Gene 29524 (Tetrahymena)

29524

Species: Tetrahymena
Alias: PreTt29524, TTHERM_01504060, 429.m00006, 64, 29524
External Links: Tetrahymena Genome Database (TGD)
Annotation:

Classification

Group: Other
Family: Ciliate-C7

Sequence

Name Sequence Type Origin Length Description Download
29524.AA Protein None 258 None Fasta, JSON
29524.kin_dom Protein Kinase Domain None 166 None Fasta, JSON
29524.NA RNA None 777 None Fasta, JSON

Protein domain

Protein domains of 29524.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 29524.AA Ciliate-C7 96-258 79 1.5e-122 394.52 In-house 1-164 (164) Show / Hide 
Range on Protein: 96-258
Range on HMM: 1-164/164
Sequence Identity: 79% (131 aa)

FRFLGQGAQGLVLLAKNSKTKMRYAIKGVQVRDSEGNIDEDLSNTVRQEVEILKKCGGSPYVVSLLDQFEGKQFSYLVLTECQ-GTLTQILERNQNKRLN
|||||||.||||||||..||.||||||||||||..||||.|. | |.||..|||.| .|||||.||.||||.||.||||.||| |||.||.|||||||||
FRFLGQGQQGLVLLAKDQKTNMRYAIKGVQVRDKQGNIDQDINNQVQQEINILKQCKDSPYVVCLLHQFEGQQFIYLVLNECQGGTLNQIIERNQNKRLN

EISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFGMADNLTYKSGYAINQYV
||||||||.||||||||||||||.|||||||||||||.|||||.|||.|||||.||.|.||||.
EISAIKYAKDIAQGLYYIHSKNCVVNDLKMDNILIDYNGNAVVCDFGLADNLTQKSKYQINQYM
Pkinase 29524.AA Pkinase 93-243 29 8.8e-27 95.77 Pfam 1-159 (293) Show / Hide 
Range on Protein: 93-243
Range on HMM: 1-159/293
Sequence Identity: 29% (47 aa)

YSDFRFLGQGAQGLVLLAKNSKTKMRYAIKGVQVRDSEGNIDEDLSNTVRQEVEILKKCGGSPYVVSLLDQFEGKQFSYLVLTECQG-----TLTQILER
|   | .|.|. | | .... .|  ..|.| . .|. . . |. . ..  .|..|.|.. ..|..| |.| || |.  |.|.  |.|      |  ....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

NQNKRL--NEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNA----VVSDFGMA
 .....   |  ...|.  |..||.|.||....  ||| .||||| .|.      ..||| |
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA
Kinase 29524.AA AGC 96-243 24 3.4e-25 60.72 In-house 1-202 (395) Show / Hide 
Range on Protein: 96-243
Range on HMM: 1-202/395
Sequence Identity: 24% (51 aa)

FRFL---GQGAQGLVLLAKNS------KTKMRYAIKGVQVRD---------SEGNIDE-------DLSNTVRQEVEILKKCGG---------SPYVVS-L
|.||   |.|. | | |..         |.  ||.| .. ..          | .. |       .    |..| .||.|| .         .|..|. |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGY----VWEERNILEKCNHTHNHPIKSHHPFIVKIL

LDQFEGKQF--SYLVLTECQ----------G-TLTQILERN-QNKRLNEISAIKYAND-------IAQGLYYIHS-KNCLVND-LKMDNILIDYHGNAVV
   |. |.    |.|.  ..          |  | ..|    ...|..|  |  ||         |. .| |.|| ..    | || .|||.| .|.   
HYSFQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKL

SDFGMA
.|||..
TDFGLC
Kinase 29524.AA CAMKL 93-243 25 1.9e-23 71.57 In-house 1-176 (297) Show / Hide 
Range on Protein: 93-243
Range on HMM: 1-176/297
Sequence Identity: 25% (45 aa)

