Gene 21795 (Tetrahymena)
21795
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 21795.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 21795.AA | Ciliate-C7 | 836-998 | 62 | 3.1e-107 | 344.77 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 836-998 Range on HMM: 1-164/164 Sequence Identity: 62% (103 aa) FKYLGQGKQGWVFLAKELSTNRRFAIKGFHVKNSQGQIFQEAFNEAQQESNMLQKCKGSSYVVNLLKKIEGKEFTYLILSECQ-GTLKELIEKNPNKRLN |..||||.||.|.|||. .||.|.||||..|...||.|.|...|..||| |.|..||.|.|||.||...||..|.||.|.||| |||...||.|.||||| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN ELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADNITKTSGYGMNEYA |.||||||||||.||..|||..|. ||||||||||||||||||.|.|||||.|. |.| .|.| EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM |
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| Pkinase | 21795.AA | Pkinase | 833-983 | 23 | 3.1e-22 | 79.69 | Pfam | 1-159 (293) | Show / Hide |
Range on Protein: 833-983 Range on HMM: 1-159/293 Sequence Identity: 23% (39 aa) FSDFKYLGQGKQGWVFLAKELSTNRRFAIKGFHVKNSQGQIFQEAFNEAQQESNMLQKCKGSSYVVNLLKKIEGKEFTYLILSECQGTLKELIEKN---- . . .|.| | |..... .|....|.| . ... . |.... .| ..... .. ..| |. | | |... |.|.|. ... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYIS --PNKRL--NELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNA----VVSDLGLA .... | ...|.. |..|| ..||...| ||| .||||| ||. ..| ||| TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA |
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| Kinase | 21795.AA | Ciliate-E1 | 839-996 | 20 | 4.5e-20 | 62.33 | In-house | 1-169 (202) | Show / Hide |
Range on Protein: 839-996 Range on HMM: 1-169/202 Sequence Identity: 20% (35 aa) LGQGKQGWVFLAKELSTN-RRFAIKGFHVKNSQGQIFQEAFNEAQQESN-MLQKCKGSSYVVNLLKKIEGKE--FTYLILSECQGTLKELIE-------- .|.| .. || || ..| . |.| . | .... |. |.. ..| . ... |. |...... |. .. ....|. .|. .||. .. IGNGSFSIVFKAKQQNNNYNQVAQK---IINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYW ---KNPNKRLNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADNITKTSGYGMNE .. .. .... .. .... .|| .|... | |.|..||||. .|| | .|.|..... . . . ... QQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQY |
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| Kinase | 21795.AA | AGC | 833-983 | 21 | 5.5e-19 | 44.3 | In-house | 1-202 (395) | Show / Hide |
Range on Protein: 833-983 Range on HMM: 1-202/395 Sequence Identity: 21% (43 aa) FSDFKYLGQGKQGWVFLAKEL------STNRRFAIKGFH----VKNSQGQIFQEAFNE--------AQQESNMLQKCKG---------SSYVVN-LLKKI | | .|.| | |.|... .|.. .|.| .. . . . . .| ..| |.|.||.. . ..|. | FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF EGKEF--TYLILSECQ----------G-TLKELIEKN-PNKRLNELSAIKYAKD-------IAEGLLHIHS-QKCISND-LKMDNILIDYNGNAVVSDLG . |. |... .. | | . . ..|..| | || |. .| ..|| .. | | || .|||.| .|. .| | QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG LA |. LC |
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| Kinase | 21795.AA | Ciliate-E2-Unclassified | 833-989 | 17 | 7.8e-19 | 61.97 | In-house | 1-221 (352) | Show / Hide |
Range on Protein: 833-989
Range on HMM: 1-221/352
Sequence Identity: 17% (39 aa)
FSDFKYLGQGKQGWVFLAKELSTNRRFAIKGFHVKNSQG-QIFQEAFNEAQQESNMLQKCK------------------GSSYVVNLLKKIEGKEFTYLI
. | .||| .| |..... ... .|.| ...... .. .. | .| . ... | . ..|... . |. |..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV
LSEC-QGTLKELIEKNPN---------------KRLNELSAI-----KYAKDIAEGLLHIHSQK-CISNDLKMDNILIDYNG---NAVVSDLGLA-----
. | .|.|.. |.|... |.. | |. .|.. | .|| ..|... .| |.| .|||.| || . ..|.|..
