Gene 26374 (Tetrahymena)
26374
Group:
Other
Family:
Ciliate-C7
Sequence
Protein domains of 26374.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | 26374.AA | Ciliate-C7 | 78-240 | 81 | 1.1e-122 | 394.98 | In-house | 1-164 (164) | Show / Hide |
Range on Protein: 78-240 Range on HMM: 1-164/164 Sequence Identity: 81% (133 aa) FRFLGQGAQGLVLLAKNSKTKMRYAIKGVQVRDPEGNIDEDNSNTVRQEIEILKKCGDSPYVVSLLDQFEGKQFSYLVLTECQ-GTLTQILERNQNKRLN |||||||.||||||||..||.||||||||||||..||||.| | |.|||.|||.| ||||||.||.||||.||.||||.||| |||.||.||||||||| FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN EISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFGMADNLTYKSGYAINQYV ||||||||.||||||||||||||.|||||||||||||.|||||.|||.|||||.||.|.||||. EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM |
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| Pkinase | 26374.AA | Pkinase | 75-225 | 29 | 9.7e-28 | 99.17 | Pfam | 1-159 (293) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-159/293 Sequence Identity: 29% (48 aa) YSDFRFLGQGAQGLVLLAKNSKTKMRYAIKGVQVRDPEGNIDEDNSNTVRQEIEILKKCGDSPYVVSLLDQFEGKQFSYLVLTECQG-----TLTQILER | | .|.|. | | .... .| ..|.| . .|. . . |. . .. .||.|.|.. ..|..| |.| || |. |.|. |.| | .... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST NQNKRL--NEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNA----VVSDFGMA ..... | ...|. |..||.|.||.... ||| .||||| .|. ..||| | WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA |
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| Kinase | 26374.AA | CAMKL | 75-225 | 27 | 3.7e-24 | 73.85 | In-house | 1-176 (297) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-176/297 Sequence Identity: 27% (48 aa) YSDFRFLGQGAQGLVLLAKN-SKTKMRYAIKGVQVR----DPEGNID------EDNSNTVRQEIEILKKCG--DSPYVVSLLDQFEGKQF------SYLV | . ||.|. | | ||.. . |. ..||| . . || . |.. .|.||.|.|. | ...|.. .| ... ||| YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV LTECQGT---LTQILERNQNKR--LNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHG--NAVVSDFGMA . |.| | . .... ..| . | | .| | ...|.||.. |.| .|||.|..| |. ..|||.. MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS |
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| Kinase | 26374.AA | AGC | 78-225 | 24 | 5.9e-24 | 57.45 | In-house | 1-202 (395) | Show / Hide |
Range on Protein: 78-225 Range on HMM: 1-202/395 Sequence Identity: 24% (51 aa) FRFL---GQGAQGLVLLAKNS------KTKMRYAIKGVQVRD---------PEGNIDE-------DNSNTVRQEIEILKKCGD---------SPYVVS-L |.|| |.|. | | |.. |. ||.| .. .. | .. | . |..| .||.|| .|..|. | FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGY----VWEERNILEKCNHTHNHPIKSHHPFIVKIL LDQFEGKQF--SYLVLTECQ----------G-TLTQILERN-QNKRLNEISAIKYAND-------IAQGLYYIHS-KNCLVND-LKMDNILIDYHGNAVV |. |. |.|. .. | | ..| ...|..| | || |. .| |.|| .. | || .|||.| .|. HYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKL SDFGMA .|||.. TDFGLC |
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| Kinase | 26374.AA | Ciliate-E2-Unclassified | 75-225 | 24 | 1.3e-22 | 75.28 | In-house | 1-194 (352) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-194/352 Sequence Identity: 24% (47 aa) YSDFRFLGQGAQGLVLLAKNSKTK----MRYAIKGVQVRDPEGNIDEDNSNTVRQEIEILK---------------KCGDSPYVVSLLDQFEGKQFSYLV | . .|||..| | .....|.| | |..| .. . . . . . .|....| . ..|..| ....|. || |.| YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV LTEC-QGTLTQILE---------------RNQNKRLNEISAI-----KYANDIAQGLYYIHSKN-CLVNDLKMDNILIDYHG---NAVVSDFGMA . | .|.| |... ..|.|.. | |. .|. | ||| |.|.|| .. |.| .|||.| | . ..||| . MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS |
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| Kinase | 26374.AA | CAMK | 80-225 | 20 | 1.3e-21 | 65.78 | In-house | 1-243 (425) | Show / Hide |
Range on Protein: 80-225 Range on HMM: 1-243/425 Sequence Identity: 20% (50 aa) FLGQGAQGLVLLAKNSKTK------------MRYAIKGVQV----------------RDPEGNID------EDNSNTVRQEIEILKKCG------DSPYV ||.|. | | |... .|. ..||| . .| ... . . . ||.||||.||. | | . TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VSLLDQFEG-------------------KQFSYLVL---TECQGT------LTQILERNQN------------KRLNEISAIKYANDIAQGLYYIHSKNC ..|.. .| ... |.|. |.| . | |. .. .|..| | .| |.... |.||.| IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI LVNDLKMDNILIDYH-----------------GNAVVSDFGMA ||| .|||.|.. .| ..|||.| VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFA |
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| Kinase | 26374.AA | Ciliate-E1 | 81-238 | 19 | 1.4e-21 | 67.27 | In-house | 1-169 (202) | Show / Hide |
Range on Protein: 81-238 Range on HMM: 1-169/202 Sequence Identity: 19% (34 aa) LGQGAQGLVLLAKNSKTK-MRYAIKGVQVRDPEGNIDEDNSNTVRQEIE-ILKKCGDSPYVVSLLDQFEGKQ--FSYLVLTECQGTLTQILE-------- .|.| ...|. ||. ... .|.| ..... |..... . . .|. |.| |.. ..|... .| ........|. .|.. |. IGNGSFSIVFKAKQQNNNYNQVAQKIINCCF---NYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYW ---RNQNKRLNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFGMADNLTYKSGYAINQ ..... ... .. . .. .|| ..|..| . |.|..||||. || | .||| ...| ... . ... QQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQY |
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| Kinase | 26374.AA | Ciliate-E2 | 75-231 | 20 | 3.4e-21 | 69.51 | In-house | 1-209 (365) | Show / Hide |
Range on Protein: 75-231
Range on HMM: 1-209/365
Sequence Identity: 20% (44 aa)
YSDFRFLGQGAQGLVLLAKNSKTK-----------------------MRYAIKGVQVRDPEGNIDEDNSN--------TVRQEIEILKKCGDSPYVVSLL
| . .|||..| | ..|. |.. . ||.| .. .. | |.. . .| .||.. ..|... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKI-NEKNILEQL-NHPNIIKMY
DQFE--GKQFSYLVLTECQG-TLTQILERN----------QNKRLNEISAIKYANDIAQ---------------GLYYIHSKN-CLVNDLKMDNILIDYH
. |. .. |||. ||| .| .... | . |...| .... |.| .| |.|||| .. |.| .|||.
