Gene 19995 (Tetrahymena)
19995
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 19995.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 19995.AA | Ciliate-C7 | 45-216 | 74 | 1.5e-117 | 378.29 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 45-216 Range on HMM: 1-164/164 Sequence Identity: 74% (128 aa) FRFLGQGAQGLVLLAKNLKNQMRYAIKGVQVRDPQGNLYDEAFNKVVQEIDILKQCRGSPYVVSLLDSFDGKQFMYLVLNECQDNFYCMVQKGTLKEIIE |||||||.||||||||. |..||||||||||||.|||......|.| |||.|||||..|||||.||..|.|.||.|||||||| |||..||| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQG--------GTLNQIIE RNQNKRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLADKLTAKSGYSTNQYV |||||||||||||||||||..||||||||||.|||||||||||||||||||.||||||.|| ||.|..|||. RNQNKRLNEISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM |
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| Pkinase | 19995.AA | Pkinase | 42-212 | 28 | 7.4e-26 | 92.51 | Pfam | 1-169 (293) | Show / Hide |
Range on Protein: 42-212 Range on HMM: 1-169/293 Sequence Identity: 28% (50 aa) YSDFRFLGQGAQGLVLLAKNLKNQMRYAIKGVQVRDPQGNLYDEAFNKVVQEIDILKQCRGSPYVVSLLDSFDGKQFMYLVLNECQDNFYCMVQKGTLKE | | .|.|. | | .... ... ..|.| . .|. . .... .|| |.| . ..|..| |.|.| |. .|.|. |. |.| |.. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVM----DLFD IIERNQNKRL--NEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNA----VVSDFGLADKL-TAKSGYST .|.. ..... | ...|.. | .||.|.||.... ||| .||||| ||. ..||||| .. . ... | YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MT |
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| Kinase | 19995.AA | AGC | 45-201 | 24 | 3.3e-24 | 58.12 | In-house | 1-202 (395) | Show / Hide |
Range on Protein: 45-201 Range on HMM: 1-202/395 Sequence Identity: 24% (50 aa) FRFL---GQGAQGLVLLAKNL------KNQMRYAIKGVQ----VRDPQGNLYDEAFNK--------VVQEIDILKQCRG---------SPYVVS-LLDSF |.|| |.|. | | |.. .. ||.| .. . . . | . . . | .| .||..|.. .|..|. | || FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF DGKQF--MYLVLNECQDNFYCM---VQKG-TLKEIIERN-QNKRLNEISAIKYAKD-------ITEGLYYIHS-KNCLVND-LKMDNILIDYNGNAVVSD |. |.|. .. |. . | | .. ...|..| | || |. .| |.|| .. | || .|||.| .|. .| QDKDHTYLYFVMEYMPR--YVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTD FGLA |||. FGLC |
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| Kinase | 19995.AA | Ciliate-E1 | 48-241 | 18 | 3.9e-21 | 65.82 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 48-241 Range on HMM: 1-202/202 Sequence Identity: 18% (39 aa) LGQGAQGLVLLAKNLKNQ-MRYAIKGVQVRDPQGNLYDEAFNKVVQEID-ILKQCRGSPYVVSLLDSF--DGKQFMYLVLNECQDNFYCMVQ---KGTLK .|.| ...|. ||. .|. .|.| ..... | .. |... .|.. |.| .. |.. ..| . | .........|..... | . . IGNGSFSIVFKAKQQNNNYNQVAQKIINCCF---NYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRL-EY EIIERNQNKRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLADKLTAKSGYSTNQYVQIKVFLNTKKKF------NQLNST . ..... ... .. .... .|| ..|..| . |.|..||||. .|| | .|||....| .. ..... ... . . ... |. . WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKI NYKMGNF ||| . NYKSDIY |
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| Kinase | 19995.AA | CAMK | 47-201 | 18 | 7.1e-20 | 60.08 | In-house | 1-243 (425) | Show / Hide |
Range on Protein: 47-201 Range on HMM: 1-243/425 Sequence Identity: 18% (46 aa) FLGQGAQGLVLLAKNLKNQ------------MRYAIKGVQV----------------RDPQGNLY------DEAFNKVVQEIDILKQCRG------SPYV ||.|. | | |... ... ..||| . .| ... .. .| .||.|.|...| | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VSLLDSFDG-------------------KQFMYLVLNECQDNFYC-MVQKG----TLKEIIERNQN-------------KRLNEISAIKYAKDITEGLYY ..|.. .. ...||.|. . ... | | . | .. . .|..| | .| . | ... | IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVME------IMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHY IHSKNCLVNDLKMDNILIDYN-----------------GNAVVSDFGLA .||.| ||| .|||.|.| .| ..|||.| CHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFA |
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| Kinase | 19995.AA | CAMKL | 42-201 | 24 | 1.4e-19 | 59.05 | In-house | 1-176 (297) | Show / Hide |
Range on Protein: 42-201 Range on HMM: 1-176/297 Sequence Identity: 24% (45 aa) YSDFRFLGQGAQGLVLLAKN-LKNQMRYAIKGVQVR----DPQGNLY------DEAFNKVVQEIDILKQCR--GSPYVVSLLDSFDGKQF------MYLV | . ||.|. | | ||.. . .. ..||| . . ||. . . .. .|| |.|. . . | ...|.. .. ... .||| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV LNECQDNFYCMVQKGT--LKEIIERNQNKR--LNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNG--NAVVSDFGLA . .. | | . |... ..| . | | .| . | ....|.||.. |.| .|||.|.|| |. ..|||.. ME--------YCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS |
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| Kinase | 19995.AA | Ciliate-E2-Unclassified | 42-250 | 20 | 3.3e-19 | 63.28 | In-house | 1-239 (352) | Show / Hide |
Range on Protein: 42-250 Range on HMM: 1-239/352 Sequence Identity: 20% (51 aa) YSDFRFLGQGAQGLVLLAKNLKNQMRY-------AIKGVQVRDPQGNLYDEAFN-KVVQEID-------------ILKQCRGSPYVVSLLDSFDGKQFMY | . .|||..| | .... |.. | |. . .. . . .. .. | .... ||... .|..| ... | || .| YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHP-HPFIVKMFYCFQDKQNIY LVLNECQDN--FYCMVQKGT----LKEIIERNQN-KRLNEISAI-----KYAKDITEGLYYIHSKN-CLVNDLKMDNILIDYNG---NAVVSDFGLADKL .|. |... .... .... ... ..... |.. | |. .|.. | .|| |.|.|| .. |.| .|||.| || . ..|||.. |. IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY TAKSG-YSTNQYVQIKVFLNTKKKFNQLNSTNYKMGNFIFQ----APECYD .. . ||| . .|..... . .. ..|. ... |||... QQNNNCD-TNQ-------Q-QKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ |
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| Kinase | 19995.AA | Ciliate-E2 | 42-205 | 21 | 1.2e-18 | 60.68 | In-house | 1-207 (365) | Show / Hide |
Range on Protein: 42-205 Range on HMM: 1-207/365 Sequence Identity: 21% (47 aa) YSDFRFLGQGAQGLVLLAKNLKNQMRYAIK-------------GVQVRDPQGNLYDEA-FNKVVQEIDILKQCR---------------GSPYVVSLLDS | . .|||..| | ..|. |.| ..||| .|.. . . . . . |||.|... . .|... . .. YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC FD--GKQFMYLVLNECQDN--FYCMVQKGTL-KEIIERNQNKRLNEISAIKYAKDITE---------------GLYYIHSKN-CLVNDLKMDNILIDYNG | .. .|||. || . |... .. . ...|| . |...| .... | |.. .| |.|||| .. |.| .|||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---- NAVVSDFGLADKLT ..||||. |.. -IKIIDFGLSKKYD |
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| Kinase | 19995.AA | S_TKc | 42-356 | 18 | 8.1e-17 | 63.11 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 42-356 Range on HMM: 1-231/231 Sequence Identity: 18% (63 aa) YSDFRFLGQGAQGLVLLAKNLKNQMRYAIKGVQVRDPQGNLYDEAFNKVVQEIDILKQCRGSPYVVSLLDSFDGKQFMYLVLNECQDNFYCMVQK--GTL | | .|.|| | | .... | . ..||| . ... .||.|||. . |..| |.|.|. ...|.|. .. |.| YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVME--------YCDGDLGDL KEIIERNQNKR----LNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLADKLTAKSGYSTNQYVQIKVFLNTKKKFNQLNSTN ...|.... .. ..| | .|.. | ..| |.||.. . ||| .|||.| . ..||||| .| . FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------------------------T YKMGNFIFQAPECYDPNDQ---------------IIGKVYYDEYKKLGVQVKQEPSNRVNTLIKLIKRYIIYSLVQGIDFNLVLNKHRPLNYDGEFQNFV | . ||| . . . |. .. .....|.|. TFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP---------------QMQMMFKKIG--------------------------------- YHKNLQQLIDGLTQFVPRNRLPIKEALI---VLKGIICF . . ..|... |. |..|. . ||| . | | -SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | 19995.AA | ULK | 42-201 | 23 | 3.3e-16 | 53.16 | In-house | 1-189 (329) | Show / Hide |
