQY
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----GTLNQIIERNQNKRLNEISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVC-----------------DFGLADNLTQKSKYQINQY
V
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M
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| Kinase | 19991.AA | CAMK | 47-208 | 15 | 1.3e-16 | 49.33 | In-house | 1-238 (425) | Show / Hide |
Range on Protein: 47-208 Range on HMM: 1-238/425 Sequence Identity: 15% (42 aa) FLGQGAQGLVLLAKDLKTQ------------MRYAIKGVQVRDLQGNL----------------------DDEVYSKVGQEIDILKQCRG------SPYV ||.|. | | |... .|. ..||| . . |... ... .| .||.|.|...| | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VSLLDSFEG-------------------KQFMYLILNECQAQIQINNQTHFTKNSQCMVQKGTLTEIIES-QL----------N---------------K ..|.. .| ...||... .| .. | . . IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVME--------------------------IMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERG RLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYN-----------------GNAVVC |..| | .| . | ... |.||.| ||| .|||.|.| .| .. RFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKII |
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| Kinase | 19991.AA | Ciliate-E2-Unclassified | 42-208 | 21 | 4.6e-15 | 48.7 | In-house | 1-189 (352) | Show / Hide |
Range on Protein: 42-208 Range on HMM: 1-189/352 Sequence Identity: 21% (42 aa) YSDFRFLGQGAQGLVLLAKDLKTQ----MRYAIKGVQVRDLQGNLDDEVYSKVGQEIDILK---------------QCRGSPYVVSLLDSFEGKQFMYLI | . .|||..| | .... |.. | |..| .. ..| . | .. .|. ..| . .|..| ... |. || .|.. YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LNECQAQIQINNQTHFTKNSQCMVQKGTLTEIIESQLN-KRLNEISAI-----KYAKDITEGLYYIHSKN-CLVNDLKMDNILIDYNG---NAVVC . |. . .. ... |..| . .. ..... |.. | |. .|.. | .|| |.|.|| .. |.| .|||.| || . .. MEYCEGGDLWQYIKKRKKQKQ--K----GNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKII |
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| Kinase | 19991.AA | S_TKc | 42-360 | 18 | 1.8e-13 | 20.52 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 42-360
Range on HMM: 1-231/231
Sequence Identity: 18% (64 aa)
YSDFRFLGQGAQGLVLLAKDLKTQMRYAIKGVQVRDLQGNLDDEVYSKVGQEIDILKQCRGSPYVVSLLDSFEGKQFMYLILNECQAQIQINNQTHFTKN
| | .|.|| | | .... ||. ..||| . .. .||.|||. . |..| |.|.|. ...|...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVME-----------------
SQCMVQK--GTLTEIIESQLNKR----LNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVCKLLTNLNKTLHYIQFTADFGLADKLTV
.. |.| ..|... .. ..| | .|.. | ..| |.||.. . ||| .|||.| . |. .||||| .|
---YCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKI--------------CDFGLARQL--
KSGYSPNQYVQINLYFNTNNKYNSFNQQNFKMGNFFYQAPECHDPTDK----------------IGKV-YYDEYQKLGVKVKQEPSNRGIDFNLVLNKHR
. | .| ||| . .| |. .. ..|.. |..
----------------------------TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG------------------
ALNYDGEFQNFVYHKNLQQLIDGLTQFVPRNRLPIKEALI---------VL
. . ..|... |. |..|. . ||| .