YSDFRFLGQGAQGLVLLAKN-SKTKMRYAIKGVQ--VRDSEGNID--------EDLSNTVRQEVEILKKCG--GSPYVVSLLDQFEGKQF------SYLV
|   . ||.|. | | ||.. . |. ..||| .       . ...        |.    .|.|..|.|.    . | ...|.. .| ...       |||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LTECQGT---LTQILERNQNKR--LNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHG--NAVVSDFGMA
.  |.|    | . .... ..|  . |  | .|   |  ...|.||..    |.| .|||.|..|  |. ..|||..
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFS
Kinase 29524.AA Ciliate-E2-Unclassified 93-243 24 8.1e-22 72.48 In-house 1-194 (352) Show / Hide 
Range on Protein: 93-243
Range on HMM: 1-194/352
Sequence Identity: 24% (48 aa)

YSDFRFLGQGAQGLVLLAKNSKTKMRY------AIKGVQVRDSEGNIDEDLSNTVRQEVEILK---------------KCGGSPYVVSLLDQFEGKQFSY
|   . .|||..| | .....|.|  |        . .. . .  | | ...|   .|....|               .   .|..| ....|. ||  |
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMN-EMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY

LVLTEC-QGTLTQILE---------------RNQNKRLNEISAI-----KYANDIAQGLYYIHSKN-CLVNDLKMDNILIDYHG---NAVVSDFGMA
.|.  | .|.| |...               ..|.|.. |  |.     .|.  | ||| |.|.|| ..  |.| .|||.|  |   .  ..||| .
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS
Kinase 29524.AA CAMK 98-243 19 1.1e-21 66.07 In-house 1-243 (425) Show / Hide 
Range on Protein: 98-243
Range on HMM: 1-243/425
Sequence Identity: 19% (48 aa)

FLGQGAQGLVLLAKNSKTK------------MRYAIKGVQVRDSEGNI----------------------DEDLSNTVRQEVEILKKCGG------SPYV
 ||.|. | | |... .|.             ..||| .  .   ..                       ..     ||.|.||.||. |       | .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSLLDQFEG-------------------KQFSYLVL---TECQGT------LTQILERNQN------------KRLNEISAIKYANDIAQGLYYIHSKNC
..|.. .|                    ... |.|.     |.|       .  | |. ..            .|..|  | .|   |.... |.||.| 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LVNDLKMDNILIDYH-----------------GNAVVSDFGMA
   ||| .|||.|..                 .|  ..|||.|
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFA
Kinase 29524.AA Ciliate-E1 99-256 18 5.7e-21 65.28 In-house 1-169 (202) Show / Hide 
Range on Protein: 99-256
Range on HMM: 1-169/202
Sequence Identity: 18% (32 aa)

LGQGAQGLVLLAKNSKTK-MRYAIKGVQVRDSEGNIDEDLSNTVRQEVEILKKCGGSPYVVSLLDQFEGKQ--FSYLVLTECQGTLTQILE---------
.|.| ...|. ||. ...   .|.| ..... .  ....  .  ... .|.|   .  |.. ..|... .|  ........|. .|.. |.         
IGNGSFSIVFKAKQQNNNYNQVAQKIINCCFNYNQNHFQ--DEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCCSLKDYLQNHNRLEYWQ

--RNQNKRLNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFGMADNLTYKSGYAINQ
  ..... ...   .. . .. .|| ..|..| .  |.|..||||.  || | .||| ...| ... . ...
QCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQNILINNQGNYVYCDFGISKFLKNNQNQQCQY
Kinase 29524.AA Ciliate-E2 93-249 20 5.5e-20 65.27 In-house 1-209 (365) Show / Hide 
Range on Protein: 93-249
Range on HMM: 1-209/365
Sequence Identity: 20% (44 aa)

YSDFRFLGQGAQGLVLLAKNSKTKMRYAIK-------------GVQ--------VRDSEGNIDEDLSNTVR---------QEVEILKKCGGSPYVVSLLD
|   . .|||..| | ..|. |.. ..|||             .|.        .. .. .. .   .  |         .| .||..   .|... . .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLN-HPNIIKMYE

QFE--GKQFSYLVLTECQG-TLTQILERN----------QNKRLNEISAIKYANDIAQ---------------GLYYIHSKN-CLVNDLKMDNILIDYHG
 |.   ..  |||.  ||| .| .... |          . |...|  ....   |.|               .| |.|||| ..  |.| .|||.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