Range on Protein: 42-201 Range on HMM: 1-189/329 Sequence Identity: 23% (46 aa) YSDFRFLGQGAQGLVLLAKNLKN----QMRYAIKGVQ----VRDPQ---GNLYDEAFNKVVQEIDILKQCR---GSPY----VVSLLDSFDGKQF--MYL |. . ||.|. | | ..| |. . .|.| .. .... | . . . . .||.|.|. .... .| |.| | ... |. YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEG---QYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYI VLNECQDNFYCMVQKGTLKEIIERNQN--------KRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAV------------VSDFGLA .. |.. |.|...|..|.. |||.| ||.. |.| .|. ..|..|. |.| .||||. . ..|||.| IMEYCNG--------GDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 19995.AA | STE20 | 42-113 | 25 | 3.8e-14 | 48.38 | In-house | 1-73 (288) | Show / Hide |
Range on Protein: 42-113 Range on HMM: 1-73/288 Sequence Identity: 25% (20 aa) YSDFRFLGQGAQGLVLLAKNLKNQMR----YAIKGVQVRDP---QGNLYDEAFNKVVQEIDILKQCRGSPYVVSLLDSF | ... .|||. | | .| . ... .||| . .... | . .. ...||.|.|||. .|..|. ..|. YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ-----DEWEDIQKEISIMKQCK-HPNIVKYYGSY |
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| Kinase | 19995.AA | Ciliate-A2 | 139-201 | 34 | 1.9e-12 | 39.8 | In-house | 85-150 (272) | Show / Hide |
Range on Protein: 139-201 Range on HMM: 85-150/272 Sequence Identity: 34% (23 aa) LKEIIE--RNQNKRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGN-AVVSDFGLA | . |. || | ... ....|. | ... |.|.|| . ||. ||||| ... .. ||||| LQDWIDKFQNQQKFIPDHQFVHFACQILDAIEYLHNKNYVLRDLSLRNILIDQDNQIIKLCDFGLA |
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| Kinase | 19995.AA | STE20 | 137-205 | 30 | 8.3e-07 | 21.24 | In-house | 93-168 (288) | Show / Hide |
Range on Protein: 137-205 Range on HMM: 93-168/288 Sequence Identity: 30% (23 aa) GTLKEIIER--NQNK-----RLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLADKLT |.| .|... . .| ..|| ... .|| |.||... |.| ||||.. .|.. .|||.. .|| GSLTDIMKHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLT |
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| Kinase | 19995.AA | TyrKc | 42-259 | 13 | 6e-06 | -126.91 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 42-259
Range on HMM: 1-280/280
Sequence Identity: 13% (42 aa)
YSDFRFLGQGAQGLVLLAKNLKNQMRYAIKGVQVRDPQGNLYDEAFNKVVQEIDILKQC-RGSPYVVSLL-DSFDGK------QFMYLVLNECQDNFYCM
. . || || | | ... . |.| .. .|. |... | .| |. ... . ...|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVME--------Y
VQKGTLKEIIERNQNKRLNEISAIKYAKDITEGLYYIHSKNCLVNDLKMDNILIDYNGNAVVSDFGLADKLTAK-------SGYS------TN-------
. .| ||. . ....| |. .... .| .| |.||||| || |.|.. |. . .|||||. ... . . |. ..
MPHGDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW
---------------------------------QY-------VQIKVFLNTKKKFNQLNSTNY--------KMGNFIFQAPECYDPN-------DQIIGK
| . . .. |. . . . .| . . .|. .
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC
V
F
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| Kinase | 19995.AA | Ciliate-A2 | 49-78 | 34 | 0.000114 | 12.47 | In-house | 1-32 (272) | Show / Hide |
Range on Protein: 49-78 Range on HMM: 1-32/272 Sequence Identity: 34% (11 aa) GQGAQGLVLLAKNL--KNQMRYAIKGVQVRDP |||. |.|.... | |||| . . |. GQGCFGCVIFVEHMDNHNNEKYAIKIQSIIDG |
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