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ
----------------DNITKT
.....|
NNNCDTNQQQKMQIWKQQMMWT
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| Kinase | 21795.AA | Ciliate-E2 | 833-988 | 18 | 1.1e-16 | 53.79 | In-house | 1-208 (365) | Show / Hide |
Range on Protein: 833-988 Range on HMM: 1-208/365 Sequence Identity: 18% (40 aa) FSDFKYLGQGKQGWVFLAKELSTNRRFAIK-------------GFHVKNSQGQIFQEA-FNEAQQESNMLQKCK---------------GSSYVVNLLKK . | .||| .| |...| .....|||| .. .| |... .. || ..... . . ..... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC IE--GKEFTYLILSECQG-TLKELIEKNPNKR---------LNELSAIKYAKDIAE---------------GLLHIHSQK-CISNDLKMDNILIDYNGNA . .. ||.. ||| .|...|..|. || ..| .... | |.. .| ..||.. .| |.| .|||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I VVSDLGLADNITK ..|.||. .... KIIDFGLSKKYDD |
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| Kinase | 21795.AA | IRE | 905-982 | 30 | 1.3e-16 | 53.74 | In-house | 63-170 (292) | Show / Hide |
Range on Protein: 905-982 Range on HMM: 63-170/292 Sequence Identity: 30% (33 aa) EGKEFTYLILSECQGTLKELIEK--------------NPNKRLN--------ELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDY--------NGN |...| || |. |||.| ...|. | ||..| .. .. .|....|| | |||. . .||| ||||.. |. EDDQFVYLALELCQGSLQDYVEQKKRNNFINSSNNSNNNNKNNNNNNNQWQIHIRMWQLIKQCMNGLQHLHSQNIVHRDLKPHNILIHMNRPNQHGENNR AVVSDLGL .. ||.|| FMISDFGL |
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| Kinase | 21795.AA | CAMK | 838-983 | 16 | 1.2e-14 | 42.92 | In-house | 1-243 (425) | Show / Hide |
Range on Protein: 838-983 Range on HMM: 1-243/425 Sequence Identity: 16% (39 aa) YLGQGKQGWVFLAKELSTN------------RRFAIKGFHV----------------KNSQGQIF------QEAFNEAQQESNMLQKCKG------SSYV ||.| | |.|... .|. ...||| .. ... .. . ..| ....|..| . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VNLLKKIEG-------------------KEFTYLIL---SECQGT-----LKELIEKNPN-------------KRLNELSAIKYAKDIAEGLLHIHSQKC ..|. .| ... |... |.| | . | .... .|..| | .| . |.... ..||.. IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI ISNDLKMDNILIDYN-----------------GNAVVSDLGLA . ||| .|||.|.| .| ..| |.| VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFA |
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| Kinase | 21795.AA | STE | 833-991 | 17 | 2.5e-14 | 47.12 | In-house | 1-217 (359) | Show / Hide |
Range on Protein: 833-991 Range on HMM: 1-217/359 Sequence Identity: 17% (38 aa) FSDFKYLGQGKQGWVFLAKEL------STNRR---------FAIKGFHVKNSQ-----------GQIFQEAFNEAQQESNMLQKCKG-SSYVVNLLKKIE . . . .|.| | |..|. .|.. .||| ...|.. ....| ... ..| ....||. . ..|. . . WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF GK-------EFTYLILSECQ-GTLKELIE-K-NPNKRLN----------ELSAIKYAKDIAEG-LLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLAD . . .... . |.| ..|. | ..|.|| | ......| .| | ..||.. | |.| .|||. . .| |.. KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG NITK---------------TSG ..|. |.. QLTDSMANIQSNNIIDCIETMQ |
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| Kinase | 21795.AA | CAMKL | 897-983 | 28 | 5.4e-14 | 40.91 | In-house | 77-176 (297) | Show / Hide |
Range on Protein: 897-983 Range on HMM: 77-176/297 Sequence Identity: 28% (29 aa) VVNLLKKIEGKEF------TYLILSECQGT---LKELIEKNPNKR--LNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNG--NAVVSDLGLA .. |. || .|. ||.. |.| | . |.|....| . | | .| . | ... ..||.. . |.| .|||.|.|| |. ..| |.. IIKLYEVIETPEHDIETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS |
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| Kinase | 21795.AA | ULK | 833-983 | 22 | 1.7e-13 | 44.33 | In-house | 1-185 (324) | Show / Hide |
Range on Protein: 833-983 Range on HMM: 1-185/324 Sequence Identity: 22% (43 aa) FSDFKYLGQGKQG-WVFLAKELST---NRRFAIKGFHVKNSQGQIFQEA------FNEAQQESNMLQKCK--GSSY--VVNLLKKIEGK--EFTYLILSE .. . ||.| | |. .. | | .|.| . .. .... . ..| . ..| | . . .| |.. | . ..|.|. YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACK--MIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEY CQG-TLKELIEKNPN-------KRLNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAV------------VSDLGLA |.| .|...|.|| . |||.| ||.. |.|..|. ..|....| |.| .|||| . ..| |.| CNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 21795.AA | S_TKc | 833-1028 | 18 | 2.9e-11 | -11.75 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 833-1028
Range on HMM: 1-231/231
Sequence Identity: 18% (46 aa)
FSDFKYLGQGKQGWVFLAKELSTNRRFAIKGFHVKNSQGQIFQEAFNEAQQESNMLQKCKGSSYVVNLLKKIEGKEFTYLILSECQG---TLKELIEKNP
. . .|.| | |..... .|.|..||| . . ...| ..|.| . ..|.|. .. .. |... | | .|...|.|..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG
NKR----LNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADNITKTS------------GYGM-------------------
.. ..| | .|.. |...| ..||.. | ||| .|||.| . ..| ||| . .| |||
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGY
----NEYAILYISFIKPNFLSFSLFTVRKLV----------ILS-------SRML
...... . .. | . |. .| .
PPFPQMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
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| Kinase | 21795.AA | TyrKc | 833-1028 | 15 | 0.000106 | -146.63 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 833-1028
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)
FSDFKYLGQGKQGWVFLAKELSTNRRFAIKGFHVKNSQGQIFQEAFNEAQQESNMLQKC-KGSSYVVNLLKKIEGKE------FTYLILSE--CQGTLKE
. | || | | |.... . |.| . .|.| .| ... | . .|.|. . .. ..|. | . | ||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDF---MREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
LIEKNPNKRLNELSAIKYAKDIAEGLLHIHSQKCISNDLKMDNILIDYNGNAVVSDLGLADNITKT-------SGYGM----NEY-----------AILY
. |. .| |. .... .||.| ..||..|| || |.|.. |. . .|| ||. .|. . | . .. .| |
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY
I-------------------SFIKPNFLS-----FSLFTVRKLVILS-------S-----------------------------------RML
.. .. | . |...| . . .
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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| Kinase | 21795.AA | CAMKL | 837-862 | 44 | 0.013085 | 3.98 | In-house | 5-31 (297) | Show / Hide |
Range on Protein: 837-862 Range on HMM: 5-31/297 Sequence Identity: 44% (12 aa) KYLGQGKQGWVFLAKE-LSTNRRFAIK | ||.| | | ||. . |... ||| KTLGKGSFGKVKLATHIRTTGEKVAIK |
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