-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 19991.AA | AGC | 45-123 | 22 | 3e-13 | 29.13 | In-house | 1-112 (395) | Show / Hide |
Range on Protein: 45-123 Range on HMM: 1-112/395 Sequence Identity: 22% (25 aa) FRFL---GQGAQGLVLLAKDL------KTQMRYAIKGVQ----VRDLQGNLDDEVYSK--------VGQEIDILKQCRG---------SPYVVS-LLDSF |.|| |.|. | | |... |. ||.| .. . ... | . ... | .| .||..|.. .|..|. | || FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF EGKQF--MYLIL . |. |... QDKDHTYLYFVM |
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| Kinase | 19991.AA | Ciliate-E2 | 42-210 | 18 | 1.5e-12 | 39.41 | In-house | 1-197 (365) | Show / Hide |
Range on Protein: 42-210 Range on HMM: 1-197/365 Sequence Identity: 18% (41 aa) YSDFRFLGQGAQGLVLLAKDLKTQMRYAIKGVQVRD---------LQGNLDDEVYSK------VGQEIDILKQCR---------------GSPYVVSLLD | . .|||..| | ..|. |.| ..||| . . .... . | . |||.|... . .|... . . YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE SFE--GKQFMYLILNECQA----QIQINNQTHFTKNSQCMVQKGTLTEIIESQLNKRLNEISAIKYAKDITE---------------GLYYIHSKN-CLV .|. .. .||.. || .. .||.. .... . . |...| .... | |.. .| |.|||| .. CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE-------------K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIH NDLKMDNILIDYNGNAVVCKL |.| .|||. .|. RDIKPENILF--------IKI |
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| Kinase | 19991.AA | Ciliate-E1 | 48-271 | 18 | 2.1e-12 | 37.1 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 48-271 Range on HMM: 1-202/202 Sequence Identity: 18% (43 aa) LGQGAQGLVLLAKDLKTQMRYAIKGVQVRDLQGNLDDEVYSKVGQEID-ILKQCRGSPYVVSLLDSFEGKQ--FMYLILNECQAQIQINNQTHFTKNSQC .|.| ...|. || ... . .. .. ...| ... . .. .|.. |.| .. |.. ..| .. .| ....|...|. . . ..|.| IGNGSFSIVFKAKQQNNNYNQVAQKIIN--CCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNH------- MVQKGTLTEIIESQL--NKRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVCKLLTNLNKTLHYIQFTADFGLADKLTVKSGYSPN . | |.. .. .. ... .. .... .|| ..|..| . |.|..||||. .|| | | |||....| .. .. ---N-RL-EYWQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYC-----------------DFGISKFLKNNQNQQC- QYVQINLYFNTNNKYN------SFNQQNFKMGNFF || . |. ...|| ||. .. . . QYKGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY |
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| Kinase | 19991.AA | Pkinase | 42-123 | 28 | 1.2e-11 | 42.22 | Pfam | 1-79 (293) | Show / Hide |
Range on Protein: 42-123 Range on HMM: 1-79/293 Sequence Identity: 28% (23 aa) YSDFRFLGQGAQGLVLLAKDLKTQMRYAIKGVQVRDLQGNLDDEVYSKVGQEIDILKQCRGSPYVVSLLDSFEGKQFMYLIL | | .|.|. | | .... .|. ..|.| . .|. . | . .|| |.| . ..|..| |.|.|| |. .|... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVM |
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| Kinase | 19991.AA | STE20 | 42-113 | 26 | 1.2e-10 | 35.42 | In-house | 1-73 (288) | Show / Hide |
Range on Protein: 42-113 Range on HMM: 1-73/288 Sequence Identity: 26% (21 aa) YSDFRFLGQGAQGLVLLAKDLKTQMR----YAIKGVQVRDL---QGNLDDEVYSKVGQEIDILKQCRGSPYVVSLLDSF | ... .|||. | | .| . .|. .||| . ... | . . .||.|.|||. .|..|. ..|. YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-----DEWEDIQKEISIMKQCK-HPNIVKYYGSY |
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| Kinase | 19991.AA | CAMKL | 42-123 | 20 | 4.8e-10 | 28.08 | In-house | 1-100 (297) | Show / Hide |
Range on Protein: 42-123 Range on HMM: 1-100/297 Sequence Identity: 20% (21 aa) YSDFRFLGQGAQGLVLLAKD-LKTQMRYAIKGVQ--VRDLQGNLD--------DEVYSKVGQEIDILKQCR--GSPYVVSLLDSFEGKQF------MYLI | . ||.|. | | ||.. . |. ..||| . . . . . . .. .|| |.|. . . | ...|.. .| ... .||. YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV L . M |
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| Kinase | 19991.AA | STE | 42-123 | 17 | 4e-08 | 24.91 | In-house | 1-116 (359) | Show / Hide |
Range on Protein: 42-123 Range on HMM: 1-116/359 Sequence Identity: 17% (20 aa) YSDFRFLGQGAQGLVLLAKDLK---------------TQMRYAIKGVQVRDLQ-----------GNLDDEVYSKVGQEIDILKQCRG-SPYVVSLLDSFE . . ...|.|| | | .|.. | |. ..||| . ... . | ..| .. .||.|.|.|. .|..| ..... WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF GK-------QFMYLIL . . .... KEGHNHKNDDELWICM |
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| Kinase | 19991.AA | Pkinase | 146-208 | 30 | 1.5e-07 | 27.76 | Pfam | 82-154 (293) | Show / Hide |
Range on Protein: 146-208 Range on HMM: 82-154/293 Sequence Identity: 30% (22 aa) VQKG----TLTEIIESQLNKRL--NEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNA----VVC ...| | ..|. . .... | ...|.. | .||.|.||.... ||| .||||| ||. .| CEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKIC |
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| Kinase | 19991.AA | ULK | 42-123 | 21 | 1.9e-07 | 22.19 | In-house | 1-99 (329) | Show / Hide |
Range on Protein: 42-123 Range on HMM: 1-99/329 Sequence Identity: 21% (21 aa) YSDFRFLGQGAQGLVLLAKDLKTQMRYAIKGVQVRDLQGNLDDEVYSK---------VGQEIDILKQCR---GSPY----VVSLLDSFEGKQF--MYLIL |. . ||.|. | | ... ||. .|. . | . .. . .. . . .||.|.|. .... .| |.| || ... |.|. YCLNHCLGKGSFGKVYKGRNKKTK-DYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM |
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| Kinase | 19991.AA | ULK | 149-202 | 32 | 3.6e-07 | 21.17 | In-house | 105-166 (329) | Show / Hide |
Range on Protein: 149-202 Range on HMM: 105-166/329 Sequence Identity: 32% (20 aa) GTLTEIIESQ--------LNKRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYN |.| ..|. . .|||.| ||.. |.| .|. ..|..|. |.| .||||. . GDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNG |
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| Kinase | 19991.AA | CAMKL | 146-208 | 28 | 1e-06 | 17.29 | In-house | 103-171 (297) | Show / Hide |
Range on Protein: 146-208 Range on HMM: 103-171/297 Sequence Identity: 28% (20 aa) VQKGT--LTEIIESQLNKR--LNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNG--NAVVC .. | | . |... ..| . | | .| . | ....|.||.. |.| .|||.|.|| |. .. CSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKII |
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| Kinase | 19991.AA | STE | 149-210 | 29 | 1.1e-05 | 16.2 | In-house | 122-188 (359) | Show / Hide |
Range on Protein: 149-210 Range on HMM: 122-188/359 Sequence Identity: 29% (22 aa) GTLTEIIE------SQLN------KRLNEISAIKYAKDITEG-LYYIHSKNCLVNDLKMDNILIDYNGNAVVCKL |.|..||. .|| .|..| ......| .| |||.||.. |.| .|||. .|| GSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------VKL |
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| Kinase | 19991.AA | AGC | 160-204 | 33 | 0.00057 | 4.57 | In-house | 140-193 (395) | Show / Hide |
Range on Protein: 160-204 Range on HMM: 140-193/395 Sequence Identity: 33% (18 aa) NKRLNEISAIKYAKD-------ITEGLYYIHS-KNCLVND-LKMDNILIDYNGN ..|..| | || |. .| |.|| .. | || .|||.| .|. EGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGH |
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| Kinase | 19991.AA | STE20 | 149-205 | 29 | 0.007716 | 6.56 | In-house | 93-156 (288) | Show / Hide |
Range on Protein: 149-205 Range on HMM: 93-156/288 Sequence Identity: 29% (19 aa) GTLTEIIES--QLNK-----RLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNA |.||.|.. ..| ..|| ... .|| |.||... |.| ||||.. .|.. GSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEV |
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