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---
GNAVVSDFGMADNLTYK
..|||.. ... .
--IKIIDFGLSKKYDDD
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| Kinase | 26374.AA | STE | 75-223 | 21 | 1.9e-19 | 65.39 | In-house | 1-192 (359) | Show / Hide |
Range on Protein: 75-223 Range on HMM: 1-192/359 Sequence Identity: 21% (42 aa) YSDFRFLGQGAQGLVLLAKNSK---------------TKMRYAIKGVQVRDPE-----------GNIDEDNSNTVRQEIEILKKCGD-SPYVVSLLDQFE . . ...|.|| | | .|.| | |. ..||| . ... . |..... . . .||.|.||| . .|..| .. .. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF GK-------QFSYLVLTECQ-GTLTQILE------RNQN------KRLNEISAIKYANDIAQG-LYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFG . . .... . |.|..|.. ...| .|..| .... .| .| |||.||.. |.| .|||. . .||| KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFG |
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| Kinase | 26374.AA | ULK | 75-225 | 25 | 4.2e-18 | 59.85 | In-house | 1-189 (329) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-189/329 Sequence Identity: 25% (49 aa) YSDFRFLGQGAQGLVLLAKNSKTK----MRYAIKGVQVRDPEGNIDEDNSN------TVRQEIEILKKCGD---SPY----VVSLLDQFEGKQF--SYLV |. . ||.|. | | ..| ||| .|.| .. . |....... ...||.|.|| . ... .| |.| || ... |.. YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACK--MIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII LTECQG-TLTQILERNQN--------KRLNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAV------------VSDFGMA . |.| .| |....|.. |||.| ||.. .|..|. ..|..|. |.| .||||. . ..||| | MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 26374.AA | ULK | 75-225 | 25 | 1.5e-17 | 58.9 | In-house | 1-185 (324) | Show / Hide |
Range on Protein: 75-225 Range on HMM: 1-185/324 Sequence Identity: 25% (49 aa) YSDFRFLGQGAQG-LVLLAKNSKT---KMRYAIKGVQ--------VRDPEGNIDEDNSNTVRQEIEILKKCG--DSPY--VVSLLDQFEGK--QFSYLVL |. . ||.|. | | ..| || . .|.| .. ... | . . ..||.|.|| .|. .| |.| || . . |... YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQE-G---QYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIM TECQG-TLTQILERNQN-------KRLNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAV------------VSDFGMA |.| .| |....|.. |||.| ||.. .|..|. ..|..|. |.| .|||| . ..||| | EYCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA |
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| Kinase | 26374.AA | S_TKc | 75-240 | 19 | 3.8e-11 | -13.37 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 75-240
Range on HMM: 1-231/231
Sequence Identity: 19% (50 aa)
YSDFRFLGQGAQGLVLLAKNSKTKMRYAIKGVQVRDPEGNIDEDNSNTVRQEIEILKKCGDSPYVVSLLDQFEGKQFSYLVLTECQG---TLTQILERNQ
| | .|.|| | | .... ||. ..||| . ...|.||.|||| . |..| |.| |. .. |.|. | | .| .......
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG
NKR----LNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFGMA--------------------DN--------------------
.. ..| | .|. |...| |.||.. . ||| .|||.| . ..|||.| .
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYP
------------------------LTYK------SGYAIN--------QYV
|.. | . ...
PFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | 26374.AA | TyrKc | 75-240 | 14 | 8.5e-05 | -145.08 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 75-240
Range on HMM: 1-280/280
Sequence Identity: 14% (42 aa)
YSDFRFLGQGAQGLVLLAKNSKTKMRYAIKGVQVRDPEGNIDEDNSNTVRQEIEILKKCG-DSPYVVSLLDQFEGKQ------FSYLVLTE--CQGTLTQ
. . || || | | ... . . |.| .. ..|..|..| | . | .| |. .. .....| . | | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD
ILERNQNKRLNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFGMADNL-----------TYK-----SG----------------
| ....| |. .... .||.| |.||||| || |.|.. . . .||||.. .. .|. .|
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY
--------------------------YAI-------------------------N-----------------------------------QYV
| | ..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
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