NAVVSDFGMADNLTYK
   ..|||.. ... .
-IKIIDFGLSKKYDDD
Kinase 29524.AA ULK 93-243 25 1.4e-19 65.12 In-house 1-189 (329) Show / Hide 
Range on Protein: 93-243
Range on HMM: 1-189/329
Sequence Identity: 25% (48 aa)

YSDFRFLGQGAQGLVLLAKNSKTK----MRYAIKGVQ---VRDSE----GNIDEDLSNTVRQEVEILKKCG---GSPY----VVSLLDQFEGKQF--SYL
|.  . ||.|. | |  ..| |||      .|.| ..    . ..    |   . . . ...|..|.||     ....    .| |.| || ...   |.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEG---QYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYI

VLTECQG-TLTQILERNQN--------KRLNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAV------------VSDFGMA
..  |.| .| |....|..        |||.|  ||..  .|..|. ..|..|.   |.| .||||. .                ..||| |
IMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA
Kinase 29524.AA ULK 93-243 26 2.8e-18 61.52 In-house 1-185 (324) Show / Hide 
Range on Protein: 93-243
Range on HMM: 1-185/324
Sequence Identity: 26% (49 aa)

YSDFRFLGQGAQG-LVLLAKNSKT---KMRYAIKGVQ---VRD--SE--GNIDEDLSNTVRQEVEILKKCG--GSPY--VVSLLDQFEGK--QFSYLVLT
|.  . ||.|. |  |  ..| ||   .  .|.| ..    ..  .|  |   . . .  ..|..|.||     .|.  .| |.| || .   . |... 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEG---QYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIME

ECQG-TLTQILERNQN-------KRLNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAV------------VSDFGMA
 |.| .| |....|..       |||.|  ||..  .|..|. ..|..|.   |.| .||||  .                ..||| |
YCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFA
Kinase 29524.AA STE 93-241 20 1.1e-17 59.07 In-house 1-192 (359) Show / Hide 
Range on Protein: 93-241
Range on HMM: 1-192/359
Sequence Identity: 20% (41 aa)

YSDFRFLGQGAQGLVLLAKNSK---------------TKMRYAIKGVQVRDSE-----------GNIDEDLSNTVRQEVEILKKCGG-SPYVVSLLDQFE
. . ...|.|| | | .|.| |               |. ..||| . .....            |....  . . .|..|.|||   .|..|  .. ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

GK-------QFSYLVLTECQ-GTLTQILE------RNQN------KRLNEISAIKYANDIAQG-LYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFG
 .       .  ....  .  |.|..|..      ...|      .|..|   .... .| .| |||.||..    |.| .|||.     .  .|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFG
Kinase 29524.AA S_TKc 93-258 19 6.3e-11 -16.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 93-258
Range on HMM: 1-231/231
Sequence Identity: 19% (49 aa)

YSDFRFLGQGAQGLVLLAKNSKTKMRYAIKGVQVRDSEGNIDEDLSNTVRQEVEILKKCGGSPYVVSLLDQFEGKQFSYLVLTECQG---TLTQILERNQ
|   | .|.|| | | .... ||. ..||| .              ...|.|..||||  . |..| |.| |.  .. |.|.  | |   .| .......
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

NKR----LNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFGMA--------------------DN--------------------
 ..    ..|  | .|.  |...| |.||.. .  ||| .|||.|   .  ..|||.|                    .                     
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYP

------------------------LTYK------SGYAIN--------QYV
                        |..          | .        ...
PFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 29524.AA TyrKc 93-258 14 0.000237 -152.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 93-258
Range on HMM: 1-280/280
Sequence Identity: 14% (42 aa)

YSDFRFLGQGAQGLVLLAKNSKTKMRYAIKGVQVRDSEGNIDEDLSNTVRQEVEILKKCG-GSPYVVSLLDQFEGKQ------FSYLVLTE--CQGTLTQ
 .  . || || | | ... .   .  |.| ..                ..| .|..| |   | .| |.     ..        .....|  . | | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

ILERNQNKRLNEISAIKYANDIAQGLYYIHSKNCLVNDLKMDNILIDYHGNAVVSDFGMADNL-----------TYK-----SG----------------
 | ....| |.    .... .||.|  |.|||||   ||   |.|..  . . .||||.. ..           .|.     .|                
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

--------------------------YAI-------------------------N-----------------------------------QYV
                          |                           |                                   .. 
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF