Gene 20891 (Tetrahymena)
20891
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 20891.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 20891.AA | Ciliate-C7 | 144-308 | 65 | 5.9e-100 | 321.1 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 144-308 Range on HMM: 1-164/164 Sequence Identity: 65% (108 aa) FRFLGQGAQGLVVLAKEKSTNKRYAIKGINIKDSKDNVDQVILGQVQQEIKMLNQCKGSPYVVNLLHQIEGNDFIFLVLTECL-GTLNEIMKNTQNERLN |||||||.||||.|||...|| ||||||....|...|.|| |..||||||..|.|||.|||||.||||.||..||.|||.||. ||||.|....||.||| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN ELSAIKYAKDIAEGLYFIHSKKGLVNDLKMDNILIDYNGNAVVCIPLLSLDQYHSNKQINKINQLT |.||||||||||.|||.||||. .|||||||||||||||||||| .. | . .|. .||| EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVC--DFGLADNLTQKSKYQINQYM |
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| Kinase | 20891.AA | AGC | 141-282 | 22 | 6.7e-22 | 52.01 | In-house | 1-193 (395) | Show / Hide |
Range on Protein: 141-282 Range on HMM: 1-193/395 Sequence Identity: 22% (43 aa) YDEFRFLGQGAQGLVVLAKEK------STNKRYAIKGINIKD---SKD--NVDQVILGQ-------VQQEIKMLNQCKG---------SPYVVN-LLHQI .. . .|.|. | | |...| .|.| ||.| .. |. |. |.... . |..| ..| .|.. .|..|. | . FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF EGNDF--IFLVLTECL----------G-TLNEIMKNT-QNERLNELSAIKYAKD-------IAEGLYFIHSKKGLV-ND-LKMDNILIDYNGN . .| ...|. . | | .... .. |..| | || |. .| ..||..| . | || .|||.| .|. QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGH |
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| Pkinase | 20891.AA | Pkinase | 141-286 | 29 | 5.2e-20 | 71.84 | Pfam | 1-154 (293) | Show / Hide |
Range on Protein: 141-286
Range on HMM: 1-154/293
Sequence Identity: 29% (48 aa)
YDEFRFLGQGAQGLVVLAKEKSTNKRYAIKGINIKDSKDNVDQVI--LGQVQQEIKMLNQCKGSPYVVNLLHQIEGNDFIFLVLTECLGTLNEIMKNT--
| | .|.|. | | ....|.|.|..|.| |. .. |...|| | .||.... . ..|..| |.. | .| | .|. | |.| |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDY
----QNERL--NELSAIKYAKDIAEGLYFIHSKKGLV-NDLKMDNILIDYNGNA----VVC
.. .. | ...|.. |..||...|| .| . ||| .||||| ||. .|
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKIC
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| Kinase | 20891.AA | CAMK | 146-264 | 16 | 1.1e-19 | 59.4 | In-house | 1-199 (425) | Show / Hide |
Range on Protein: 146-264 Range on HMM: 1-199/425 Sequence Identity: 16% (32 aa) FLGQGAQGLVVLAKEKSTN------------KRYAIKGINIKDSKDNV----------------------DQVILGQVQQEIKMLNQCKG------SPYV ||.|. | | |...|.|. ...||| |. | ||.. ... . .|..||.......| | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VNLLHQIEG-------------------NDFIFLVL--TECLGT-------LNEIMKNTQN------------ERLNELSAIKYAKDIAEGLYFIHSKK ..|.. .| ......|. .| .. | ..... |..| | .| . |.... ..||.. IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN |
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| Kinase | 20891.AA | STE | 141-264 | 18 | 7.5e-18 | 59.71 | In-house | 1-172 (359) | Show / Hide |
Range on Protein: 141-264 Range on HMM: 1-172/359 Sequence Identity: 18% (32 aa) YDEFRFLGQGAQGLVVLAKEK------STNKR---------YAIKGINIKDSK-----------DNVDQVILGQVQQEIKMLNQCKG-SPYVVNLLHQIE .. ...|.|| | |..|. . .|.. .||| .|..... .|... .. |...|||....|. .|..|. . . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF GN-------DFIFLVLTECL-GTLNEIMK---NTQN---------ERLNELSAIKYAKDIAEG-LYFIHSKK . | ..... . |.| .|.| ... |..| ......| .| ||..||.. KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH |
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| Kinase | 20891.AA | Ciliate-E2-Unclassified | 141-287 | 21 | 4.4e-15 | 48.77 | In-house | 1-188 (352) | Show / Hide |
Range on Protein: 141-287 Range on HMM: 1-188/352 Sequence Identity: 21% (40 aa) YDEFRFLGQGAQGLVVLAKEKSTNKRYAIKGINIKDSKD-NVDQVILGQVQQEIKMLNQCK------------------GSPYVVNLLHQIEGNDFIFLV | . .|||..| | ....|.... ||.| .. . ... . . . .|.| .|. | .|..|..... . . |..| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LTECLG-TLNEIMKNTQN---------------ERLNELSAI-----KYAKDIAEGLYFIHSKK-GLVNDLKMDNILIDYNG-NAVVCI . | | .| ...|. . ... | |. .|.. | .|| ..|.|. . |.| .|||.| || | ..| MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKI |
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| Kinase | 20891.AA | Ciliate-E1 | 147-331 | 17 | 5.5e-15 | 45.59 | In-house | 1-202 (202) | Show / Hide |
Range on Protein: 147-331
Range on HMM: 1-202/202
Sequence Identity: 17% (37 aa)
LGQGAQGLVVLAKEKSTN-KRYAIKGINIKD--SKDNVDQVILGQVQQEIKMLNQCKGSPYVVNLLHQIE-GNDFIF-LVLTECLGTLNEIMK-------
.|.| ...|. || ...| . .|.| ||... .... ...| ....|... |. |..... .|. . |. .....| .|.. ..
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQDEI----KEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEY
----NTQNERLNELSAIKYAKDIAEGLYFIHSKKGLVNDLKMDNILIDYNGNAVVC-IPLLSLDQYHSNKQI---NKINQLTLDQLIISPNN--LDMLLM
.... .... .. .... .|| .|... . |.|..||||. .|| | | . . .. ....|.|. . .. . . . .|. . .
WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQYKGYTHYYYPPEQYNCPEQEHNKNQKI
NMQSSFY
|..| |
NYKSDIY
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| Kinase | 20891.AA | ULK | 141-280 | 24 | 1.2e-14 | 47.62 | In-house | 1-166 (329) | Show / Hide |
Range on Protein: 141-280 Range on HMM: 1-166/329 Sequence Identity: 24% (41 aa) YDEFRFLGQGAQGLVVLAKEKST----NKRYAIKGINIK-DSKDNVD---QVILGQVQQEIKMLNQCK---GSPY----VVNLLHQIEGNDF--IFLVLT | . ||.|. | | .. | | |. .|.| | .. ...| . |... ....||| . . | .... .| |.. | .. |.... YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME ECLG-TLNEIMKNTQN--------ERLNELSAIKYAKDIAEGLYFIHSKKGLVNDLKMDNILIDYN | | .| ...|. .. ||.| ||.. |.|..|. ..|... |.| .||||. . YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNG |
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| Kinase | 20891.AA | Ciliate-E2 | 141-287 | 18 | 1.7e-14 | 46.12 | In-house | 1-197 (365) | Show / Hide |
Range on Protein: 141-287 Range on HMM: 1-197/365 Sequence Identity: 18% (37 aa) YDEFRFLGQGAQGLVVLAKEKSTNKRYAIK--------------GINIKDSKDNVDQVILGQVQQEIKMLNQCK---------------GSPYVVNLLHQ |. . .|||..| | ..| ....|..||| . . . .. . . |. |||..... . .|..... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC IE--GNDFIFLVLTECLG-TLNEIMKNT----------QNERLNELSAIKYAKDIAE---------------GLYFIHSKK-GLVNDLKMDNILIDYNGN . .. |.||. | | .| ...|| . ....| .... | |.. .| ..|||. . |.| .|||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----- AVVCI ..| --IKI |
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| Kinase | 20891.AA | CAMKL | 141-286 | 25 | 1.7e-14 | 42.51 | In-house | 1-171 (297) | Show / Hide |
Range on Protein: 141-286 Range on HMM: 1-171/297 Sequence Identity: 25% (43 aa) YDEFRFLGQGAQGLVVLAKE-KSTNKRYAIKGIN--IKDSKDNVDQVILG-------QVQQEIKMLNQCK--GSPYVVNLLHQIEGNDF------IFLVL |. . ||.|. | | ||. . |....||| |. . ...... .| ...||. . . . . | .. |.. || .. |.||. YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM TECLGT---LNEIMKNTQNER--LNELSAIKYAKDIAEGLYFIHSKKGLV-NDLKMDNILIDYNG--NAVVC | | | . .. . | . | | .| . | ......||.. | |.| .|||.|.|| |. .. EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG-IVHRDIKPENILLDENGNNNIKII |
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| Kinase | 20891.AA | S_TKc | 141-460 | 16 | 6e-13 | 13.01 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 141-460
Range on HMM: 1-231/231
Sequence Identity: 16% (57 aa)
YDEFRFLGQGAQGLVVLAKEKSTNKRYAIKGINIKDSKDNVDQVILGQVQQEIKMLNQCKGSPYVVNLLHQIEGNDFIFLVLTECLG---TLNEIMKNTQ
|. | .|.|| | | ....|.|....||| |. ....||..| . . |..|.|. .. |....|. | | .| ...|. .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG
NER----LNELSAIKYAKDIAEGLYFIHSKKGLV-NDLKMDNILIDYNGNAVVC-------IPLLSLDQYHSNKQINKINQLTLDQLIISPNNLDMLLMN
.. ..| | .|.. |...| ..||. | . ||| .|||.| . .| .
RHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------------------------------------
MQSSFYISKKRNEASYSAYLYLQQLIHPKKGNILCQAPECYDSSKFDTYSKEYIKLGIAVKKQPSQ-RSEACSLGYLIYTMISGFQANLVFSKHQPLQYN
. | ||| . . .. |.| ..| |..| |..
--------------------------TTFCGTPWYMAPEVL---------------------GYGKCKCDWWSCGCILYEMLCGYPPFP--------QMQ
ADFQNFNYEKQLRYIIDGLTKFIPRERLKVKEVLI----------I
. |.. .... .|... .. |..|. . |.| .
MMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 20891.AA | STE-Unique | 227-286 | 28 | 8.1e-08 | 23.24 | In-house | 379-452 (616) | Show / Hide |
Range on Protein: 227-286 Range on HMM: 379-452/616 Sequence Identity: 28% (21 aa) GTLNEIMKNTQN-------ERLNELSAIKYAKDIAEGLYFIHSKK--GLVNDLKMDNILIDYNG-----NAVVC ||| .| |.. . | .|.|.. |.||| ..||.. . ||| .||... | ....| GTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKIC |
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| Kinase | 20891.AA | STE-Unique | 142-209 | 23 | 2.2e-07 | 21.65 | In-house | 1-67 (616) | Show / Hide |
Range on Protein: 142-209 Range on HMM: 1-67/616 Sequence Identity: 23% (16 aa) DEFRFLGQGAQGLVVLAKEKSTNKRYAIKGINIKDSKDNVDQVILGQVQQEIKMLNQCKGSPYVVNLL . ..|.|. | |.... |....|.||| | .| || . . || . .. ....|... NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLH-HQNIVKYY |
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| Kinase | 20891.AA | TyrKc | 141-362 | 12 | 0.000165 | -149.72 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 141-362
Range on HMM: 1-280/280
Sequence Identity: 12% (38 aa)
YDEFRFLGQGAQGLVVLAKEKSTNKRYAIKGINIKDSKDNVDQVILGQVQQEIKMLNQC-KGSPYVVNLLHQIEG--------NDFIFLVLTECLGTLNE
. || || | |.... | |.| .. . .|.... . . | .|.|. . .. ..| |..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
IMKNTQNERLNELSAIKYAKDIAEGLYFIHSKKGLVNDLKMDNILIDYNGNAVVCIPLLSLDQYHS-----NKQINKIN---QLT-------------LD
...... |. .... .||.| ..|||. || |.|.. |. . .. || | |. .|. . . .
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY
Q--------------------LIISPN-------NLDMLLMNMQSSFYISKKRNE--------ASYSAYLYLQQLIHP------KKGNILCQA
. .| . ... . | .. . .. | .| | .| .
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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